Effect of Gamma-oryzanol-enriched Rice Bran Oil on Triglyceride Levels and TG/HDL Ratio in the Patients with Hypertriglyceridemia: Double-Blind Randomized Clinical Trial

2021 ◽  
Vol 104 (Suppl. 1) ◽  
pp. S70-S76
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Rice Bran ◽  
Rice Bran Oil ◽  
Serum Triglyceride ◽  
Treated Group ◽  
Lipid Lowering ◽  
P Value ◽  
Double Blind ◽  
Gamma Oryzanol

Background: Hypertriglyceridemia may contribute to hardening or thickening of the artery walls which increases the risk of stroke and heart disease. Therefore, the normal level of serum triglyceride can prevent both cardiovascular and cerebrovascular diseases. Gamma-oryzanol, a phytosterol compound presents in rice bran oil, has been shown to exhibit lipid-lowering effects in both animals and human. Objective: To evaluate the effect of gamma-oryzanol-enriched-rice bran oil from Thai brown rice, prepared by innovation technology, on plasma triglyceride (TG) level in patients with hypertriglyceridemia. Materials and Methods: Double-blind randomized clinical trial was carried out in 54 subjects with hypertriglyceridemia. They were divided into two groups (27 patients per group) and treated with RBOh (gamma-oryzanol-enriched rice bran oil, 20,000 ppm of gamma-oryzanol), and RBOn (cooking oil, gamma-oryzanol 5,000 ppm). The treatments were performed for 8 weeks. Physical examinations and laboratory tests were performed at weeks 0 (as baseline), 4th and 8th of the study. Lifestyle modifications were conducted in both groups. Results: Significant reduction of plasma TG levels at the 4th and 8th weeks of the treatment were found in RBOh-treated group with p-value = 0.024 and 0.006, respectively. In RBOn-treated group, significant reduction of plasma TG and increase in HDL levels and was observed at the 4th week, but not the 8th week of the treatment, with p-value = 0.001 and 0.020, respectively. TG/HDL cholesterol ratio was significantly reduce at the 4th and 8th week in RBOh-treated group (p-value = 0.011 and 0.048, respectively) and at the 4th week in RBOn-treated group (p-value = 0.003). No serious side effects were found throughout the study period in any group of treatment. Conclusion: Rice bran oil containing gamma oryzanol could reduce the TG level in hypertriglyceridemic patients. The RBOh, gamma oryzanol-enriched rice bran oil, showed prominent effects in reducing serum TG level and TG/HDL ratio. Therefore, RBOh intakes might be able to help prevent the occurrence of cerebrovascular and cardiovascular disease in the patients with hypertriglyceridemia. Keywords: Hypertriglyceridemia, Rice bran oil, Gamma-oryzanol, TG/HDL ratio

A Randomized, Double Blind Clinical Study to Assess the Effects of a Gamma-oryzanol-enriched Rice Bran Oil on Lipid Profile in the Hypercholesterolemic Patients

2021 ◽  
Vol 104 (Suppl. 1) ◽  
pp. S64-S69
Keyword(s):  
Risk Factor ◽  
Cholesterol Level ◽  
Rice Bran ◽  
Serum Cholesterol ◽  
Disease Risk ◽  
Rice Bran Oil ◽  
P Value ◽  
Significant Difference ◽  
Gamma Oryzanol ◽  
The Impact

Background: Hypercholesterolemia is a risk factor for developing coronary artery disease. Lifestyle modification including an intake of healthy food as well as medication have approved effect in lowering serum cholesterol. Objective: The primary objective of the present study was to determine the impact of a gamma-oryzanol-enriched rice bran oil, a product of Thailand, on serum cholesterol level. Materials and Methods: A total of in 54 hypercholesterolemic patients were divided into two groups; RBOh (20,000 ppm of gammaoryzanol, n = 27), and RBOn (5,000 ppm gamma-oryzanol, n = 27). The assigned RBO (15 ml) was intake each day for 8 weeks. Fasting serum lipids were measured at baseline and at the 4th and 8th weeks of the intervention. All patients were advised about lifestyle modifications. Results: When compared to the baseline, subjects received RBOh showed a significant difference in 2 parameters including a reduction of cholesterol level at 8th weeks (p-value = 0.0101), and decrease in LDL-C level at the end of 8th weeks (p-value = 0.0013). In the group treated with RBOn, a significant increase in HDL-C level at the end of 8th weeks (p-value = 0.0303) without any effect on total cholesterol or LDL was observed. No sign of toxic effect on liver or renal functions was seen in both treatment groups. Conclusion: RBO with gamma-oryzanol-enriched could decrease cholesterol and LDL-C level in hypercholesterolemic patients. Therefore, gamma-oryzanol-enriched RBO is a functional food that may reduce cardiovascular disease risk factor. Keywords: Hypercholesterolemia, Rice bran oil, Gamma-oryzanol, Oryza sativa

scholarly journals The Effect of Paracetamol on the Patient-Controlled Pain After Coronary Artery Bypass Surgery: A Randomized Clinical Trial Study

2022 ◽  
Author(s):  
Maziar Mahjoubifard ◽  
Yalda Moeini ◽  
Elham Feizabad ◽  
Ali Abdolrazaghnejad
Keyword(s):  
Clinical Trial ◽  
Coronary Artery ◽  
Pain Score ◽  
Randomized Clinical Trial ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Bypass Graft ◽  
P Value ◽  
Double Blind ◽  
The Mean

Background: Pain is one of the patients' common problems, and usual morbidity after coronary artery bypass graft (CABG). This study aimed to assess the effect of Paracetamol and fentanyl in reducing post-CABG pain. Methods: This double-blind randomized clinical trial was conducted on 160 patients undergoing elective CABG (80 in group F (Fentanyl) and 80 in group P (Paracetamol)), at the cardiac surgery department of hospitals affiliated with Zahedan University of Medical Sciences. In group F, 50μg of Fentanyl (intravenous (IV)) was injected followed by a solution of 10 μg/cc at a rate of 4 cc/hr. For patients in group P, 15 mg/kg of Paracetamol (IV) was administered followed by a solution of 25 μg/cc at a rate of 4 cc/hr. Patients have been infused with the named drugs within the first 24 hours after the operation. Pain severity was assessed by the visual pain score (VAS) tool at baseline, and two, four, eight, twelve, and twenty-four hours after the surgery. Results: The mean of pain score in 12 (P-value=0.002) and 24 (P-value<0.0001) hours after surgery in group P was significantly less than that of group F. The mean heart rate in patients receiving Paracetamol was significantly (P-value = 0.005) less than that of patients receiving Fentanyl for 4 hours after surgery. The mean of increasing creatinine postoperatively in two groups was significant. The mean of increasing AST and ALT postoperatively in group P was significant with no case of liver function impairment. Conclusion: It seems Paracetamol is a good choice for reducing post-CABG pain with no significant complication, although further and more comprehensive research is needed.

scholarly journals Microbial evaluation of the effectiveness of different methods for cleansing clear orthodontic retainers: A randomized clinical trial

2016 ◽  
Vol 87 (3) ◽  
pp. 460-465 ◽  
Author(s):  
Rehaf H. Albanna ◽  
Hisham M. Farawanah ◽  
Abdullah M. Aldrees
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Bacterial Species ◽  
In Vitro Tests ◽  
P Value ◽  
Full Time ◽  
Eligibility Criteria ◽  
Double Blind ◽  
Bacterial Quantification

ABSTRACT Objective: To compare effectiveness of brushing an Essix retainer with water only and brushing followed by soaking in one of three commercial cleansing tablets. Materials and Methods: A double-blind, parallel, randomized clinical trial with a split-mouth design was completed with 60 volunteers with specific eligibility criteria assigned to three groups to compare the cleansing effectiveness of brushing an Essix retainer with water only, followed by soaking in one of three alkaline peroxide–based commercial cleansing tablets (Retainer Brite®, Kukis®, and Corega®). Each participant wore an upper Essix retainer (with an electronic microsensor) on a full-time basis for 14 days and used one of the three products on one side of the retainer for 15 min/d. The effectiveness of the cleansing tablets was tested by the scanning electron microscopy, bacterial identification, bacterial quantification, and disk diffusion methods. Results: Bacterial quantification tests demonstrated nonsignificant statistical differences between the control and test sides of the three cleansing tablets: Retainer Brite®, Kukis®, and Corega® (Mann-Whitney test P-values were .6, .37, and .5, respectively). A Kruskal-Wallis test also showed nonstatistical difference in the bacterial counts between the three groups (P-value = .5). In vitro tests showed a minimal inhibition zone of Staphylococcus epidermidis only with Corega® tablets. Conclusions: Using chemical cleansing tablets after mechanical cleansing did not significantly reduce the bacterial count in Essix retainers when compared to use of mechanical cleansing alone. However, the tablets seem to be effective against “cocci” bacterial species.

RESEARCH ON PREPARATION OF&NBSP; GAMMA ORYZANOL ANTI-AGING CREAM

2017 ◽  
pp. 15-21
Author(s):  
Thi Minh Nguyet Le ◽  
Thi Kim Lien Phan
Keyword(s):  
Product Quality ◽  
Rice Bran ◽  
Rice Bran Oil ◽  
Aging Effect ◽  
Triterpene Alcohols ◽  
Beneficial Effects ◽  
Long Time ◽  
Formulation Parameters ◽  
Rice Water ◽  
Gamma Oryzanol

Background and Objectives: For a long time, Asian women have known to use rice water, rice bran for skin care, lightening dark spots and slowing down the aging process. Gamma Oryzanol, an ester mixture of trans-ferulic acid with phytosterols and triterpene alcohols extracted from rice bran oil, has been shown to have beneficial effects on the skin, especially its antioxidant and anti-aging effect. The aims of this research were to formulate Gamma Oryzanol-loaded anti-aging cream and to evaluate the product quality. Materials and Methods: Gamma Oryzanol was imported from Japan. Some formulation parameters such as emulsifi-ers, performance modifiers were investigated and the product quality was evaluated according to the criteria of drugs and cosmetics. Results: The excipients were chosen including 1% (w/w) of Lunamer with 3% (w/w) of Prolipid as emulsifiers and 8% (w/w) of mango seed butter as a state modifier in the formulation of Gamma Oryzanol anti-aging cream. The cream is ivory-white, thick, smooth, fragrant-smelling and satisfied all criteria of developed specification. Conclusion: The study was successful in the preparation of Gamma Oryzanol anti-aging cream. Key words: Gamma Oryzanol, anti-aging cream, Franz cells.

Sign in / Sign up

Export Citation Format

Share Document