A RETROSPECTIVE ANALYSIS OF CUMULATIVE FLUID BALANCE AND
ITS EFFECT ON RECOVERY IN PATIENTS WITH WHIPPLES SURGERY.
Introduction- Large amount of uid is administered in whipples owing to its long duration of surgery and major resection of pancreas and gastrointestinal structures. Excessive uid may lead to cellular swelling ,disruption of renal architecture and tension in the renal capsule leading to AKI. Thus the primary objective of the study was to study the effect of positive cumulative uid balance on development of postoperative Acute kidney injury (AKI) and length of intensive care stay (ICU). Secondary objective was to nd the effect of positive uid balance on development of sepsis and surgical complications. Methodology- A retrospective analysis was conducted in 106 patients undergoing whipples surgery. Results-Cumulative uid balance in rst 24 hours was 6.5 ± 1.9 litres. Acute kidney injury occurred in 20.6% of patients. On bivariate analysis, older age, longer duration of surgery and the highest lactate were found to be statistically signicantly associated with the development of acute kidney injury. The same factors were also found signicant in the multivariate analysis for development of AKI. Conclusion- Increased positive cumulative uid balance at 24 hours did not increase the development of AKI or increased the length of intensive care stay in patients undergoing whipples surgery .