Faculty Opinions recommendation of Newborn antibodies to SARS-CoV-2 detected in cord blood after maternal vaccination - a case report.

2021 ◽

Vol 21 (1) ◽

Author(s):

Gilbert Paul ◽

Rudnick Chad

Keyword(s):

Single Dose ◽

Case Report ◽

Severe Acute Respiratory Syndrome ◽

Cord Blood ◽

Messenger Rna ◽

Igg Antibodies ◽

Case Presentation ◽

Safety And Efficacy ◽

Maternal Vaccination ◽

Placental Passage

Abstract Background Maternal vaccination for Influenza and Tetanus, Diphtheria, acellular Pertussis (TDaP) have been well studied in terms of safety and efficacy for protection of the newborn by placental passage of antibodies. Similar newborn protection would be expected after maternal vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). There is a significant and urgent need for research regarding safety and efficacy of vaccination against SARS-CoV-2 during pregnancy. Case presentation A vigorous, healthy, full-term female was born to a COVID-19 naïve mother who had received a single dose of messenger RNA (mRNA) vaccine for SARS-CoV-2 3 weeks prior to delivery. IgG cord blood antibodies were detected to SARS-CoV-2 at the time of birth. Conclusion Here, we report the first known case of an infant with SARS-CoV-2 IgG antibodies detectable in cord blood after maternal vaccination.

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Immune and hematopoietic reconstitution after transplantation of cord blood progenitor cells: case report and review of the literature

Leukemia ◽

10.1038/sj.leu.2401738 ◽

2000 ◽

Vol 14 (5) ◽

pp. 931-934 ◽

Cited By ~ 8

Author(s):

R Elhasid ◽

M Weyl Ben Arush ◽

S Pollack ◽

K Tavor ◽

S Streichman ◽

...

Keyword(s):

Case Report ◽

Cord Blood ◽

Progenitor Cells ◽

Review Of The Literature ◽

Hematopoietic Reconstitution

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A Case Report to Assess Passive Immunity in a COVID Positive Pregnant Patient

American Journal of Perinatology ◽

10.1055/s-0040-1715643 ◽

2020 ◽

Vol 37 (12) ◽

pp. 1280-1282

Author(s):

Lorraine E. Toner ◽

Shari E. Gelber ◽

Juan A. Pena ◽

Nathan S. Fox ◽

Andrei Rebarber

Keyword(s):

Case Report ◽

Cord Blood ◽

Pregnant Patient ◽

Passive Immunity ◽

Molecular Testing ◽

Transplacental Passage ◽

Blood Samples ◽

Key Points ◽

Fetal Cord Blood ◽

Red Blood Cell Isoimmunization

Introduction Data regarding transplacental passage of maternal coronavirus disease 2019 (COVID-19) antibodies and potential immunity in the newborn is limited. Case Report We present a 25-year-old multigravida with known red blood cell isoimmunization, who was found to be COVID-19 positive at 27 weeks of gestation while undergoing serial periumbilical blood sampling and intrauterine transfusions. Maternal COVID-19 antibody was detected 2 weeks after positive molecular testing. Antibodies were never detected on cord blood samples from two intrauterine fetal cord blood samples as well as neonatal cord blood at the time of delivery. Conclusion This case demonstrates a lack of passive immunity of COVID-19 antibodies from a positive pregnant woman to her fetus, neither in utero nor at the time of birth. Further studies are needed to understand if passage of antibodies can occur and if that can confer passive immunity in the newborn. Key Points

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