scholarly journals SURGICAL TREATMENT OF COMPLICATED FORMS OF ERYSIPELAS

2021 ◽  
Vol 48 (1) ◽  
Author(s):  
L. A. Vasylevska
Keyword(s):  
Surgical Treatment ◽  
General Population ◽  
Blood Serum ◽  
Pathological Process ◽  
City Hospital ◽  
Sensitive Test ◽  
Non Profit ◽  
Upper And Lower Extremities ◽  
Pathological Focus

Abstract Purpose of the study. The goal of the article is to find out the frequency of complicated forms of erysipelas among the general population of the disease and to determine the main directions for their surgical treatment. Materials and methods. 114 case histories of patients who were hospitalized in the center of purulent-septic surgery of the Non-profit municipal enterprise «City Hospital № 3» in Zaporozhye for the period 2019–2020 were analyzed retrospectively and prospectively. Results. It was found that most often the focus was localized on the upper and lower extremities. In the complex treatment of patients with surgical forms of erysipelas, the main place belongs to antibiotic therapy (ABT) and early surgical treatment of the area of the pathological process. Determination of the level of procalcitonin in blood serum makes it possible to assess the progression of the inflammatory process and is a sensitive test for the effectiveness of treatment. Conclusions. The incidence of complicated forms of erysipelas requiring surgery in the general population was 78,9%. Patients with circular erysipelas need the most extensive surgery, when it is necessary to perform an autopsy within the area of inflammation with longitudinal and transverse wavy autopsies throughout the pathological focus. Determination of the level of procalcitonin in blood serum makes it possible to assess the progress of the process and is a sensitive test for the effectiveness of treatment. Keywords: surgical forms of erysipelas, procalcitonin.

scholarly journals SURGICAL TREATMENT OF COMPLICATED FORMS OF ERYSIPELAS

2020 ◽  
Vol 47 (4) ◽  
Author(s):  
L. A. Vasylevska
Keyword(s):  
Surgical Treatment ◽  
General Population ◽  
Blood Serum ◽  
Pathological Process ◽  
City Hospital ◽  
Sensitive Test ◽  
Non Profit ◽  
Upper And Lower Extremities ◽  
Pathological Focus

Abstract Purpose of the study. The goal of the article is to find out the frequency of complicated forms of erysipelas among the general population of the disease and to determine the main directions for their surgical treatment. Materials and methods. 114 case histories of patients who were hospitalized in the center of purulent-septic surgery of the Non-profit municipal enterprise "City Hospital № 3" in Zaporozhye for the period 2019–2020 were analyzed retrospectively and prospectively. Results. It was found that most often the focus was localized on the upper and lower extremities. In the complex treatment of patients with surgical forms of erysipelas, the main place belongs to antibiotic therapy (ABT) and early surgical treatment of the area of the pathological process. Determination of the level of procalcitonin in blood serum makes it possible to assess the progression of the inflammatory process and is a sensitive test for the effectiveness of treatment. Conclusions. The incidence of complicated forms of erysipelas requiring surgery in the general population was 78,9%. Patients with circular erysipelas need the most extensive surgery, when it is necessary to perform an autopsy within the area of inflammation with longitudinal and transverse wavy autopsies throughout the pathological focus. Determination of the level of procalcitonin in blood serum makes it possible to assess the progress of the process and is a sensitive test for the effectiveness of treatment. Keywords: surgical forms of erysipelas, procalcitonin

scholarly journals The use of procalcitonin in patients with surgical forms of erysipelas

2021 ◽  
Vol 26 (1) ◽  
pp. 196-200
Author(s):  
S.D. Shapoval ◽  
L.A. Vasylevska
Keyword(s):  
Diagnostic Marker ◽  
Prognostic Significance ◽  
Pathological Process ◽  
City Hospital ◽  
Sensitive Test ◽  
Case Histories ◽  
Non Profit ◽  
Early Surgical Treatment ◽  
The Ideal

The ideal marker of bacterial infection should not only allow for early diagnosis, but also provide information about the course and prognosis of the disease. Nowadays the most well-studied and widely used in clinical practice is procalcitonin (PCT), but its value in surgical forms of erysipelas is insufficiently defined. The aim of the article is to determine the diagnostic and prognostic significance of procalcitonin in patients with surgical forms of erysipelas.114 case histories of patients who were hospitalized in the center of purulent-septic surgery of the Non-profit municipal enterprise "City Hospital №3" in Zaporozhye for 2019-2020 period were analyzed retrospectively and prospectively. It was found that most often the focus was localized on the lower extremities. In the complex treatment of patients with erysipelas, the main place belongs to antibiotic therapy (ABT) and early surgical treatment of the area of the pathological process. Determination of the level of procalcitonin in the serum makes it possible to assess the progression and generalization of the process and is a sensitive test for the effectiveness of treatment.Radical surgery and timely targeted ABT are key elements of success in the treatment of surgical forms of erysipelas and are not subject to revision. Procalcitonin is a diagnostic marker that can predict the development of sepsis.

Prognostic value of the determination of humoral anti-brain antibodies in inflammatory diseases of the middle ear

1982 ◽  
Vol 63 (6) ◽  
pp. 42-44
Author(s):  
A. I. Bikbaeva ◽  
S. V. Chuikin ◽  
V. V. Speransky
Keyword(s):  
Blood Serum ◽  
Otitis Media ◽  
Middle Ear ◽  
Prognostic Value ◽  
Inflammatory Diseases ◽  
Pathological Process ◽  
Sharp Drop ◽  
Suppurative Otitis Media ◽  
Intracranial Complications

In the study of blood serum in 118 patients with different forms of otitis media, higher titers of anti-brain antibodies were found than in healthy ones. There was a correlation between the titer value and the intensity of the pathological process in the middle ear. A prognostically unfavorable sign in the occurrence of otogenic intracranial complications is the disappearance or a sharp drop in the titer of anti-brain antibodies during an exacerbation of chronic suppurative otitis media.

Quantitative Method for Determination of DDT and DDT Metabolites in Blood Serum

1970 ◽  
Vol 53 (6) ◽  
pp. 1287-1292 ◽  
Author(s):  
William E Dale ◽  
James W Miles ◽  
Thomas B Gaixes
Keyword(s):  
General Population ◽  
Oral Dose ◽  
Blood Serum ◽  
Extraction Method ◽  
Quantitative Method ◽  
Manufacturing Plant ◽  
Hexane Extraction ◽  
Ddt Metabolites ◽  
Pre Treatment

Abstract A new method for the extraction and determination of DDT and related materials in blood has been developed. Rats were given a single oral dose of 14C-labeled DDT, and it was demonstrated by parallel gas chromatographic and radiometric measurements that in vivointroduced DDT and related materials could not be removed quantitatively from serum by simple hexane extraction. Pre-treatment of the serum with equal volumes of formic acid released the binding of DDT and DDT metabolites and permitted the extraction of these materials with n-hexane, yielding 95% recovery. When applied to sera of men from the general population and of men who had been exposed to DDT for more than 10 years in a manufacturing plant, this method gave consistently higher results than did the simple hexane extraction method.

scholarly journals VARIETY OF DIAGNOSED MICROORGANISMS IN PATIENTS WITH ERYSIPELAS

2021 ◽  
pp. 140-143
Author(s):  
L. A. Vasilevskaya ◽  
S. D. Shapoval
Keyword(s):  
General Population ◽  
Soft Tissues ◽  
Lower Extremities ◽  
Clinical Situation ◽  
Point Of View ◽  
Quantitative Composition ◽  
City Hospital ◽  
Gram Negative ◽  
Non Profit ◽  
Surgical Infection

Purpose. The purpose is to find out the frequency of surgical forms of erysipelas among the general population of the disease. Materials and methods. Traditionally, there is a widespread point of view about streptococcal etiology of erysipelas. However, recently, staphylococcus or microbial associations are increasingly sown from the focus of inflammation in patients. The relevance of studying the course of erysipelas is determined by the tendency to relapse, a significant increase in complications of the disease in recent years and the final phenomena. The existing clinical situation is largely explained by changes in the spectrum of pathogens of purulent surgical infection of soft tissues. Its leading pathogens are mainly staphylococci and streptococci, as well as gram - negative aerobic bacteria. The nature of the clinical course of the disease, including the nature of the local inflammatory focus, depends on the totality of the pathogenic properties of microbes that form the microbial landscape. It was found that most often the local focus was localized on the lower extremities. 114 case histories of patients who were hospitalized in the center of purulent-septic surgery in the Non-profit municipal enterprise “City Hospital № 3” in Zaporizhzhia for the period 2019-2020 were analyzed retrospectively and prospectively. All patients were diagnosed with erysipelas on admission, according to the forms: erythematous - 24 (21.0%), bullous - 28 (24.6%), phlegmonous form - 48 (42.1%), necrotic - 14 (12.3%). %). Disease relapses were noted in 21 patients. In terms of gender: men - 47 (41.2%), women - 67 (58.8%). The patients' age was 62.1 ± 2.6 years. Automated devices "Vitek-2" or "BaCT ALERT" (France) were used to determine the sensitivity of microorganisms in a purulent focus to antibacterial drugs. Statistical analysis was performed using the “Statgraphics Plus for Windows 7.0” software package. Research results and their analysis. It was found that most often the local focus was localized on the lower extremities. A total of 26 types of bacteria were identified from the wound contents of patients with destructive forms of erysipelas. No bacterial growth was found in 3 (4.8%) patients, and mixed flora was isolated in 27 (45.8%) patients. Gram-positive flora accounted for 61.0%, gram-negative flora - 35.6%, anaerobes - were not found, fungi - 3.4%. Conclusions. The number of destructive forms of erysipelas among the general population of the disease is more than 50%. The study of purulent-necrotic foci in patients with destructive forms of erysipelas makes it possible to determine the qualitative and quantitative composition of microflora, sensitivity to antibiotics, and make adjustments to the conduction of antibiotic therapy.

scholarly journals Some aspects of surgical treatment of erysipelas

2020 ◽  
Vol 87 (9-10) ◽  
pp. 59-62
Author(s):  
L. A. Vasylevska ◽  
S. D. Shapoval
Keyword(s):  
Blood Serum ◽  
Surgical Intervention ◽  
Diagnostic Marker ◽  
Process Zone ◽  
Clinical Signs ◽  
Pathological Process ◽  
Muscular Pain ◽  
General Weakness ◽  
Severe Intoxication

Objective. To study the incidence and to determine the main trends of treatment of the erysipelas surgical forms. Materials and methods. There were retrospectively and prospectively analyzed 114 histories of the patients’ cases, who were treated in stationary in the centre of purulent-septic surgery of the Municipal Hospital No 3 of Zaporizhzhya in 2019 - 2020 yrs. Results. Mostly often the affection site was localized on the lower extremities. In bullous and phlegmonous forms of erysipelas the most frequent clinical signs of intoxication were general weakness, hyperthermia, muscular pain. In necrotic form of erysipelas the signs of severe intoxication with nausea, regurgitation and confusion were observed. In complex treatment of erysipelas the main principles are antibioticotherapy and early surgical processing of the pathological process zone. Determination of indices of the procalcitonin content in the blood serum gives possibility to estimate progression and generalization of the process and constitutes a sensitive test for efficacy of the treatment conducted. Conclusion. Radical surgical intervention and timely targeted antibioticotherapy constitutes basic elements of successful treatment for surgical forms of erysipelas, and this position must not be revised. Procalcitonin content in the blood serum constitutes a diagnostic marker, permitting to prognosticate the sepsis development timely.

Polarographic study of hydrolysis of [8-lysine]vasopressin and its derivatives with blood serum of pregnant women

1980 ◽  
Vol 45 (4) ◽  
pp. 1099-1108 ◽  
Author(s):  
Mikuláš Chavko ◽  
Michal Bartík ◽  
Evžen Kasafírek
Keyword(s):  
Blood Serum ◽  
Pregnant Women ◽  
Degree Of Hydrolysis ◽  
Polarographic Study ◽  
Ph Optimum ◽  
Lysine Vasopressin ◽  
Rate Of Hydrolysis ◽  
Hydrolysis Of ◽  
Vasopressin Analogues

A polarographic study of the hydrolysis of [8-lysine]vasopressin and some hormonogens of the vasopressin series with the blood serum of women in the last week of pregnancy was studied. The dependence of hydrolysis on pH (pH optimum: 7.4-7.50, substrate concentration (Km 1.2 . 10-5M), pH stability and thermal stability were determined. The rate of hydrolysis of individual vasopressin analogues decreases in the order: [8-lysine]vasopressin > Nα-glycyl-prolyl[8-lysine]-vasopressin > Nα-leucyl-[8-lysine]vasopressin > Nα-alanyl-[8-lysine]vasopressin > Nα-phenyl alanyl-[8-lysine]vasopressin > Nα-diglycyl-[8-lysine]vasopressin > Nα-prolyl-[8-lysine]vasopressin > Nα-triglycyl-[8-lysine]vasopressin > Nα-sarcosyl-glycyl-[8-lysine]vasopressin. The degree of hydrolysis gradually increases to a multiple with the length of the pregnancy in consequence of the presence of oxytocine. However, vasopressin is also hydrolysed to a small extent with the enzymes from the blood sera of non-pregnant women. Under similar analytical conditions oxytocin was not hydrolysed with the sera of non-pregnant women and therefore oxytocin is a more suitable substrate than vasopressin for polarographic determination of serum oxytocinase.

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