Prevalence of metabolic syndrome among patients with superficial mycotic infections in a tertiary care hospital

<p class="abstract"><strong>Background:</strong> Incidence of metabolic syndrome and superficial mycotic infection is progressively increasing worldwide. Skin disorders, usually neglected and frequently underdiagnosed in patients with metabolic syndrome. So, the objective of the study is to linkup between metabolic syndrome and superficial mycotic infections.</p><p class="abstract"><strong>Methods:</strong> Total 300 diagnosed patients of superficial mycotic infection out of 1000 patients in a 5 months period from January 2019 to May 2019 who gave consent were chosen at random from the patients attending the OPD consultancy. Thorough clinical evaluation and routine hematological investigations, oral glucose tolerance test (OGTT), fasting lipid profile were tested and BMI and blood pressure were recorded to diagnose metabolic syndrome. Fungal infections were confirmed by KOH mount.<strong></strong></p><p class="abstract"><strong>Results:</strong> Among 1000 patients attended in OPD consultancy, majority of the patients were female (60%). Among them 300 patients have got different superficial fungal infections (female was 223 and male 77). Among this 300-study population, age variation is significant. There were highest female patients in age group from 36 yrs- 45 yrs. Tinea corporis was the most frequent fungal infection in female (65%), <em>Tinea cruris</em> is highest in male (21%). The most alarming is that among that 300 patients 45% patients have got raised OGTT,91% patient has increased BMI, female predominant. 59.3% has raised blood pressure and increased serum cholesterol in 70.1% patients. </p><p class="abstract"><strong>Conclusions:</strong> Superficial fungal infections are epidemic worldwide. In our study the new era is that presence of metabolic syndrome among patients with superficial mycotic infections. So early detection and treatment of metabolic syndrome helps in cure of superficial mycotic infections.</p><p class="abstract"> </p>

Chronic gastroduodenal pathology in children with atopic dermatitis complicated by mycotic infection

Objective: To identify the features of chronic gastroduodenal pathology in children with atopic dermatitis (AD) complicated by secondary mycotic infection.Methods: The examination of mucous membrane micro-biocenosis of stomach and duodenum was performed in 64 children aged 3–16 years with diseases of gastrointestinal tract and AD complicated by fungal infection. 45 out of 64 patients, having been under medical supervision, had a combined damage of skin and gastrointestinal tract with Candida fungi. In-depth clinical and mycological study was performed represented by esophagogastroduodenoscopy with biopsy of intestine mucous membrane. The detection of circulating candida antigens in blood serum was conducted with method of amperometric enzyme biosensor. Helicobacter pylori were detected using urease test.Results: Children with AD combined with secondary mycotic infection had a damage of the upper parts of gastrointestinal tract and skin with Candida fungi in 70.3% of cases. Gastroduodenitis accounted for 66.7%; peptic ulcer disease was 33.3% in the structure of gastrodudenal pathology. Candida albicans fungi were plated in 80 % of cases; all children had a candida antigen in the blood serum.Conclusions: Children with AD, complicated by mycotic infection, and chronic gastrodudenal pathology should be examined for candidiasis of upper parts of gastrointestinal tract. If there is a candidiasis they should be prescribed with systemic antimycotics and dietary adjustment.

Infection with Drechslera hawaiiensis. Case report and literature review

This article reports an orofacial infection caused by Drechslera hawaiiensis that normally is mortal to the patient. The case was surgically treated in Cali - Colombia in 1984 by teeth removal, and osteototomy of affected bone in the hard palate and the base of the vomer bone. Twenty years later the patient resulted infected by Dreschslera curvularia but survived both infections. A literature review (Pubmed - 2011) showed that only another case report by Drechslera hawaiiensis the patient survived. This other case was reported in the Anderson Hospital Institute in 1984. It is unknown if there is a chronic infection stage and the transmission mode of this pathogen. In patients with chronic symptoms affecting the paranasal sinuses and nasal cavity it is possible to suspect this rare disease. Key words: Oral facial infection, mycotic infection, Drechslera hawaiiensis.