scholarly journals “ROLE OF TB PCR IN CLINICALLY DIAGNOSED AND TREATED CASES OF TUBERCULAR PLEURAL EFFUSION”.

2020 ◽  
pp. 1-3
Author(s):  
Sunil Jadhav ◽  
Mahendra Biradar ◽  
Ashish Deshmukh ◽  
Hafiz Deshmukh ◽  
Shivprasad Kasat
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pleural Effusion ◽  
Pleural Fluid ◽  
Tertiary Care ◽  
Tertiary Care Centre ◽  
Major Health Problem ◽  
Primary Tuberculosis ◽  
Automated Method ◽  
Tb Pcr

Background: Tuberculosis is still a major health problem worldwide. It is estimated that about one-third of the world's population is infected with mycobacterium tuberculosis. While pulmonary tuberculosis is most common presentation; pleural effusion is one of the common complications of primary tuberculosis or in conjunction with pulmonary infiltrate typical of post primary tuberculosis. Diagnosis of pleural tuberculosis (TB) remains a challenge due to its nonspecific clinical presentation and paucibacillary nature.TB PCR is a self-automated method from Roche for the detection of mycobacterium tuberculosis. This test allows for detection and identification of MTB from direct specimens within 24 – 48 hours of the receipt in the laboratory. We determined the role of TB PCR in diagnosis of tubercular etiology in pleural effusion in our study. Materials and methods: Prospective and analytical studyin a tertiary care centre of the study area was conducted after Ethics Committee permission. The study period was from June 2018 to December 2019.Data of 36tubercular pleural effusion patients was retrieved. Role of TB PCR in the diagnosis of tubercular etiology was assessed. Results: Pleural fluid samples collectedwere sent for various investigations like Routine microscopy, cytology, Pleural fluid pH, protein, LDH and TB PCR. Serum protein and serum LDH were also done.The diagnosis of Tubercular Pleural Effusion was made by clinical examination, radiological presentation, results of pleural fluid investigations and response to Anti Tubercular treatment collectively. Out of the 36 patients diagnosed to have tubercular pleural effusion, 8(22%) patient’s pleural fluid TB PCR report was positive. Conclusion:TB PCR is not a useful test in the diagnosis of tubercular etiology in pleural effusion.

scholarly journals Study of Diagnostic Importance of Adenosine Deaminase (ADA) Level in Pleural Effusions

2015 ◽  
Vol 2 (2) ◽  
pp. 104 ◽  
Author(s):  
Sachin Kate ◽  
B. K. Mutha ◽  
Gauri Kulkarni ◽  
Chetan Mahajan ◽  
Sushma Dugad
Keyword(s):  
Pleural Effusion ◽  
Adenosine Deaminase ◽  
Pleural Fluid ◽  
Sensitivity And Specificity ◽  
Predictive Value ◽  
Tertiary Care ◽  
High Sensitivity ◽  
Pleural Effusions ◽  
Tertiary Care Centre ◽  
Adenosine Deaminase Activity

<strong>Introduction</strong>: Pleural effusion is the abnormal accumulation of fluid in the pleural space. TB is the most common cause of pleural effusion worldwide (30-60%). The pleural fluid activity of adenosine deaminase (ADA) is one of the best, providing reliable basis for a treatment decision, particularly in excluding the diagnosis of tuberculosis, due to its high sensitivity.<strong> Aims and Objectives</strong>: To assess the importance of adenosine deaminase(ADA) level in the diagnosis of pleural effusion. To assess Adenosine Deaminase Activity (ADA) in tuberculosis pleural effusion and assess the sensitivity and specificity of ADA levels. <strong>Materials and Methods</strong>: This study was performed at the Department of Pulmonary Medicine at tertiary care centre. The study comprised of 75 patients of pleural effusion having Age &gt; 14 years, Clinical and Radiological evidence of Pleural Effusions&amp;Patients willing for ADA examination. Patients having Age &gt; 65 years, minimal nontappable effusion, not giving consent for ADA examination patient were excluded from the study. Detailed history, thorough physical examination, radiological findings, haematological and biochemical findings were recorded in the proforma. Pleural aspiration was performed on all patients. Macroscopic findings, cytological, microbiological and biochemical analysis of pleural fluid were performed in all patients including ADA level. PCR for Mycobacterium tuberculosis was also assessed in pleural fluid. Pleural fluid Adenosine deaminase level was measured by Giusti and Galanti method. <strong>Result</strong>: In our study out of 45 patients with tuberculosis pleural effusion ADA was more than 40IU/L in 42 (93.33%) and less than40IU/L in 3 (6.66 %). Our study showed a mean ADA of 107.7 IU/L Using a cut off of greater 40IU/L we got a sensitivity and specificity of 93.3% and 90% respectively and Positive predictive value 93.3% and Negative predictive value 90%. <strong>Conclusion</strong>: Pleural fluid ADA activity has been shown to be a valuable biochemical marker that has a high sensitivity and specificity for TB diagnosis.

scholarly journals Role of Colposcopy in Evaluation of Abnormal Cytology a Tertiary Care Centre Experience

2020 ◽  
Vol 10 (3) ◽  
pp. 130-134
Author(s):  
Sachan Rekha ◽  
Shukla Ayushi ◽  
Sachan Pushpalata ◽  
Patel ML ◽  
Shankhwar Pushpalata
Keyword(s):  
Tertiary Care ◽  
Care Centre ◽  
Abnormal Cytology ◽  
Tertiary Care Centre

scholarly journals CLINICOPATHOLOGICAL STUDY OF CARCINOMA ORAL CAVITY & PATTERN OF METASTASIS- EXPERIENCE IN A TERTIARY CARE CENTRE

2020 ◽  
pp. 1-3
Author(s):  
Bijan Basak ◽  
Soutrik Kumar ◽  
Kaustuv Das Biswas ◽  
Sayan Hazra ◽  
Debarshi Jana
Keyword(s):  
Indian Subcontinent ◽  
Treatment Options ◽  
Tertiary Care ◽  
Neck Surgery ◽  
Tertiary Care Centre ◽  
Major Health Problem ◽  
Node Metastases ◽  
Long Term Prognosis ◽  
Head Neck Surgery ◽  
Head Neck

Oral cancer (code 145.9, ICD 9) encompasses all malignancies originating in oral tissues & it is a major health problem in many parts of the world. Although incidence is relatively low in the western countries, in the Indian subcontinent & other parts of Asia it remains one of the commonest cancers. The study was conducted on the patients attending the ENT & HEAD-NECK SURGERY OPD at the INSTITUTE OF OTORHINOLARYNGOLOGY & HEAD-NECK SURGERY, IPGME&R, Kolkata during a period of 1 year from 1st March 2019 to 29th February 2020. Buccal mucosa was the commonest site & most cases presented in late stage with cervical lymph node metastases entailing poorer prognosis. People should be made aware of the warning symptoms, need for early diagnosis & treatment options available through IEC (information, education & communication programmes) in order to provide better treatment outcomes, improved long term prognosis & thereby reducing the morbidity & mortality of people at large.

scholarly journals ROLE OF HEMATOLOGICAL PARAMETERS IN EARLY DIAGNOSIS OF COVID-19 IN A TERTIARY CARE CENTRE

2021 ◽  
Vol 5 (6) ◽  
Author(s):  
Angira Saha ◽  
Sakar Saxena ◽  
Romi Srivastava ◽  
Sanjeev Narang
Keyword(s):  
Early Diagnosis ◽  
Hematological Parameters ◽  
Tertiary Care ◽  
Tertiary Care Centre ◽  
College Hospital ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio ◽  
Significant Difference

Aim: To evaluate the role of biomarkers from blood samples of COVID-19 patients admitted in Index Medical College Hospital & R.C. Material & Methods: Hematological parameters such as Neutrophil lymphocyte ratio (NLR), Platelet lymphocyte ratio (PLR) & Systemic Inflammatory Index (SII) were studied in RT-PCR positive patients to evaluate the utility of these parameters for early diagnosis of COVID-19. Results: The study showed that there was statistically significant difference in test groups in reference to Neutrophil lymphocyte ratio (NLR) & SII values (p<0.05). But no statistically significant difference was observed between test groups in reference to Platelet lymphocyte ratio (PLR) values (p>0.05). Conclusion: Leukocyte, Neutrophil, NLR & SII values can be used in the early diagnosis of COVID-19. Keywords: NLR, SII, Leukocyte, Neutrophil

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