scholarly journals NASOPHARYNGEAL CARCINOMA- A CLINICOPATHOLOGICAL STUDY

2020 ◽  
pp. 1-2
Author(s):  
Anchal Gupta ◽  
Syed Peerzada Tehmid Ul Haque ◽  
Padam Singh Jamwal
Keyword(s):  
Squamous Cell Carcinoma ◽  
Nasopharyngeal Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Region ◽  
Medical Intervention ◽  
Histopathological Study ◽  
Neck Node ◽  
Contrast Enhanced Ct

Background: Nasopharyngeal carcinoma is commonly a squamous cell carcinoma arising from the epithelial lining of nasopharynx more frequently seen at the fossa of Rosenmüller. Materials and methods: It included 25 patients attending Department of ENT and Head & Neck Surgery, SMGS Hospital, Jammu with nasopharyngeal carcinoma from March 2017 to March 2020 were retrospectively analysed. Thorough clinical examination of the head and neck was done. Radiological examination including chest x-ray, contrast enhanced CT and/or MRI of the head and neck region was carried out. Fine-needle aspiration cytology (FNAC) from the neck node and biopsy from the nasopharyngeal mass for histopathological study was done to arrive at a diagnosis. Results: A total of 25 histopathologically confirmed cases of nasopharyngeal carcinoma were seen with a M:F ratio of 1.8:1. The peak age was found to be 30-50 years in males and 50-59 years in females. Highest incidence was in the 5th decade of life.The most common presentation is neck swelling seen in 92% patients followed by epistaxis, hearing loss and nasal obstruction.14(56%) patients were histologically diagnosed with Non Keratinizing undifferentiated, 9(36%) were Non keratinizing differentiated and 2(8%) were Keratinizing squamous cell carcinoma.15(60%) patients presented with Stage Ⅳ disease at the time of presentation,7(28%) patients presented with Stage Ⅲ disease and 3(12%) patients presented with Stage Ⅱ disease. Conclusion: Screening patients with early symptoms of NPC as it is eminently done in countries endemic for the disease, will aid in its early detection, diagnosis and curative medical intervention and thus reducing morbidity and mortality.

scholarly journals Correlation between T and N Stages of Head and Neck Squamous Cell Carcinoma

2015 ◽  
Vol 10 (4) ◽  
pp. 26-31
Author(s):  
Krishna Koirala ◽  
Bimal Sinha ◽  
Dharma Kanta Baskota
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Region ◽  
Neck Squamous Cell Carcinoma ◽  
Neck Node ◽  
Head And Neck Region ◽  
N Stage ◽  
N Status

Background and Objective: Squamous cell carcinoma of the head and neck region is a common pathological entity. Advanced primary lesion (T) and neck node metastasis (N) both are bad prognostic features for the carcinoma. Purpose of this prospective cross sectional study is to see if T stage of primary Head and Neck squamous cell carcinoma correlates with N stage of Neck node metastasis.Materials and Methods: Patients of all ages and both sex with biopsy proven squamous cell carcinoma of Head and Neck region were included in the study. After detailed history taking and clinical examination to identify the clinical T and N status of the disease, biopsy was taken from the primary site under local or general anesthesia. Fine Needle Aspiration Cytology (FNAC) of the palpable neck node (s) was performed. Correlation of T stage of the primary tumor was seen with that of N stage of the neck by applying the statistical tests.Results: There was significant correlation of the T status of the primary head and neck carcinoma with N status of the secondary neck.Conclusion: The T status of primary head and neck squamous cell carcinoma correlates with the N status of Neck in general. By knowing the T status of the primary tumor, we can predict the nodal status in most of the cases of head and neck carcinomas which can be used in planning the treatment modalities also.JCMS Nepal 2014; 10(4):26-31

scholarly journals Leiomyosarcoma of the Tracheostomy Site in a Patient with History of Laryngeal Squamous Cell Carcinoma

2021 ◽  
pp. 912-917
Author(s):  
Zainub Ajmal ◽  
Abdul Moiz Khan ◽  
Lezah McCarthy ◽  
Allison Lupinetti ◽  
Syed Mehdi
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
English Literature ◽  
Neck Region ◽  
Multiple Risk Factors ◽  
History Of ◽  
Rare Malignancy

Leiomyosarcoma (LMS) of the trachea is an extremely rare malignancy with only a few reported cases in English literature. As such the diagnosis can be frequently missed or delayed. We present a case of a 69-year-old male who underwent tracheostomy for airway obstruction secondary to glottic squamous cell carcinoma and treated definitely with radiation therapy. Subsequently, the patient developed LMS of the tracheostomy site. The case further details multiple risk factors that could contribute to development of LMS including radiation exposure, prior malignancy, and chronic inflammation. These risk factors have been well established for LMS in other sites but less so in the head and neck region, which is the subject of our discussion. We also review the current guidelines for head and neck as well as limb sarcomas and discussed role of surgery or radiation and their accompanying challenges in management of this rare malignancy.

Mucosal Adenoid Squamous Cell Carcinoma of the Head and Neck

1996 ◽  
Vol 105 (5) ◽  
pp. 409-413 ◽  
Author(s):  
Alfio Ferlito ◽  
Kenneth O. Devaney ◽  
Christopher M. Milroy ◽  
Alessandra Rinaldo ◽  
Antonino Carbone
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Adenosquamous Carcinoma ◽  
Neck Region ◽  
Metastatic Adenocarcinoma ◽  
Head And Neck Region ◽  
Adenoid Cystic ◽  
Basaloid Squamous

Adenoid squamous cell carcinoma is an uncommon variant of squamous cell carcinoma. The lesion is histologically distinctive and it is usually localized on the skin of the head and neck region; it only rarely involves the mucosal sites. The differential diagnoses include adenosquamous carcinoma, adenoid cystic carcinoma, mucoepidermoid carcinoma, basaloid squamous cell carcinoma, and metastatic adenocarcinoma. Surgery is the treatment of choice. The biologic behavior of this neoplasm is more aggressive when it involves mucosal areas, and the prognosis seems worse than that of conventional squamous cell carcinoma.

Squamous cell carcinoma of the head and neck: Management after excisional biopsy of a solitary metastatic neck node

1993 ◽  
Vol 25 (4) ◽  
pp. 619-622 ◽  
Author(s):  
Yvonne Mack ◽  
James T. Parsons ◽  
William M. Mendenhall ◽  
Scott P. Stringer ◽  
Nicholas J. Cassisi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Excisional Biopsy ◽  
Neck Node

scholarly journals Quantification analysis of tissue eosinophilia in squamous cell carcinoma of the head and neck region

2018 ◽  
Vol 7 (1) ◽  
pp. 165 ◽  
Author(s):  
M Sabzijate ◽  
AH Khatibi ◽  
T Ghiasian ◽  
S Rahrotaban ◽  
E Rastegar ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Region ◽  
Head And Neck Region ◽  
Tissue Eosinophilia ◽  
Quantification Analysis

(S,R)3-(4-Hydroxyphenyl)-4,5-Dihydro-5-Isoxazole Acetic Acid Methyl Ester Inhibits Epithelial-to-Mesenchymal Transition through TGF-β/Smad4 Axis in Nasopharyngeal Carcinoma

2021 ◽  
Vol 21 ◽  
Author(s):  
Qibing Chen ◽  
Yan Wang ◽  
Fen Li ◽  
Xiang Cheng ◽  
Yu Xiao ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Nasopharyngeal Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Epithelial To Mesenchymal Transition ◽  
Immunofluorescence Assay ◽  
Migration And Invasion ◽  
Mesenchymal Transition

Background: Macrophage migration inhibitory factor (MIF), originally reported as an inflammation regulating molecule, is elevated in various cancer cells, which may promote carcinogenesis. Meanwhile, ISO-1 is a potent small molecular inhibitor of MIF, which has not been investigated in nasopharyngeal carcinoma (NPC); hence the impact of ISO-1 on NPC cells remains to be illustrated. Objective: This study intended to explore the biological function of ISO-1 in NPC cells in vitro and prove a possibility of ISO-1 being a novel agent in NPC treatments. Methods: Gene expression of MIF in Head and Neck squamous cell carcinoma were obtained from The Cancer Genome Atlas (TCGA) database. Nasal pharyngeal tissues were collected from adult patients undergoing nasopharyngeal biopsy for MIF level detection. Proliferation of NPC cell lines 5-8B and 6-10B was studied using Cell Counting Kit-8 (CCK-8) assay and plate-colony-formation assay, apoptosis was determined by flow cytometry and TUNEL staining, migration and invasion capacities were measured by wound-healing assay and transwell assay, all to explore the function of ISO-1 in NPC cells in vitro. Epithelial-to-mesenchymal transition (EMT) level of NPC cells was determined by Western blot analysis and immunofluorescence assay. Results: Transcript level of MIF was significantly higher in head and neck squamous cell carcinoma. Protein MIF was overexpressed in human NPC tissues compared to non-cancerous ones, and its expression could be compromised by ISO-1 in vitro. 100μM ISO-1 significantly hindered NPC cells migration and invasion capacities in vitro but acted relatively poorly on proliferation and apoptosis. Immunofluorescence assay and Western blotting implied a down-regulated EMT level through TGF-β/Smad4 axis in ISO-1 treated NPC cells compared to the vehicle. Conclusion: This study indicated that MIF antagonist ISO-1 holds impact on NPC progression by influencing the migration and invasion of NPC cells ISO-1 inhibits the EMT process of NPC cells through TGF-β/Smad4 axis, supporting that prudent application of ISO-1 may be a potential adjuvant treatment for NPC.

scholarly journals Significant Neutrophilic Emperipolesis in Squamous Cell Carcinoma

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Seza Tetikkurt ◽  
Faruk Taş ◽  
Funda Emre ◽  
Şule Özsoy ◽  
Zeki Tolga Bilece
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Treatment Response ◽  
Squamous Cell ◽  
Tumor Recurrence ◽  
Neck Region ◽  
Excisional Biopsy ◽  
Malignant Cell ◽  
Antituberculous Treatment

A 53-year-old man was admitted for tooth mobility. A mass was identified at the tooth base by CT. Histopathology of the excisional biopsy revealed a moderately differentiated squamous cell carcinoma. Many intact neutrophils were observed within the malignant cell cytoplasm. The patient underwent partial maxillectomy and bilateral neck dissection. Significant neutrophilic emperipolesis was detected in the resected material. Four tumor recurrences developed in the head and neck region during follow-up. Surgery and chemoradiotherapy was performed. The latest tumor recurrence occurred in the peripharyngeal and the posterior parotideal region. The patient was started on pembrolizumab therapy and nearly complete treatment response occurred. Pembrolizumab was discontinued due to the adrenal insufficiency and pulmonary tuberculosis that developed as a treatment side effect. Pembrolizumab was commenced again when tumor recurrence occurred. The patient is currently alive with ongoing pembrolizumab and antituberculous treatment. We present this case to remark the presence of a significant neutrophilic emperipolesis in the squamous cell carcinoma of the hard palate and maxilla which is rarely encountered. Emperipolesis may predict tumor behavior and the consequences of immune-modulating treatment response in squamous cell carcinomas of the head and neck in regard to the findings of our case.

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