Faculty Opinions recommendation of Blinatumomab Nonresponse and High-Disease Burden Are Associated With Inferior Outcomes After CD19-CAR for B-ALL.

2022 ◽  
Author(s):  
Jan Starý ◽  
Krystof Seferna
Keyword(s):  
Disease Burden ◽  
High Disease Burden

576 PREDICTORS OF HIGH DISEASE BURDEN IN CHILDREN WITH ACUTE RECURRENT OR CHRONIC PANCREATITIS*

2021 ◽  
Vol 160 (6) ◽  
pp. S-112-S-113
Author(s):  
Aliye Uc ◽  
Laura Rubin ◽  
Gretchen Cress ◽  
Ying Yuan ◽  
Mark Lowe
Keyword(s):  
Chronic Pancreatitis ◽  
Disease Burden ◽  
High Disease Burden

scholarly journals Genomics research in Africa and its impact on global health: insights from African researchers

2018 ◽  
Vol 3 ◽  
Author(s):  
N. S. Munung ◽  
B. M. Mayosi ◽  
J. de Vries
Keyword(s):  
Global Health ◽  
Disease Surveillance ◽  
Disease Burden ◽  
Research Priorities ◽  
Treatment And Prevention ◽  
Genomics Research ◽  
African Populations ◽  
Research Findings ◽  
Depth Interviews ◽  
High Disease Burden

Africa may be heading for an era of genomics medicine. There are also expectations that genomics may play a role in reducing global health inequities. However, the near lack of genomics studies on African populations has led to concerns that genomics may widen, rather than close, the global health inequity gap. To prevent a possible genomics divide, the genomics ‘revolution’ has been extended to Africa. This is motivated, in part, by Africa's rich genetic diversity and high disease burden. What remains unclear, however, are the prospects of using genomics technology for healthcare in Africa. In this qualitative study, we explored the views of 17 genomics researchers in Africa on the prospects and challenges of genomics medicine in Africa. Interviewees were researchers in Africa who were involved in genomics research projects in Africa. Analysis of in-depth interviews suggest that genomics medicine may have an impact on disease surveillance, diagnosis, treatment and prevention. However, Africa's capacity for genomics medicine, current research priorities in genomics and the translation of research findings will be key defining factors impacting on the ability of genomics medicine to improve healthcare in Africa.

scholarly journals Barriers for the injured indigenous person to return to work

2014 ◽  
Vol 9 ◽  
Author(s):  
Howard Flavell
Keyword(s):  
Life Expectancy ◽  
Return To Work ◽  
Disease Burden ◽  
Torres Strait Islander ◽  
Torres Strait Islander People ◽  
Community Activities ◽  
Meaningful Participation ◽  
Torres Strait ◽  
High Disease Burden

Aboriginal and Torres Strait Islander people carry a high disease burden with a consequent reduced life expectancy. There are reduced opportunities for conventional employment with further difficulties if the person has a disability. Nevertheless meaningful participation in community activities can occur. This paper will explore these issues giving examples of how this can be facilitated.

scholarly journals Characterizing the High Disease Burden of Transthyretin Amyloidosis for Patients and Caregivers

2018 ◽  
Vol 7 (2) ◽  
pp. 349-364 ◽  
Author(s):  
Michelle Stewart ◽  
Shannon Shaffer ◽  
Brian Murphy ◽  
Jane Loftus ◽  
Jose Alvir ◽  
...  
Keyword(s):  
Disease Burden ◽  
Transthyretin Amyloidosis ◽  
High Disease Burden

scholarly journals How biomarker patterns can be utilized to identify individuals with a high disease burden: a bioinformatics approach towards predictive, preventive, and personalized (3P) medicine

2021 ◽  
Author(s):  
Nina Bertele ◽  
Alexander Karabatsiakis ◽  
Claudia Buss ◽  
Anat Talmon
Keyword(s):  
High Risk ◽  
Childhood Maltreatment ◽  
Disease Burden ◽  
Targeted Prevention ◽  
Prevention Intervention ◽  
Reactive Protein ◽  
Leverage Point ◽  
Low Cortisol ◽  
Somatic Diseases ◽  
High Disease Burden

AbstractPrevalences of non-communicable diseases such as depression and a range of somatic diseases are continuously increasing requiring simple and inexpensive ways to identify high-risk individuals to target with predictive and preventive approaches. Using k-mean cluster analytics, in study 1, we identified biochemical clusters (based on C-reactive protein, interleukin-6, fibrinogen, cortisol, and creatinine) and examined their link to diseases. Analyses were conducted in a US American sample (from the Midlife in the US study, N = 1234) and validated in a Japanese sample (from the Midlife in Japan study, N = 378). In study 2, we investigated the link of the biochemical clusters from study 1 to childhood maltreatment (CM). The three identified biochemical clusters included one cluster (with high inflammatory signaling and low cortisol and creatinine concentrations) indicating the highest disease burden. This high-risk cluster also reported the highest CM exposure. The current study demonstrates how biomarkers can be utilized to identify individuals with a high disease burden and thus, may help to target these high-risk individuals with tailored prevention/intervention, towards personalized medicine. Furthermore, our findings raise the question whether the found biochemical clusters have predictive character, as a tool to identify high-risk individuals enabling targeted prevention. The finding that CM was mostly prevalent in the high-risk cluster provides first hints that the clusters could indeed have predictive character and highlight CM as a central disease susceptibility factor and possibly as a leverage point for disease prevention/intervention.

scholarly journals The presence and spectrum of bacteria colonising mobile phones of staff and caregivers in high disease burden paediatric and neonatal wards in an urban teaching hospital in Durban, South Africa

2017 ◽  
Vol 32 (1) ◽  
pp. 9-11
Author(s):  
Raziya Bobat ◽  
Moherndran Archary ◽  
Melissa Lawler ◽  
Sajeeda Mawlana ◽  
Kimesh L. Naidoo ◽  
...  
Keyword(s):  
Mobile Phones ◽  
Nursing Staff ◽  
Disease Burden ◽  
Cross Sectional Study ◽  
P Value ◽  
Cross Sectional ◽  
General Wards ◽  
Staphylococcus Spp ◽  
Hospital Acquired ◽  
High Disease Burden

Background: Hospital acquired infections are on the increase worldwide. A possible source for transmission is the presence of microorganisms on mobile phones which are carried by increasing numbers of medical and nursing staff, students, and caregivers.Methods: A cross-sectional study was performed. Samples were obtained from medical and nursing staff, students, and caregivers from the paediatric wards (85 beds), and the neonatal unit (40 beds) at King Edward VIII Hospital (KEH), Durban. Mobile phones of participants were sampled, with sterile swabs, without prior warning. The swabs were transported promptly to the laboratory and cultured onto colistin, nalidixic acid agar and MacConkey agar plates. All positive cultures were identified using standard laboratory tests.Results: Of the 100 mobile phones sampled, 30 were contaminated with bacteria. Gram-positive microorganisms were more frequently cultured than Gram-negative microorganisms (29 vs. 7). Significantly more caregivers had contaminated phones (54.17% vs. 22.37%, p value = 0.003). Caregivers’ phones were predominantly contaminated with Staphylococcus spp. (41.67%). More phones in the general wards (37.5%) and nursery (32.5%) were contaminated compared to the gastroenteritis ward (10%).Conclusions: Our results indicate that one third of the mobile phones carried in the paediatric wards are contaminated. Caregivers had the highest likelihood of carrying mobile phones that were contaminated, with the lowest rate among the nursing staff. Caregivers’ phones were also more likely to have multiple microorganisms. The lowest rate of contamination was found in the gastroenteritis ward, possibly due to a heightened awareness of the need for handwashing.

scholarly journals Assessment of spatial and temporal variation of water quality in mid hills of North West Himalyas- a Water Quality Index approach

2019 ◽  
Vol 14 (1) ◽  
pp. 37-48
Author(s):  
Ajay Kumar Singh ◽  
Satish Kumar Bhardwaj
Keyword(s):  
Water Quality ◽  
Drinking Water ◽  
Water Quality Index ◽  
Quality Index ◽  
Disease Burden ◽  
Water Sources ◽  
Spatial And Temporal Variation ◽  
North West ◽  
High Disease Burden

Today, the quality of drinking water across the globe has become an environmental concern because of its degradation due to urbanization, industrialization, transportation etc. Solan, a rapidly developing district and an industrial hub, in the recent past has faced water borne diarrhoeal disease outbreaks. Therefore, the study was undertaken to assess the water quality of disease burden regions during monsoon and post monsoon seasons. pH of the water sources was in the range of 6.92- 7.43 and was well within normal limits. Electrical conductivity of water ranged from 151.40- 414.65 µS/cm. The water sources of high disease burden regions exhibited higher EC than the prescribed ICMR standards. DO (range 7.43- 8.56 mg/l) was normal in all disease burden regions. BOD (range 12.25- 23.25 mg/l) was higher than the BIS limits in all regions. The COD, TDS and turbidity (range 75.75- 157.50 mg/l, 2.24- 81.01 mg/l and 1.85- 5.05 NTU respectively) were within BIS limits. The concentrations (mg/l) of Ca, Pb, Hg, Zn and Cr was found in the ranges of 37.2- 122.9, 0.17- 0.51, 0.00- 0.03, 0.74- 8.99 and 0.04- 0.10, respectively. The high disease burden regions exhibited relatively higher contents of Ca, Hg and Cr as compared to lower one and the BIS limits. However, contents of Pb and Zn were above BIS limits in all the regions. The concentration (mg/l) of Mg, NO3-, Cl- and As was in the ranges of 14.25- 30.61, 5.10- 9.88, 16.42- 74.96 , 0.001- 0.014 respectively, which were below prescribed standards. Cd was detected (0.001 mg/l) in Solan region only, however it was within BIS limits. Water Quality Index (WQI) computed by using nine parameters varied from 78.58- 219.78 (very poor to unsafe drinking water class). Interestingly, water sources of all the high disease burden regions were unsafe for drinking (WQI: 102.02- 167.04). Water quality deteriorated more in the monsoons. The study therefore warrants remedial actions of water resource protection and conservation for provision of potable water.

Sign in / Sign up

Export Citation Format

Share Document