STUDY OF ACID BASE BALANCE IN CHRONIC SEVERE ANAEMIA

2021 ◽  
pp. 48-51
Author(s):  
Balbinder Kumar ◽  
Ganesh Narayan Jha ◽  
Debarshi Jana
Keyword(s):  
Respiratory Infections ◽  
Venous Blood ◽  
Blood Gases ◽  
Severe Anaemia ◽  
Clinical State ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Parameters ◽  
Base Balance

Aim of the study role of acid base balance in chronic severe anaemic patients admitted in Department of Medicine, Darbhanga Medical College and Hospital, Laheriasarai, Bihar. Study subject include 50 chronic and severe anaemic patients. All the fty cases underwent detailed haematological, biochemical, electrocardiographic, roentgenographic studies followed by extensive analysis of blood for blood gases and acid base parameters at the onset. Some were further studied for venous blood lactate and the effect of intravenous frusemide on the acid base parameters and the clinical state of the patient. Twenty normal controls were also studied. Work in future on the problem of chronic severe anaemia should include cases with cardiac failure and other complications like respiratory infections etc. and they should be studied for myocardial function, glomerular ltration rate and renal anion transport in addition to blood gases and acid base study as done by us. The role of ionotropic agents should be studied in such cases in isolation from that with diuretics. The administration of oxygen alone with a mask is also expected to improve almost all parameters quickly and should be studied.

Changes in acid-base balance and blood gases during muscular activity and recovery

1959 ◽  
Vol 14 (3) ◽  
pp. 328-332 ◽  
Author(s):  
R. De Lanne ◽  
J. R. Barnes ◽  
L. Brouha ◽  
F. Massart
Keyword(s):  
Environmental Temperature ◽  
Venous Blood ◽  
Muscular Activity ◽  
Blood Gases ◽  
Blood Oxygen ◽  
Ambient Conditions ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance ◽  
Males And Females

Changes in the blood gases and acid-base balance during muscular work and recovery were investigated for males and females under various controlled environmental conditions. Changes in venous blood oxygen and carbon dioxide are influenced both by the intensity and duration of the exercise and by the environmental temperature. The pH of the blood is similarly affected. The direct measurement of pH was found to be a better index of the variation in the acid-base balance than the pH calculated from Henderson's equation at a fixed CO2 pressure. Lactic acid in the blood is, like the blood gases, influenced by ambient conditions, but is more closely related to the intensity than to the duration of the exercise. Submitted on October 28, 1958

Effects of monensin and yeast supplementation on blood acid-base balance in finishing feedlot steers fed a high-grain, high-protein diet

2006 ◽  
Vol 82 (5) ◽  
pp. 653-659 ◽  
Author(s):  
C. Castillo ◽  
J. Hernández ◽  
J. Méndez ◽  
P. García-Partida ◽  
V. Pereira ◽  
...  
Keyword(s):  
Venous Blood ◽  
Lactate Production ◽  
High Protein Diet ◽  
Study Groups ◽  
Control Group ◽  
Yeast Culture ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Parameters ◽  
Base Balance

AbstractThe aim of this study was to evaluate the effects of two dietary supplements (monensin and a live yeast culture) on acid-base balance in steers maintained in a commercial feedlot system, considering effects over the finishing productive cycle. Steers (no. =42) were allotted randomly to one of the three study groups: (1) control group (no supplementation, C), (2) monensin supplementation (MON), and (3) live Saccharomyces cerevisiae strain 47 supplementation (SACC). Venous blood samples were collected for the measurement of acid-base parameters and l-lactate. Production parameters were also used as a complementary tool for understanding the internal changes associated with supplementation. During the finishing period, MON steers tended to gain more efficiently than C and SACC steers. In the C group, the finishing-period diet caused a progressive decline in blood bases, in line with the high-grain diet consumption. In contrast, supplemented animals did not show this trend, although lower HCO3− and base excess values were registered in SACC steers than in MON, indicating that ionophore supplementation is less effective for reducing blood base consumption than yeast supplementation. In our study, the lack of the expected response to yeast supplementation may be attributable to the high crude protein content of the ration, a common feature of commercial feedlot industries.

DIGITALIS TOLERANCE IN YOUNG PUPPIES

PEDIATRICS ◽  
1970 ◽  
Vol 46 (5) ◽  
pp. 730-736
Author(s):  
Katherine H. Halloran ◽  
Steven C. Schimpff ◽  
Jean G. Nicolas ◽  
Norman S. Talner
Keyword(s):  
Blood Gases ◽  
Acid Base Balance ◽  
Acid Base ◽  
Littermate Control ◽  
Premature Ventricular Contractions ◽  
Toxic Dose ◽  
Arterial Blood ◽  
Wide Range ◽  
Base Balance ◽  
The Mean

Tolerance to acetyl strophanthidin, a rapid-acting cardiac aglycone, was determined in 28 anesthetized mongrel puppies, ages 16 to 56 days, and compared to tolerance in 16 littermate puppies in whom acute hypercapnic acidemia was produced. The tolerance was also compared to that of four adult mongrel dogs. The toxic dose was defined as the intravenous amount required to produce four consecutive premature ventricular contractions. A marked variation in the toxic dose was found in the 28 control puppies (range 83 to 353 µg/kg, mean 169 µg/kg) which could not be correlated with age, arterial blood gases or pH, serum potassium or sodium, arterial pressure, or heart rate. The toxic dose was significantly greater in the puppies than in the adult dogs, in whom the mean toxic dose was 64 µg/kg (range 50 to 89 µg/kg). A significant increase in tolerance was also observed in the puppies with hypercapnic acidemia (mean toxic dose 220 µg/kg, range 93 to 375 µg/kg) in comparison to tolerance in the control puppies and despite the wide range of tolerance, each of the puppies with hypercapnic acidemia showed greater tolerance than its littermate control puppy. Assessment of the clinical implications of these findings will require study of the effects of alterations in acid-base balance on the inotropic effect of acetyl strophanthidin in addition to the toxic electrophysiologic effects.

Role of organic anions in renal response to dietary acid and base loads

1989 ◽  
Vol 257 (2) ◽  
pp. F170-F176 ◽  
Author(s):  
J. C. Brown ◽  
R. K. Packer ◽  
M. A. Knepper
Keyword(s):  
Organic Anion ◽  
Organic Anions ◽  
Acid Excretion ◽  
Acid Base Balance ◽  
Acid Base ◽  
Urine Ph ◽  
Renal Response ◽  
Base Balance ◽  
Net Acid Excretion

Bicarbonate is formed when organic anions are oxidized systemically. Therefore, changes in organic anion excretion can affect systemic acid-base balance. To assess the role of organic anions in urinary acid-base excretion, we measured urinary excretion in control rats, NaHCO3-loaded rats, and NH4Cl-loaded rats. Total organic anions were measured by the titration method of Van Slyke. As expected, NaHCO3 loading increased urine pH and decreased net acid excretion (NH4+ + titratable acid - HCO3-), whereas NH4Cl loading had the opposite effect. Organic anion excretion was increased in response to NaHCO3 loading and decreased in response to NH4Cl loading. We quantified the overall effect of organic ion plus inorganic buffer ion excretion on acid-base balance. The amounts of organic anions excreted by all animals in this study were greater than the amounts of NH4+, HCO3-, or titratable acidity excreted. In addition, in response to acid and alkali loading, changes in urinary organic anion excretion were 40-50% as large as changes in net acid excretion. We conclude that, in rats, regulation of organic anion excretion can contribute importantly to the overall renal response to acid-base disturbances.

Electrolytes, Blood Gases, and Acid–Base Balance

2017 ◽  
pp. 873-938
Author(s):  
Isabel A. Lea ◽  
Susan J. Borghoff ◽  
Gregory S. Travlos
Keyword(s):  
Blood Gases ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance

scholarly journals ASSOCIATION OF ACID-BASE PARAMETERS WITH LACTATE LEVEL IN CRITICALLY ILL PATIENTS WITH METABOLIC ACIDOSIS

2018 ◽  
Vol 24 (2) ◽  
pp. 141
Author(s):  
Donaliazarti Donaliazarti ◽  
Rismawati Yaswir ◽  
Hanifah Maani ◽  
Efrida Efrida
Keyword(s):  
Metabolic Acidosis ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Lactate Level ◽  
Linear Regression Analysis ◽  
P Value ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Parameters ◽  
Base Balance

Metabolic acidosis is prevalent among critically ill patients and the common cause of metabolic acidosis in ICU is lactic acidosis. However, not all ICUs can provide lactate measurement. The traditional method that uses Henderson-Hasselbach equation (completed with BE and AG) and alternative method consisting of Stewart and its modification (BDEgap and SIG), are acid-base balance parameters commonly used by clinicians to determine metabolic acidosis in critically ill patients. The objective of this study was to discover the association between acid-base parameters (BE, AGobserved, AGcalculated, SIG, BDEgap) with lactate level in critically ill patients with metabolic acidosis. This was an analytical study with a cross-sectional design. Eighty-four critically ill patients hospitalized in the ICU department Dr. M. Djamil Padang Hospital were recruited in this study from January to September 2016. Blood gas analysis and lactate measurement were performed by potentiometric and amperometric method while electrolytes and albumin measurement were done by ISE and colorimetric method (BCG). Linear regression analysis was used to evaluate the association between acid-base parameters with lactate level based on p-value less than 0.05. Fourty five (54%) were females and thirty-nine (46%) were males with participant’s ages ranged from 18 to 81 years old. Postoperative was the most reason for ICU admission (88%). Linear regression analysis showed that p-value for BE, AGobserved, AGcalculated, SIG and BDEgap were 119; 0.967; 0.001; 0.001; 0.689, respectively. Acid-base balance parameters which were mostly associated with lactate level in critically ill patients with metabolic acidosis were AGcalculated and SIG. 

scholarly journals Clinical assessment of acid-base balance in Netherland Dwarf rabbit

2020 ◽  
Author(s):  
J. M. Chapel ◽  
J. L. Benedito ◽  
J. Hernández ◽  
P. Famigli-Bergamini ◽  
C. Castillo
Keyword(s):  
Reference Values ◽  
Venous Blood ◽  
Meat Production ◽  
Acid Base Balance ◽  
Acid Base ◽  
Sodium Potassium ◽  
Mean Values ◽  
Base Balance ◽  
Biochemical Profiles ◽  
Made In

Abstract Pet rabbits have increased their popularity in a lot of countries. However, most of the laboratory profiles in rabbit medicine come from the observations made in rabbit as biomodels or meat production. So that further researches are necessary to obtain reference values for hematology and biochemical profiles in pet rabbits and the different breeds, especially, in relation to acid-base balance. The aim of this report was to offer the mean values of the main parameters connected with acid-base profile in Netherland Dwarf breed. Thirty-five healthy rabbits (15 males and 20 females) were studied. Venous blood sample from lateral saphenous vein was analyzed to measure: haematocrit, haemoglobin, blood urea nitrogen, glucose, blood pH, partial pressure of CO2 (pCO2), total CO2, ions bicarbonate, chloride, sodium, potassium, base excess and anion Gap. Results showed a shorter range that those reported by different researchers. Moreover, differences between genders were showed in pCO2, its values were higher in males. It may be associated with a greater cellular metabolism. Values obtained in this research should be taken into account by veterinary clinicians for this breed in their clinical assessments. Besides, these values provide new results in parameters with few reference values.

Sign in / Sign up

Export Citation Format

Share Document