Faculty Opinions recommendation of Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6.

Author(s):  
Andrius Kazlauskas
2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Kevin P. Mouillesseaux ◽  
David S. Wiley ◽  
Lauren M. Saunders ◽  
Lyndsay A. Wylie ◽  
Erich J. Kushner ◽  
...  

2007 ◽  
Vol 25 (4) ◽  
pp. 221-228
Author(s):  
Petra Sternberg ◽  
Daniel K. Struve

Abstract A major goal in the production of tree whips is to produce appropriately sized, well-branched liners with a crown form similar to that of a mature tree. Pruning is used to induce lateral branching. This can result in poor tree quality, reduced growth and the practice is labor intensive. An alternative to mechanical pruning, foliar Cyclanilide® (CYC) sprays at 0, 56, 1 12 and 223 ppm were applied to container grown whips to determine its effect on branching of Amelanchier; Cercis, Malus and Tilia whips. Most species responded to CYC sprays with increased lateral branching if treated during active shoot elongation. Cyclanilide® sprays of 1 12 ppm produced the greatest number of branches. Sprays at 56 ppm resulted in reduced branching (relative to 112 ppm), while sprays of 223 ppm did not increase the number of branches, relative to sprays of 112 ppm, but reduced growth. Cyclanilide® sprays reduced height growth, relative to untreated whips, but did not alter height diameter growth. Cyclanilide® foliar applications to container -grown whips during periods of active shoot elongation increased branching in one-year-old whips that normally do not branch until the second year of production. Further, the origin of lateral branching can be controlled by timing of CYC application. The results indicate that CYC foliar sprays can be an important tool in the production of one-year-old branched whips.


2021 ◽  
pp. 2102661
Author(s):  
Ariel A. Szklanny ◽  
Majd Machour ◽  
Idan Redenski ◽  
Václav Chochola ◽  
Idit Goldfracht ◽  
...  

2017 ◽  
Vol 14 (127) ◽  
pp. 20160992 ◽  
Author(s):  
B. Zeller-Plumhoff ◽  
T. Roose ◽  
G. F. Clough ◽  
P. Schneider

The supply of oxygen in sufficient quantity is vital for the correct functioning of all organs in the human body, in particular for skeletal muscle during exercise. Disease is often associated with both an inhibition of the microvascular supply capability and is thought to relate to changes in the structure of blood vessel networks. Different methods exist to investigate the influence of the microvascular structure on tissue oxygenation, varying over a range of application areas, i.e. biological in vivo and in vitro experiments, imaging and mathematical modelling. Ideally, all of these methods should be combined within the same framework in order to fully understand the processes involved. This review discusses the mathematical models of skeletal muscle oxygenation currently available that are based upon images taken of the muscle microvasculature in vivo and ex vivo . Imaging systems suitable for capturing the blood vessel networks are discussed and respective contrasting methods presented. The review further informs the association between anatomical characteristics in health and disease. With this review we give the reader a tool to understand and establish the workflow of developing an image-based model of skeletal muscle oxygenation. Finally, we give an outlook for improvements needed for measurements and imaging techniques to adequately investigate the microvascular capability for oxygen exchange.


2020 ◽  
Vol 21 (11) ◽  
pp. 3790
Author(s):  
Greg Hutchings ◽  
Krzysztof Janowicz ◽  
Lisa Moncrieff ◽  
Claudia Dompe ◽  
Ewa Strauss ◽  
...  

Neovascularization and angiogenesis are vital processes in the repair of damaged tissue, creating new blood vessel networks and increasing oxygen and nutrient supply for regeneration. The importance of Adipose-derived Mesenchymal Stem Cells (ASCs) contained in the adipose tissue surrounding blood vessel networks to these processes remains unknown and the exact mechanisms responsible for directing adipogenic cell fate remain to be discovered. As adipose tissue contains a heterogenous population of partially differentiated cells of adipocyte lineage; tissue repair, angiogenesis and neovascularization may be closely linked to the function of ASCs in a complex relationship. This review aims to investigate the link between ASCs and angiogenesis/neovascularization, with references to current studies. The molecular mechanisms of these processes, as well as ASC differentiation and proliferation are described in detail. ASCs may differentiate into endothelial cells during neovascularization; however, recent clinical trials have suggested that ASCs may also stimulate angiogenesis and neovascularization indirectly through the release of paracrine factors.


2017 ◽  
Vol 11 (6) ◽  
pp. 883-894 ◽  
Author(s):  
Naomichi Furushiro ◽  
Hideo Yokota ◽  
Sakiko Nakamura ◽  
Kazuhiro Fujisaki ◽  
Yutaka Yamagata ◽  
...  

This study aims to verify whether the three-dimensional internal information acquisition system we have developed can be applied successfully to the microstructures of consecutively precision-machined biological samples, and to those of metallic samples. Therefore, this study mainly deals with biological hard tissue samples like bones. In this paper, we first studied the precision-machining characteristics of bones. From this, we determined that, to obtain machined surfaces sufficient for internal observations, we need to determine the maximum uncut chip thickness and the cutting speeds, taking the bone’s anisotropy into consideration. Next, we acquired three-dimensional internal information on consecutively precision-machined bone samples using the three-dimensional internal acquisition system we developed. Subsequently, we visualized the internal structures of these machined samples. Our tiling observations acquired an 18×9×3 mm segment as a 6.2×6.2×10μm resolution image. We obtained a three-dimensionally reconstructed image of complex blood vessel networks inside the bone by making the acquired images binary.


2020 ◽  
Vol 5 (6) ◽  
pp. 2000103 ◽  
Author(s):  
Yih Yang Chen ◽  
Benjamin R. Kingston ◽  
Warren C. W. Chan

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