Faculty Opinions recommendation of Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation.

2015 ◽  
Author(s):  
Anna Gloyn ◽  
Natasha Hui Jin Ng
Keyword(s):  
Gastric Bypass ◽  
Fat Mass ◽  
Gut Microbiome ◽  
Vertical Banded Gastroplasty ◽  
Human Gut ◽  
Banded Gastroplasty ◽  
Human Gut Microbiome ◽  
Long Term Changes

scholarly journals Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation

2015 ◽  
Vol 22 (2) ◽  
pp. 228-238 ◽  
Author(s):  
Valentina Tremaroli ◽  
Fredrik Karlsson ◽  
Malin Werling ◽  
Marcus Ståhlman ◽  
Petia Kovatcheva-Datchary ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Fat Mass ◽  
Gut Microbiome ◽  
Vertical Banded Gastroplasty ◽  
Human Gut ◽  
Banded Gastroplasty ◽  
Human Gut Microbiome ◽  
Long Term Changes

scholarly journals Taxonomic signatures of cause-specific mortality risk in human gut microbiome

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Aaro Salosensaari ◽  
Ville Laitinen ◽  
Aki S. Havulinna ◽  
Guillaume Meric ◽  
Susan Cheng ◽  
...  
Keyword(s):  
Mortality Risk ◽  
Gut Microbiome ◽  
Human Gut ◽  
Cross Sectional ◽  
Microbiome Composition ◽  
Human Gut Microbiome ◽  
Non Invasive ◽  
Sequencing Technologies

AbstractThe collection of fecal material and developments in sequencing technologies have enabled standardised and non-invasive gut microbiome profiling. Microbiome composition from several large cohorts have been cross-sectionally linked to various lifestyle factors and diseases. In spite of these advances, prospective associations between microbiome composition and health have remained uncharacterised due to the lack of sufficiently large and representative population cohorts with comprehensive follow-up data. Here, we analyse the long-term association between gut microbiome variation and mortality in a well-phenotyped and representative population cohort from Finland (n = 7211). We report robust taxonomic and functional microbiome signatures related to the Enterobacteriaceae family that are associated with mortality risk during a 15-year follow-up. Our results extend previous cross-sectional studies, and help to establish the basis for examining long-term associations between human gut microbiome composition, incident outcomes, and general health status.

scholarly journals Temporospatial shifts in the human gut microbiome and metabolome after gastric bypass surgery

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Zehra Esra Ilhan ◽  
John K. DiBaise ◽  
Sydney E. Dautel ◽  
Nancy G. Isern ◽  
Young-Mo Kim ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Gut Microbiome ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Human Gut ◽  
Human Gut Microbiome

Long-term results of a randomized clinical trial comparing Roux-en-$\hbox{Y}$ gastric bypass with vertical banded gastroplasty

2012 ◽  
Vol 100 (2) ◽  
pp. 222-230 ◽  
Author(s):  
M. Werling ◽  
L. Fändriks ◽  
P. Björklund ◽  
A. Maleckas ◽  
J. Brandberg ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Gastric Bypass ◽  
Randomized Clinical Trial ◽  
Vertical Banded Gastroplasty ◽  
Long Term Results ◽  
Banded Gastroplasty

scholarly journals The Unique Impact of COVID-19 on Human Gut Microbiome Research

2021 ◽  
Vol 8 ◽  
Author(s):  
Ella Burchill ◽  
Eva Lymberopoulos ◽  
Elisa Menozzi ◽  
Sanjay Budhdeo ◽  
James R. McIlroy ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Gut Microbiome ◽  
Indirect Effects ◽  
Population Level ◽  
Faecal Microbiota ◽  
Human Gut ◽  
Human Gut Microbiome ◽  
Microbiome Research ◽  
Potential Impact

The coronavirus (COVID-19) pandemic has disrupted clinical trials globally, with unique implications for research into the human gut microbiome. In this mini-review, we explore the direct and indirect influences of the pandemic on the gut microbiome and how these can affect research and clinical trials. We explore the direct bidirectional relationships between the COVID-19 virus and the gut and lung microbiomes. We then consider the significant indirect effects of the pandemic, such as repeated lockdowns, increased hand hygiene, and changes to mood and diet, that could all lead to longstanding changes to the gut microbiome at an individual and a population level. Together, these changes may affect long term microbiome research, both in observational as well as in population studies, requiring urgent attention. Finally, we explore the unique implications for clinical trials using faecal microbiota transplants (FMT), which are increasingly investigated as potential treatments for a range of diseases. The pandemic introduces new barriers to participation in trials, while the direct and indirect effects laid out above can present a confounding factor. This affects recruitment and sample size, as well as study design and statistical analyses. Therefore, the potential impact of the pandemic on gut microbiome research is significant and needs to be specifically addressed by the research community and funders.

scholarly journals Establishing What Constitutes a Healthy Human Gut Microbiome: State of the Science, Regulatory Considerations, and Future Directions

2019 ◽  
Vol 149 (11) ◽  
pp. 1882-1895 ◽  
Author(s):  
Michael I McBurney ◽  
Cindy Davis ◽  
Claire M Fraser ◽  
Barbara O Schneeman ◽  
Curtis Huttenhower ◽  
...  
Keyword(s):  
Human Health ◽  
Gut Microbiome ◽  
Interindividual Variation ◽  
Sufficient Evidence ◽  
Human Gut ◽  
Future Studies ◽  
Human Gut Microbiome ◽  
Host Health ◽  
Short And Long Term

ABSTRACTOn December 17, 2018, the North American branch of the International Life Sciences Institute (ILSI North America) convened a workshop “Can We Begin to Define a Healthy Gut Microbiome Through Quantifiable Characteristics?” with >40 invited academic, government, and industry experts in Washington, DC. The workshop objectives were to 1) develop a collective expert assessment of the state of the evidence on the human gut microbiome and associated human health benefits, 2) see if there was sufficient evidence to establish measurable gut microbiome characteristics that could serve as indicators of “health,” 3) identify short- and long-term research needs to fully characterize healthy gut microbiome–host relationships, and 4) publish the findings. Conclusions were as follows: 1) mechanistic links of specific changes in gut microbiome structure with function or markers of human health are not yet established; 2) it is not established if dysbiosis is a cause, consequence, or both of changes in human gut epithelial function and disease; 3) microbiome communities are highly individualized, show a high degree of interindividual variation to perturbation, and tend to be stable over years; 4) the complexity of microbiome-host interactions requires a comprehensive, multidisciplinary research agenda to elucidate relationships between gut microbiome and host health; 5) biomarkers and/or surrogate indicators of host function and pathogenic processes based on the microbiome need to be determined and validated, along with normal ranges, using approaches similar to those used to establish biomarkers and/or surrogate indicators based on host metabolic phenotypes; 6) future studies measuring responses to an exposure or intervention need to combine validated microbiome-related biomarkers and/or surrogate indicators with multiomics characterization of the microbiome; and 7) because static genetic sampling misses important short- and long-term microbiome-related dynamic changes to host health, future studies must be powered to account for inter- and intraindividual variation and should use repeated measures within individuals.

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