The Effects of Resveratrol Supplementation on Bone Tissue SIRT1 levels in old Female Rats with Diabetic

2019 ◽  
Author(s):  
Kübra Kıyar ◽  
Ömer Ünal ◽  
Saltuk Buğra Baltacı ◽  
Nilüfer Akgün Ünal ◽  
Rasim Mogulkoc ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Female Rats

The Effects of Melatonin Administration on Bone Tissue SIRT1 levels in old Female Rats with Diabetic

2019 ◽  
Author(s):  
Ömer Ünal ◽  
Saltuk Buğra Baltacı ◽  
Nilüfer Akgün Ünal ◽  
Rasim Mogulkoc ◽  
Abdulkerim Kasım Baltaci
Keyword(s):  
Bone Tissue ◽  
Female Rats ◽  
Melatonin Administration

Protective Effect of Melatonin on Bone Tissue in Elderly Diabetic Female Rats

2019 ◽  
Author(s):  
Ömer Ünal ◽  
Saltuk Buğra Baltacı ◽  
Nilüfer  Akgün Ünal ◽  
Rasim Mogulkoc ◽  
Abdülkerim Kasım Baltacı
Keyword(s):  
Protective Effect ◽  
Bone Tissue ◽  
Female Rats

scholarly journals Indirect study of the effect of α-tocopherol and acetylsalicylic acid on the mineral composition of bone tissue in the offspring of female rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin: long-term observations

RSC Advances ◽  
2019 ◽  
Vol 9 (14) ◽  
pp. 8016-8024 ◽  
Author(s):  
Maciej Dobrzynski ◽  
Piotr Kuropka ◽  
Malgorzata Tarnowska ◽  
Krzysztof Dudek ◽  
Marzena Styczynska ◽  
...  
Keyword(s):  
Acetylsalicylic Acid ◽  
Bone Tissue ◽  
Mineral Composition ◽  
Female Rats ◽  
Tetrachlorodibenzo P Dioxin

This paper discusses problems related to the influence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the mineral composition of the calvaria in the offspring of female rats.

scholarly journals Application of biomaterials in experimentally induced alveolar bone osteoporosis

2003 ◽  
Vol 50 (1) ◽  
pp. 13-17
Author(s):  
Zorica Ajdukovic ◽  
Dragan Mihailovic ◽  
Stevo Najman ◽  
Vojin Savic ◽  
Ljiljana Aleksov ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Alveolar Bone ◽  
Maxillofacial Surgery ◽  
Female Rats ◽  
Tissue Formation ◽  
Therapeutic Approaches ◽  
Autologous Plasma ◽  
Left Mandible ◽  
And Control ◽  
Bone Tissue Formation

Rehabilitation of alveolar bone with tissue defect caused by advanced osteoporosis is a common problem in stomatology and maxillofacial surgery. One of therapeutic approaches is implantation of biomaterials. The aim of this study was to estimate biocompatibility, osteoconductive and reparative capabilities of biomaterials in wound healing of rats which are experimentally treated with corticosteroids during 12 weeks to produce osteoporosis. The syngenic Sprague Dolly female rats 6-8 weeks old were divided into the experimental and control groups. In the experimental group comprising 5 subgroups, the bone defects were made in the left mandible by 1.4 mm borer, in sterile conditions. In the first subgroup of rats healing wasspontaneous. In other four subgroups hydroxyapatite (HAp) composite, a mixture of HAp and autologous plasma, a mixture of HAp and fibrin glue, and glass jonomer bone cement were used, respectively. The best results were obtained with a mixture of HAp with plasma. Histologically, the new bone tissue was found in both spongious and compact mandibular parts. Our. results suggest that HAp can help in new bone tissue formation in animals treated with corticosteroids.

scholarly journals Modulating effect of selected pharmaceuticals on bone in female rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

RSC Advances ◽  
2018 ◽  
Vol 8 (48) ◽  
pp. 27537-27545 ◽  
Author(s):  
Maciej Dobrzynski ◽  
Celina Pezowicz ◽  
Magdalena Tomanik ◽  
Piotr Kuropka ◽  
Krzysztof Dudek ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Tissue ◽  
Female Rats ◽  
Tetrachlorodibenzo P Dioxin

This paper discusses the problems regarding the influence of TCDD on the mechanical properties and structure of the bone tissue in female rats treated with the dioxin.

scholarly journals Protective Effect of Chokeberry (Aronia melanocarpa L.) Extract Against Cadmium Impact on the Biomechanical Properties of the Femur: A Study in a Rat Model of Low and Moderate Lifetime Women Exposure to this Heavy Metal

2017 ◽  
Author(s):  
Małgorzata M. Brzóska ◽  
Alicja Roszczenko ◽  
Joanna Rogalska ◽  
Małgorzata Gałażyn-Sidorczuk ◽  
Magdalena Mężyńska
Keyword(s):  
Bone Tissue ◽  
Chronic Exposure ◽  
Biomechanical Properties ◽  
Female Rats ◽  
Bone Collagen ◽  
Bending Test ◽  
Three Point Bending ◽  
Low Level ◽  
Aronia Melanocarpa ◽  
Natural Agent

The hypothesis that consumption of Aronia melanocarpa berries (chokeberries) extract, recently reported by us to improve bone metabolism in female rats at low-level and moderate chronic exposure to cadmium (1 and 5 mg Cd/kg diet for up to 24 months), may increase the bone resistance to fracture was investigated. Biomechanical properties of the neck (bending test with vertical head loading) and diaphysis (three-point bending test) of the femur of rats administered 0.1% aqueous chokeberry extract (65.74% of polyphenols) or/and Cd in the diet (1 and 5 mg Cd/kg) for 3, 10, 17, and 24 months were evaluated. Moreover, procollagen I was assayed in the bone tissue. The low-level and moderate exposure to Cd decreased procollagen I concentration in the bone tissue and weakened biomechanical properties of the femoral neck and diaphysis. Chokeberry extract administration under the exposure to Cd improved the bone collagen biosynthesis and femur biomechanical properties. The results allow for the conclusion that consumption of chokeberry products under exposure to Cd may improve the bone biomechanical properties and protect from fracture. This study provides support for Aronia melanocarpa berries being a promising natural agent for the skeleton protection under low-level and moderate chronic exposure to Cd.

scholarly journals Formulating a functional drink with antiosteoporosis effects

2021 ◽  
Vol 9 (2) ◽  
pp. 354-363
Author(s):  
Marietta Aslanova ◽  
Anastasia Semenova ◽  
Olga Derevitskaya
Keyword(s):  
Connective Tissue ◽  
Dietary Fiber ◽  
Bone Tissue ◽  
Blood Parameters ◽  
Female Rats ◽  
Laboratory Rats ◽  
Functional Product ◽  
Pumpkin Powder ◽  
Functional Drink ◽  
Peptide Fractions

Introduction. Osteoporosis is one of the most common diseases of the musculoskeletal system in modern clinical practice. Its prevention and treatment requires a diet with a sufficient intake of calcium, vitamins, and connective tissue proteins that regenerate cartilage and bone tissue. We aimed to formulate a functional product based on collagen fermentolysate to prevent osteoporosis and prove its effects in experiments on laboratory rats. Study objects and methods. Our study objects were collagen fermentolysate obtained from pork ears and legs (1:1) and the functional product based on it. The biological experiment was carried out on Wistar female rats exposed to osteoporosis through complete ovariectomy. Their femurs were analyzed for the contents of phosphorus, magnesium, and calcium, as well as cytometric and biochemical blood parameters. Results and discussion. The formulated functional product based on collagen fermentolysate contained 41% of the most easily assimilable peptide fractions with a low molecular weight of 10 to 20 kDa. Other components included pumpkin powder, dietary fiber, calcium, chondroprotectors, and vitamins E, C, and D3. Compared to the control, the experimental rats that received the functional product had increased contents of calcium and magnesium in the bone tissue (by 25.0 and 3.0%, respectively), a decreased content of phosphorus (by 7.0%), a calcium-to-phosphorus ratio restored to 2.4:1.0, and a higher concentration of osteocalcin in the blood serum (by 15%). Conclusion. The developed functional product based on collagen fermentolysate can be used as an additional source of connective tissue protein, calcium, vitamins C, E, and D3, dietary fiber, and chondroprotectors to prevent osteoporosis.

Basal Lamina Formation in DMBA Induced Mammary Carcinoma

1977 ◽  
Vol 35 ◽  
pp. 534-535
Author(s):  
I. Russo ◽  
J. Saby ◽  
J. Russo
Keyword(s):  
Mammary Carcinoma ◽  
Virgin Female ◽  
Mammary Glands ◽  
Sesame Oil ◽  
Female Rats ◽  
Ultrastructural Changes ◽  
Post Inoculation ◽  
Intermediate Type ◽  
Sprague Dawley ◽  
Intercellular Spaces

It has been previously demonstrated that DMBA-induced rat mammary carcinoma originates in the terminal end bud (TEB) of the mammary gland by proliferation of intermediate type cells (1). The earliest lesion identified is the intraductal proliferation (IDP), which gives rise to intraductal carcinomas. These evolve to cribriform, papillary and comedo types (2). In the present work, we report the ultrastructural changes that take place in the IDP for the formation of a cribriform pattern.Fifty-five-day-old Sprague Dawley virgin female rats were inoculated intra- gastrically with 20 mg 7,12-dimethylbenz(a)anthracene (DMBA) in 1 ml sesame oil. Non-inoculated, age-matched females were used as controls. Mammary glands from both control and experimental rats were removed weekly from the time of inoculation until 86 days post-inoculation. The glands were fixed and processed for electron microscopy (2).The first change observed in IDP's was the widening of intercellular spaces and the secretion of an electron dense material into these spaces (Fig. 1).

Morphological Changes in the Rat Granulosa Cell Surface During Differentiation Induced by Estradiol and Gonadotropins

1977 ◽  
Vol 35 ◽  
pp. 484-485
Author(s):  
P. Bagavandoss ◽  
JoAnne S. Richards ◽  
A. Rees Midgley
Keyword(s):  
Cell Surface ◽  
Granulosa Cell ◽  
Morphological Changes ◽  
Follicular Development ◽  
Female Rats ◽  
Functional Changes ◽  
Group 4 ◽  
Group 3 ◽  
Group 5 ◽  
Group 2

During follicular development in the mammalian ovary, several functional changes occur in the granulosa cells in response to steroid hormones and gonadotropins (1,2). In particular, marked changes in the content of membrane-associated receptors for the gonadotropins have been observed (1).We report here scanning electron microscope observations of morphological changes that occur on the granulosa cell surface in response to the administration of estradiol, human follicle stimulating hormone (hFSH), and human chorionic gonadotropin (hCG).Immature female rats that were hypophysectcmized on day 24 of age were treated in the following manner. Group 1: control groups were injected once a day with 0.1 ml phosphate buffered saline (PBS) for 3 days; group 2: estradiol (1.5 mg/0.2 ml propylene glycol) once a day for 3 days; group 3: estradiol for 3 days followed by 2 days of hFSH (1 μg/0.1 ml) twice daily, group 4: same as in group 3; group 5: same as in group 3 with a final injection of hCG (5 IU/0.1 ml) on the fifth day.

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