The Effects of Melatonin Administration on Bone Tissue SIRT1 levels in old Female Rats with Diabetic

2019 ◽  
Author(s):  
Ömer Ünal ◽  
Saltuk Buğra Baltacı ◽  
Nilüfer Akgün Ünal ◽  
Rasim Mogulkoc ◽  
Abdulkerim Kasım Baltaci
Keyword(s):  
Bone Tissue ◽  
Female Rats ◽  
Melatonin Administration

Protective Effect of Melatonin on Bone Tissue in Elderly Diabetic Female Rats

2019 ◽  
Author(s):  
Ömer Ünal ◽  
Saltuk Buğra Baltacı ◽  
Nilüfer  Akgün Ünal ◽  
Rasim Mogulkoc ◽  
Abdülkerim Kasım Baltacı
Keyword(s):  
Protective Effect ◽  
Bone Tissue ◽  
Female Rats

scholarly journals Indirect study of the effect of α-tocopherol and acetylsalicylic acid on the mineral composition of bone tissue in the offspring of female rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin: long-term observations

RSC Advances ◽  
2019 ◽  
Vol 9 (14) ◽  
pp. 8016-8024 ◽  
Author(s):  
Maciej Dobrzynski ◽  
Piotr Kuropka ◽  
Malgorzata Tarnowska ◽  
Krzysztof Dudek ◽  
Marzena Styczynska ◽  
...  
Keyword(s):  
Acetylsalicylic Acid ◽  
Bone Tissue ◽  
Mineral Composition ◽  
Female Rats ◽  
Tetrachlorodibenzo P Dioxin

This paper discusses problems related to the influence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the mineral composition of the calvaria in the offspring of female rats.

scholarly journals Melatonin may prevent or reverse polycystic ovary syndrome in rats

2019 ◽  
Vol 65 (7) ◽  
pp. 1008-1014
Author(s):  
Leonardo Augusto Lombardi ◽  
Leandro Sabará de Mattos ◽  
Ricardo Santos Simões ◽  
Rinaldo Florencio-Silva ◽  
Gisela Rodrigues da Silva Sasso ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Corpus Luteum ◽  
Rat Model ◽  
Polycystic Ovary ◽  
Female Rats ◽  
Ovarian Cysts ◽  
Ovary Syndrome ◽  
Ki 67 ◽  
Melatonin Administration ◽  
Before And After

SUMMARY OBJECTIVE To evaluate the ovarian effects of melatonin (Mel) in a rat model of polycystic-ovary-syndrome (PCOS) before and after permanent estrus induction. METHODS Thirty-two adult-female rats with regular estrous cycle were equally divided into four groups: 1) GCtrl – at estrous phase. 2) GPCOS - at permanent-estrous phase. 3) GMel1 – treated for 60 days with Mel (0.4 mg/Kg) during permanent estrus induction and 4) GMel2 – rats with PCOS and treated for 60 days with Mel. After that, the animals were euthanized, and the ovaries were removed and processed for paraffin embedding. Sections were stained with H.E. for histomorphometry or subjected to immunohistochemistry for Ki-67 and cleaved caspase-3 (Casp-3) detections. RESULTS The GPCOS showed lack of corpus luteum and several ovarian cysts, as well as interstitial-like cells. The presence of corpus luteum and a significant increase in primary and antral follicles were observed in Mel-treated groups, which also showed a decrease in the number of ovarian cysts and in the area occupied by interstitial-like cells. These results were more evident in GMel1. The percentage of Ki-67-positive cells was significantly higher in the Mel-treated groups, mainly in the GMel2, as compared to GPCOS. On the other hand, the percentage of Casp-3-positive cells was significantly lower in granulosa cells of GMel1, whereas it was significantly higher in the interstitial-like cells of GMel2, in comparison to GPCOS. CONCLUSION Melatonin administration prevents the permanent estrus state in the PCOS rat model. This effect is more efficient when melatonin is administered before permanent estrus induction.

scholarly journals Application of biomaterials in experimentally induced alveolar bone osteoporosis

2003 ◽  
Vol 50 (1) ◽  
pp. 13-17
Author(s):  
Zorica Ajdukovic ◽  
Dragan Mihailovic ◽  
Stevo Najman ◽  
Vojin Savic ◽  
Ljiljana Aleksov ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Alveolar Bone ◽  
Maxillofacial Surgery ◽  
Female Rats ◽  
Tissue Formation ◽  
Therapeutic Approaches ◽  
Autologous Plasma ◽  
Left Mandible ◽  
And Control ◽  
Bone Tissue Formation

Rehabilitation of alveolar bone with tissue defect caused by advanced osteoporosis is a common problem in stomatology and maxillofacial surgery. One of therapeutic approaches is implantation of biomaterials. The aim of this study was to estimate biocompatibility, osteoconductive and reparative capabilities of biomaterials in wound healing of rats which are experimentally treated with corticosteroids during 12 weeks to produce osteoporosis. The syngenic Sprague Dolly female rats 6-8 weeks old were divided into the experimental and control groups. In the experimental group comprising 5 subgroups, the bone defects were made in the left mandible by 1.4 mm borer, in sterile conditions. In the first subgroup of rats healing wasspontaneous. In other four subgroups hydroxyapatite (HAp) composite, a mixture of HAp and autologous plasma, a mixture of HAp and fibrin glue, and glass jonomer bone cement were used, respectively. The best results were obtained with a mixture of HAp with plasma. Histologically, the new bone tissue was found in both spongious and compact mandibular parts. Our. results suggest that HAp can help in new bone tissue formation in animals treated with corticosteroids.

scholarly journals Effect of a Short-Term and Long-Term Melatonin Administration on Mammary Carcinogenesis in Female Sprague-Dawley Rats Influenced by Repeated Psychoemotional Stress

2007 ◽  
Vol 76 (3) ◽  
pp. 371-377 ◽  
Author(s):  
M. Kassayová ◽  
E. Adámeková ◽  
B. Bojková ◽  
P. Kubatka ◽  
I. Ahlers ◽  
...  
Keyword(s):  
Mammary Carcinogenesis ◽  
Tumour Volume ◽  
Female Rats ◽  
Sprague Dawley ◽  
Short Term ◽  
Psychoemotional Stress ◽  
Sprague Dawley Rats ◽  
Melatonin Administration ◽  
Term Administration

The aim of this study was to evaluate the effect of melatonin (MEL) on N-methyl-N-nitrosourea (NMU)-induced mammary carcinogenesis in female Sprague-Dawley rats exposed to repeated psychoemotional stress - immobilization in boxes. NMU was applied intraperitoneally in two doses each of 50 mg/kg b.w. between 40 - 50 postnatal days. Melatonin was administered in drinking water at a concentration of 4 μg/ml daily from 15:00 h to 8:00 h. The application was initiated 5 days prior to the fi rst NMU dose and lasted 15 days, i.e. during the promotion phase of tumour development, or long-term until the end of the experiment (week 20). Immobilization (2 h per day) began on the third day after the second carcinogen application and lasted for 7 consecutive days. Short-term MEL administration to immobilized animals increased incidence by 22%, decreased tumour frequency per animal by 26% and reduced tumour volume gain (by 21%) when compared to the immobilized group without MEL application. Decreased frequency per animal by 28% and more than a 40% decrease in tumour volume gain and cumulative volume were the most pronounced changes in the animals drinking MEL until the end of the experiment. Long-term MEL administration reduced the number and size of mammary tumours more markedly than its short-term administration. Melatonin decreased certain attributes of mammary carcinogenesis in female rats influenced by psychoemotional stress.

scholarly journals Modulating effect of selected pharmaceuticals on bone in female rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

RSC Advances ◽  
2018 ◽  
Vol 8 (48) ◽  
pp. 27537-27545 ◽  
Author(s):  
Maciej Dobrzynski ◽  
Celina Pezowicz ◽  
Magdalena Tomanik ◽  
Piotr Kuropka ◽  
Krzysztof Dudek ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Tissue ◽  
Female Rats ◽  
Tetrachlorodibenzo P Dioxin

This paper discusses the problems regarding the influence of TCDD on the mechanical properties and structure of the bone tissue in female rats treated with the dioxin.

The Effects of Resveratrol Supplementation on Bone Tissue SIRT1 levels in old Female Rats with Diabetic

2019 ◽  
Author(s):  
Kübra Kıyar ◽  
Ömer Ünal ◽  
Saltuk Buğra Baltacı ◽  
Nilüfer Akgün Ünal ◽  
Rasim Mogulkoc ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Female Rats

scholarly journals Protective Effect of Chokeberry (Aronia melanocarpa L.) Extract Against Cadmium Impact on the Biomechanical Properties of the Femur: A Study in a Rat Model of Low and Moderate Lifetime Women Exposure to this Heavy Metal

2017 ◽  
Author(s):  
Małgorzata M. Brzóska ◽  
Alicja Roszczenko ◽  
Joanna Rogalska ◽  
Małgorzata Gałażyn-Sidorczuk ◽  
Magdalena Mężyńska
Keyword(s):  
Bone Tissue ◽  
Chronic Exposure ◽  
Biomechanical Properties ◽  
Female Rats ◽  
Bone Collagen ◽  
Bending Test ◽  
Three Point Bending ◽  
Low Level ◽  
Aronia Melanocarpa ◽  
Natural Agent

The hypothesis that consumption of Aronia melanocarpa berries (chokeberries) extract, recently reported by us to improve bone metabolism in female rats at low-level and moderate chronic exposure to cadmium (1 and 5 mg Cd/kg diet for up to 24 months), may increase the bone resistance to fracture was investigated. Biomechanical properties of the neck (bending test with vertical head loading) and diaphysis (three-point bending test) of the femur of rats administered 0.1% aqueous chokeberry extract (65.74% of polyphenols) or/and Cd in the diet (1 and 5 mg Cd/kg) for 3, 10, 17, and 24 months were evaluated. Moreover, procollagen I was assayed in the bone tissue. The low-level and moderate exposure to Cd decreased procollagen I concentration in the bone tissue and weakened biomechanical properties of the femoral neck and diaphysis. Chokeberry extract administration under the exposure to Cd improved the bone collagen biosynthesis and femur biomechanical properties. The results allow for the conclusion that consumption of chokeberry products under exposure to Cd may improve the bone biomechanical properties and protect from fracture. This study provides support for Aronia melanocarpa berries being a promising natural agent for the skeleton protection under low-level and moderate chronic exposure to Cd.

scholarly journals Formulating a functional drink with antiosteoporosis effects

2021 ◽  
Vol 9 (2) ◽  
pp. 354-363
Author(s):  
Marietta Aslanova ◽  
Anastasia Semenova ◽  
Olga Derevitskaya
Keyword(s):  
Connective Tissue ◽  
Dietary Fiber ◽  
Bone Tissue ◽  
Blood Parameters ◽  
Female Rats ◽  
Laboratory Rats ◽  
Functional Product ◽  
Pumpkin Powder ◽  
Functional Drink ◽  
Peptide Fractions

Introduction. Osteoporosis is one of the most common diseases of the musculoskeletal system in modern clinical practice. Its prevention and treatment requires a diet with a sufficient intake of calcium, vitamins, and connective tissue proteins that regenerate cartilage and bone tissue. We aimed to formulate a functional product based on collagen fermentolysate to prevent osteoporosis and prove its effects in experiments on laboratory rats. Study objects and methods. Our study objects were collagen fermentolysate obtained from pork ears and legs (1:1) and the functional product based on it. The biological experiment was carried out on Wistar female rats exposed to osteoporosis through complete ovariectomy. Their femurs were analyzed for the contents of phosphorus, magnesium, and calcium, as well as cytometric and biochemical blood parameters. Results and discussion. The formulated functional product based on collagen fermentolysate contained 41% of the most easily assimilable peptide fractions with a low molecular weight of 10 to 20 kDa. Other components included pumpkin powder, dietary fiber, calcium, chondroprotectors, and vitamins E, C, and D3. Compared to the control, the experimental rats that received the functional product had increased contents of calcium and magnesium in the bone tissue (by 25.0 and 3.0%, respectively), a decreased content of phosphorus (by 7.0%), a calcium-to-phosphorus ratio restored to 2.4:1.0, and a higher concentration of osteocalcin in the blood serum (by 15%). Conclusion. The developed functional product based on collagen fermentolysate can be used as an additional source of connective tissue protein, calcium, vitamins C, E, and D3, dietary fiber, and chondroprotectors to prevent osteoporosis.

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