MUSCULAR TUBERCULOSIS: RARE PRESENTATION OF A COMMON ENTITY

2021 ◽  
pp. 20-21
Author(s):  
Vertika Gupta ◽  
Rashmi Gautam ◽  
Bhuvan Adhlakha ◽  
Sarita Devdhar ◽  
Arun Chaudhary
Keyword(s):  
Histopathological Examination ◽  
Giant Cells ◽  
Excision Biopsy ◽  
Epithelioid Cells ◽  
Rare Presentation ◽  
Triceps Muscle ◽  
Antituberculosis Therapy ◽  
Foamy Macrophages ◽  
Global Health Problem

Tuberculosis is a global health problem mainly affecting people in developing countries although muscular involvement is rarely seen. Authors hereby, describe a case of tuberculosis of triceps muscle in a 35-year-old immunocompetent female who presented with swelling in right upper arm. Radiological examination ruled out involvement of underlying bones. Excision biopsy was performed and on histopathological examination cyst wall showed presence of foamy macrophages in sheets, inammatory cells and few scattered epithelioid cells but no well-formed granulomas or giant cells were seen. ZN stain for acid fast bacilli was positive. Based on the above ndings a diagnosis of tuberculosis of triceps muscle was made. The patient responded well to antituberculosis therapy and is currently on follow up.

scholarly journals Trichilemmal cyst of the neck: case report and review of the literature

2021 ◽  
pp. 13-17
Author(s):  
Othman El Houari ◽  
Amal Hajjij ◽  
Ilias Tahiri ◽  
Mohamed Said Anajar ◽  
Loubna Taali ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Neck Surgery ◽  
Cervical Region ◽  
Malignant Degeneration ◽  
Review Of The Literature ◽  
Rare Presentation ◽  
Follicular Cyst ◽  
Trichilemmal Cyst ◽  
The Right

Introduction: Trichilemmal cysts are lesions originating in the isthmus of the hair follicle. They are more common in women and occur in 90% on the scalp. Presentation of case: A 10-year-old female patient presented with a hard, slightly painful, nonexophytic mass in the right cervical region (Ia). After surgical resection in healthy margins, the diagnosis of trichilemmal cyst was made on histopathological examination. Discussion: The age of the patient as well as the cervical location of this type of lesion is an extremely rare presentation of trichilemmal cyst. Follow-up is rigorous in search of a triad: ichthyosis, keratosis, deafness, particularly in this patient. Conclusion: Close follow-up in this clinical case is indicated because the risk of malignant degeneration and development of similar lesions is present. Keywords: Follicular cyst; KID syndrome; Trichilemmal cyst; Neck surgery; Trichilemmal carcinoma

Skin endometriosis between the breasts of a young girl: A case study and literature review

2019 ◽  
Vol 11 (4) ◽  
pp. 207-209
Author(s):  
Mohammad Reza Taghavi ◽  
Samaneh Mollazadeh ◽  
Mohammad Bagheri Mansoori ◽  
Mehdi Asadi
Keyword(s):  
Uterine Cavity ◽  
Diagnostic Procedures ◽  
Excision Biopsy ◽  
Common Complication ◽  
Rare Presentation ◽  
Young Females ◽  
Periodic Discharges ◽  
History Of

Objective: Endometriosis is defined as the presence of functional endometrial glands and stroma outside the uterine cavity. Skin involvement is a rare presentation of this common complication. The purpose of this study is to introduce a markedly atypical case of the skin endometriosis with periodic pains located between the breasts of the 24-year-old girl. Care report: In this case, the patient with unknown periodic discharges and painful lesion presented in different consulting diagnostics centers for her complaint. After various diagnostic procedures and treatments, she underwent an excision biopsy to evaluate endometriosis. The history of periodic fluid findings of this case aid to indicate endometriosis. This case also emphasizes the significance of suspecting not only the atypical locations of endometriosis but also presentations of endometriosis. Follow-up tests indicated that she was risk-free of endometriosis relapsing status. Conclusion: The atypical endometriosis sites can present with varied ranges of symptoms, especially ones occurred periodically with menses in young females.

Evaluation of the Clinical Profile and Treatment Outcomes of Ocular and Adnexal Rhinosporidiosis in a Tertiary Eye Care Centre

1970 ◽  
Vol 12 (3) ◽  
pp. 149-151
Author(s):  
Prateek Agarwal ◽  
Usha Kim ◽  
Vipul Arora
Keyword(s):  
Histopathological Examination ◽  
Treatment Modalities ◽  
Excision Biopsy ◽  
Care Centre ◽  
Lacrimal Sac ◽  
Eye Care ◽  
Recurrence Rates ◽  
The Mean ◽  
Conclusive Diagnosis

Aim: To describe the demographics, histopathology, treatment modalities, outcomes, and recurrence rates for patients diagnosed with ocular and adnexal rhinosporidiosis.Methods: This prospective descriptive study was conducted at the Department of Orbit, Oculoplasty, and Oncology at a tertiary eye care centre in South India. Fifty patients with a clinical diagnosis of ocular and adnexal rhinosporidiosis who presented from March 2005 to October 2007 were included. All patients underwent complete conjunctival and lid mass excision with cautery, and all patients with rhinosporidiosis of the lacrimal system underwent dacryocystectomy.Results: The mean age at presentation was 30.42 years (SD, 16.89 years; range, 1-70 years). The mean follow-up was 14.2 months (range, 12-18 months). The most common site was the conjunctiva (n = 26; 52%), followed by the lacrimal sac (n = 13; 26%) and the eyelids (n = 11; 22%). There was a single recurrence (2%) involving the lacrimal sac. Endonasal polypectomy and exploration of the sac region was done. There were no further recurrences during subsequent follow-up. The diagnosis was confirmed histopathologically for all patients.Conclusions: Rhinosporidiosis is an ocular disorder with high recurrence rates. Histopathological examination following excision biopsy is recommended for all patients for a conclusive diagnosis. Recurrence rates can be low if complete meticulous excision is performed coupled with cauterization of the lesion.

Tuberculoma of the Conus Medullaris: Case Report

Neurosurgery ◽  
2002 ◽  
Vol 50 (3) ◽  
pp. 651-653 ◽  
Author(s):  
Kudret Türeyen
Keyword(s):  
Histopathological Examination ◽  
Inflammatory Cells ◽  
Mass Effect ◽  
Giant Cells ◽  
Conus Medullaris ◽  
Antituberculosis Therapy ◽  
Patient Reported ◽  
History Of ◽  
Leg Weakness ◽  
Muscle Groups

Abstract OBJECTIVE AND IMPORTANCE: Intramedullary spinal tuberculoma is a rare form of central nervous system tuberculosis. This article describes an affected patient who presented with left leg paresis. CLINICAL PRESENTATION: A 46-year-old man presented with a 7-day history of left leg weakness. The patient's medical history included infection with pulmonary tuberculosis 15 years previously, at which time he had been treated with antituberculosis therapy. The neurological examination performed at admission revealed left leg paresis with Grade 2/5 power in all muscle groups. The patient reported no urinary or bowel problems. INTERVENTION: Surgery was performed with the patient in the prone position. The procedure involved laminectomies at T11, T12, and L1, followed by a midline myelotomy. The mass was excised completely. Histopathological examination revealed a granulomatous lesion that contained Langhans' giant cells, inflammatory cells, and evidence of caseating necrosis. The patient was prescribed a 6-month course of antituberculosis therapy with pyrazinamide, isoniazid, and rifampin. CONCLUSION: The outcome was favorable. Recently, a number of authors have reported success with medical management of intraspinal tuberculoma. Intraspinal tuberculoma produces a mass effect that can jeopardize spinal cord function. The optimal treatment is a combination of microsurgical resection and antituberculosis chemotherapy.

scholarly journals Lupus Vulgaris Causing Nasal Destruction: Rare Presentation in Current Time

2012 ◽  
Vol 1 (1) ◽  
pp. 43-45
Author(s):  
Md Rokon Uddin ◽  
Farzana Akhter ◽  
Ahmed Minhaz Shumon
Keyword(s):  
Clinical Examination ◽  
Histopathological Examination ◽  
Giant Cells ◽  
Mantoux Test ◽  
Lupus Vulgaris ◽  
Rare Presentation ◽  
Current Time ◽  
Conclusive Diagnosis

A 42-years old lady reported with slowly progressive reddish lesions over the nose, followed by atrophy and ulceration for about 6 years. Clinical examination revealed atrophied, ulcerated, erythematous lesions over central face, forehead and neck destroying whole nose. Mantoux test resulted 16×18 mm on 48 hours observation. Histopathological examination of the lesion showed noncaseating grunuloma along with Langhans giant cells in the upper dermis surrounded by lymphocytes. The conclusive diagnosis was lupus vulgaris based on above findings. Six months therapy with INH 300 mg plus rifampicin 600 mg supplemented by initial 2 months ethambutol 1000 mg plus pyrazinamide 1500 mg daily resulted clean-looking perforation with healthy margin. DOI: http://dx.doi.org/10.3329/jemc.v1i1.11140J Enam Med Col 2011; 1(1): 43-45

Recurrence-free management of type 2 variant of giant cell tumour of extensor tendon sheath of thumb

2020 ◽  
Vol 13 (10) ◽  
pp. e235762
Author(s):  
Sathish Muthu ◽  
Saravanan Annamalai ◽  
Aditya Thakur ◽  
Eswar Ramakrishnan
Keyword(s):  
Histopathological Examination ◽  
Vertical Plane ◽  
Extensor Tendon ◽  
Tendon Sheath ◽  
Giant Cells ◽  
Excision Biopsy ◽  
First Metatarsal ◽  
History Of ◽  
Polyhedral Cells ◽  
Type Giant

A 30-year-old woman presented with swelling in her right thumb of 3-month duration which was slow-growing in nature without a history of trauma. On examination, firm non-tender swelling with ill-defined border over the dorsomedial aspect of the first metacarpal was noted. The swelling was mobile only in the vertical plane with restricted adduction and abduction. Plain X-ray revealed mild erosion of the first metacarpal head. Diagnostic ultrasound confirmed the lesion to arise from the extensor tendon sheath of diffuse type without any bony involvement. A wide local excision biopsy of the swelling was planned. Intraoperatively, a 3×2 cm greyish-white mass, bony hard in consistency with lobulated surface was found arising from the tendon sheath of the extensor tendon of the thumb; it was completely excised with a wide margin. Histopathological examination revealed polyhedral cells admixed with osteoclastic type giant cells. Biopsy from the first metatarsal was normal. The patient is on follow-up for the last 5 years with no evidence of recurrence.

scholarly journals Clinicopathological study of granulomatous lobular mastitis

2019 ◽  
Vol 6 (3) ◽  
pp. 881
Author(s):  
Sapna Goel ◽  
Kanwar Singh Goel
Keyword(s):  
Histopathological Examination ◽  
Granulomatous Inflammation ◽  
Giant Cells ◽  
Contraceptive Pills ◽  
Mammary Duct ◽  
Uncommon Disease ◽  
Oral Steroids ◽  
Cystic Changes ◽  
Age Range

Background: Granulomatous lobular mastitis is an uncommon disease. This condition may resemble malignancy and tuberculosis. It is characterised by granulomatous inflammation with multinucleated giant cells, epithelioid histiocytes. The inflammation is centred on lobules. The purpose of this study is to review the clinical and pathological aspects in 8 cases of granulomatous lobular mastitis and review of pertinent literature.Methods: This is a prospective observational study. A total of 8 patients were studied. Investigations done. Patient were treated by erythromycin 250mg qid, tinidazole 500mg bid, for 7 days and steroids for two months. The lumps were excised, sinuses were excised and abscesses were drained, and oral steroids were given. Follow-up was done for 6 months.Results: Most of the patients were multiparous and lactating, with age range from 18 to 36 years. Clinically the lesion was felt as malignant in 3 patients and benign in 5 patients. Most patients were using contraceptive pills. There was suppuration in 3 patients and sinuses were found in 2 patients. Histopathological examination revealed granulomatous inflammation centred on lobules.Conclusions: The diagnosis of granulomatous lobular mastitis should be made very carefully to avoid any confusion with malignancy, tuberculosis, fungal infection, sarcoidosis, mammary duct ectasia, cystic changes in breast with over palpation and puerperal mastitis with over palpation. Though it is rare disease, but complete understanding by pathologist and surgeon is required for improving its identification.

Malignant Gastrointestinal Leiomyosarcoma and Gastrointestinal Stromal Tumor With Prominent Osteoclast-like Giant Cells

2004 ◽  
Vol 128 (4) ◽  
pp. 440-443 ◽  
Author(s):  
Luigi Insabato ◽  
Dolores Di Vizio ◽  
Giuseppe Ciancia ◽  
Guido Pettinato ◽  
Luigi Tornillo ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumor ◽  
Giant Cells ◽  
Stromal Tumor ◽  
Muscle Actin ◽  
Clinicopathologic Features ◽  
Epithelioid Cells ◽  
Stromal Tumors ◽  
Spindle Cells

Abstract Context.—One case of leiomyosarcoma and one case of gastrointestinal stromal tumor with prominent osteoclast-like giant cells have so far been reported in the digestive tract. Objective.—To ascertain the clinicopathologic features and biologic behavior of these tumors, we report 3 additional cases of leiomyosarcoma of the gastrointestinal tract and one malignant gastrointestinal stromal tumor. Design.—Histologic and immunohistochemical examinations were performed. Clinical and follow-up data were recorded, and the literature was reviewed. Results.—The age of the patients ranged from 50 to 68 years (mean, 62 years). One of the lesions arose in the stomach, one in the ileum, and 2 in the colon. Three tumors showed a strong positivity for muscle actin and desmin and were diagnosed as leiomyosarcomas, 2 of them showing spindle cells and 1 of them showing epithelioid cells. The fourth tumor reacted strongly positive for c-Kit (CD117) and vimentin, and it was diagnosed as an epithelioid malignant gastrointestinal stromal tumor. All tumors were characterized by numerous osteoclast-like giant cells that were unevenly distributed and that, using immunohistochemistry, reacted strongly with CD68. Conclusions.—Malignant stromal tumors with osteoclast-like giant cells of the gastrointestinal tract are rare entities, are more commonly of a myogenic origin such as leiomyosarcoma, and seem to have an aggressive behavior.

scholarly journals Obstructive Pseudotumor of Tuberculosis in a Young Woman: A Rare Presentation

2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
Seyyed Reza Fatemi ◽  
M. Ghobakhlou ◽  
L. Alizadeh
Keyword(s):  
Computed Tomography ◽  
Histopathological Examination ◽  
Extrapulmonary Tuberculosis ◽  
Exploratory Laparotomy ◽  
Upper Endoscopy ◽  
Retroperitoneal Mass ◽  
Rare Presentation ◽  
Difficult Diagnosis ◽  
Antituberculosis Therapy ◽  
High Index Of Suspicion

Retroperitoneal pseudotumor is an extremely rare presentation of extrapulmonary tuberculosis. The diagnosis of this paucibacillary disease is difficult which is usually misdiagnosed as a malignant tumor. High index of suspicion is required for early diagnosis and treatment of retroperitoneal pseudotumor which can affect prognosis of this disease. Because of its rarity and difficult diagnosis, we report an 18-year-old immunocompetent girl who presented with abdominal pain and vomiting. Upper endoscopy showed an exudative mass between the second and third parts of duodenum. Abdominal computed tomography (CT) revealed a large retroperitoneal mass with extension into small bowel. Exploratory laparotomy and histopathological examination of tissue showed calcified granuloma. Ziehl-Neelsen staining and PCR confirmed the tuberculosis. The patient was successfully treated with standard antituberculosis therapy.

scholarly journals Chemo-adjuvant therapy in recurrent conjunctival intraepithelial neoplasia

2020 ◽  
Vol 2 (3) ◽  
pp. 232-237
Author(s):  
Poh Fong She ◽  
Khairidzan Mohd Kamal ◽  
Akmal Haliza Zamli ◽  
Norra Harun ◽  
Safinaz Mohd Khialdin
Keyword(s):  
Adjuvant Therapy ◽  
Histopathological Examination ◽  
Anterior Segment ◽  
Intraepithelial Neoplasia ◽  
Excision Biopsy ◽  
Medical Illness ◽  
Progressive Growth ◽  
The Right ◽  
Conjunctival Intraepithelial Neoplasia

A 68-year-old Malay male with no known medical illness presented with progressive growth of right conjunctival mass over a few months. Anterior segment examination of the right eye showed an inferior perilimbal elevated gelatinous conjunctival mass measuring 6 mm vertically x 14 mm horizontally with 360° corneal vascularisation. Excision biopsy and histopathological examination revealed areas of dysplastic cells involving the full epithelial thickness, suggestive of conjunctival intraepithelial neoplasia. The patient defaulted follow-up and presented later with recurrence involving the superior two-thirds of the cornea. Pulsed dosing of topical 5-fluorouracil 1% was initiated 4 times daily for a week with 21-day breaks for a total of 4 cycles. Regression of the lesion was noted after two cycles of 5-fluorouracil.

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