scholarly journals Using mathematics to avoid blindness in diabetics

2018 ◽  
Vol 2 (1) ◽  
pp. 42-70
Author(s):  
Arieh Helfgott ◽  
Ariella E.R. Helfgott ◽  
Sean Mullany
Keyword(s):  
Laser Surgery ◽  
High Sensitivity ◽  
Navier Stokes ◽  
Pumping Rate ◽  
Simultaneous Application ◽  
Flow Equations ◽  
Retinal Blood Vessels ◽  
Laser Treatments ◽  
Volume Doubling ◽  
Sustained Recovery

Purpose: Avoid diabetic-blindness by applying five simple mathematically-inspired treatments that achieve life-long recovery from advanced diabetic retinopathy (ADR), without laser treatments or Avastin (Hoffmann-La Roche, Basel, Switzerland) injections.Methods: A mathematical model of ADR is derived; it is based on fluid leakage from abnormal ‘holes’ in small retinal blood vessels. First, the volume of a microscopic fluid droplet leaking from a single small vein-hole during a single heartbeat is derived from the Navier-Stokes flow-equations. Then, total fluid volume leaking into the retina from all M vein holes in N heartbeats is determined. Six parameters in the equations of the model with significant influence on leakage rates and leaked volumes are identified. These insights are used to design and then apply five simple, novel, and eff icient therapeutic treatments, T1 to T5, that may achieve recovery from ADR without laser surgery or Avastin injections. Daily rates, as well as total volumes, of macular fluid accumulation, removal (by eye-pumps), and leakage are calculated from optical coherence tomography (OCT)-measured macular thicknesses.Results: Ten years ago, this paper’s primary author, Arieh Helfgott (AH), suffered from ADR that no longer responded to laser surgery. After simultaneous application of treatments T1-T5, AH recovered from ADR in 42 days and has been free of ADR for over ten years, without needing Avastin injections. Leakage-volumes were shown to be very sensitive to small changes in hole diameters. In ADR, modest increases of 2.4%, 5.7%, 10.7%, 15%, and 19% in hole diameters induce impressive 10%, 25%, 50%, 75%, and 100% (volume-doubling) increases in leakage volumes, respectively. In recovery from ADR, modest decreases of −2.6%, −5.4%, −8.5%, −12%, and −15.9% in hole diameters induce equally impressive −10%, −20%, −30%, −40%, and −50% (volume-halving) decreases in leakage volumes, respectively.Conclusion: In AH’s case, mathematics helped in avoiding blindness from ADR. Simultaneous application of mathematics-inspired treatments T1-T5 resulted in reduced leakage from holes, elimination of retinal swelling (RS), and sustained recovery from ADR. With high sensitivity to hole diameters, advancing DR can easily become unmanageable, while recovery from ADR may possibly be achievable in approximately six weeks using efficient blood pressure (BP) control and small ‘repairs’ leading to reduction in hole diameters. The pumping rate of the eye is colossal; eye pumps can remove a macula-volume-equivalent in approximately 44 days. This is very helpful in recovery from ADR, and spectacular for such microscopic pumps 

Numerical simulation of undular jumps on graveled bed using volume of fluid method

2012 ◽  
Vol 66 (5) ◽  
pp. 909-917 ◽  
Author(s):  
Fatemeh Rostami ◽  
Saeed Reza Sabbagh Yazdi ◽  
Md Azlin Md Said ◽  
Mahdi Shahrokhi
Keyword(s):  
Free Surface ◽  
Open Channel ◽  
Flow Model ◽  
High Sensitivity ◽  
Navier Stokes ◽  
Stationary Waves ◽  
Hydraulic Jumps ◽  
Volume Of Fluid Method ◽  
Flow Equations ◽  
Proposed Model

Undular hydraulic jumps are characterized by a smooth rise of the free surface, followed by a train of stationary waves. These jumps sometimes occur in natural waterways and rivers. Numerical difficulties are especially distinct when the flow condition is close to the critical value because of the high sensitivity of the near-critical flow field to flow and channel conditions. Furthermore, the free surface has a wavy shape, which may indicate the occurrence of several transitions from supercritical to subcritical states and vice versa (i.e., undular hydraulic jumps). In this study, a flow model is used to predict an undular hydraulic jump in a rectangular open channel. The model is based on the general two-dimensional, Reynolds-averaged, Navier–Stokes flow equations. The resulting set of partial differential equations is solved using the FLOW-3D solver. The results are compared with the experimental data to validate the model. The comparative analysis shows that the proposed model yields good results. Several types of undular hydraulic jumps occurring in different situations are then simulated to prove the potential application of the model.

scholarly journals Revisiting Surface-Subsurface Exchange at Intertidal Zone with a Coupled 2D Hydrodynamic and 3D Variably-Saturated Groundwater Model

Water ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 902
Author(s):  
Zhi Li ◽  
Ben R. Hodges
Keyword(s):  
Intertidal Zone ◽  
Coastal Wetlands ◽  
High Performance ◽  
Stokes Equations ◽  
Wave Model ◽  
Surface Flow ◽  
Richards Equation ◽  
Navier Stokes ◽  
Dynamic Surface ◽  
Flow Equations

A new high-performance numerical model (Frehg) is developed to simulate water flow in shallow coastal wetlands. Frehg solves the 2D depth-integrated, hydrostatic, Navier–Stokes equations (i.e., shallow-water equations) in the surface domain and the 3D variably-saturated Richards equation in the subsurface domain. The two domains are asynchronously coupled to model surface-subsurface exchange. The Frehg model is applied to evaluate model sensitivity to a variety of simplifications that are commonly adopted for shallow wetland models, especially the use of the diffusive wave approximation in place of the traditional Saint-Venant equations for surface flow. The results suggest that a dynamic model for momentum is preferred over diffusive wave model for shallow coastal wetlands and marshes because the latter fails to capture flow unsteadiness. Under the combined effects of evaporation and wetting/drying, using diffusive wave model leads to discrepancies in modeled surface-subsurface exchange flux in the intertidal zone where strong exchange processes occur. It indicates shallow wetland models should be built with (i) dynamic surface flow equations that capture the timing of inundation, (ii) complex topographic features that render accurate spatial extent of inundation, and (iii) variably-saturated subsurface flow solver that is capable of modeling moisture change in the subsurface due to evaporation and infiltration.

Essential Ingredients for the Computation of Steady and Unsteady Blade Boundary Layers

1991 ◽  
Vol 113 (4) ◽  
pp. 608-616 ◽  
Author(s):  
H. M. Jang ◽  
J. A. Ekaterinaris ◽  
M. F. Platzer ◽  
T. Cebeci
Keyword(s):  
Boundary Layer ◽  
Boundary Layers ◽  
Stokes Equations ◽  
Inviscid Flow ◽  
Reynolds Numbers ◽  
Navier Stokes ◽  
Transitional Region ◽  
Low Reynolds Numbers ◽  
Flow Equations ◽  
Low Reynolds

Two methods are described for calculating pressure distributions and boundary layers on blades subjected to low Reynolds numbers and ramp-type motion. The first is based on an interactive scheme in which the inviscid flow is computed by a panel method and the boundary layer flow by an inverse method that makes use of the Hilbert integral to couple the solutions of the inviscid and viscous flow equations. The second method is based on the solution of the compressible Navier–Stokes equations with an embedded grid technique that permits accurate calculation of boundary layer flows. Studies for the Eppler-387 and NACA-0012 airfoils indicate that both methods can be used to calculate the behavior of unsteady blade boundary layers at low Reynolds numbers provided that the location of transition is computed with the en method and the transitional region is modeled properly.

Feedback Control of Turbulence

1994 ◽  
Vol 47 (6S) ◽  
pp. S3-S13 ◽  
Author(s):  
Parviz Moin ◽  
Thomas Bewley
Keyword(s):  
Feedback Control ◽  
Turbulent Flows ◽  
Systems Approach ◽  
Stokes Equations ◽  
Navier Stokes ◽  
Small Scale ◽  
Flow Equations ◽  
Active Feedback ◽  
Active Feedback Control ◽  
Mathematical Techniques

A brief review of current approaches to active feedback control of the fluctuations arising in turbulent flows is presented, emphasizing the mathematical techniques involved. Active feedback control schemes are categorized and compared by examining the extent to which they are based on the governing flow equations. These schemes are broken down into the following categories: adaptive schemes, schemes based on heuristic physical arguments, schemes based on a dynamical systems approach, and schemes based on optimal control theory applied directly to the Navier-Stokes equations. Recent advances in methods of implementing small scale flow control ideas are also reviewed.

Numerical Solutions of the Viscous Flow Equations for a Class of Closed Flows

1965 ◽  
Vol 69 (658) ◽  
pp. 714-718 ◽  
Author(s):  
Ronald D. Mills
Keyword(s):  
Moving Boundary ◽  
Numerical Solutions ◽  
Stokes Equations ◽  
Fluid Motion ◽  
Navier Stokes ◽  
Steady Flows ◽  
Flow Equations ◽  
Steady Streaming ◽  
Difference Formula ◽  
Surface Passing

The Navier-Stokes equations are solved iteratively on a small digital computer for the class of flows generated within a rectangular “cavity” by a surface passing over its open end. Solutions are presented for depth/breadth ratios ƛ=0.5 (shallow), 10 (square), 20 (deep) and Reynolds number 100. Flow photographs ore obtained which largely confirm the predicted flows. The theoretical velocity profiles and pressure distributions through the centre of the vortex in the square cavity are calculated.In an appendix an improved finite difference formula is given for the vorticity generated at a moving boundary.Since Thorn began his pioneering work some thirty-five years ago the number of numerical solutions which have been obtained for the equations of incompressible viscous fluid motion remains small (see bibliographies of Thom and Apelt, Fromm). The known solutions are principally for steady streaming flows, although two methods have now been used with success for non-steady flows (Payne jets and Fromm flow past obstacles). By contrast this paper is concerned with the class of closed flows generated in a rectangular region of varying depth/breadth ratio by a surface passing over an open end. This problem has been considered for a number of reasons.

scholarly journals Aerodynamic Dissipation

1958 ◽  
Vol 8 ◽  
pp. 966-974
Author(s):  
H. E. Petschek
Keyword(s):  
Stokes Equations ◽  
Viscosity Coefficient ◽  
Mean Free Path ◽  
Navier Stokes ◽  
Small Scale ◽  
Minimum Length ◽  
Ionized Gas ◽  
Navier Stokes Equations ◽  
Flow Equations ◽  
Rate Of Dissipation

Analyses of aerodynamic dissipation in ordinary un-ionized gases are all based upon the Navier-Stokes equations. These equations relate the rate of dissipation to the local gradients in velocity and temperature through the viscosity and heat conduction coefficients. Although it is true that in many flow situations the magnitude of the total dissipation in the gas does not depend on the magnitude of the viscosity coefficient, this coefficient does determine the minimum scale of variations observed in the gas and the form of the Navier-Stokes equations determines the type of phenomena which are observed on a small scale. In order to discuss dissipation in an ionized gas in the presence of a magnetic field, it is therefore necessary to re-examine the derivation of the basic flow equations. This paper attempts to do this for a case of a completely ionized gas and demonstrates that the basic microscopic dissipation mechanism is appreciably different. For example, it is shown that the minimum length in which the properties of the flow field can change noticeably is appreciably less than one mean free path.

Reliability of Convective Diffusion Process in Stenosis Blood Vessels

2008 ◽  
Vol 3 (1) ◽  
Author(s):  
R.K. Saket ◽  
Anil Kumar
Keyword(s):  
Mass Transport ◽  
Diffusion Process ◽  
Numerical Solutions ◽  
Stokes Equations ◽  
Wall Stress ◽  
Navier Stokes ◽  
Navier Stokes Equations ◽  
Flow Equations ◽  
Recirculation Flow ◽  
Convection Diffusion Equation

This paper presents a convective dominated reliable diffusion process in an axi-symmetric tube with a local constriction simulating a stenos artery considering the porosity effects. The investigations demonstrate the effects of wall shear stress and recirculation flow on the concentration distribution in the vessels lumen and on wall mass transfer keeping the porosity in view. The flow is governed by the incompressible Navier-Stokes equations for Newtonian fluid in porous medium. The convection diffusion equation has been used for the mass transport. The effect of porosity is examined on the velocity field and wall stress. The numerical solutions of the flow equations and the coupled mass transport equations have been obtained using a finite difference method. This paper explains the reliable effects of flow porosity on the mass transport.

THE WING-BODY AEROELASTIC ANALYSES USING THE INVERSE DESIGN METHOD

2010 ◽  
Vol 24 (13) ◽  
pp. 1479-1482
Author(s):  
SEUNG JUN LEE ◽  
DONG-KYUN IM ◽  
IN LEE ◽  
JANG-HYUK KWON
Keyword(s):  
Design Method ◽  
The Body ◽  
Inverse Design ◽  
Navier Stokes ◽  
Full Potential ◽  
Small Disturbance ◽  
Body Effect ◽  
Flow Equations ◽  
Applicable Range ◽  
Inverse Design Method

Flutter phenomenon is one of the most dangerous problems in aeroelasticity. When it occurs, the aircraft structure can fail in a few second. In recent aeroelastic research, computational fluid dynamics (CFD) techniques become important means to predict the aeroelastic unstable responses accurately. Among various flow equations like Navier-Stokes, Euler, full potential and so forth, the transonic small disturbance (TSD) theory is widely recognized as one of the most efficient theories. However, the small disturbance assumption limits the applicable range of the TSD theory to the thin wings. For a missile which usually has small aspect ratio wings, the influence of body aerodynamics on the wing surface may be significant. Thus, the flutter stability including the body effect should be verified. In this research an inverse design method is used to complement the aerodynamic deficiency derived from the fuselage. MGM (modified Garabedian-McFadden) inverse design method is used to optimize the aerodynamic field of a full aircraft model. Furthermore, the present TSD aeroelastic analyses do not require the grid regeneration process. The MGM inverse design method converges faster than other conventional aerodynamic theories. Consequently, the inverse designed aeroelastic analyses show that the flutter stability has been lowered by the body effect.

scholarly journals Reynolds, Maxwell, and the Radiometer, Revisited

2010 ◽  
Author(s):  
Holger Martin
Keyword(s):  
Heat Transfer ◽  
Stokes Equations ◽  
Historical Review ◽  
Theoretical Work ◽  
Creeping Flow ◽  
Navier Stokes ◽  
Molecular Flow ◽  
Flow Equations ◽  
Thermal Transpiration ◽  
Crookes Radiometer

In 1969, S. G. Brush and C. W. F. Everitt published a historical review, that was reprinted as subchapter 5.5 Maxwell, Osborne Reynolds, and the radiometer, in Stephen G. Brush’s famous book The Kind of Motion We Call Heat. This review covers the history of the explanation of the forces acting on the vanes of Crookes radiometer up to the end of the 19th century. The forces moving the vanes in Crookes radiometer (which are not due to radiation pressure, as initially believed by Crookes and Maxwell) have been recognized as thermal effects of the remaining gas by Reynolds — from his experimental and theoretical work on Thermal Transpiration and Impulsion, in 1879 — and by the development of the differential equations describing Thermal Creeping Flow, induced by tangential stresses due to a temperature gradient on a solid surface by Maxwell, earlier in the same year, 1879. These fundamental physical laws have not yet made their way into the majority of textbooks of heat transfer and fluid mechanics so far. A literature research about the terms of Thermal Transpiration and Thermal Creeping Flow, in connection with the radiometer forces, resulted in a large number of interesting papers; not only the original ones as mentioned in subchapter 5.5 of Brush’s book, but many more in the earlier twentieth century, by Martin Knudsen, Wilhelm Westphal, Albert Einstein, Theodor Sexl, Paul Epstein and others. The forces as calculated from free molecular flow (by Knudsen), increase linearly with pressure, while the forces from Maxwell’s Thermal Creeping Flow decrease with pressure. In an intermediate range of pressures, depending on the characteristic geometrical dimensions of flow channels or radiometer vanes, an appropriate interpolation between these two kinds of forces, as suggested by Wilhelm Westphal and later by G. Hettner, goes through a maximum. Albert Einstein’s approximate solution of the problem happens to give the order of magnitude of the forces in the maximum range. A comprehensive formula and a graph of the these forces versus pressure combines all the relevant theories by Knudsen (1910), Einstein (1924), Maxwell (1879) (and Hettner (1926), Sexl (1928), and Epstein (1929) who found mathematical solutions for Maxwells creeping flow equations for non-isothermal spheres and circular discs, which are important for thermophoresis and for the radiometer). The mechanism of Thermal Creeping Flow will become of increasing interest in micro- and submicro-channels in various new applications, so it ought to be known to every graduate student of heat transfer in the future. That’s one of the reasons why some authors have recently questioned the validity of the classical Navier-Stokes, Fourier, and Fick equations: Dieter Straub (1996) published a book on an Alternative Mathematical Theory of Non-equilibrium Phenomena. Howard Brenner (since 2005) wrote a number of papers, like Navier-Stokes, revisited, and Bi-velocity hydrodynamics, explicitly pointing to the forces acting on the vanes of the lightmill, to thermophoresis and related phenomena. Franz Durst (since 2006) also developed modifications of the classical Navier-Stokes equations. So, Reynolds, Maxwell, and the radiometer may finally have initiated a revision of the fundamental equations of thermofluiddynamics and heat- and mass transfer.

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