CYTOLOGICAL DIAGNOSIS OF LEISHMANIAL LYMPHADENITIS

2021 ◽  
pp. 24-25
Author(s):  
S. Karthik ◽  
K. Poornima ◽  
A. B. Harke
Keyword(s):  
Endemic Area ◽  
Cytological Diagnosis ◽  
Self Healing ◽  
Indian States ◽  
Obligate Intracellular ◽  
Clinical Syndromes ◽  
Inguinal Lymphadenopathy ◽  
Visceral Disease ◽  
Genus Leishmania

Leishmaniasis is a chronic inammatory disease caused by obligate intracellular kinetoplast containing parasite of the genus Leishmania. Leishmaniasis produces varied group of clinical syndromes ranging from self-healing cutaneous ulceration to fatal visceral disease. In India it is endemic in Bihar, Sub-Himalayan regions and other north Indian states. We present a rare Cytology case of Leishmaniasis in a young boy, hailing from a non-endemic area, presenting as Isolated Inguinal Lymphadenopathy.

Infections caused by obligate intracellular bacteria

2017 ◽  
Author(s):  
Philippa C. Matthews
Keyword(s):  
Clinical Significance ◽  
Classification System ◽  
Q Fever ◽  
Intracellular Bacteria ◽  
Rickettsial Infection ◽  
Obligate Intracellular ◽  
Treatment And Prevention ◽  
Clinical Syndromes ◽  
Obligate Intracellular Bacteria ◽  
The Tropics

This chapter consists of short notes, diagrams, and tables to summarize infections caused by obligate intracellular bacteria. The chapter begins with a classification system to divide these organisms into Rickettsia, Anaplasma, Chlamydia, Coxiella, and Bartonella species. Separate sections then follow on the infections of most clinical significance for the tropics and subtropics, including the typhus group (caused by rickettsial infection) and Q fever. For ease of reference, each topic is broken down into sections, including classification, epidemiology, microbiology, pathophysiology, clinical syndromes, diagnosis, treatment, and prevention.

scholarly journals Can We Harness Immune Responses to Improve Drug Treatment in Leishmaniasis?

2020 ◽  
Vol 8 (7) ◽  
pp. 1069
Author(s):  
Raphael Taiwo Aruleba ◽  
Katharine C. Carter ◽  
Frank Brombacher ◽  
Ramona Hurdayal
Keyword(s):  
Immune Responses ◽  
Economic Status ◽  
Clinical Manifestations ◽  
Steady Increase ◽  
Clinical Use ◽  
Self Healing ◽  
Cutaneous Lesions ◽  
Vector Borne ◽  
Visceral Disease ◽  
Control And Eradication

Leishmaniasis is a vector-borne parasitic disease that has been neglected in priority for control and eradication of malaria, tuberculosis, and HIV/AIDS. Collectively, over one seventh of the world’s population is at risk of being infected with 0.7–1.2 million new infections reported annually. Clinical manifestations range from self-healing cutaneous lesions to fatal visceral disease. The first anti-leishmanial drugs were introduced in the 1950′s and, despite several shortcomings, remain the mainstay for treatment. Regardless of this and the steady increase in infections over the years, particularly among populations of low economic status, research on leishmaniasis remains under funded. This review looks at the drugs currently in clinical use and how they interact with the host immune response. Employing chemoimmunotherapeutic approaches may be one viable alternative to improve the efficacy of novel/existing drugs and extend their lifespan in clinical use.

scholarly journals Use of clinical syndromes to target antibiotic prescribing in seriously ill children in malaria endemic area: observational study

BMJ ◽  
2005 ◽  
Vol 330 (7498) ◽  
pp. 995 ◽  
Author(s):  
James A Berkley ◽  
Kathryn Maitland ◽  
Isaiah Mwangi ◽  
Caroline Ngetsa ◽  
Saleem Mwarumba ◽  
...  
Keyword(s):  
Observational Study ◽  
Endemic Area ◽  
Antibiotic Prescribing ◽  
Malaria Endemic Area ◽  
Clinical Syndromes ◽  
Seriously Ill

scholarly journals Cutaneous Leishmaniasis: Treatment Options and Possibilities for Drug Repurposing

2019 ◽  
Vol 2 (1) ◽  
pp. 9-19
Author(s):  
Aziz Alsohaimi
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Amphotericin B ◽  
Treatment Options ◽  
Geographic Location ◽  
Drug Repurposing ◽  
Current Treatment ◽  
Obligate Intracellular ◽  
Mucocutaneous Leishmaniasis ◽  
High Degree ◽  
Genus Leishmania

Leishmaniasis is a tropical disease caused by aprotozoan which is obligate intracellular parasite belongs to the genus Leishmania. There are 3 forms of the disease: visceral leishmaniasis, cutaneous leishmaniasis which is the most common, and mucocutaneous leishmaniasis. The most important compounds used to treat leishmaniasis were meglumine antimoniate (e.g. glucantime), sodium stibogluconate (e.g. pentostam) and pentavalent antimonials. There are other drugs that may be used such as pentamidine and amphotericin B. Until now, the pentavalent antimonial compounds remain the corner stone in the treatment of cutaneous leishmaniasis although this group possesses high degree of toxicity. Other treatment options include the pentamidines and liposomal amphotericin B (AmBisome). Combination therapies using AmBisome and miltefosine are another effective alternative to antimonial compounds. Other latest therapeutic options include photodynamic therapy, tamoxifen and imiquimod. The proper choice of antileishmanial therapy depends on the geographic location, host immune status, availability of the drug, and expertise of the treating physician. The present review summarizes the current treatment options available for cutaneous leishmaniasis as well as some drugs on the horizon that show promising results in the treatment of cutaneous leishmaniasis.

Autonomous self-healing polyisoprene elastomers with high modulus and good toughness based on the synergy of dynamic ionic crosslinks and highly disordered crystals

2020 ◽  
Vol 11 (41) ◽  
pp. 6549-6558
Author(s):  
Yohei Miwa ◽  
Mayu Yamada ◽  
Yu Shinke ◽  
Shoichi Kutsumizu
Keyword(s):  
Mechanical Properties ◽  
Room Temperature ◽  
Self Healing ◽  
High Modulus ◽  
Disordered Crystals ◽  
Ionic Crosslinks

We designed a novel polyisoprene elastomer with high mechanical properties and autonomous self-healing capability at room temperature facilitated by the coexistence of dynamic ionic crosslinks and crystalline components that slowly reassembled.

Congenital self-healing histiocytosis

1982 ◽  
Vol 118 (4) ◽  
pp. 267-272 ◽  
Author(s):  
E. Bonifazi
Keyword(s):  
Self Healing

The Nature of Clinical Syndromes

1952 ◽  
Vol 36 (4) ◽  
pp. 911-920 ◽  
Author(s):  
Julius Bauer
Keyword(s):  
Clinical Syndromes
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