Mathematical Analysis of Queueing-Inventory Model with Compliment and Multiple Working Vacations

In this paper, we provide independent continuous review of stock for two commodities, namely commodity 1(C1) and 2 (C2). The type 1(T1) customer demands C1 and Type 2(T2) customer demands C2 but C2 is also given to T1 customer as a compliment (i.e. C2 is also given as a compliment to C1). The arrival pattern of customers is from a finite source of population. The ordering policies of both commodities are independent and also, each customer demands service with positive time. A single finite retrial orbit is allowed for any customer, when the demanding item is stocked out or the server is busy. The pre-emptive priority service policy is assigned to T1 customer over T2 customer. The server may go for the working vacation as C1 becomes zero, in which T2 customer who is taking his service is allowed to orbit whenever T1 customer demands the service with both commodities and when the orbit is not full. The joint limiting distributions of four random variables are studied under steady state. Long run expected total cost rate and measures of system performance are derived.

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MAKE-OR-BUY DECISIONS ON TECHNOLOGY-INTENSIVE PRODUCTS: INSIGHTS FROM THE CONSUMER GOODS INDUSTRY

International Journal of Innovation Management ◽

10.1142/s1363919618500469 ◽

2018 ◽

Vol 22 (06) ◽

pp. 1850046

Author(s):

ALEXANDER BREM ◽

ROBERT ELSNER

Keyword(s):

Consumer Goods ◽

Short Range ◽

Core Competencies ◽

Manufacturing Companies ◽

Function Type ◽

Company Strategy ◽

Long Run ◽

Aggregation Scheme

Make-or-buy decisions on technology-intensive components represent a key task in the management of technologies. Against this background, this paper presents an analysis of a technology company which gave key insights into their make-or-buy decisions on the strategic and operative level. The results show two kinds of make-or-buy decisions, called type 1 and type 2. In contrast to type 1 make-or-buy decisions whose scope is mostly limited to the production and quality function, type 2 decisions are strongly linked to engineering and R&D activities. Moreover, two new decision matrices are introduced: a ‘product/subsystem aggregation’ scheme and a ‘make-or-buy controlling’ matrix. In an environment in which companies move towards greater use of outsourcing, the framework ensures that company strategy and core competencies are followed in the long run despite short-range deviations of make-or-buy analysis results. These findings might be helpful and suitable to other manufacturing companies that deal with technology-intensive components on a strategic and operative level.

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Shiga taxin type 2 but not type 1 induces interleukin-12 expression from peripheral blood mononuclear cells via activated nuclear transcription factor-kB

Gastroenterology ◽

10.1016/s0016-5085(01)81612-7 ◽

2001 ◽

Vol 120 (5) ◽

pp. A324-A324

Author(s):

M TATEWAKI ◽

H NAKAO ◽

H NOGAMI ◽

E HOSHINO ◽

H MOTEGI ◽

...

Keyword(s):

Transcription Factor ◽

Peripheral Blood Mononuclear Cells ◽

Peripheral Blood ◽

Mononuclear Cells ◽

Interleukin 12 ◽

Peripheral Blood Mononuclear ◽

Nuclear Transcription Factor ◽

Blood Mononuclear Cells

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Type 2 Diabetes Overtakes Type 1 in Hispanic Girls

Family Practice News ◽

10.1016/s0300-7073(08)70963-0 ◽

2008 ◽

Vol 38 (15) ◽

pp. 18

Author(s):

SHERRY BOSCHERT

Keyword(s):

Type 2 Diabetes

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Appropriateness and Timing of Kidney and/or Pancreas Transplants in Type 1 and Type 2 Diabetes

Advances in Renal Replacement Therapy ◽

10.1053/jarr.2001.21709 ◽

2001 ◽

Vol 8 (1) ◽

pp. 70-82 ◽

Cited By ~ 7

Author(s):

Amy L. Friedman

Keyword(s):

Type 2 Diabetes

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The efficacy and safety of LY2963016 among patients with Type 1 and Type 2 diabetes previously treated with insulin glargine

Diabetologie und Stoffwechsel ◽

10.1055/s-0035-1549538 ◽

2015 ◽

Vol 10 (S 01) ◽

Author(s):

D Dahl ◽

LB Lacaya ◽

RK Pollom ◽

LL Ilag ◽

JS Zielonka

Keyword(s):

Type 2 Diabetes ◽

Insulin Glargine ◽

Efficacy And Safety ◽

Previously Treated

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Cross-sectional survey study to understand behaviours, thoughts and perceptions of Mealtime Insulin (MTI) usage in patients with Type 1 and Type 2 Diabetes (T1D, T2D)

Diabetologie und Stoffwechsel ◽

10.1055/s-0036-1580968 ◽

2016 ◽

Vol 11 (S 01) ◽

Author(s):

K van Brunt ◽

SM Corrigan ◽

R Pedersini ◽

J Rooney

Keyword(s):

Type 2 Diabetes ◽

Survey Study ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Mealtime Insulin

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Molecular analysis of FVIII gene in severe HA patients of Costa Rica

Hämostaseologie ◽

10.1055/s-0037-1619099 ◽

2010 ◽

Vol 30 (S 01) ◽

pp. S150-S152

Author(s):

G. Jiménez-Cruz ◽

M. Mendez ◽

P. Chaverri ◽

P. Alvarado ◽

W. Schröder ◽

...

Keyword(s):

Factor Viii ◽

Coagulation Factor ◽

Costa Rican ◽

Factor Viii Gene ◽

Intron 22 Inversion ◽

Intron 1 ◽

Polymerase Chain ◽

Inversion Analysis

SummaryHaemophilia A (HA) is X-chromosome linked bleeding disorders caused by deficiency of the coagulation factor VIII (FVIII). It is caused by FVIII gene intron 22 inversion (Inv22) in approximately 45% and by intron 1 inversion (Inv1) in 5% of the patients. Both inversions occur as a result of intrachromosomal recombination between homologous regions, in intron 1 or 22 and their extragenic copy located telomeric to the FVIII gene. The aim of this study was to analyze the presence of these mutations in 25 HA Costa Rican families. Patients, methods: We studied 34 HA patients and 110 unrelated obligate members and possible carriers for the presence of Inv22or Inv1. Standard analyses of the factor VIII gene were used incl. Southern blot and long-range polymerase chain reaction for inversion analysis. Results: We found altered Inv22 restriction profiles in 21 patients and 37 carriers. It was found type 1 and type 2 of the inversion of Inv22. During the screening for Inv1 among the HA patient, who were Inv22 negative, we did not found this mutation. Discussion: Our data highlight the importance of the analysis of Inv22 for their association with development of inhibitors in the HA patients and we are continuous searching of Inv1 mutation. This knowledge represents a step for genetic counseling and prevention of the inhibitor development.

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Polymorphisms of the Plasminogen Activator Inhibitor- 1 Gene in Type 1 and Type 2 Diabetes, and in Patients with Diabetic Retinopathy

Thrombosis and Haemostasis ◽

10.1055/s-0038-1642514 ◽

1994 ◽

Vol 71 (06) ◽

pp. 731-736 ◽

Cited By ~ 29

Author(s):

M W Mansfield ◽

M H Stickland ◽

A M Carter ◽

P J Grant

Keyword(s):

Diabetic Retinopathy ◽

Plasminogen Activator Inhibitor ◽

Allelic Frequency ◽

Repeat Sequence ◽

Dinucleotide Repeat ◽

Plasminogen Activator Inhibitor 1 ◽

The Difference ◽

Pai 1

SummaryTo identify whether genotype contributes to the difference in PAI-1 levels in type 1 and type 2 diabetic subjects and whether genotype relates to the development of retinopathy, a Hind III restriction fragment length polymorphism and two dinucleotide repeat polymorphisms were studied. In 519 Caucasian diabetic subjects (192 type 1, 327 type 2) and 123 Caucasian control subjects there were no differences in the frequency of the Hind III restriction alleles (type 1 vs type 2 vs control: allele 1 0.397 vs 0.420 vs 0.448; allele 2 0.603 vs 0.580 vs 0.552) nor in the allelic frequency at either dinucleotide repeat sequence. In 86 subjects with no retinopathy at 15 years or more from diagnosis of diabetes and 190 subjects with diabetic retinopathy there was no difference in the frequency of Hind III restriction alleles (retinopathy present vs retinopathy absent: allele 1 0.400 vs 0.467; allele 2 0.600 vs 0.533) nor in the allelic frequencies at either dinucleotide repeat sequence. The results indicate that there is no or minimal influence of the PAI-1 gene on either PAI-1 levels or the development of diabetic retinopathy in patients with diabetes mellitus.

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