scholarly journals Chronic gastroduodenal pathology in children with atopic dermatitis complicated by mycotic infection

2020 ◽  
pp. 41-45
Author(s):  
I. G. Alekseeva ◽  
T. G. Malanicheva ◽  
S. N. Denisova ◽  
A. Nее ◽  
O. V. Kachalova
Keyword(s):  
Helicobacter Pylori ◽  
Atopic Dermatitis ◽  
Peptic Ulcer ◽  
Gastrointestinal Tract ◽  
Blood Serum ◽  
Mucous Membrane ◽  
Ulcer Disease ◽  
Mycotic Infection ◽  
Urease Test ◽  
Enzyme Biosensor

Objective: To identify the features of chronic gastroduodenal pathology in children with atopic dermatitis (AD) complicated by secondary mycotic infection.Methods: The examination of mucous membrane micro-biocenosis of stomach and duodenum was performed in 64 children aged 3–16 years with diseases of gastrointestinal tract and AD complicated by fungal infection. 45 out of 64 patients, having been under medical supervision, had a combined damage of skin and gastrointestinal tract with Candida fungi. In-depth clinical and mycological study was performed represented by esophagogastroduodenoscopy with biopsy of intestine mucous membrane. The detection of circulating candida antigens in blood serum was conducted with method of amperometric enzyme biosensor. Helicobacter pylori were detected using urease test.Results: Children with AD combined with secondary mycotic infection had a damage of the upper parts of gastrointestinal tract and skin with Candida fungi in 70.3% of cases. Gastroduodenitis accounted for 66.7%; peptic ulcer disease was 33.3% in the structure of gastrodudenal pathology. Candida albicans fungi were plated in 80 % of cases; all children had a candida antigen in the blood serum.Conclusions: Children with AD, complicated by mycotic infection, and chronic gastrodudenal pathology should be examined for candidiasis of upper parts of gastrointestinal tract. If there is a candidiasis they should be prescribed with systemic antimycotics and dietary adjustment. 

scholarly journals Efficacy of a triple therapy for Helicobacter pylori eradication in a well-developed urban area in Brazil

2004 ◽  
Vol 122 (2) ◽  
pp. 73-75 ◽  
Author(s):  
Patrick Bellelis ◽  
Eliana Sueco Tibana Samano ◽  
Ricardo Cruz Nunes ◽  
Lia de Melo Ribeiro ◽  
Ethel Zimberg Chehter ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Triple Therapy ◽  
Urban Area ◽  
Gastric Ulcers ◽  
Upper Endoscopy ◽  
Helicobacter Pylori Eradication ◽  
Ulcer Disease ◽  
Urease Test

CONTEXT: Helicobacter pylori eradication has become the standard treatment for peptic ulcer disease. Triple therapy with omeprazole plus two antibiotics has been used. Due to the lack of ideal treatment and the high rates of primary resistance to nitroimidazoles, the use of clarithromycin has been adopted. OBJECTIVE: To determine the Helicobacter pylori eradication rates using lansoprazole, amoxicillin and clarithromycin for seven days, in patients with peptic ulcer disease in a well developed urban area in Brazil. METHODS: This was a retrospective, open-label study carried out at the School of Medicine of the Fundação ABC. It included 130 patients with peptic ulcer disease (upper endoscopy) who had been tested positive for Helicobacter pylori infection (urease test, histology or breath test), without previous treatment. Patients were treated with lansoprazole 30 mg, amoxicillin 1,000 mg and clarithromycin 500 mg b.i.d., for seven days. Eradication was verified after 90 days. RESULTS: Follow-up data were available for 94 patients. Their mean age was 52.23 years; 51.54% were woman, 84.31% white, 37.69% smokers, 20.77% using nonsteroidal anti-inflammatory drugs and 8.46% alcoholics. Upper endoscopy revealed that 78.46% had duodenal ulcers and 21.53% had gastric ulcers (a 4:1 DU:GU ratio). The eradication rates were 85.11% per protocol and 61.54% by intention to treat; 97% had no adverse effects. CONCLUSION: Triple therapy using lansoprazole, amoxicillin and clarithromycin is well tolerated with high eradication rates and forms a good alternative for developing countries.

scholarly journals Prevalence of Helicobacter pylori in patients with peptic ulcer disease

2018 ◽  
Vol 5 (4) ◽  
pp. 1315
Author(s):  
Mrutyunjay I. Uppin ◽  
Kapildev K. Hannurkar
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Histopathological Examination ◽  
Rapid Urease Test ◽  
Duodenal Ulcers ◽  
Ulcer Disease ◽  
Urease Test ◽  
H Pylori ◽  
Upper Gastrointestinal

Background: Prevalence of Helicobacter pylori (H. pylori) emerges throughout the world and instigates peptic ulcer disease (PUD). The study was conducted with the aim to determine the prevalence of H. pylori in patients with PUD undergoing upper gastrointestinal endoscopy.Methods: This prospective study was conducted on 150 cases of PUD from August 2009 to February 2011. Endoscopy was done in all cases. Biopsy was done and sent for histopathological examination and rapid urease test for confirmation of presence of H. pylori.Results: Out of 150 patients with mean age of 45.76 years, 109 patients were diagnosed to have been infected with Helicobacter pylori (72.66%). Out of 89 patients with gastric ulcer, 61 patients were infected with Helicobacter pylori (68.53%). Forty two out of 51 patients (82.35%) with duodenal ulcers and 06 of 10 patients (60%) with carcinoma of stomach were positive for H. pylori. The remaining patients were found to be negative for the H. pylori infection.Conclusions: The findings of the study conclude that H. pylori was consistently associated with PUD.

scholarly journals Helicobacter pylori CagA seropositivity in adult Bangladeshi patients with peptic ulcer and erosion

2020 ◽  
Vol 14 (1) ◽  
pp. 36-40
Author(s):  
Fahmida Rahman ◽  
Khandaker Shadia ◽  
Salma Khatun ◽  
Mafruha Mahmud ◽  
Indrajit Kumar Dutta ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Enzyme Linked Immunosorbent Assay ◽  
Rapid Urease Test ◽  
Igg Antibody ◽  
Ulcer Disease ◽  
Urease Test ◽  
Urease Production ◽  
Stool Antigen ◽  
H Pylori

Background: CagA IgG antibody in sera might indicate presence of virulent Helicobacter pylori in patients with peptic ulcer disease. Present study was performed to find out the prevalence of CagA IgG antibody in patients with peptic ulcer/erosion. Methods: Any case that had peptic ulcer/erosion, plus positive for rapid urease test (RUT) or H. pylori stool antigen (HpSAg) or serum anti-H. pylori IgG/IgA were included in the study and named as H. pylori positive case. H. pylori positive cases were tested for CagA IgG antibody. Anti-H. pylori IgG, IgA and CagA IgG antibodies were determined by enzyme-linked immunosorbent assay (ELISA) and stool antigen by rapid immunochromatographic test (ICT). Urease production in biopsy sample was detected by RUT. Results: Total 86 H. pylori positive patients were included in the study. Out of 86 patients, CagA IgG was positive in 34 (39.5%; 95% CI: 0.30,0.50) cases. CagA seropositivity rate in ulcer and erosion cases were 58.8% (95% CI: 0.36,0.78) and 34.8% (95% CI: 0.25,0.47) respectively. H. pylori stool antigen and IgA antibodies were positive in all (100%) CagA antibody positive ulcer cases while the rates were significantly less among the CagA antibody negative cases (42.8% and 28.6%; p<0.05). However, in CagA antibody positive erosion cases, the rates were not significantly different from CagA antibody negative cases. Conclusion: The study has demonstrated that the CagA positive strain is less prevalent in erosion than ulcer cases. Ibrahim Med. Coll. J. 2020; 14(1): 36-40

scholarly journals Clarithromycin-based triple therapy for Helicobacter pylori treatment in peptic ulcer patients

2010 ◽  
Vol 4 (11) ◽  
pp. 712-716 ◽  
Author(s):  
Guilherme Felga ◽  
Fernando Marcuz Silva ◽  
Ricardo Correa Barbuti ◽  
Tomas Navarro-Rodriguez ◽  
Schlioma Zaterka ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Risk Factor ◽  
Peptic Ulcer ◽  
Proton Pump Inhibitor ◽  
Adverse Effects ◽  
Proton Pump ◽  
First Line ◽  
Ulcer Disease ◽  
Urease Test ◽  
H Pylori

Introduction: The scheme proton pump inhibitor/amoxicillin/clarithromycin (PPI/AC) is still the first-line treatment for Helicobacter pylori (H. pylori) infections despite evidence suggesting its failure in up to 20% to 30% of patients. Methodology: This study involved 493 patients who were prescribed omeprazole (20 mg twice a day) or another proton pump inhibitor in equivalent dosage, amoxicillin (1 g twice a day), and clarithromycin (500 mg twice a day) for seven days. Efficacy was determined by negative urease test and absence of H. pylori on gastric biopsy samples twelve weeks after the end of treatment. Safety was defined according to the adverse effects reported. Mean age of the patients was (± SD) 48.96 ± 13, and demographic and clinical data were recorded for correlation with treatment outcomes. Results: Out of 493 patients, 316 (64.1%) presented duodenal ulcer, 111 (22.5%) gastric ulcer, and 66 (14.4%) simultaneous gastric and duodenal ulcers. Additionally, 267 (54.2%) patients had at least one risk factor for peptic ulcer disease, smoking being the most common (99 [36.5%]). Successful eradication was achieved in 408 patients. The eradication rates per protocol, and according to the intention to treat, were 88.8% and 82.7%, respectively.  Of 164 (35.5%) patients who presented adverse effects, 100 (61%) reported them as mild and only six (3.7%) patients had to discontinue treatment. Previous use of tobacco and non-steroid anti-inflammatory drugs was the only risk factor for treatment failure (P 0.00). Conclusion: PPI/AC is still a valuable and remarkably tolerable option for first-line H. pylori eradication in Brazil.

scholarly journals Peptic ulcer disease

KYAMC Journal ◽  
2013 ◽  
Vol 3 (2) ◽  
pp. 270-272
Author(s):  
Md. Zulfikar Ali
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Gastrointestinal Tract ◽  
Peptic Ulcer Disease ◽  
Acidic Environment ◽  
Ulcer Disease

A peptic ulcer, also known as peptic ulcer disease (PUD) is the most common ulcer of an area of the gastrointestinal tract that is usually acidic and thus extremely painful. It is defined as mucosal erosions equal to or greater than 0.5 cm. As many as 70%-90% of such ulcers are associated with Helicobacter pylori, a spiral-shaped bacterium that lives in the acidic environment of the stomach. KYAMC Journal Vol. 3, No.-2, January 2013, Page 270-272 DOI: http://dx.doi.org/10.3329/kyamcj.v3i2.15164

scholarly journals The prevalence of Helicobacter pylori in perforated peptic ulcer disease

2018 ◽  
Vol 5 (5) ◽  
pp. 1720
Author(s):  
Babar Rehmani ◽  
Priyank Pathak
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Rapid Urease Test ◽  
Peptic Ulcer Perforation ◽  
Mucosal Biopsy ◽  
Ulcer Disease ◽  
Ulcer Perforation ◽  
Urease Test ◽  
H Pylori

Background: Although the role of Helicobacter pylori infection in noncomplicated peptic ulcer disease has been definitively established, the precise relationship between the organism and ulcer complications is doubtful. Recurrent ulcer disease after peptic ulcer perforation mainly occurs in patients with H. pylori infection, which suggests that the microorganism plays an important role in this complication.Methods: This observational study was conducted in the Department of General Surgery, Himalayan Institute of Medical Sciences (HIMS), Swami Ram Nagar, Dehradun, over a period of January 2013 to December 2013 and included 75 subjects who underwent exploratory laparotomy for peptic ulcer perforation. The tests used for the diagnosis of H. pylori are mucosal biopsy at the time of surgery, Rapid urease test (RUT), Stool antigen test.Results: In this study, H. pylori infection was found to be present in 61% of these patients as detected by biopsy. There were 66 males and 9 females. Infection with H. pylori is almost universal in patients aged more than 70 years.Conclusions: In the Indian context patients presenting with perforation should be tested for infection with H. pylori utilizing a gastric antral mucosal biopsy taken at the time of operation for histological analysis and eradication therapy should be advised to all those who are found positive.

scholarly journals Comparison of home made and commercial rapid urease tests for detection of helicobacter pylori in patients with gastroduodenitis and peptic ulcer

2015 ◽  
Vol 1 (2) ◽  
pp. 11-14
Author(s):  
Yuba Raj Sharma ◽  
Amrita Wagley ◽  
Sunil Singh
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Predictive Value ◽  
Gold Standard ◽  
Rapid Urease Test ◽  
Ulcer Disease ◽  
Urease Test ◽  
The Common ◽  
H Pylori ◽  
Sensitivity Specificity

Introductions: Helicobacter pylori is one of the common and medically prominent infections worldwide and an established etiological factor for peptic ulcer disease. This study was conducted to compare the results of two types of Rapid Urease Tests (RUT) for H. pylori infection.Methods: This study was conducted in patients with gastro duodenal diseases visiting Kantipur Hospital from June to August 2010. Antral biopsies were collected from sixty patients visiting endoscopy unit. The diagnosis was of H. pylori infection carried out using two types of rapid urease tests (commercial and homemade) as well as Histopathology.Results: H. pylori infection was detected in 34 (56.67%) of 60 by histological test, 24 (40%) by homemade kit method and 28 (46.67%) by commercial RUT method. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for RUT (commercial kit) considering histology as gold standard were 76.74%, 92.31%, 92.85% and 75% respectively. The sensitivity, specificity, PPV and NPV for RUT (homemade kit) were 58.82%, 84.62%, 83.3% and 61.11% respectively.Conclusions: Homemade rapid urease test was sensitive and specific for detection of H. pylori infection than commercial test.

A STUDY ON PREVALENCE OF HELICOBACTER PYLORI IN BLEEDING PEPTIC ULCER USING RAPID UREASE TEST

2021 ◽  
pp. 82-83
Author(s):  
Lokesh M N ◽  
Anil Kumar K N ◽  
Madan M
Keyword(s):  
Duodenal Ulcer ◽  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Bleeding Peptic Ulcer ◽  
Ulcer Bleeding ◽  
Rapid Urease Test ◽  
Ulcer Disease ◽  
Urease Test ◽  
H Pylori

BACKGROUND: Helicobacter pylori (H. pylori) is the leading cause of peptic ulcer disease in India. Timely diagnosis and proper treatment is required for the eradication of H. pylori infection and prevention of its associated complications. AIMS AND OBJECTIVES: This study aims to evaluate the prevalence of H. pylori infection in patients presenting with bleeding peptic ulcer. MATERIAL AND METHODS: This is prospective study conducted from January 2019 till January 2021 in patients with bleeding peptic ulcer admitted at BGS Global Institute of Medical Sciences. All the patients under went endoscopy and biopsy was taken from Antral region for Rapid Urease Test. RESULT: 164 patients were included in the study with duodenal ulcer bleeding in 129 (78.6%) patients, gastric ulcer in 30 (18.3%) patients and both gastric and duodenal ulcer in 5 (3.1%) patients. Positivity for RUT was seen in 147 patients (89.6%). CONCLUSION: Early intervention in the patients with peptic ulcer disease in the form of endoscopic biopsy will help in prevention of recurrent bleeding episodes and other associated complications.

scholarly journals A comparative study between benign and malignant conditions of upper gastrointestinal tract of helicobacter pylori using upper gastrointestinal scopy in a tertiary care hospital, Kanchipuram, Tamil Nadu, India

2017 ◽  
Vol 4 (3) ◽  
pp. 1082
Author(s):  
Dhinesh Babu K. ◽  
M. Bhaskar
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
The Other ◽  
Rapid Urease Test ◽  
Gi Tract ◽  
Duodenal Ulcers ◽  
Ulcer Disease ◽  
Upper Gi ◽  
Urease Test ◽  
Upper Gastrointestinal

Background: Acid peptic disease comprises of a wide spectrum of diseases, which cause considerable morbidity. The objective of this study was to study the prevalence of Helicobacter pylori in patients with dyspepsia and symptomatic patients undergoing upper gastrointestinal endoscopy (UGIE) in Karpaga Vinayaga Medical College and Hospital, Kanchipuram, Tamilnadu, India and to study the association of Helicobacter pylori   with acid peptic diseases and malignant conditions of upper Gastro intestinal tract.Methods: 389 cases of dyspepsia, studied clinically, were subjected to UGIE, during which 4 biopsies, two each from the antrum and the pathological areas were taken. One of the antral area and the other of the pathological finding were immediately subjected to Rapid urease test. Positive test for Helicobacter pylori was indicated by change in colour of the medium from yellow to pink or red. The other two biopsy specimens were sent for routine histopathology and special staining with Giemsa stain. The case was taken as Helicobacter pylori positive when the rapid urease test and/or histopathological examination was positive.Results: Out of 468 patients, with mean age of 41.8 years, 171 patients were diagnosed to have been infected with Helicobacter pylori (44.21%). Out of 49 patients with gastric and duodenal ulcers, 37 patients were infected with Helicobacter pylori (75.51%). In which 22 out of 25 patients (88%) with duodenal ulcers and 10 out of 14 patients (71.4%) with gastric ulcers were positive for H. pylori while only 8 out of 10 patients (80%) with gastric cancer were positive for H. pylori.Conclusions: In this study, we found that Helicobacter pylori were consistently associated with peptic ulcer disease and malignant conditions of upper GI tract, which is in broad agreement with the studies done earlier. Thus, we conclude that, Helicobacter pylori infection may have a major role in the etiopathogenesis of peptic ulcer disease and malignant conditions of upper GI tract appear to be no significant association between Helicobacter pylori  infection and unexplained dyspepsia.

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