Rice Bran Oil Containing Gamma-Oryzanol Improves Lipid Profiles and Antioxidant Status in Hyperlipidemic Subjects: A Randomized Double-Blind Controlled Trial

2019 ◽  
Vol 25 (3) ◽  
pp. 353-358 ◽  
Author(s):  
Akkarach Bumrungpert ◽  
Rewadee Chongsuwat ◽  
Chanchira Phosat ◽  
Arisa Butacnum
Keyword(s):  
Rice Bran ◽  
Antioxidant Status ◽  
Rice Bran Oil ◽  
Controlled Trial ◽  
Lipid Profiles ◽  
Double Blind ◽  
Gamma Oryzanol

Effect of Gamma-oryzanol-enriched Rice Bran Oil on Triglyceride Levels and TG/HDL Ratio in the Patients with Hypertriglyceridemia: Double-Blind Randomized Clinical Trial

2021 ◽  
Vol 104 (Suppl. 1) ◽  
pp. S70-S76
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Rice Bran ◽  
Rice Bran Oil ◽  
Serum Triglyceride ◽  
Treated Group ◽  
Lipid Lowering ◽  
P Value ◽  
Double Blind ◽  
Gamma Oryzanol

Background: Hypertriglyceridemia may contribute to hardening or thickening of the artery walls which increases the risk of stroke and heart disease. Therefore, the normal level of serum triglyceride can prevent both cardiovascular and cerebrovascular diseases. Gamma-oryzanol, a phytosterol compound presents in rice bran oil, has been shown to exhibit lipid-lowering effects in both animals and human. Objective: To evaluate the effect of gamma-oryzanol-enriched-rice bran oil from Thai brown rice, prepared by innovation technology, on plasma triglyceride (TG) level in patients with hypertriglyceridemia. Materials and Methods: Double-blind randomized clinical trial was carried out in 54 subjects with hypertriglyceridemia. They were divided into two groups (27 patients per group) and treated with RBOh (gamma-oryzanol-enriched rice bran oil, 20,000 ppm of gamma-oryzanol), and RBOn (cooking oil, gamma-oryzanol 5,000 ppm). The treatments were performed for 8 weeks. Physical examinations and laboratory tests were performed at weeks 0 (as baseline), 4th and 8th of the study. Lifestyle modifications were conducted in both groups. Results: Significant reduction of plasma TG levels at the 4th and 8th weeks of the treatment were found in RBOh-treated group with p-value = 0.024 and 0.006, respectively. In RBOn-treated group, significant reduction of plasma TG and increase in HDL levels and was observed at the 4th week, but not the 8th week of the treatment, with p-value = 0.001 and 0.020, respectively. TG/HDL cholesterol ratio was significantly reduce at the 4th and 8th week in RBOh-treated group (p-value = 0.011 and 0.048, respectively) and at the 4th week in RBOn-treated group (p-value = 0.003). No serious side effects were found throughout the study period in any group of treatment. Conclusion: Rice bran oil containing gamma oryzanol could reduce the TG level in hypertriglyceridemic patients. The RBOh, gamma oryzanol-enriched rice bran oil, showed prominent effects in reducing serum TG level and TG/HDL ratio. Therefore, RBOh intakes might be able to help prevent the occurrence of cerebrovascular and cardiovascular disease in the patients with hypertriglyceridemia. Keywords: Hypertriglyceridemia, Rice bran oil, Gamma-oryzanol, TG/HDL ratio

RESEARCH ON PREPARATION OF  GAMMA ORYZANOL ANTI-AGING CREAM

2017 ◽  
pp. 15-21
Author(s):  
Thi Minh Nguyet Le ◽  
Thi Kim Lien Phan
Keyword(s):  
Product Quality ◽  
Rice Bran ◽  
Rice Bran Oil ◽  
Aging Effect ◽  
Triterpene Alcohols ◽  
Beneficial Effects ◽  
Long Time ◽  
Formulation Parameters ◽  
Rice Water ◽  
Gamma Oryzanol

Background and Objectives: For a long time, Asian women have known to use rice water, rice bran for skin care, lightening dark spots and slowing down the aging process. Gamma Oryzanol, an ester mixture of trans-ferulic acid with phytosterols and triterpene alcohols extracted from rice bran oil, has been shown to have beneficial effects on the skin, especially its antioxidant and anti-aging effect. The aims of this research were to formulate Gamma Oryzanol-loaded anti-aging cream and to evaluate the product quality. Materials and Methods: Gamma Oryzanol was imported from Japan. Some formulation parameters such as emulsifi-ers, performance modifiers were investigated and the product quality was evaluated according to the criteria of drugs and cosmetics. Results: The excipients were chosen including 1% (w/w) of Lunamer with 3% (w/w) of Prolipid as emulsifiers and 8% (w/w) of mango seed butter as a state modifier in the formulation of Gamma Oryzanol anti-aging cream. The cream is ivory-white, thick, smooth, fragrant-smelling and satisfied all criteria of developed specification. Conclusion: The study was successful in the preparation of Gamma Oryzanol anti-aging cream. Key words: Gamma Oryzanol, anti-aging cream, Franz cells.

scholarly journals The effects of synbiotic supplementation on markers of insulin metabolism and lipid profiles in gestational diabetes: a randomised, double-blind, placebo-controlled trial

2016 ◽  
Vol 116 (8) ◽  
pp. 1394-1401 ◽  
Author(s):  
Shahnaz Ahmadi ◽  
Mehri Jamilian ◽  
Maryam Tajabadi-Ebrahimi ◽  
Parvaneh Jafari ◽  
Zatollah Asemi
Keyword(s):  
Gestational Diabetes ◽  
Controlled Trial ◽  
Lipid Profiles ◽  
Model Assessment ◽  
Double Blind ◽  
Insulin Metabolism ◽  
Double Blind Placebo ◽  
Vldl Cholesterol ◽  
Freeze Dried ◽  
Synbiotic Supplementation

AbstractTo the best of our knowledge, data on the effects of synbiotic supplementation on markers of insulin metabolism and lipid concentrations in patients with gestational diabetes mellitus (GDM) are scarce. The aim of the current study was to determine the effects of synbiotic supplementation on markers of insulin metabolism and lipid profiles in GDM patients. In total, seventy patients with GDM aged 18–40 years were assigned to two groups – the synbiotic group (n 35) and the placebo group (n 35) – in this randomised, double-blind, placebo-controlled trial. Patients in the synbiotic group received a daily capsule that contained three viable and freeze-dried strains: Lactobacillus acidophilus, Lactobacillus casei and Bifidobacterium bifidum (2×109 colony-forming units/g each) plus 800 mg inulin for 6 weeks. Fasting blood samples were collected at the beginning and week 6 to quantify related markers. After 6 weeks of intervention, compared with the placebo, synbiotic supplementation led to a significant decrease in serum insulin levels (−1·5 (sd 5·9) v. +4·8 (sd 11·5) µIU/ml, P=0·005), homoeostatic model assessment for insulin resistance (−0·4 (sd 1·3) v. +1·1 (sd 2·7), P=0·003) and homoeostatic model assessment for β cell function (−5·1 (sd 24·2) v. +18·9 (sd 45·6), P=0·008) and a significant increase in quantitative insulin sensitivity check index (+0·01 (sd 0·01) v. −0·007 (sd 0·02), P=0·02). In addition, synbiotic intake significantly decreased serum TAG (−14·8 (sd 56·5) v. +30·4 (sd 37·8) mg/dl, P<0·001) and VLDL-cholesterol concentrations (−3·0 (sd 11·3) v. +6·1 (sd 7·6) mg/dl, P<0·001) compared with the placebo. Overall, the results of this study demonstrate that taking synbiotic supplements for 6 weeks among patients with GDM had beneficial effects on markers of insulin metabolism, TAG and VLDL-cholesterol concentrations.

A Randomized, Double Blind Clinical Study to Assess the Effects of a Gamma-oryzanol-enriched Rice Bran Oil on Lipid Profile in the Hypercholesterolemic Patients

2021 ◽  
Vol 104 (Suppl. 1) ◽  
pp. S64-S69
Keyword(s):  
Risk Factor ◽  
Cholesterol Level ◽  
Rice Bran ◽  
Serum Cholesterol ◽  
Disease Risk ◽  
Rice Bran Oil ◽  
P Value ◽  
Significant Difference ◽  
Gamma Oryzanol ◽  
The Impact

Background: Hypercholesterolemia is a risk factor for developing coronary artery disease. Lifestyle modification including an intake of healthy food as well as medication have approved effect in lowering serum cholesterol. Objective: The primary objective of the present study was to determine the impact of a gamma-oryzanol-enriched rice bran oil, a product of Thailand, on serum cholesterol level. Materials and Methods: A total of in 54 hypercholesterolemic patients were divided into two groups; RBOh (20,000 ppm of gammaoryzanol, n = 27), and RBOn (5,000 ppm gamma-oryzanol, n = 27). The assigned RBO (15 ml) was intake each day for 8 weeks. Fasting serum lipids were measured at baseline and at the 4th and 8th weeks of the intervention. All patients were advised about lifestyle modifications. Results: When compared to the baseline, subjects received RBOh showed a significant difference in 2 parameters including a reduction of cholesterol level at 8th weeks (p-value = 0.0101), and decrease in LDL-C level at the end of 8th weeks (p-value = 0.0013). In the group treated with RBOn, a significant increase in HDL-C level at the end of 8th weeks (p-value = 0.0303) without any effect on total cholesterol or LDL was observed. No sign of toxic effect on liver or renal functions was seen in both treatment groups. Conclusion: RBO with gamma-oryzanol-enriched could decrease cholesterol and LDL-C level in hypercholesterolemic patients. Therefore, gamma-oryzanol-enriched RBO is a functional food that may reduce cardiovascular disease risk factor. Keywords: Hypercholesterolemia, Rice bran oil, Gamma-oryzanol, Oryza sativa

Bioactive components in rice bran oil improve lipid profiles in rats fed a high-cholesterol diet

2005 ◽  
Vol 25 (6) ◽  
pp. 597-606 ◽  
Author(s):  
Tae-Youl Ha ◽  
Songyi Han ◽  
Sung-Ran Kim ◽  
In-Hwan Kim ◽  
Hyun-Yu Lee ◽  
...  
Keyword(s):  
Rice Bran ◽  
Rice Bran Oil ◽  
Lipid Profiles ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
Bioactive Components ◽  
High Cholesterol

scholarly journals The Concentrations of Tocols and ^|^gamma;-Oryzanol Compounds in Rice Bran Oil Obtained by Fractional Extraction with Supercritical Carbon Dioxide

2014 ◽  
Vol 63 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Sung Won Yoon ◽  
Young-Gil Pyo ◽  
Junsoo Lee ◽  
Jeom-Sig Lee ◽  
Byung Hee Kim ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Rice Bran ◽  
Rice Bran Oil ◽  
Gamma Oryzanol ◽  
Supercritical Carbon

scholarly journals Degradation Kinetics of Gamma-Oryzanol in Antioxidant-Stripped Rice Bran Oil during Thermal Oxidation

2009 ◽  
Vol 58 (10) ◽  
pp. 491-497 ◽  
Author(s):  
Pramote Khuwijitjaru ◽  
Thippawan Yuenyong ◽  
Rungnaphar Pongsawatmanit ◽  
Shuji Adachi
Keyword(s):  
Thermal Oxidation ◽  
Rice Bran ◽  
Rice Bran Oil ◽  
Degradation Kinetics ◽  
Gamma Oryzanol ◽  
Kinetics Of

scholarly journals Rice bran oil could favorably ameliorate atherogenicity and insulin resistance indices among men with coronary artery disease: post hoc analysis of a randomized controlled trial

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Marjan Mahdavi-Roshan ◽  
Arsalan Salari ◽  
Azin Vakilpour ◽  
Amir Savar Rakhsh ◽  
Zeinab Ghorbani
Keyword(s):  
Insulin Resistance ◽  
Coronary Artery Disease ◽  
Randomized Controlled Trial ◽  
Coronary Artery ◽  
Rice Bran ◽  
Rice Bran Oil ◽  
Controlled Trial ◽  
P Value ◽  
Randomized Controlled ◽  
Artery Disease

Abstract Background Despite recent advances in recognizing more reliable indicators to estimate the coronary artery disease (CAD) patients’ response to treatment and prognosis, less attention has been paid to evaluating them in clinical trials. Hence, the present research was conducted to study the impact of rice bran oil (RBO) versus sunflower oil (SFO) on various atherogenicity and insulin resistance markers. Methods In the present 8-week randomized controlled trial, 40 CAD men with an average age of 56 years were allocated randomly into the intervention or control group to use RBO or SFO (30 g/day) plus a standardized dietary plan. As a further analysis, eight atherosclerosis-related indices were calculated before and after the study. Results Analysis of covariance test in which potential confounders and baseline levels were considered, indicated that using RBO compared to SFO reduced Castelli’s risk index I and II (adjusted means:3.29, 1.52 vs. 4.61, 2.20, respectively), atherogenic coefficient (2.29 vs. 3.61), lipoprotein combine index (6.54 vs. 17.53), and cholesterol index (0.46 vs. 1.20) after the trial (P-value ≤ 0.002). Also, the RBO group yielded significantly lower triglyceride glucose index (8.73 vs. 9.13) (P-value = 0.010). Further, marginally significant amelioration in triglyceride/HDL ratio and atherogenic index of plasma (1.48 and 0.13 vs. 1.86 and 0.24 respectively) were noted (P-value = 0.07). Spearman correlation analysis detected significant positive correlations between alterations in TNF-α serum levels (ng/L) and the majority of evaluated indices (P-value < 0.05). Conclusion Taken together, incorporating 30 g of RBO into the patient’s usual diet appeared effective in ameliorating atherogenicity and insulin resistance indicators among men with CAD, probably in relation to its anti-inflammatory properties. Trial registration The protocol of the current trial was retrospectively recorded in the Iranian clinical trial registration system (IRCT) with the registration number of IRCT20190313043045N1 (URL: https://en.irct.ir/trial/38346; Registration date: 2019-04-27).

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