scholarly journals Docking and Homology Modelling of Human T-Helper Cells for Various SCFV Fragments Domains to Block the Access of GP120

2019 ◽  
Vol 8 (9S3) ◽  
pp. 720-723
Keyword(s):  
T Helper Cells ◽  
Homology Modelling ◽  
The Body ◽  
T Helper ◽  
Cd4 Cells ◽  
Human Immune System ◽  
Immunodeficiency Virus ◽  
Human Immune ◽  
Hiv Gp120 ◽  
Cd4 Lymphocytes

HIV (Human Immunodeficiency Virus) is a virus which directly attacks human immune system as well as certain body organs such as brain kidneys and heart. The resistant framework is comprised of unique cells, which are associated with shielding the body from contaminations and a few tumors. The essential cells assaulted by HIV are the CD4+ lymphocytes, which help direct invulnerable capacity in the body. Since CD4+ cells are required for appropriate resistant framework work, when enough CD4+ lymphocytes have been devastated by HIV, the safe framework scarcely works. A considerable lot of the issues experienced by individuals contaminated with HIV result from a disappointment of the resistant framework to shield them from certain artful diseases (OIs) and tumors. This situation is utilized in a reasonable universe of bioinformatics in order to shape conceivable structure of the HIV gp120 which is reason for T cell contamination and a structure of the cd4+, to think about the coupling example of the gp120 and cd4+ through the docking procedure.

scholarly journals Molecular mimicry of HIV gp120: Possible implications on prevention and therapy of AIDS

2005 ◽  
Vol 13 (3-4) ◽  
pp. 126-130
Author(s):  
Nevena Veljkovic
Keyword(s):  
Immune System ◽  
Immune Responses ◽  
Molecular Mimicry ◽  
Human Immune System ◽  
Host Cell Proteins ◽  
Immunodeficiency Virus ◽  
Human Proteins ◽  
Human Immune ◽  
Hiv Gp120 ◽  
Hiv 1

A broad range of similarities between HIV-1 gp120 and human proteins-especially those participating in immune responses-highlight gp120 as a pleiotropic protein which can influence many important functions of the human immune system. The molecular mimicry that serves to the human immunodeficiency virus as potent destructive arms against immune system could be the weak point we are in search of over decades. Examples involving sequence and informational similarities of HIV-1 gp120 and immunerelated host cell proteins important for prevention and treatment of HIV infection are presented. .

scholarly journals Identification of HIV virus in Najaf city, Iraq

2020 ◽  
Vol 11 (3) ◽  
pp. 4866-4871
Author(s):  
Thualfakar Hayder Hasan ◽  
Raad A. Al-Harmoosh ◽  
Huda Jameel Baker Al-khilkhali
Keyword(s):  
Immune System ◽  
Central Africa ◽  
Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Human Immune System ◽  
Hiv Virus ◽  
Immunodeficiency Virus ◽  
Mucus Membrane ◽  
Elisa Technique ◽  
Human Immune

Acquired Immune Deficiency Syndrome (ADIS) is a disease of the human immune system that results in a decline in the efficiency of the human immune system step by step to leave people exposed to many infections and tumours. It caused by the Human Immunodeficiency Virus (HIV). The first appeared of HIV in West Central Africa in the late 19th or early 20th century. The direct contact from personal mucus membrane or bloodstream and physical fluid (blood, vaginal semen fluid and breastfeeding milk) containing the virus is the unique viral transmission route. Out of 80 blood samples were taken from different areas of Najaf city, Iraq, for ages from 20 to 60 years (males and females) to the period from 1/1/2019 to 19/12/2019. The surface antigen of the HIV was detected by the ELISA technique and mini VIDAS by a virus-specific kit. Out of 80 different patients by physical examination infected with ADIS: HIV viruses were the most incidences with 12 isolates (15%) while, there were 66 isolates (82.5%) were belonged to other infections and two strains (2.5%) were negative to any viral infection.

scholarly journals Use of a Novel Chimeric Mouse Model with a Functionally Active Human Immune System To Study Human Immunodeficiency Virus Type 1 Infection

2007 ◽  
Vol 14 (4) ◽  
pp. 391-396 ◽  
Author(s):  
Dong Sung An ◽  
Betty Poon ◽  
Raphael Ho Tsong Fang ◽  
Kees Weijer ◽  
Bianca Blom ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Human Immunodeficiency Virus ◽  
Peripheral Blood ◽  
Small Animal ◽  
Small Animal Model ◽  
Human Immune System ◽  
Immunodeficiency Virus ◽  
Human Immune ◽  
Hiv 1

ABSTRACT The goal of this study was to develop a small-animal model to study human immunodeficiency virus type 1 (HIV-1) pathogenesis in blood and primary and secondary lymphoid organs. Rag2−/−γc −/− mice that are neonatally injected with human CD34+ cells develop a functional human immune system (HIS), with human hematopoietic cells being found in the thymuses, peripheral blood, spleens, and bone marrow of the animals (hereafter these animals are referred to as HIS-Rag2−/−γc −/− mice). HIS-Rag2−/−γc −/− mice were infected with small amounts of CCR5-tropic HIV-1. Viral replication and immunophenotypic changes in the human cells in peripheral blood and lymphoid organs were examined. The productive infection of human cells in peripheral blood, thymus and spleen tissue, and bone marrow was detected. Ratios of CD4+ T cells to CD8+ T cells in the infected animals declined. Although no specific anti-HIV-1 immune responses were detected, immunoglobulin M (IgM) and IgG antibodies to an unidentified fetal calf serum protein present in the virus preparation were found in the inoculated animals. Thus, we have shown that the HIS-Rag2−/−γc −/− mouse model can be used for infection with low doses of CCR5-tropic HIV-1, which is most commonly transmitted during primary infections. HIS-Rag2−/−γc −/− mice can serve as a small-animal model for investigating HIV-1 pathogenesis and testing potential HIV-1 therapies, and studies with this model may replace some long and costly studies with nonhuman primates.

Experimental Study of Biological Material Preparation Based on Optical and Mechanical Dynamics

2014 ◽  
Vol 556-562 ◽  
pp. 366-370
Author(s):  
Jun Mei Wan ◽  
Ming Zhang Ao
Keyword(s):  
Konjac Glucomannan ◽  
The Body ◽  
Molar Ratio ◽  
Human Immune System ◽  
Scientific Analysis ◽  
Human Experiments ◽  
Data Statistics ◽  
Human Immune ◽  
Main Components ◽  
Mechanical Dynamics

The main components of Konjac glucomannan are glucose and glucomannan that are byڂ1-4 bond [ molar ratio is 1.6: (1~4) ] of high molecular weight non-ionic glucomannan, special glucose and mannose's ڂ-1-4chain structure isn't affected by the human digestive enzymes, and does not generate heat. According to the peculiar properties of konjac glucomannan, through the scientific experiment in the body of a rabbit to verify its unique immunological function, and then the human experiments after the effective experimental data statistics scientific analysis, finally the system can obtain the effect of konjac glucomannan on human immune system.

scholarly journals Activated Memory CD4+ T Helper Cells Repopulate the Intestine Early following Antiretroviral Therapy of Simian Immunodeficiency Virus-Infected Rhesus Macaques but Exhibit a Decreased Potential To Produce Interleukin-2

1999 ◽  
Vol 73 (8) ◽  
pp. 6661-6669 ◽  
Author(s):  
Joseph J. Mattapallil ◽  
Zeljka Smit-McBride ◽  
Peter Dailey ◽  
Satya Dandekar
Keyword(s):  
T Cells ◽  
Antiretroviral Therapy ◽  
Simian Immunodeficiency Virus ◽  
Intestinal Mucosa ◽  
T Helper Cells ◽  
Interleukin 2 ◽  
T Helper ◽  
Viral Loads ◽  
Immunodeficiency Virus ◽  
Siv Infection

ABSTRACT Using the simian immunodeficiency virus (SIV)-infected rhesus macaque model, we performed a longitudinal study to determine the effect of antiretroviral therapy on the phenotype and functional potential of CD4+ T cells repopulating intestinal mucosa in human immunodeficiency virus infection. Severe depletion of CD4+ and CD4+ CD8+ T cells occurred in the intestinal mucosa during primary SIV infection. The majority of these cells were of activated memory phenotype. Phosphonate 9-[2-(phosphomethoxypropyl]adenine (PMPA) treatment led to a moderate suppression of intestinal viral loads and repopulation of intestinal mucosa by predominantly activated memory CD4+ T-helper cells. This repopulation was independent of the level of viral suppression. Compared to preinfection values, the frequency of naive CD4+ T cells increased following PMPA therapy, suggesting that new CD4+ T cells were repopulating the intestinal mucosa. Repopulation by CD4+ CD8+ T cells was not observed in either jejunum or colon lamina propria. The majority of CD4+ T cells repopulating the intestinal mucosa following PMPA therapy were CD29hi and CD11ahi. A subset of repopulating intestinal CD4+ T cells expressed Ki-67 antigen, indicating that local proliferation may play a role in the repopulation process. Although the majority of repopulating CD4+ T cells in the intestinal mucosa were functionally capable of providing B- and T-cell help, as evidenced by their expression of CD28, these CD4+ T cells were found to have a reduced capacity to produce interleukin-2 (IL-2) compared to the potential of CD4+ T cells prior to SIV infection. Persistent viral infection may play a role in suppressing the potential of repopulating CD4+ T cells to produce IL-2. Hence, successful antiretroviral therapy should aim at complete suppression of viral loads in mucosal lymphoid tissues, such as intestinal mucosa.

scholarly journals PENERAPAN MODEL ARIMA DALAM PERAMALAN ANAK USIA 5–14 Th YANG TERINFEKSI HIV DI INDONESIA

2019 ◽  
Vol 1 (1) ◽  
pp. 74-82
Author(s):  
Wigid Hariadi ◽  
Sulantari Sulantari
Keyword(s):  
Human Immunodeficiency Virus ◽  
Immune System ◽  
Arima Model ◽  
Hiv Disease ◽  
Human Immune System ◽  
The Public ◽  
Number Of Children ◽  
Hiv Virus ◽  
Immunodeficiency Virus ◽  
Human Immune

Human Immunodeficiency Virus (HIV) is dangerous diseases for humans, and until now has not found a cure. Virus HIV is attacks the human immune system so that someone is susceptible to disease. This causes if someone is infected with HIV, then the person can experience an danger condition, it will even effect is death. In recent years, the number of children aged 5 – 14 years old that infected with HIV continues to increase. Therefore the author was moved to write about the application of the ARIMA model in forecasting the number of children aged 5 – 14 years old that infected with HIV in Indonesia by 2023. With the hope that the public or the govermment can find out the potential dangers of HIV disease, especially in children aged 5 – 14 years old. So that the public and govermment can jointly eradicate the spread of the HIV virus, especially in chidren. the result are obtained that the model that is suitable for use in forecasting is the ARIMA(0,1,2) models, with error value obtained is 0.057429. with the forecast value of the number of children aged 5 – 14 years old that infected with HIV in Indonesia from 2019 – 2023 in a row is : 570.82, 647.12, 734.14, 823.85, 944.83.

scholarly journals Efficient Acquisition of Fully Human Antibody Genes against Self-Proteins by Sorting Single B Cells Stimulated with Vaccines Based on Nitrated T Helper Cell Epitopes

2019 ◽  
Vol 2019 ◽  
pp. 1-16
Author(s):  
Liangliang Jiang ◽  
Tao Jiang ◽  
Jianhua Luo ◽  
Yanliang Kang ◽  
Yue Tong ◽  
...  
Keyword(s):  
T Cells ◽  
Immune System ◽  
B Cells ◽  
B Cell ◽  
Immune Tolerance ◽  
Human Antibody ◽  
T Helper ◽  
Human Immune System ◽  
Helper Epitope ◽  
Human Immune

Single B cell antibody technology is a method for isolating antigen-specific B cells from human peripheral blood and obtaining antibody genes in developing antibody drugs. However, owing to immune tolerance to autoantigen, human autoantigen-specific B cells are difficult to acquire by conventional single B cell technology. In this study, we constructed a nitrated T-cell epitope named NitraTh by incorporating p-nitrophenylalanine into a universal T helper epitope. NitraTh had enhanced ability to activate CD4+ T cells and can be recognized by CD4+ T cells with different HLA class II haplotypes. This NitraTh can also break immune tolerance to autoantigens, such as human epidermal growth factor receptor 2 (HER2) and cannabinoid receptor 1, and induce strong specific IgM+ B cell responses in vitro. HER2-NitraTh vaccine can also stimulate the generation of HER2-specific IgG+ B cells in human immune system mice, which was established by cotransplanting lymphocytes and autologous dendritic cells in immunodeficient mice. We obtained 30 fully human IgG antibody genes by sorting single B cells from the human immune system mice immunized with HER2-NitraTh vaccine. The analysis of antibody genes showed that sorted B cells underwent the extensive somatic mutation of the antibody genes. We randomly selected eight genes for cloning, six of which expressed antibodies that can bind to HER2. Hence, we provided a convenient and effective method in acquiring fully human antibody genes against self-proteins, which can be used in developing therapeutic antibody drugs.

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