The aim: to determine the initial indicators of bone mineral density in children and adolescents with fractures of long bones, to assess the status of vitamin D. Methods. We studied the data of densitometric and laboratory methods of studying 46 sick children (39 (84.8%) boys and 7 (15.2%) girls) with long bone fractures at the age from 6 to 18 years. Bone mineral density was assessed by the method of dual-energy X-ray absorptiometry on a bone densitometer using the Eurasian regulatory database. Results. In 9 sick children with fractures, osteopenia of the I degree was revealed, in one patient - osteopenia of the II degree, in 5 patients - osteoporosis of the I degree, in the remaining 31 children the indicators of bone mineral density corresponded to normal values. Low calcium levels in 56.4% of boys and 57.1% of girls, along with increased alkaline phosphatase activity in 94.8% of boys and 100% of girls, testified to impaired bone formation. The results showed that 61.5% of boys were deficient and 57.1% of girls were deficient in vitamin D. Conclusion. Low bone mineral density, the presence of hypovitaminosis D in children and adolescents with low-energy fractures, given the importance of these indicators for fracture healing, require correction of the revealed violations: the choice of more gentle treatment methods, the appointment of adequate drug therapy, dynamic monitoring of the effectiveness of the prescribed therapy, and in children with a confirmed diagnosis of osteoporosis - studies of bone mineral density in dynamics. Key words: bone mineral density, low-energy fractures of long bones, hypovitaminosis D, osteoporosis, fractures in children and adolescents, Uzbekistan.
Autologous implantation of BMP2-expressing dermal fibroblasts to improve bone mineral density and architecture in rabbit long bones
