scholarly journals Newborn antibodies to SARS-CoV-2 detected in cord blood after maternal vaccination – a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Gilbert Paul ◽  
Rudnick Chad
Keyword(s):  
Single Dose ◽  
Case Report ◽  
Severe Acute Respiratory Syndrome ◽  
Cord Blood ◽  
Messenger Rna ◽  
Igg Antibodies ◽  
Case Presentation ◽  
Safety And Efficacy ◽  
Maternal Vaccination ◽  
Placental Passage

Abstract Background Maternal vaccination for Influenza and Tetanus, Diphtheria, acellular Pertussis (TDaP) have been well studied in terms of safety and efficacy for protection of the newborn by placental passage of antibodies. Similar newborn protection would be expected after maternal vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). There is a significant and urgent need for research regarding safety and efficacy of vaccination against SARS-CoV-2 during pregnancy. Case presentation A vigorous, healthy, full-term female was born to a COVID-19 naïve mother who had received a single dose of messenger RNA (mRNA) vaccine for SARS-CoV-2 3 weeks prior to delivery. IgG cord blood antibodies were detected to SARS-CoV-2 at the time of birth. Conclusion Here, we report the first known case of an infant with SARS-CoV-2 IgG antibodies detectable in cord blood after maternal vaccination.

scholarly journals Newborn Antibodies to SARS-CoV-2 detected in cord blood after maternal vaccination

2021 ◽  
Author(s):  
Paul Gilbert ◽  
Chad Rudnick
Keyword(s):  
Single Dose ◽  
Cord Blood ◽  
Full Term ◽  
Igg Antibodies ◽  
Case Presentation ◽  
Safety And Efficacy ◽  
S Protein ◽  
Maternal Vaccination ◽  
Placental Passage

AbstractBackgroundMaternal vaccination for Influenza and TDaP have been well studied in terms of safety and efficacy for protection of the newborn by placental passage of antibodies. Similar newborn protection would be expected after maternal vaccination against SARS-CoV-2 (the virus responsible for COVID-19). There is a significant and urgent need for research regarding safety and efficacy of vaccination against SARS-CoV-2 during pregnancy. Here, we report the first known case of an infant with SARS-CoV-2 IgG antibodies detectable in cord blood after maternal vaccination.Case presentationA vigorous, healthy, full-term female was born to a COVID-19 naïve mother who had received a single dose of mRNA vaccine for SARS-CoV-2 three weeks prior to delivery. Cord blood antibodies (IgG) were detected to the S-protein of SARS-CoV-2 at time of delivery.ConclusionHere, we report the first known case of an infant with SARS-CoV-2 IgG antibodies detectable in cord blood after maternal vaccination.

scholarly journals Multidisciplinary Management of Intrathoracic Goiter: A Case Report

2019 ◽  
pp. 1-3
Author(s):  
Silvia Ippolito ◽  
Jessica Sabatino ◽  
Davide Inversini ◽  
Matteo Annoni ◽  
Maria Laura Tanda
Keyword(s):  
Case Report ◽  
Total Thyroidectomy ◽  
Gold Standard ◽  
Multidisciplinary Approach ◽  
Medical Complications ◽  
Multidisciplinary Management ◽  
Case Presentation ◽  
Safety And Efficacy ◽  
Intrathoracic Goiter

Introduction: Intrathoracic goiters are associated with compression of nearby structures, triggering severe compressive symptoms. Total thyroidectomy is the gold standard to treat these cases. Case Presentation: A patient with a huge intrathoracic goiter suffering from compressive symptoms underwent a thorough clinical, functional and imaging assessment and underwent total thyroidectomy in an Endocrino-Metabolic surgical referral center; after the surgery she suffered from transient hypocalcaemia but was discharged without major complications and continued periodical endocrinological follow-up. Conclusion: Management of intra-thoracic goiter requires a multidisciplinary approach of a skilled team both pre, during and after surgery to maximize the safety and efficacy of the procedure and reduce or promptly manage surgical or medical complications.

scholarly journals Therapeutic approach to Sars-COV-2 in early treatment of patient not-hospitalized: a case report.

2020 ◽  
Author(s):  
Daniela Marasco ◽  
Salvatore Del Prete ◽  
Rosalaura Sabetta ◽  
Arturo Armone Caruso ◽  
Roberto Capaldi ◽  
...  
Keyword(s):  
Case Report ◽  
Severe Acute Respiratory Syndrome ◽  
Inflammatory Response ◽  
Rna Virus ◽  
International Committee ◽  
Therapeutic Approaches ◽  
Human Coronavirus ◽  
Case Presentation ◽  
Inflammatory Mechanism ◽  
H1n1 Pneumonia

Abstract Background: Sars-CoV-2 induces a massive inflammatory response mediated by macrophages, activated thanks to IFNγ secreted by T lymphocytes. Viral H1N1 pneumonia has been reported that h could have the same inflammatory mechanism that we can observe in COVID-19 patients 16). We tested this theory on a 55-year-old male patient, Sars-COV-2 positive.Case presentation: We treated our patient using clinical data and therapeutic approaches from a team of Chinese researchers, established during the beginning of the epidemic in December 2019. The new member of the human coronavirus, officially called SARS - CoV - 2 (severe acute respiratory syndrome coronavirus 2) by the International Committee on Taxonomy of Viruses (ICTV) is a new RNA virus strain that has not been previously identified in humans (1). This patient showed a Sars Cov-2 infection and was treated early with glucocorticoids. The patient immediately showed a regression of fever and an improvement of symptoms. Conclusions: We hypothesize that the initial stages of the infection can be treated with glucocorticoid therapy.

scholarly journals COVID-19 mRNA vaccine in pregnancy and newborn passive immunization: a case report

2021 ◽  
Author(s):  
Nadine El Kassis ◽  
Wael Abdallah ◽  
Rim Abou Chakra ◽  
Wissam Arab ◽  
Serge Sassine ◽  
...  
Keyword(s):  
Case Report ◽  
Pregnant Woman ◽  
Cesarean Section ◽  
Protective Effect ◽  
Passive Immunization ◽  
Prior History ◽  
Case Presentation ◽  
Maternal Vaccination ◽  
History Of ◽  
In Pregnancy

Aim: Evaluating the newborn passive immunization after maternal vaccination against SARS-COV-2. Case presentation: We present the case of a pregnant woman, with no prior history of COVID-19 infection, who got her second dose of mRNA vaccine against SARS-COV-2, 3 days before the start of her spontaneous labor. She was delivered by cesarean section after dynamical dystocia. Placental cord blood was retrieved immediately and sent to evaluate the titers of COVID-19 antibodies. Vaccine-generated antibodies were present in the umbilical cord with IgG spike >100 AU/ml. Conclusion: By reviewing the literature, vaccination seems to give hope about the potential protective effect of the maternal vaccination on her baby. Thus, pregnant women deserve a priority in the COVID-19 vaccination program.

scholarly journals Trichrome-positive intrahepatic cytoplasmic globules are potential histopathological clue for COVID-19-induced hepatitis: a case report

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Dina Sweed ◽  
Mohamed Ramadan El Shanshory ◽  
Eman Mohammed Elaskary ◽  
Hassnaa Atef Hassan ◽  
Enas Sweed ◽  
...  
Keyword(s):  
Case Report ◽  
Severe Acute Respiratory Syndrome ◽  
Liver Biopsy ◽  
Respiratory System ◽  
Hepatitis A ◽  
Liver Enzymes ◽  
Dramatic Improvement ◽  
Case Presentation ◽  
Elevated Liver Enzymes ◽  
History Of

Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection mainly affects respiratory system. Later, liver affection has also been reported in the form of marked elevated liver enzymes. However, the association of coronavirus disease-19 (COVID-19) and autoimmune diseases is not clear. Case presentation A female patient with a known history of autoimmune hemolytic anemia (AIHH) for which she was treated with prednisolone was admitted for uncontrolled anemia followed by fever and elevated liver enzymes. All the laboratory and radiological investigations were not typical for COVID-19 or any other etiology. Liver biopsy revealed numerous pale eosinophilic trichrome-positive intracytoplasmic globules. The pathology raised the suspicion for SARS-CoV-2-associated hepatitis, which was confirmed by a positive IgG titer. The patient showed a dramatic improvement on the maintenance dose of prednisolone. Conclusions AIHA patients co-infected with SARS-CoV-2 may be at risk of uncontrolled disease and should continue their treatment regimen. Histopathology has a role in the diagnosis of liver affection due to SARS-CoV-2 infection.

scholarly journals Unusual Presentation of Kawasaki Disease with Multisystem Inflammation and Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2: A Case Report

2020 ◽  
Author(s):  
Haena Kim ◽  
Jung Yeon Shim ◽  
Jae-Hoon Ko ◽  
Aram Yang ◽  
Jae Won Shim ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Severe Acute Respiratory Syndrome ◽  
Signs And Symptoms ◽  
Enzyme Linked Immunosorbent Assay ◽  
Igg Antibodies ◽  
Case Presentation ◽  
History Of ◽  
Polymerase Chain ◽  
High Index Of Suspicion ◽  
Inflammatory Syndrome

Abstract Background: Since mid-April 2020, cases of multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease (COVID-19) that mimic Kawasaki disease (KD) have been reported in Europe and North America. However, no cases have been in East Asia, where KD is more prevalent.Case presentation: A previously healthy 11-year-old boy was admitted with a 4-day history of fever and abdominal pain. He had no contact history to any patient with COVID-19. Blood acute inflammatory markers were highly elevated. He was treated with antibiotics for suspected bacterial enteritis, but he suddenly developed hypotension. Inotropics and intravenous immunoglobulin were administered to manage septic shock. On hospitalization day 6, he developed signs and symptoms of KD (conjunctival injection, strawberry tongue, cracked lip, and coronary artery dilatation) in addition to pleural/pericardial effusion and mesenteric lymphadenitis. The results of microbiologic tests, including reverse-transcription polymerase chain reaction for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), were negative. Fluorescent immunoassay and enzyme-linked immunosorbent assay revealed abundant IgG antibodies against SARS-CoV-2 in his serum, but no IgM antibodies. He was discharged successfully on day 13.Conclusion: MIS-C may occur in children with a previously asymptomatic COVID-19 infection. A high index of suspicion is required for this novel syndrome in unusual cases of KD or KD shock syndrome with multisystem inflammation, even when there is no clear history of contact or symptoms of COVID-19.

scholarly journals Therapeutic approach to Sars-COV-2 in early treatment of patient not-hospitalized: a case report.

2020 ◽  
Author(s):  
Daniela Marasco ◽  
Salvatore Del Prete ◽  
Rosalaura Sabetta ◽  
Arturo Armone Caruso ◽  
Guido Consolmagno ◽  
...  
Keyword(s):  
Case Report ◽  
Severe Acute Respiratory Syndrome ◽  
Inflammatory Response ◽  
Rna Virus ◽  
International Committee ◽  
Therapeutic Approaches ◽  
Human Coronavirus ◽  
Case Presentation ◽  
Spanish Influenza ◽  
Inflammatory Mechanism

Abstract Background: Sars-CoV-2 induces a massive inflammatory response mediated by macrophages, activated thanks to IFNγ secreted by T lymphocytes. Viral Spanish influenza has been reported that h could have the similar inflammatory mechanism that we can observe in COVID-19 patients 16). We tested this theory on a 55-year-old male patient, Sars-COV-2 positive. Case presentation: We treated our patient using clinical data and therapeutic approaches from a team of Chinese researchers, established during the beginning of the epidemic in December 2019. The new member of the human coronavirus, officially called SARS - CoV - 2 (severe acute respiratory syndrome coronavirus 2) by the International Committee on Taxonomy of Viruses (ICTV) is a new RNA virus strain that has not been previously identified in humans (1). This patient showed a Sars Cov-2 infection and was treated early with glucocorticoids. The patient immediately showed a regression of fever and an improvement of symptoms. Conclusions: We hypothesize that the initial stages of the infection can be treated with glucocorticoid therapy.

scholarly journals A single BNT162b2 dose protects against SARS-CoV-2: A case report of a family cluster of COVID-19.

2021 ◽  
Vol 32 (3) ◽  
pp. 172-176
Author(s):  
José Antonio Morales-Contreras ◽  
◽  
Jesús Arturo Ruiz-Quiñonez ◽  
Alberto Roblero-Hernández ◽  
Gibran Horemheb-Rubio ◽  
...  
Keyword(s):  
Single Dose ◽  
Case Report ◽  
Healthcare Workers ◽  
Transmission Rate ◽  
Vaccine Dose ◽  
Case Presentation ◽  
High Transmission ◽  
First Case ◽  
The Family ◽  
Antibody Titers

Background. Coronavirus 2019 (COVID-19) disease is an infectious disease caused by the virus "Severe Acute Respiratory Syndrome Coronavirus 2" (SARS-CoV-2). This virus generated a pandemic in 2020 and has affected millions of people worldwide. Facing the need to prevent its contagion, the vaccine BNT162b2 was approved in December 2020 in Mexico and started administered in healthcare workers. Case presentation. We presented here, two healthcare workers vaccinated with one single dose of BNT162b2, who lives in a family nucleus with high transmission rate of SARS-CoV-2. These healthcare workers, identified in the manuscript as patient E and F, were asymptomatic and their real-time RT-PCR test for SARS-CoV-2 resulted negative, while the rest of the family (patients A-D) were SARS-CoV-2 positive. The antibody titers IgG anti-spike of patient F (after the second dose; 1080 Au/mL) turned out greater than patient E (before the second dose; 37.1 Au/mL). Discussion. To our knowledge this is the first case report of the protective effect of single BNT162b2 vaccine dose in the context of high transmission rates within a family nucleus. Despite changes induced by BNT162b2 in the antibody titers with single or double dose vaccination, a single dose of BNT162b2 showed to be sufficient for immunization of patients against COVID-19.

scholarly journals Acute Pancreatitis may Occur in COVID-19 Patients with Clearance of SARS-CoV-2 in Lung: A Case Report

2020 ◽  
Author(s):  
Hong Zhao ◽  
Junwei Su ◽  
Kaijin Xu ◽  
Yu Shi ◽  
Yunqing Qiu ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Case Report ◽  
Severe Acute Respiratory Syndrome ◽  
Female Patient ◽  
Case Presentation ◽  
Support Treatment

Abstract Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is mostly causes lung damages, but also lead to gastroenterology injury. SARS-CoV-2 - associated acute pancreatitis has been reported, however, clearance of SARS-CoV-2 and the pancreatitis was not clear.Case presentation: A 62 year old diabetic female patient suffer from coronavirus diseases (COVID-19) and detection of SARS-CoV-2 turned negative on day 11 and day 12 in sputum. Two days latter, the patient was diagnosed with acute pancreatitis. Through the support treatment, the patient got better and discharged from our hospital 18 days later.Conclusions: Our case provided an initial view of SARS-CoV-2 infection with acute pancreatitis and the acute pancreatitis may occur in COVID-19 patients with clearance of SARS-CoV-2 in lung.

Sign in / Sign up

Export Citation Format

Share Document