STUDY TO EVALUATE THE EFFICACY OF PLATELET-RICH PLASMA INJECTION IN THE MANAGEMENT OF CHRONIC NONHEALING WOUNDS

2021 ◽  
pp. 191-193
Author(s):  
Koteshwar Rao Mattigunta ◽  
S. Muqthiyar Ahamed
Keyword(s):  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Cost Effective ◽  
Complete Healing ◽  
Area Measurement ◽  
P Value ◽  
Wound Area ◽  
Area Reduction ◽  
Plasma Injection ◽  
A Prospective Study

Objective: The aim was to evaluate the efcacy of platelet-rich plasma (PRP) in treating chronic non healing wounds. Non healing ulcers are a signicant health problem with a high costs in Background: terms of human and material resources. The application of autologous PRP has been a signicant breakthrough for treating non healing ulcers ,as it is an easy and cost-effective method and provides the necessary growth factors that enhance wound healing. A prospective study was conducted from September 2018 to March 2020 at Narayana Medi Methodology: cal college. A total of 30 cases with chronic non healing ulcers of various causes (traumatic, diabetic, pressure, venous ulcers),at least six weeks old with wound area measurement between 2 cm2and 10 cm2are injected with autologous platelet-rich plasma injection twice weekly. Wound contraction was measured every 4th day and represented as a percentage of healing wound area and followed up for 6 weeks. The mean age± SD of the patients was 49.36±14.05.According to Results: the etiology, non healing ulcers are again classied as traumatic, diabetic, decubitus ulcers, venous and others (postoperative wounds, Hansen's disease)which constitutes 40%,27%,17%,3%,13% respectively. The healing rates of the various ulcers were monitored in weekly intervals till the sixth week. Among 30 patients,17 patients(57%) showed complete healing ,3 patients (10%) showed 99-90% healing ,5 patients (17%) showed 80-89% healing ,5 patients(17%) showed 80-89% healing ,4 patients (13%) showed 50-79% healing,1 patients (3%) showed <50% healing. Area reduction was statistically signicant (p-value is <0.001) Conclusion: Conventional therapies do not provide good healing for chronic nonhealing ulcers as they are not able to provide the necessary growth factors essential for the healing process.PRP is a safe, affordable, biocompatible, and simple OPD based procedure for treating nonhealing ulcers.

scholarly journals A Cost-Effective Transparency-Based Digital Imaging for Efficient and Accurate Wound Area Measurement

PLoS ONE ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. e38069 ◽  
Author(s):  
Pei-Nan Li ◽  
Hong Li ◽  
Mo-Li Wu ◽  
Shou-Yu Wang ◽  
Qing-You Kong ◽  
...  
Keyword(s):  
Digital Imaging ◽  
Cost Effective ◽  
Area Measurement ◽  
Wound Area

scholarly journals ON IMPROVING THE TREATMENT OF PATIENTS WITH CHRONIC WOUNDS OF VENOUS GENESIS

2019 ◽  
Vol 19 (3) ◽  
pp. 75-78
Author(s):  
Ya.V. Rybalka
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Platelet Rich Plasma ◽  
Control Group ◽  
Wound Area ◽  
Area Reduction ◽  
Autologous Platelet Rich Plasma ◽  
Group 2 ◽  
Autologous Platelet ◽  
Group 1

Introduction. The analysis of the effectiveness of applying autologous platelet-rich plasma was performed in order to improve the results of surgical treatment of patients with wounds that heal slowly. Materials. The study is based on the analysis of the treatment of 61 patients who suffered from slow-healing wounds of venous genesis with a diameter of no more than 8 cm on the lower extremities and took the treatment at the surgical ward. The proposed method was based on obtaining autologous enriched platelet plasma followed by its injection along the periphery of the wound. The degree of reduction of the wound surface area was assessed by the method of contact planimetry per day. The patients of the 1st group demonstrated the wound area reduction by 5.1 ± 0.6%, and the patients of the group 2 – by 1.8 ± 0.4% (p <0005). The results indicate an increase in the rate of wound healing in patients in group 1 compared with patients in group 2. During the entire follow-up period (12 weeks), complete wound epithelialisation occurred in 21 (70%) patients in group 1 and in 10 (33.3%) patients of the group 2. The wound area decreased by more than 50% in 6 patients of group 1 (20%) and in 2 (7%) patients of the control group. The wound area decreased less than by 50% in 3 patients in group 1 (10%), and in 19 patients in group 2 (60%). The use of PRP therapy has been proven to have a significant positive effect on the process of wound healing compared with the use of standard methods used for the control group. Conclusion: increase in the wound healing pace in patients of group 1 (test) compared with patients of group 2 (control) can be explained by using autologous platelet-enriched plasma as an additional means to the standard therapy.

scholarly journals Correlation between placental location and development of preeclampsia

2019 ◽  
Vol 8 (11) ◽  
pp. 4155
Author(s):  
Prashaant Uikey ◽  
Vaishali Gurwani ◽  
Megha Tajne
Keyword(s):  
Prospective Study ◽  
Screening Test ◽  
Odds Ratio ◽  
Cost Effective ◽  
Antenatal Clinic ◽  
P Value ◽  
Singleton Pregnancy ◽  
Urine Albumin ◽  
Obstetrics And Gynaecology ◽  
A Prospective Study

Background: Preeclampsia occurs in presence of placenta. Blood supply distribution within the uterus is not similar in central versus lateral sites implicating that, the site of placenta is likely to have a profound effect on the pregnancy outcome. In the light of these observations, a prospective study was designed to find out if the lateral location of placenta as seen by ultrasound between 18-24 weeks of gestation can be used to predict the development of preeclampsia.Methods: This prospective study was conducted in the department of Obstetrics and Gynaecology in IGGMC, Nagpur between January 2017 and June 2018. Pregnant women, with singleton pregnancy and without any risk factor, attending the antenatal clinic were subjected to USG between 18-24 weeks of gestation. Accordingly, patients were divided into 2 groups, 51 with lateral placenta and 51 with central placenta. All 102 women were followed till term. The end point of the study was development of preeclampsia i.e. BP >140/90 and urine albumin >300 mg in 24 hours sample. The data obtained was analysed using appropriate statistical tests.Results: Out of 102 patients, 80.9% were from lateral placenta group and only 19.1% were from central placenta. Sensitivity of this as screening test for preeclampsia was 80.9% while specificity was 58%, Odds ratio being 5.875. In predicting preeclampsia, lateral placenta had a meaningful effect with p value <0.001.Conclusions: Placental laterality, as determined by USG between 18-24 weeks of gestation, is a simple and cost-effective screening test for development of preeclampsia.

MANAGEMENT OF ADHESIVE CAPSULITIS OF SHOULDER JOINT BY SINGLE PLATELET RICH PLASMA INJECTION

2021 ◽  
Vol 5 (3) ◽  
Author(s):  
Himanshu Suman ◽  
Puneet Kumar Acharya ◽  
Jyoti Krishna ◽  
Yash Sharma ◽  
Oaj Dosaj
Keyword(s):  
Glenohumeral Joint ◽  
Platelet Rich Plasma ◽  
Adhesive Capsulitis ◽  
Cost Effective ◽  
College Hospital ◽  
Duration Of Symptoms ◽  
Medical College ◽  
Vas Score ◽  
Plasma Injection ◽  
Hospital Patients

Introduction: Adhesive capsulitis is a painful impairment characterized by the restriction of movement of shoulder due to the adhesions across the glenohumeral joint, injection of platelet-rich plasma is effective treatment to reduce the pain and restore the movement of shoulder. Aim: To assess the effectiveness single PRP injection in management of adhesive capsulitis. Material and Methods: This study enrolled 12 patients experiencing the shoulder pain for at least 3 months and attending our medical college hospital. Patients with adhesive capsulitis were given a single injection of PRP (4 ml) and followed up for 12 weeks, VAS scores and Disability Index scores were recorded and compared with the baseline scores. Result:  In present study majority of patients were females with mean duration of symptoms was 3 months. Post PRP treatment all the patients have shown significant improvement on pains VAS score, movement VAS score on 2nd, 6th, and 12th weeks follow up. Conclusion:  Present studies conclude that the AC is more prevalent among females which can be treated effectively with PRP technique. PRP as is a simple, safe and cost-effective management of AC without any adverse effects. Keywords: Adhesive Capsulitis, Platelet-Rich Plasma, Corticosteroid, Intra-articular

A Prospective Study of Clinical Outcomes in Laryngopharyngeal Reflux Diseases Following Treatment with Proton Pump Inhibitors in a Tertiary Care Hospital in Kerala

2021 ◽  
Vol 8 (28) ◽  
pp. 2538-2543
Author(s):  
Binu Raju George ◽  
Ajayan P.V ◽  
Saify Samad
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Laryngopharyngeal Reflux ◽  
Cost Effective ◽  
Reflux Symptom ◽  
P Value ◽  
Reflux Symptom Index ◽  
Symptom Index ◽  
A Prospective Study

BACKGROUND Laryngopharyngeal reflux (LPR) is found to be a common disease encountered in Otolaryngology practice. LPR presents clinically with symptoms of laryngeal irritation, frequent throat clearing, cough, and hoarseness of voice. The main diagnostic methods currently used are Fiber-optic laryngoscopy and in some centers pH monitoring. Proton pump inhibitors (PPIs) are used and found to be cost-effective and useful for the treatment of LPR. The main objective of this study was to study the effectiveness of PPIs in alleviating the symptoms assessed using Reflux Symptom Index (RSI) score and Reflux Finding Scores (RFS). METHODS A prospective study was carried out on 100 patients attending the ENT OPD of Government Medical College and Hospital, Thrissur, Kerala. Patients were evaluated for improvement in symptoms of Laryngopharyngeal reflux disease following use of proton pump inhibitors, using Reflux symptom index and Reflux finding scores using 70 degree / flexible nasopharyngolaryngoscopy. Patients with clinical findings of LPRD with RSI score > 13 and RFS score > 7 were given a standard treatment protocol followed in our ENT department using Tab. Pantoprazole 40 mg twice daily before food and the treatment response was assessed by proper follow up at 6 weeks and 12 weeks. On each follow up visit, improvement in RSI and RFS scores with Proton pump inhibitor therapy was assessed. Data collected was then tabulated and analysed. RESULTS The study was conducted in 100 patients, 59 % of whom were females and 41 % males. Mean RSI score changed from 18.9 at the beginning to 14.5 at 6 weeks of treatment and 9.0 at 12 weeks of treatment with Proton pump inhibitor. Mean RFS score changed from 10.7 at the beginning to 8.7 at 6 weeks of treatment and to 5.9 at 12 weeks of treatment. Comparison of mean Reflux Symptom Index and mean Reflux Finding Scores before and after treatment revealed improvement and the result was statistically significant (p value < 0.001). CONCLUSIONS The use of RSI and RFS scores in the assessment of PPIs at fixed intervals is cost effective and avoids time consuming and cost intensive examinations. These scores also help in early diagnosis and long term follow up of LPR patient. Fixed time interval PPI treatment significantly improved RSI and RFS scores in LPR patients. The mean RSI score changed from 18.9 at the beginning of treatment to 14.5 at 6 weeks after treatment (p value < 0.001) and 9.0 after 12 weeks of treatment; (p value < 0.001) The mean RFS score changed from 10.7 at the beginning of treatment to 8.7 at 6 weeks after treatment (p value < 0.001) and 5.9 after 12 weeks of treatment; (p value < 0.001). KEYWORDS Laryngopharyngeal Reflux, Reflux Symptom Index, Reflux Finding Score

scholarly journals Treatment of venous ulcers with growth factors: systematic review and meta-analysis

2019 ◽  
Vol 72 (1) ◽  
pp. 200-210 ◽  
Author(s):  
Magali Rezende de Carvalho ◽  
Isabelle Andrade Silveira ◽  
Beatriz Guitton Renaud Baptista de Oliveira
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Growth Factors ◽  
Growth Factor ◽  
Randomized Clinical Trials ◽  
Platelet Rich Plasma ◽  
Meta Analysis ◽  
Intervention Group ◽  
Complete Healing ◽  
Venous Ulcers

ABSTRACT Objective: To identify evidence about the effects of growth factor application on venous ulcer healing. Method: Systematic review and meta-analysis, including Randomized Clinical Trials. Searches: Ovid MEDLINE, EMBASE, CINAHL, Cochrane CENTRAL, LILACS, Web of Science, Digital Library of Theses and Dissertations; Google Scholar and list of references. Results: 802 participants were recruited from the 10 included studies: 472 in the intervention group (growth factors) and 330 as control. The relative risk for the complete healing outcome was 1.06 [95% CI 0.92-1.22], p = 0.41. Participants who received Platelet-Rich Plasma and Epidermal Growth Factor showed a slight tendency to achieve complete healing, but without statistical relevance (p <0.05). Most of the studies were classified as moderate risk of bias. Conclusion: The effect of the application of growth factors for complete healing in venous ulcers is not clear, and clinical trials with methodological quality are required for more accurate recommendations.

scholarly journals Evolução Cicatricial de feridas Crônicas no Uso de Plasma Rico em Plaquetas: série de casos

2018 ◽  
Vol 86 (24) ◽  
Author(s):  
Natália dos Santos Freitas Maues ◽  
Bruna Maiara Ferreira Barreto Pires ◽  
Beatriz Guitton Renaud Baptista de Olive ◽  
Hye Chung Kang ◽  
Marilda Andrade ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Healing Process ◽  
Reduction Rate ◽  
Blood Collection ◽  
Wound Area ◽  
Area Reduction ◽  
Three Stages ◽  
Series Study ◽  
Data Collection Procedure

Objetiva-se avaliar a efetividade do Plasma Rico em Plaquetas (PRP) no processo de cicatrização de feridascrônicas. Trata-se de um estudo de série de casos. Desfechos primários: percentual de feridas cicatrizadas;taxa de redução da área das feridas. Desfechos secundários: alteração do tecido no leito das feridas;quantidade de exsudato da lesão, odor e dor. Os dados foram coletados entre os meses de novembro de 2013a março de 2014, com tempo de seguimento de 12 semanas. O procedimento de coleta de dados foi realizadoem três etapas: anamnese, coleta e tratamento do sangue e a realização do curativo com utilização do PRP. Aamostra foi composta por 5 pacientes com úlceras de perna. Houve uma ferida completamente cicatrizada eas demais feridas apresentaram taxa de redução da área de 34%, 30%, 12% e 11%. Conclui-se que o PRPfavoreceu o processo de reparo tecidual.Palavras-chave: Ferimentos e Lesões; Cicatrização; Fator de Crescimento Derivado de Plaquetas. AbstractThe aim of this study was to evaluate the effectiveness of Platelet-Rich Plasma (PRP) in the healing process ofchronic wounds. This is a cases series study. Primary outcomes: percentage of healed wounds; reduction rateof the wound area. Secondary outcomes: alteration of tissue in the wound bed; amount of exudate from thewound, odor and pain. Data were collected from November 2013 to March 2014, with a follow-up time of 12weeks. The data collection procedure was performed in three stages: anamnesis, blood collection andtreatment and dressing using PRP. The sample consisted of 5 patients with leg ulcers. There was a completelyhealed wound and the remaining wounds presented an area reduction rate of 34%, 30%, 12% and 11%. It isconcluded that PRP favored the tissue repair process.Keywords: Injury and Wounds; Healing; Growth Factor Derived from Platelets.

scholarly journals Effect of autologous platelet-rich plasma in the promotion of healing of chronic ulcers

2017 ◽  
Vol 5 (1) ◽  
pp. 15 ◽  
Author(s):  
Mohamed M. Raslan ◽  
Nader M. Milad ◽  
Ahmed Abd AlAziz
Keyword(s):  
Platelet Rich Plasma ◽  
Case Series ◽  
Cost Effective ◽  
Complete Healing ◽  
Major Advance ◽  
Average Decrease ◽  
Chronic Ulcers ◽  
Autologous Platelet Rich Plasma ◽  
The Mean ◽  
Autologous Platelet

Background: Chronic ulcers are a big health problem worldwide. Having a great impact at personal, social and professional levels. The use of autologous Platelet Rich Plasma (PRP) is a major advance in the treatment of these ulcers as an easy and cost-effective method. Platelets provide numerous growth factors enhancing tissue healing. The aim of this study was to evaluate the safety and efficacy of autologous platelet-rich plasma as a treatment of chronic non-healing ulcers.Methods: Autologous PRP was prepared from whole blood by centrifugation and activated by 10% calcium chloride. Twenty-Four (24) patients with non-healing ulcers of different etiologies, whom they met our inclusion criteria, were treated with PRP injected every two weeks locally into their wounds until healing. The ulcer dimensions were measured every week. The follow-up period was 12 weeks after healing.Results: The mean age of the study population 41±21 years. Complete healing was achieved in all patients. The mean rate of healing (average decrease in ulcer dimensions) was 0.48 cm/week. The rate of healing was greater at the week following injection. The mean time for healing was 6.11 weeks.Conclusions: Author witnessed the useful effects of PRP application on enhancing wound healing. The results from our case series showed that PRP is a safe and effective treatment for the promotion of healing chronic ulcers. Further research and controlled, randomized prospective clinical trials on larger patient population are important to validate our results.

scholarly journals Efficacy of platelet rich plasma injection in treatment of plantar fasciitis

2017 ◽  
Vol 3 (3) ◽  
pp. 451
Author(s):  
Rahul Kadam ◽  
Sukant Vijay ◽  
Abhay Chhallani ◽  
Santosh Pandhare ◽  
Abhishek Gupta ◽  
...  
Keyword(s):  
Growth Factors ◽  
Plantar Fasciitis ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Activity Level ◽  
Long Term Results ◽  
Vas Score ◽  
Plasma Injection ◽  
The Mean

<p class="abstract"><strong>Background:</strong> Platelet rich plasma is a recently introduced therapy for treatment of chronic painful conditions in orthopaedics, it acts mainly by promoting healing process. PRP has an increased concentration of platelets which initiate tissue repair by releasing growth factors.<span class="apple-converted-space"> </span>Increased concentrations of autologous platelets yield high concentrations of growth factors, subsequently leading to intensified healing of soft tissue on a cellular level. This study was conducted to evaluate the efficacy of platelet rich plasma injection in treatment of plantar fasciitis<span lang="EN-IN">.</span></p><p class="abstract"><strong>Methods:</strong> This study was conducted on the patients coming to orthopaedic OPD at MGM medical college and hospital, kamothe, Navi Mumbai. Total of 40 planter fasciitis cases were taken in this study. Out these 40 patients 23 were Male and 17 were female. The mean age 45.85 (range 25-75). Patients were followed up for 3 months with regular interval and at each visit vas score was evaluated and noted.Total duration of study was 3 months from October 2016 to December 2016.<strong></strong></p><p class="abstract"><strong>Results:</strong> The mean pre injection vas score was 7.15 (Male – 7.13, Female – 6.70). The mean vas score at time of follow up after one week was 6.20 (Male – 6.22 Female – 6.18). The mean vas score at time of follow up after 6 week was 5.62 (Male – 5.66 Female – 5.70).  The mean vas score at time of follow up after 3 months was 3.20 (Male – 3.13 Female – 3.29)<span lang="EN-IN">. </span></p><p class="abstract"><strong>Conclusions:</strong> PRP in plantar fasciitis shows promising short term results providing patients with gradual sustained pain relief, improving daily function and lifestyle activity level. However long term results needs to be evaluated<span lang="EN-IN">.</span></p>

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