scholarly journals THE EFFECT OF OPHIOCEPHALUS STRIATUS EXTRACT ON SERUM ADIPONECTIN LEVEL OF CANCER CACHEXIA PATIENTS

2020 ◽  
pp. 1-3
Author(s):  
Anna Puteri Gozali ◽  
Savita Handayani* ◽  
Dairion Gatot
Keyword(s):  
Clinical Trial ◽  
Insulin Sensitivity ◽  
Cancer Cachexia ◽  
Adiponectin Level ◽  
Serum Adiponectin ◽  
Serum Adiponectin Level ◽  
Open Label ◽  
Potential Source ◽  
Before And After ◽  
Ethics Commission

One of the most common manifestations of advanced cancer is the development of metabolic symptoms called cancer cachexia. Adiponectin plays a role in increasing insulin sensitivity, anti-inammation, antiatherogenic, proapoptotic, and anti-proliferative. Ophiocephalus striatus or snakehead sh is a potential source of albumin. This study aims to determine the effects of Ophiocephalus striatus extract on serum adiponectin levels of cancer cachexia patients. This study was an open label clinical trial with the design of one group pretest posttest. The study was conducted on January-June 2019 at Haji Adam Malik Hospital in Medan with the approval of the USU FK Research Ethics Commission. Data were analyzed using the SPPS program where p <0.05 was considered signicant. The results of this study showed there were signicant differences in the serum adiponectin levels of the subjects before and after administration of Ophiocephalus striatus extract for two weeks. The increase in serum albumin levels of cancer cachexia patients was obtained after administration of 5000mg Ophiocephalus striatusextract twice a day for two weeks.

scholarly journals THE EFFECT OF OPHIOCEPHALUS STRIATUS EXTRACT ON SERUM LEPTIN LEVEL OF CANCER CACHEXIA PATIENTS

2020 ◽  
Vol 8 (1) ◽  
pp. 1-7
Keyword(s):  
Adipose Tissue ◽  
Energy Homeostasis ◽  
Cancer Cachexia ◽  
Open Label ◽  
Tissue Mass ◽  
Serum Leptin ◽  
Abnormal Growth ◽  
Significant Difference ◽  
Before And After ◽  
Ethics Commission

Cancer is a disease caused by the abnormal growth of tissue cells that turn into cancer cells. Cancer can cause severe adverse effects for nutritional status. One of the nutritional problems that need attention in cancer patients is cachexia. The pathophysiology of cancer cahexia is multifactorial and not fully understood. Until now, the inflammation is a common concept raised by several studies on cancer cachexia. Leptin is a hormone produced by adipose tissue and is a member of adipocytokines that play a role in adipose tissue signaling hormones. Leptin plays an important role in signaling that regulates energy homeostasis is both central and peripheral, reduce appetite, adipose tissue mass and body weight. Cork fish or Snakehead (Family Channidae) are known to contain higher protein than other fish species. Cork fish is a potential source of albumin. This study was conducted with the aim to determine the effect of cork fish extract on serum leptin levels in cancer cahexia patients. This study is an open label clinical trial with one group pretest-posttest design. The study was conducted in July - December 2019 at the Haji Adam Malik Hospital in Medan with the approval of the USU FK Research Ethics Commission. Data were analyzed using SPPS program where p <0.05 was considered significant. This study showed that there was a significant difference in the serum leptin levels of the subjects before and after receiving Ophiocephalus striatus extract for two weeks.

scholarly journals Effect of a weight loss program on serum adiponectin and insulin resistance among overweight and obese premenopausal females

2020 ◽  
Vol 95 (1) ◽  
Author(s):  
Walaa H. Foula ◽  
Rana H. Emara ◽  
Mona K. Eldeeb ◽  
Samiha A. Mokhtar ◽  
Fikrat A. El-Sahn
Keyword(s):  
Public Health ◽  
Insulin Resistance ◽  
Weight Loss ◽  
Adiponectin Level ◽  
Normal Weight ◽  
Weight Loss Program ◽  
Serum Adiponectin ◽  
Health Clinic ◽  
Serum Adiponectin Level ◽  
Health Crisis

Abstract Background Obesity has emerged as a public health crisis in many populations including Egypt. Adipose tissue produces a number of adipokines, one of them is adiponectin which has attracted much attention because of its antidiabetic and antiatherogenic effects. Objective To determine the effect of a weight loss program on serum adiponectin level and insulin resistance among overweight and obese adult premenopausal females. Study design A pre-postintervention study was carried out among 95 premenopausal overweight and obese females (body mass index ≥ 25 kg/m2) aged 20 to 40 years at the integrated health clinic affiliated to the High Institute of Public Health, Alexandria, Egypt, from February 2016 to February 2017. All participants underwent a weight loss program based on a reduced calorie balanced diet and advised to increase their physical activity. Dietary instructions and follow-up were done weekly throughout 16 weeks. Blood samples were collected to investigate serum adiponectin level and insulin resistance at the beginning and the end of the intervention. Results After 16 weeks, a significant decrease in body weight by 9.7% was associated with a significant increase in serum adiponectin from 13.3 ± 4.9 μg/ml to 18.5 ± 5.6 μg/ml. Both fasting insulin and insulin resistance had decreased significantly by 13.6% and 13.7%, respectively. Conclusion A weight reduction program depending on a reduced calorie diet for 16 weeks was associated with a significant increase in total adiponectin level and reduction in insulin resistance. An emphasis on the importance of keeping normal weight through nutritional education and the promotion of healthy diets is recommended to reduce the risk of occurrence of insulin resistance, type 2 diabetes, and cardiovascular diseases.

scholarly journals Effect of Glimepiride on Serum Adiponectin Level in Subjects With Type 2 Diabetes

Diabetes Care ◽  
2003 ◽  
Vol 26 (7) ◽  
pp. 2215-2216 ◽  
Author(s):  
S. Nagasaka ◽  
A. Taniguchi ◽  
Y. Aiso ◽  
T. Yatagai ◽  
T. Nakamura ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adiponectin Level ◽  
Serum Adiponectin ◽  
Serum Adiponectin Level
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