scholarly journals PROFIL VERUKA VULGARIS DI POLIKLINIK KULIT DAN KELAMIN RSUP PROF. DR. R. D. KANDOU MANADO PERIODE JANUARI - DESEMBER 2013

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Preisy G. I. Tampi ◽  
Ferra O. Mawu ◽  
Nurdjannah J. Niode
Keyword(s):  
Young Adults ◽  
Human Papillomavirus ◽  
Retrospective Study ◽  
Squamous Epithelium ◽  
Hpv Infection ◽  
Indirect Contact ◽  
Verruca Vulgaris ◽  
Common Warts ◽  
Children And Young Adults

Abstract: Verruca vulgaris (common warts) is a benign proliferation of squamous epithelium caused by Human papillomavirus (HPV) infection, especially type 2 and 1. Verruca vulgaris can occur at any age, but more often among children and young adults. Warts are spread by direct or indirect contact. The lesions appear most commonly in areas affected by trauma such as the hands, fingers, elbows, and knees, albeit, they can occur in other places. This study aimed to determine the profile of verruca vulgaris in Dermatovenereology Clinic of Prof. Dr. R. D. Kandou Hospital Manado period January – December 2013. This was a retrospective study based on gender, age, occupation, location of the lesion, and therapy. The results showed that of 4099 new cases there were 43 cases of verruca vulgaris (1.05%), most were females (51.16%), and aged 5-14 years (30.22%). They were commonly students (32.56%), the location of lesion at the upper extremity (32.56%), and the treatment of the lesion with electrical surgery (93.02%). Keywords: verruca vulgaris Abstrak: Veruka vulgaris (common warts atau kutil) adalah proliferasi jinak epitel skuamous yang disebabkan oleh infeksi Human Papillomavirus (HPV), terutama tipe 2 dan 1. Veruka vulgaris dapat menyerang semua kelompok usia, tetapi lebih sering pada anak dan dewasa muda. Penyebaran virus ini dapat melalui kontak langsung maupun secara tidak langsung. Veruka sering timbul pada daerah yang terkena trauma seperti tangan, jari, siku dan lutut, namun dapat timbul di mana saja pada kulit. Penelitian ini bertujuan untuk mengetahui profil veruka vulgaris di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode Januari-Desember 2013. Penelitian ini bersifat deskriptif retrospektif dengan variabel jenis kelamin, umur, pekerjaan, lokasi lesi, dan penatalaksanaan. Hasil penelitian menunjukkan bahwa dari 4099 kasus baru terdapat 43 kasus veruka vulgaris (1,05%), terbanyak ialah pasien perempuan (51,16%), dengan kelompok umur 5-14 tahun (30,22%), terbanyak pada siswa (32,56%), lokasi lesi ekstremitas atas (32,56%), dan penatalaksanaan lesi dengan bedah listrik (93,02%).Kata kunci: veruka vulgaris

scholarly journals Management of Root Like Man: Case from Gatot Soebroto, The Indonesian Army National Hospital

1970 ◽  
Vol 1 (3) ◽  
Author(s):  
Ali Sundoro ◽  
Laureen Supit ◽  
Asrofi S. Surachman ◽  
Harun Adam ◽  
Budiman Budiman ◽  
...  
Keyword(s):  
Hpv Infection ◽  
Treatment Modalities ◽  
Team Approach ◽  
Body Parts ◽  
Papilloma Virus ◽  
Verruca Vulgaris ◽  
Common Warts ◽  
Cutaneous Warts

Background: Patients and clinicians experience the frustration of cutaneous viral warts due to human papilloma virus (HPV) infection. Verruca vulgaris, the common warts, appear in various forms at different body sites. Over 118 types of papilloma virus have been identified. The most common cutaneous warts are caused by types 1, 2, 4, 27, 57, and 19 HPV. The rare cases of generalized warts around the world are suspected to be caused by type 2 HPV. There are many treatment modalities for this disease but none is 100% effective yet. Patient and Method :We report a 39-year-old male with generalized warts on various body parts (scalp, forehead, trunk, arms, lower leg and foot). The team consist of plastic surgeons, dermatologist, psychiatrist, pathologist, medical rehabilitationist, and internist. The treatment goals were to remove all warts, prevent recurrence of the disease, and improve the immunological status of the patient. Serial excisions were performed and closure attained using a combination of primary sutures, skin grafts (split- and full-thickness), and skin flaps. 5 Fluorouracil was administered on the raw surfaces before closure. Staged excisions were performed 11 times, with 3-4 weeks interval over a1-year period. Interferon and cimetidine injection were also given to augment the immune system.Results : All lesions were successfully excised and reconstructed. On a few fingers, hypertrophic scar and minor contracture ensued after closure by skin graft. Patient is able to carry out daily living activities independently. Patient was profoundly delighted and his quality of life improved.Summary : Management of a rare generalized verruca vulgaris through a team approach, by multiple staged excision, 5-FU application before defect closure, combined with antiviral therapy, proved effective in a case.

scholarly journals Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults

Cancers ◽  
2014 ◽  
Vol 6 (3) ◽  
pp. 1691-1704 ◽  
Author(s):  
Gypsyamber D'Souza ◽  
Nicole Kluz ◽  
Alicia Wentz ◽  
Renee Youngfellow ◽  
Anne Griffioen ◽  
...  
Keyword(s):  
Young Adults ◽  
Human Papillomavirus ◽  
High Risk ◽  
Hpv Infection

Birth weight, type 2 diabetes, and insulin resistance in Pima Indian children and young adults

Diabetes Care ◽  
1999 ◽  
Vol 22 (6) ◽  
pp. 944-950 ◽  
Author(s):  
D. Dabelea ◽  
D. J. Pettitt ◽  
R. L. Hanson ◽  
G. Imperatore ◽  
P. H. Bennett ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Young Adults ◽  
Birth Weight ◽  
Indian Children ◽  
Children And Young Adults

Use of Methotrexate in Children and Young Adults Affected by Ulcerative Colitis: A Retrospective Study

2011 ◽  
Vol 106 ◽  
pp. S459
Author(s):  
Alessia Ghiselli ◽  
Cristina Calzolari ◽  
Patrizia Perazzo ◽  
Paola Soriani ◽  
Carmen Madia ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Young Adults ◽  
Retrospective Study ◽  
Children And Young Adults

scholarly journals Human papillomavirus infection among male adolescents and young adults with perinatally-acquired HIV and without HIV in Thailand

2019 ◽  
Vol 30 (10) ◽  
pp. 960-968 ◽  
Author(s):  
Orasri Wittawatmongkol ◽  
Sivaporn Gatechompol ◽  
Stephen J Kerr ◽  
Amphan Chalermchockcharoenkit ◽  
Nipat Teeratakulpisarn ◽  
...  
Keyword(s):  
Young Adults ◽  
Human Papillomavirus ◽  
High Risk ◽  
Hpv Infection ◽  
Adolescents And Young Adults ◽  
Prior History ◽  
Cd4 Cell Count ◽  
Male Adolescents ◽  
Perinatally Acquired ◽  
High Risk Hpv

HIV infection may increase the risk of persistent human papillomavirus (HPV) infection and complications. Male adolescents and young adults (AYAs) with perinatally-acquired HIV (PHIV) and without HIV in Thailand were matched by age and lifetime number of sexual partners. HPV infection at oral, anal, penile, and scrotal sites was detected by polymerase chain reaction. A total of 49 PHIV and 47 HIV-uninfected male AYAs (median age 18 [17–20] years) were enrolled (June 2013–September 2014). Overall, 18 were men who have sex with men (MSM) (12% of PHIV, 26% of HIV-uninfected AYAs; P = 0.12). Among the PHIV, the median (interquartile range) CD4 cell count was 573 (434–747) cells/mm3and 69% had HIV RNA <40 copies/ml. The prevalence of any HPV infection was 61% in PHIV and 49% in HIV-uninfected AYAs ( P = 0.23) and that of high-risk HPV was 33% in PHIV and 28% in HIV-uninfected AYAs ( P = 0.59). Among those with HPV, 55% had any high-risk HPV type and 28% had HPV-16 and/or HPV-18. In multivariate models, smoking (OR 6.10, 95% CI, 1.19–31.35, P = 0.01) and prior history of STI symptoms (OR 5.01, 95% CI, 1.63–15.40, P = 0.004) were associated with high-risk HPV infection. HPV vaccination in early adolescence presents a valuable but missed prevention opportunity.

scholarly journals Phylogenetic Analysis of the Human Papillomavirus Type 2 (HPV-2), HPV-27, and HPV-57 Group, Which Is Associated with Common Warts

Virology ◽  
1997 ◽  
Vol 239 (2) ◽  
pp. 296-302 ◽  
Author(s):  
Shih-Yen Chan ◽  
Sung-Hock Chew ◽  
Kiyofumi Egawa ◽  
Elke-Ingrid Grußendorf-Conen ◽  
Yumi Honda ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Human Papillomavirus ◽  
Common Warts

scholarly journals EPCT-01. PHASE I STUDY OF DAY101 (TAK580) IN CHILDREN AND YOUNG ADULTS WITH RADIOGRAPHICALLY RECURRENT OR PROGRESSIVE LOW-GRADE GLIOMA (LGG)

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii304-iii304
Author(s):  
Karen Wright ◽  
Emily Krzykwa ◽  
Lianne Greenspan ◽  
Susan Chi ◽  
Kee Kiat Yeo ◽  
...  
Keyword(s):  
Young Adults ◽  
Phase I ◽  
Phase I Study ◽  
Pediatric Patients ◽  
Mapk Pathway ◽  
Pharmacokinetic Parameters ◽  
Low Grade ◽  
Children And Young Adults ◽  
Dose Levels

Abstract BACKGROUND We report a phase I study examining pharmacokinetics, safety and recommended dosage of the type 2 RAF inhibitor DAY101 in children/young adults with radiographically recurrent/progressive LGGs harboring MAPK pathway alterations. METHODS Applying a 3 + 3 design, patients &lt; 18 years of age with radiographically recurrent/progressive LGG received oral DAY101 weekly for 4-week cycles up to a maximum of 2 years, if deriving clinical benefit. The starting DAY101 dosage was 280 mg/m2. Dose limiting toxicities were determined after one cycle. RESULTS We treated nine eligible patients at 280, 350, and 420 mg/m2. Eight patients had KIAA1549:BRAF fusions. One patient with NF1 did not have a biopsy. There were no DLTs. Weekly administration of DAY101 in children resulted in dose-proportional increases in Cmax and AUC similar to that described in adults. A 2.2-fold mg/kg exposure difference was observed with respect to weight-based dosing and suggested a correlation to best radiographic RANO responses of 2 complete responses, 2 partial responses, 3 stable disease, and 2 progressive disease (independently-reviewed). Median time to response was 10.5 weeks (range: 8–32 weeks). CONCLUSION The phase 1A data provide initial pharmacokinetic parameters to describe oral weekly dosing of DAY101 in pediatric patients with radiographically recurrent/progressive LGG. Plasma exposures of DAY101 achieved in adults can be reached in pediatric patients. Oral weekly DAY101 is well-tolerated and possesses anti-tumor activity. The amended protocol will explore additional dose levels and the potential for differential dosing to achieve similar responses across a variety of BSAs.

scholarly journals Detection of Human Papillomavirus Type 2 Related Sequence in Oral Papilloma

1998 ◽  
Vol 16 (3) ◽  
pp. 125-130 ◽  
Author(s):  
Taihei Yamaguchi ◽  
Masanobu Shindoh ◽  
Akira Amemiya ◽  
Nobuo Inoue ◽  
Masaaki Kawamura ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Blot Hybridization ◽  
Southern Blot Hybridization ◽  
Hpv Infection ◽  
Related Sequence ◽  
Copy Numbers ◽  
Labeled Probe ◽  
Virus Capsid Antigen

Oral papilloma is a benign tumourous lesion. Part of this lesion is associated with human papillomavirus (HPV) infection. We analysed the genetical and histopathological evidence for HPV type 2 infection in three oral papillomas. Southern blot hybridization showed HPV 2a sequence in one lesion. Cells of the positive specimen appeared to contain high copy numbers of the viral DNA in an episomal state.In situstaining demonstrated virus capsid antigen in koilocytotic cells and surrounding cells in the hyperplastic epithelial layer. Two other specimens contained no HPV sequences by labeled probe of full length linear HPVs 2a, 6b, 11, 16, 18, 31 and 33 DNA under low stringency hybridization conditions. These results showed the possibility that HPV 2 plays a role in oral papilloma.

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