scholarly journals ADIPOSE DERIVED STEM CELLS- A REVIEW OF THEIR CURRENT ROLE IN RECONSTRUCTIVE SURGERY AND REGENERATIVE MEDICINE

2021 ◽  
pp. 23-25
Author(s):  
Sheeja Rajan ◽  
Rithwik Rajesh
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Plastic Surgery ◽  
Adipose Derived Stem Cells ◽  
Invasive Procedures ◽  
Multipotent Stem Cells ◽  
Paracrine Effects ◽  
Fat Grafts ◽  
Subcutaneous Tissues ◽  
Multipotential Differentiation

Adipocytes are now known to have immense capacity for self-renewal and as well as multipotential differentiation. Adipose derived stem cells (ADSC) are multipotent stem cells of mesenchymal origin, located ubiquitously in human body. Unlike the bone marrow stem cells, they are easy to harvest from subcutaneous tissues by minimally invasive procedures. Several advances in isolation, invitro culture and replication of adipose derived stem cells have occurred in last decade. Cell assisted lipo-transfers for enhancing the survival of autologous fat grafts (AFG) by enriching them with ADSC is being practiced in Plastic surgery. Because of their potential for angiogenesis, tissue regeneration, immunomodulatory and paracrine effects, fat grafts nd considerable applications in Plastic surgery and Regenerative medicine. This paper explores the current research into applications, techniques of harvest, culture and tissue engineering of ADSC and the concerns about the oncogenic potentiation and genetic stability of the cultured cell lines.

scholarly journals A Comprehensive Understanding of UA-ADRCs (Uncultured, Autologous, Fresh, Unmodified, Adipose Derived Regenerative Cells, Isolated at Point of Care) in Regenerative Medicine

2020 ◽  
Author(s):  
Eckhard Alt ◽  
Glenn Winnier ◽  
Alexander Haenel ◽  
Ralf Rothoerl ◽  
Oender Solakoglu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Regenerative Medicine ◽  
Tissue Regeneration ◽  
Point Of Care ◽  
Adipose Derived Stem Cells ◽  
Multipotent Stem Cells ◽  
Physiological Capacity ◽  
Regenerative Cells ◽  
Regenerate Tissue

It has become practically impossible to survey the literature on cells derived from adipose tissue with the aim to apply them in regenerative medicine. The aim of this review is to provide a jump start to understanding the potential of UA-ADRCs (uncultured, unmodified, fresh, autologous adipose derived regenerative cells isolated at the point of care) in regenerative medicine. We show that serious and adequate clinical research demonstrates that tissue regeneration with UA-ADRCs is safe and effective. ADRCs are neither 'fat stem cells' nor could they exclusively be isolated from adipose tissue, as ADRCs contain the same adult (depending on the definition) pluripotent or multipotent stem cells that are ubiquitously present in the walls of small blood vessels. Of note, the specific isolation procedure used has significant impact on the number and viability of the cells and hence on safety and efficacy of UA-ADRCs. Furthermore, there is no need to further separate adipose-derived stem cells (ASCs) from ADRCs if the latter were adequately isolated from adipose tissue. Most importantly, UA-ADRCs have the physiological capacity to adequately regenerate tissue without need for manipulating, stimulating and/or (genetically) reprogramming the cells for this purpose. Tissue regeneration with UA-ADRCs fulfills the criteria of homologous use.

scholarly journals Paracrine Effects of Adipose-Derived Stem Cells on Keratinocytes and Dermal Fibroblasts

2012 ◽  
Vol 24 (2) ◽  
pp. 136 ◽  
Author(s):  
Seung Ho Lee ◽  
Sang Yun Jin ◽  
Jin Seok Song ◽  
Kyle K. Seo ◽  
Kwang Hyun Cho
Keyword(s):  
Stem Cells ◽  
Dermal Fibroblasts ◽  
Adipose Derived Stem Cells ◽  
Paracrine Effects

scholarly journals Changing Expression Profiles and Inclination to Competing Endogenous RNA Networks on MAPK Signaling Pathways of Human Adipose-Derived Stem Cells in a Direct Current Electric Field

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Mingzhu Jin ◽  
Yujing Zhang ◽  
Yuanyuan Bian ◽  
Ruiqun Qi ◽  
Xinghua Gao
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Signaling Pathway ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Keratinocyte Differentiation ◽  
Adipose Derived Stem Cells ◽  
Competing Endogenous Rna ◽  
Direct Current Electric Field ◽  
Current Electric Field

Adipose-derived stem cells (ADSCs) are an abundant cell source and provide an easy way to harvest mesenchymal stem cells, which are the focus of considerable attention in regenerative medicine. Electric fields (EF) play roles in many biological events and have been reported to promote cell proliferation, migration, and differentiation. In this study, ADSCs were treated with a direct current electric field (DCEF) of either 0 (control group) or 300 mV/mm (EF group) for six hours. RNA screening and analysis revealed that 66, 164, 26, and 1310 circRNAs, lncRNAs, miRNAs, and mRNAs, respectively, were differentially expressed in the DCEF-treated ADSCs compared with untreated ADSCs. Differentially expressed mRNAs were enriched in the MAPK signaling pathway, TNF signaling pathway, and some other pathways. ANXA1, ERRFI1, JAG1, EPHA2, PRR9, and H2AFY2 were related to the keratinocyte differentiation process. Competing endogenous RNA (ceRNA) networks were constructed on the basis of genes in the MAPK signaling pathway. Twenty-one RNAs in the above networks were randomly chosen, and their expression was validated using qRT-PCR, which showed the same expression trends as the RNA sequencing analysis. The MAPK signaling pathway is of great importance in the ADSC processes that occur in a DCEF, including keratinocyte differentiation. Several ceRNAs may participate in the regulation of MAPK signaling. This study may give new insight into the proliferation, migration, and differentiation of ADSCs, which will be valuable for tissue engineering and regenerative medicine.

Allogeneic adipose-derived stem cells promote survival of fat grafts in immunocompetent diabetic rats

2015 ◽  
Vol 364 (2) ◽  
pp. 357-367 ◽  
Author(s):  
Jun Zhang ◽  
Xiaozhi Bai ◽  
Bin Zhao ◽  
Yunchuan Wang ◽  
Linlin Su ◽  
...  
Keyword(s):  
Stem Cells ◽  
Diabetic Rats ◽  
Adipose Derived Stem Cells ◽  
Fat Grafts

scholarly journals Recent Advance in Source, Property, Differentiation, and Applications of Infrapatellar Fat Pad Adipose-Derived Stem Cells

2020 ◽  
Vol 2020 ◽  
pp. 1-14 ◽  
Author(s):  
Yu-chen Zhong ◽  
Shi-chun Wang ◽  
Yin-he Han ◽  
Yu Wen
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Regenerative Medicine ◽  
3D Culture ◽  
Infrapatellar Fat Pad ◽  
Adipose Derived Stem Cells ◽  
Fat Pad ◽  
Stem Cell Source ◽  
Marrow Mesenchymal Stem Cells ◽  
And Function

Infrapatellar fat pad (IPFP) can be easily obtained during knee surgery, which avoids the damage to patients for obtaining IPFP. Infrapatellar fat pad adipose-derived stem cells (IPFP-ASCs) are also called infrapatellar fat pad mesenchymal stem cells (IPFP-MSCs) because the morphology of IPFP-ASCs is similar to that of bone marrow mesenchymal stem cells (BM-MSCs). IPFP-ASCs are attracting more and more attention due to their characteristics suitable to regenerative medicine such as strong proliferation and differentiation, anti-inflammation, antiaging, secreting cytokines, multipotential capacity, and 3D culture. IPFP-ASCs can repair articular cartilage and relieve the pain caused by osteoarthritis, so most of IPFP-related review articles focus on osteoarthritis. This article reviews the anatomy and function of IPFP, as well as the discovery, amplification, multipotential capacity, and application of IPFP-ASCs in order to explain why IPFP-ASC is a superior stem cell source in regenerative medicine.

scholarly journals Concise Review: Adipose-Derived Stem Cells as a Novel Tool for Future Regenerative Medicine

Stem Cells ◽  
2012 ◽  
Vol 30 (5) ◽  
pp. 804-810 ◽  
Author(s):  
Hiroshi Mizuno ◽  
Morikuni Tobita ◽  
A. Cagri Uysal
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Adipose Derived Stem Cells ◽  
Concise Review

scholarly journals Dental Stem Cell Banking and Applications of Dental Stem Cells for Regenerative Medicine

2021 ◽  
Author(s):  
Karley Bates ◽  
Vincent S. Gallicchio
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Cell Biology ◽  
Deciduous Teeth ◽  
Third Molars ◽  
Dental Stem Cells ◽  
Multipotent Stem Cells ◽  
Stem Cell Banking

Since the identification of mesenchymal stem cells, stem cell biology is a greatly researched field of regenerative medicine and tissue engineering therapies and has become an essential part of dentistry. Mesenchymal stem cells are multipotent stem cells that can differentiate into many cell types. Dental mesenchymal stem cell populations have been identified in dental pulp, human exfoliated deciduous teeth, periodontal ligament, dental follicle of third molars, tooth germ of third molars, gingiva of periodontium, alveolar bone, and apical papilla. Dental stem cells are the most natural, noninvasive source of stem cells that have been identified, and they have gained recent attention due to their accessibility and the associated relatively low cost of integration into regenerative therapy. Long-term preservation of dental stem cells is becoming a popular consideration and mirrors the ideology of banking umbilical cord blood. This review outlines the recent progress in the mesenchymal stem cells used in dentistry as well as some advancements that are being made in preserving dental stem cells for future personalized medicine. The aim of this study was to completely and concisely review the current use of adult dental stem cells specifically oral sources of stem cells, banking of dental stem cells, and applications or uses of dental stem cells specifically in oral regions and in a clinical setting.

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