DYNAMICS OF THE INDICATORS OF MICROCIRCULATOR-TISSUE SYSTEMS WITH THE COMBINED USE OF PROTEOLYTIC COLLAGENASIS ULTRAPHONOPHORESIS AND METHODS FRACTIONAL LASER THERAPY IN TREATMENT SCARLIFIC SKIN CHANGES IN PATIENTS WITH METABOLIC SYNDROME

2021 ◽  
pp. 70-78
Author(s):  
Сергей Николаевич Нагорнев ◽  
Кристина Вадимовна Казанцева ◽  
Валерий Константинович Фролков ◽  
Галина Анатольевна Пузырева
Keyword(s):  
Metabolic Syndrome ◽  
Laser Therapy ◽  
Human Life ◽  
Inhibitory Effect ◽  
Fractional Laser ◽  
Corrective Effect ◽  
Complete Restoration ◽  
Rate Of Oxygen Consumption ◽  
Tissue System ◽  
Tissue Systems

В статье анализируется роль микроциркуляторных нарушений в патогенезе рубцовых изменений кожи, в том числе у пациентов с проявлениями метаболического синдрома. Исходные показатели микроциркуляторно-тканевых систем у пациентов с метаболическим синдромом свидетельствуют о более низких значениях уровня общей перфузии, чем у пациентов без признаков метаболических нарушений, что свидетельствует об угнетающем влиянии инсулинорезистентности на микроциркуляцию. Выявленная положительная динамика показателей микроциркуляторно-тканевой системы при проведении ультрафонофореза ферменкола в сочетании с методикой фракционной лазерной терапии позволяет рассматривать сосуды микроциркуляторного звена в качестве основной мишени при проведении коррекции рубцовых изменений кожи. Наблюдаемое через 4 недели после заключительной процедуры усиление нутритивного компонента кровотока и связанного с ним повышения скорости потребления кислорода и уровня окислительного метаболизма указывает на формирование пролонгированного эффекта. Преимущественное влияние рассмотренного способа коррекции рубцо-измененной кожи на отдельные компартменты микроциркуляторно-тканевой системы свидетельствует об эффективности технологии комплексного применения фракционного фототермолиза и ультрафонофореза коллагеназ, обладающей патогенетически ориентированным терапевтическим действием. Наличие в качестве фонового заболевания метаболического синдрома существенно ограничивает выраженность корригирующего эффекта, что обуславливает необходимость применения средств и методов из арсенала восстановительной медицины на основе преимущественного использования немедикаментозных лечебных факторов, которые, обладая выраженным саногенетическим потенциалом, позволяют максимально полно восстановить нарушенные функции при метаболическом синдроме и улучшить качество жизни человека The article analyzes the role of microcirculatory disorders in the pathogenesis of cicatricial changes in the skin, including in patients with manifestations of metabolic syndrome. The initial parameters of microcirculatory-tissue systems in patients with metabolic syndrome indicate lower values of the level of general perfusion than in patients without signs of metabolic disorders, which indicates the inhibitory effect of insulin resistance on microcirculation. The revealed positive dynamics of the indicators of the microcirculatory-tissue system during ultraphonophoresis of fermencol in combination with the method of fractional laser therapy allows us to consider the vessels of the microcirculatory link as the main target when correcting cicatricial changes in the skin. The increase in the nutritional component of the blood flow and the associated increase in the rate of oxygen consumption and the level of oxidative metabolism observed 4 weeks after the final procedure indicates the formation of a prolonged effect. The predominant influence of the considered method of correction of scar-altered skin on individual compartments of the microcirculatory-tissue system indicates the effectiveness of the technology of complex application of fractional photothermolysis and ultraphonophoresis of collagenases, which has a pathogenetically oriented therapeutic effect. The presence of metabolic syndrome as a background disease significantly limits the severity of the corrective effect, which necessitates the use of means and methods from the arsenal of restorative medicine based on the predominant use of non-drug therapeutic factors, which, having a pronounced sanogenetic potential, allow the most complete restoration of impaired functions in MS and improve the quality human life

004 Safety and Efficacy of CO2 Fractional Laser Therapy in Women with Vestibulodynia

2020 ◽  
Vol 17 (7) ◽  
pp. S220
Author(s):  
S. Goldstein ◽  
S. Kellogg ◽  
F. Murina ◽  
N. Kim ◽  
I. Goldstein
Keyword(s):  
Laser Therapy ◽  
Fractional Laser ◽  
Safety And Efficacy ◽  
Co2 Fractional Laser

019 Safety and Efficacy of CO2 Fractional Laser Therapy in Women with Vestibulodynia

2020 ◽  
Vol 17 (1) ◽  
pp. S9
Author(s):  
S. Goldstein ◽  
S. Kellogg Spadt ◽  
F. Murina ◽  
N. Kim ◽  
I. Goldstein
Keyword(s):  
Laser Therapy ◽  
Fractional Laser ◽  
Safety And Efficacy ◽  
Co2 Fractional Laser

Halothane Selectively Inhibits Nonshivering Thermogenesis 

1995 ◽  
Vol 82 (2) ◽  
pp. 491-501 ◽  
Author(s):  
Andrea Dicker ◽  
Kerstin B. E. Ohlson ◽  
Lennart Johnson ◽  
Barbara Cannon ◽  
Sten G.E. Lindahl ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Inhibitory Effect ◽  
Nonshivering Thermogenesis ◽  
Halothane Anesthesia ◽  
Control Series ◽  
Mechanically Ventilated ◽  
Anesthetized Rats ◽  
Rate Of Oxygen Consumption ◽  
Spontaneously Breathing ◽  
Thermogenic Response

Background During halothane anesthesia, infants fail to increase oxygen consumption in response to a cold stimulus in the form of an increase in temperature gradient between body and environment. Based on recent observations with isolated brown-fat cells, it seemed feasible that this inability to respond could be due to an inhibition of nonshivering thermogenesis during halothane anesthesia. Methods The rate of oxygen consumption was measured in cold-acclimated hamsters and rats. The rate evoked by norepinephrine injection in hamsters at an environmental temperature of approximately 24 degrees C was used as a measure of the capacity for nonshivering thermogenesis. Anesthesia was induced by 3% halothane and maintained by 1.5% halothane. One experimental series with spontaneously breathing hamsters and a second control series with spontaneously breathing rats and with rats whose lungs were mechanically ventilated were conducted. Results Norepinephrine injection led to a fourfold increase in the rate of oxygen consumption in control hamsters; after this response had subsided, a second injection led to a similar effect. Halothane anesthesia caused an approximately 20% decrease in resting metabolic rate (P < 0.05) and a 70% inhibition of the thermogenic response to norepinephrine (P < 0.001). The halothane concentration yielding half-maximal inhibitory effect was estimated to be less than 1.0%. After the animals had recovered from halothane anesthesia, a completely restored thermogenic response to norepinephrine was observed. The inhibitory effect of halothane also was observed in hamsters maintained at normothermia and was therefore not secondary to the slight hypothermia that otherwise developed during anesthesia. In a series of control experiments, it was confirmed that rats also showed large thermogenic responses to norepinephrine injections, and it was found that, in spontaneously breathing halothane-anesthetized rats, the thermogenic response to norepinephrine was also much inhibited. Further, in halothane-anesthetized rats whose lungs were mechanically ventilated, and where blood gases were kept at virtually normal levels, the thermogenic response to norepinephrine was found to be similarly markedly inhibited. Conclusions A much diminished or abolished thermogenic response to injected norepinephrine was demonstrated in halothane-anesthetized animals. This implies that there would be a diminished ability to elicit nonshivering thermogenesis even when this process is physiologically induced. Such a diminished ability could in part explain the susceptibility of neonates and infants to hypothermia during halothane anesthesia.

scholarly journals The efficacy of autologous platelet-rich plasma combined with erbium fractional laser therapy for facial acne scars or acne

2013 ◽  
Vol 8 (1) ◽  
pp. 233-237 ◽  
Author(s):  
JIANG-TING ZHU ◽  
MIN XUAN ◽  
YA-NI ZHANG ◽  
HONG-WEI LIU ◽  
JIN-HUI CAI ◽  
...  
Keyword(s):  
Laser Therapy ◽  
Platelet Rich Plasma ◽  
Fractional Laser ◽  
Acne Scars ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet ◽  
Facial Acne

Effects of ablative 10,600-nm carbon dioxide fractional laser therapy on suppurative diseases of the skin: A case series of 12 patients

2009 ◽  
Vol 41 (8) ◽  
pp. 550-554 ◽  
Author(s):  
Sung Bin Cho ◽  
Jin Young Jung ◽  
Dong Jin Ryu ◽  
Sang Ju Lee ◽  
Ju Hee Lee
Keyword(s):  
Carbon Dioxide ◽  
Laser Therapy ◽  
Case Series ◽  
Fractional Laser

Laser Therapy in Metabolic Syndrome-Related Kidney Injury

2013 ◽  
Vol 89 (4) ◽  
pp. 953-960 ◽  
Author(s):  
Alvaro C. Ucero ◽  
Bettina Sabban ◽  
Alberto Benito-Martin ◽  
Susana Carrasco ◽  
Stephan Joeken ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Laser Therapy ◽  
Kidney Injury

scholarly journals Determinants of activity of brown adipose tissue in lymphoma patients

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Cornelia Brendle ◽  
Norbert Stefan ◽  
Eva Grams ◽  
Martin Soekler ◽  
Christian la Fougère ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Multivariate Regression Analysis ◽  
Inhibitory Effect ◽  
Cancer History ◽  
Bat Activity ◽  
The Metabolic Syndrome ◽  
Brown Adipose ◽  
Pet Ct

AbstractThe determinants of brown adipose tissue (BAT) activity are not yet known in detail but might serve as future therapeutic targets against obesity and the metabolic syndrome. We analyzed 235 datasets of lymphoma patients with two PET/CT examinations at different time points retrospectively. We assessed the anthropometric characteristics, features related to the metabolic syndrome, thyroid dysfunction, season of the PET/CT examination, weight change, prior cancer history, lymphoma subgroups, disease activity, and specific lymphoma-related therapies, and evaluated their association with BAT activity. We found BAT activity in 12% of all examinations, and the incidence of BAT activity after initially negative examinations was 10%. In multivariate regression analysis, the prevalence of BAT activity was associated with age, body mass index, sex, the season of the examination, diabetes mellitus, arterial hypertension, and medication on the beta-receptors. New BAT activity arose more often in patients without preceding lymphoma-related therapy. No specific medication was associated with BAT activity. In conclusion, this study confirms the potential connection of BAT with the metabolic syndrome. Preceding lymphoma-related therapy might have an inhibitory effect on the recruitment of BAT.

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