scholarly journals BIOLOGICAL MARKERS OF MMP-8 (MATRIX METALLOPROTEINASE 8) AND TIMP-1 (TISSUE INHIBITOR OF METALLOPROTEINASES 1) IN THE ORAL FLUID IN VARIOUS FORMS OF LICHEN PLANUS AND THEIR ROLE IN ASSESSING THE CLINICAL COURSE OF THE DISEASE

2021 ◽  
Vol 11 (3) ◽  
pp. 80-85
Author(s):  
Ekaterina Gorbatova ◽  
Marina Kozlova ◽  
Nikolay Kushlinskii ◽  
Larisa Dzikovitskaya ◽  
Predrag Bogojevich
Keyword(s):  
Lichen Planus ◽  
Biological Markers ◽  
Oral Lichen Planus ◽  
Oral Fluid ◽  
Precancerous Lesions ◽  
Before And After ◽  
Group 2 ◽  
Long Term Prognosis ◽  
Mixed Saliva ◽  
Oral Lichen

Early detection of tumor transformation of lichen planus presents a real challenge, since squamous cell carcinoma can develop both from unchanged epithelium, and against the background of inflammatory or precancerous lesions. Another aspect of untimely diagnosis is the unfavorable long-term prognosis of lichen planus, so after complex treatment, 50% of patients have a relapse: 80% — within 2 years and 20% — within 4 years. The aim of this study was to analyze the levels of MMP-8, TIMP-1 and their ratio of MP-8/TIMP-1 in the oral fluid of patients with varied forms of lichen planus. We examined and treated 24 women (35–70 years old). 14 women with oral lichen planus of the mucosa in a typical form were assigned to Group 1; 10 patients with an exudative-hyperemic form - Group 2. Concentrations of the biological markers MMP-8 and TIMP-1 were determined in the oral fluid before and after treatment. Results of the study showed that to assess the severity of oral lichen planus it is essential to evaluate concentration ratio of biological markers MMP-8/TIMP-1 in mixed saliva. Dynamic changes in MMP-8/TIMP-1 levels should be monitored at least once in a quarter.

scholarly journals Evaluation of Cellular Proliferative Activity in Patients with Oral Lichen Planus and Hepatitis C through AgNOR Method

2014 ◽  
Vol 25 (6) ◽  
pp. 461-465
Author(s):  
João Paulo De Carli ◽  
Soluete Oliveira da Silva ◽  
Maria Salete Sandini Linden ◽  
Carmen Silvia Busin ◽  
Luiz Renato Paranhos ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Lichen Planus ◽  
Oral Mucosa ◽  
Oral Lichen Planus ◽  
Clinical Signs ◽  
Hcv Infection ◽  
Control Group ◽  
Proliferative Potential ◽  
Group 2 ◽  
Oral Lichen

The objective of this study was to evaluate the cellular proliferative potential of oral lichen planus (OLP) lesions from patients without hepatitis C virus (HCV) by means of AgNOR method, as well as the cellular proliferative potential of the normal oral mucosa from patients with HCV, treated or untreated by interferon and ribavirin. A cross-sectional study was developed to investigate four groups: 10 HCV+ patients without clinical signs of OLP who had never been treated for HCV infection - Group 1; 10 HCV+ patients that were under interferon and ribavirin treatment - Group 2; 15 patients with reticular OLP lesions histopathologically confirmed, without HCV - Group 3; and 15 blood donors without HCV infection and no clinical signs of OLP GROUP 4 Control Group. The cytological material of all groups was collected by the liquid-based cytology technique. Then, the sedimented material from each patient was filled with the Nucleolar Organizer Regions impregnation by silver method (AgNOR). The count of NORs was performed on 100 epithelial cell nuclei per patient using the Image Tool(tm) software. The Tukey HSD test was used to compare the median value of NORs among the groups and showed that the oral mucosa of HCV+ patients previously treated with anti-HCV drugs (GROUP 2), presented a higher average number of NORs in relation to others (p<0.05). The anti-HCV treatment may be related to increased cell proliferation of oral mucosa, indicating a possible relationship between OLP and HCV+ patients treated with interferon and ribavirin.

Proinflammatory cytokine levels in saliva before and after treatment of (erosive) oral lichen planus with dexamethasone

Oral Diseases ◽  
2006 ◽  
Vol 12 (2) ◽  
pp. 112-116 ◽  
Author(s):  
NL Rhodus ◽  
B Cheng ◽  
W Bowles ◽  
S Myers ◽  
L Miller ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Proinflammatory Cytokine ◽  
Oral Lichen Planus ◽  
Cytokine Levels ◽  
Before And After ◽  
Oral Lichen

scholarly journals Is Topical Application of Hyaluronic Acid in Oral Lichen Planus Effective? A Randomized Controlled Crossover Study

2020 ◽  
Vol 10 (22) ◽  
pp. 7988
Author(s):  
Corinna Bruckmann ◽  
Rudolf Seemann ◽  
Klemens Rappersberger ◽  
Xiaohui Rausch-Fan ◽  
Hady Haririan ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Clinical Severity ◽  
Clinical Parameters ◽  
Whole Saliva ◽  
Before And After ◽  
Crossover Phase ◽  
Lost To Follow Up ◽  
Oral Lichen

Hyaluronic acid (HA) has anti-inflammatory and anti-edematous effects and, thus, could be promising in the treatment of oral lichen planus (OLP). The aim of the study was to evaluate the effects of topical hyaluronic acid, compared to placebo, on salivary levels of calprotectin, interleukin-6 (IL-6), and bacteria, as well as clinical and subjective parameters. Fourteen patients with confirmed OLP were included. After random selection, patients started with either 0.2% hyaluronic acid or a placebo gel for 6 weeks. Following a wash-out period, the groups changed the application. Whole saliva, clinical parameters, and questionnaires were evaluated before and after the intervention, as well as after the crossover phase. Salivary calprotectin, IL-6, and inflammation-related bacteria were determined by ELISA and PCR, respectively. There were no significant differences in clinical or subjective outcome parameters, salivary levels of IL-6, calprotectin, or bacteria after the application of hyaluronic acid, compared to placebo. However, only nine patients completed the study, as five out of seven patients starting with placebo were lost to follow-up. Significant effects of HA on inflammatory mediators and clinical parameters in OLP patients could not be proven, although a trend in clinical severity improvement could be observed.

scholarly journals Evaluation of Combined Topical Ozone and Steroid Therapy in Management of Oral Lichen Planus

2018 ◽  
Vol 6 (5) ◽  
pp. 879-884 ◽  
Author(s):  
Basma Mostafa ◽  
Mai Zakaria
Keyword(s):  
Lichen Planus ◽  
Steroid Therapy ◽  
Oral Lichen Planus ◽  
Topical Steroid ◽  
Topical Steroids ◽  
Before And After ◽  
Reported Data ◽  
Oral Lichen ◽  
Effective Adjunct ◽  
Subsequent Improvement

AIM: The present study aims to assess the therapeutic effect of the combination of topical ozone and steroid therapy in comparison to topical ozone alone versus topical steroid as a control in the management of atrophic - erosive oral lichen planus (OLP).METHODS: Sixty-six patients are having atrophic-erosive OLP were included in the study. They were randomly divided into three equal groups to be treated with topical corticosteroids alone (steroid group) as control, topical ozone alone (ozone group) or combination of topical steroids and ozone (combined group). Assessment of pain and sign scores was done before and after each treatment modality.RESULTS: The results revealed that the greatest significant percentage of change and subsequent improvement in pain and sign scores were recorded in the combined group.CONCLUSION: Reported data in this study using the combination of ozone and steroid therapy could provide a new promising safe and effective adjunct therapy for management of OLP.

scholarly journals Complete Blood Count as a Diagnostic Marker in Oral Lichen Planus

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 1766-1771
Author(s):  
Indra G ◽  
Maragathavalli G ◽  
Deepika Rajendran
Keyword(s):  
Oral Cancer ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Blood Count ◽  
Diagnostic Marker ◽  
Complete Blood Count ◽  
Precancerous Lesions ◽  
Oral Submucous Fibrosis ◽  
Oral Precancerous Lesions ◽  
Oral Lichen

Oral precancerous lesions and conditions like oral lichen planus, leukoplakia, or oral submucous fibrosis have the potential to develop into oral cancer. Oral cancer accounts for approximately 3 % of all malignancies. Oral lichen planus is a premalignant condition occurring in the oral cavity due to various factors. Blood investigations are routinely done minimally invasive procedures carried out for various diagnostic purposes. The study aims to identify if the complete blood count (CBC) can be used as a pathologic diagnostic marker in an oral premalignant disorder like oral lichen planus. A total of 64 patients (38 female, 26 male) were taken into the study between the period July 2019 - March 2020. Each patient is exposed to blood investigations, and their results are studied. The results of the study show a minimal variation in the blood results. In conclusion, to determine if it can be used as a pathological diagnostic marker in premalignant disorders like oral lichen planus, further studies must be carried out in larger populations.

scholarly journals Effects of Hepatitis C Virus Elimination by Direct-Acting Antiviral Agents on the Occurrence of Oral Lichen Planus and Periodontal Pathogen Load: A Preliminary Report

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Yumiko Nagao ◽  
Masahide Tsuji
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Periodontal Disease ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Periodontal Pathogen ◽  
Periodontal Pathogens ◽  
Periodontal Bacteria ◽  
Before And After ◽  
Oral Lichen

Objective. The association between hepatitis C virus (HCV) and oral lichen planus (OLP) is well known, but the association with periodontal disease has been reported less often. The purpose of this study was to investigate the effects of periodontal bacteria and OLP lesions before and after HCV elimination. Subjects and Methods. The subjects were four OLP patients (mean age 72.5 years) with HCV infection. Six types of periodontal bacteria (Aggregatibacter actinomycetemcomitans, Prevotella intermedia, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Fusobacterium nucleatum) were quantified in saliva, and changes in OLP were examined before and after elimination of HCV by antiviral therapy. Biochemical blood tests also were performed. Results. The total number of periodontal bacteria, the numbers of P. gingivalis, T. forsythia, T. denticola, and F. nucleatum, and the risk of presenting with the red-complex bacteria (P. gingivalis, T. forsythia, and T.denticola), leading to periodontal disease progression, decreased after HCV elimination. OLP disappeared in three of the four patients and decreased in the other after sustained virological responses (SVRs). Conclusion. HCV elimination not only improved OLP lesions but also reduced the number of periodontal pathogens and the amount of red-complex periodontal pathogens.

Expression of IFN-γ before and after treatment of oral lichen planus with 0.1% fluocinolone acetonide in orabase

2009 ◽  
Vol 38 (9) ◽  
pp. 689-694 ◽  
Author(s):  
Pornpan Youngnak-Piboonratanakit ◽  
Kittipong Dhanuthai ◽  
Kobkan Thongprasom ◽  
Pimporn Luckprom ◽  
Wilairat Sarideechaigul ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Fluocinolone Acetonide ◽  
Before And After ◽  
Ifn Γ ◽  
Oral Lichen

scholarly journals Steroids Alone, Versus Steroids with Antihistamines, in the Treatment of Oral Lichen Planus – A Comparative Study from Chennai, India

2021 ◽  
Vol 10 (37) ◽  
pp. 3277-3282
Author(s):  
Deepigaa Manivasagam ◽  
Arvind Muthukrishnan
Keyword(s):  
Mast Cells ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Combined Therapy ◽  
Topical Steroids ◽  
Rapid Reduction ◽  
Severity Of Disease ◽  
Group 2 ◽  
Oral Lichen ◽  
Group 1

BACKGROUND Lichen planus (LP) is a chronic T cell mediated autoimmune disorder affecting the skin and mucosa of the oral cavity. Mainstays of treatment are corticosteroids which are mostly used topically, and severe cases require systemic management. Recalcitrant or severe cases may require steroid sparing immune-modulators. Mast cells are predominant in the active phase of LP and antihistamines reduce mast cell numbers. The purpose of this study was to evaluate the effectiveness of antihistamines in oral lichen planus. METHODS This study was conducted from June 2019 to March 2020 in oral medicine department. A total of 54 patients were included in which group – 1 (n = 27) patients were treated with both systemic antihistamine with topical steroids, group – 2 (n = 27) patients were treated with topical steroids only. The Challacombe scale was used to assess the severity of disease at baseline, 15 days and 30 days. RESULTS Results showed that patients were in the age group of 51 - 60 years (27.8 %), female predilection (63 %), erosive OLP (50 %) and reticular OLP (38.8 %) was most commonly reported. Mean difference and standard deviation at first review and second review for group 1 was 9.85 ± 2.349, 8.14 ± 2.685; group 2 was 4.74 ± 2.297, 4.37 ± 2.436 respectively with a statistically significant value (< 0.05). In between the reviews, group - 1 showed a rapid reduction in severity of disease when compared to group - 2. CONCLUSIONS A combined therapy of topical steroids and systemic antihistamines was more effective in active reduction of disease and are easily available with no adverse effects reported. KEY WORDS Antihistamines; Challacombe Scale; Mast Cells; Oral Lichen Planus

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