scholarly journals Characteristics of immune response and role of cytokines in atopic dermatitis

2015 ◽  
Vol 12 (1) ◽  
pp. 3-14
Author(s):  
O G Elisyutina ◽  
E S Fedenko ◽  
M N Boldyreva ◽  
G O Gudima
Keyword(s):  
Immune Response ◽  
Atopic Dermatitis ◽  
Genetic Disorders ◽  
Multifactorial Disease ◽  
Endogenous Factors ◽  
Immune Mechanisms ◽  
New Methods ◽  
Methods Of Treatment

AD is a multifactorial disease, which is based on genetic disorders, immune mechanisms and influence of exogenous and endogenous factors. Study of immunopathogenesis of atopic dermatitis, it’s specific biomarkers, triggers is very important for understanding of causes and mechanisms of the disease as well as for developing of new methods of treatment. The review describes the current views on the immune response in AD.

scholarly journals The correction of epidermal barrier dysfunction in atopic dermatitis patients

2016 ◽  
Vol 13 (3) ◽  
pp. 59-64
Author(s):  
O G Elisyutina ◽  
O V Shtyrbul ◽  
E N Zemskaya
Keyword(s):  
Atopic Dermatitis ◽  
Genetic Disorders ◽  
Multifactorial Disease ◽  
Complex Treatment ◽  
Barrier Dysfunction ◽  
Epidermal Barrier ◽  
Endogenous Factors ◽  
Leading Role ◽  
Mechanisms Of Development

Atopic dermatitis is chronic inflammatory multifactorial disease, which has genetic disorders, immune mechanisms of development and is under the ainfluence of a combination of exogenous and endogenous factors. Recently a leading role of the epidermal barrier dysfunction in the pathogenesis of atopic dermatitis was shown. The article presents data about emollient for skin care efficacy - Cetaphil® RESTORADERM, which consists of preceramides and filaggrin breakdown products in complex treatment of atopic dermatitis patients.

scholarly journals Role of Immune Response and Some Microbial Agents in Atopic Dermatitis

2020 ◽  
Vol 8 (6) ◽  
pp. 7
Author(s):  
Suzan Yousif Jasim ◽  
Mayssaa E. Abdalah ◽  
Bahir Abdul Razzaq Mshimesh
Keyword(s):  
Immune Response ◽  
Atopic Dermatitis ◽  
Microbial Agents

scholarly journals IMMUNE MECHANISMS FOR DEVELOPMENT OF CONTROLLED AND PARTIALLY CONTROLLED ASTHMA

2019 ◽  
Vol 21 (3) ◽  
pp. 495-502 ◽  
Author(s):  
T. I. Vitkina ◽  
T. P. Novgorodtseva ◽  
E. P. Kalinina ◽  
E. G. Lobanova ◽  
M. V. Antonyuk
Keyword(s):  
Immune Response ◽  
Management Strategies ◽  
Objective Evaluation ◽  
The Body ◽  
Immune Mechanisms ◽  
Persistent Inflammation ◽  
Th17 Lymphocytes ◽  
Group I ◽  
Asthma Patients

Despite a significant amount of works specifying immune mechanisms of bronchial asthma (BA), different phenotypes observed in this pathology need to be studied. The aim of present study was to analyze functional activity of Th1, Th2 и Th17 lymphocytes, and to determine features of inflammation in controlled and partly controlled asthma.We examined eighty-four BA patients that were divided into 2 groups, depending on the control of symptoms and the clinical course of BA. Group I included 45 patients with controlled BA, whereas group II included 39 patients with partially controlled asthma. The subsets of Th1, Th2, and Th17 lymphocytes were assessed by serum cytokine levels (TNFα, IFNγ, IL-2, IL-4, IL-6, IL-10, IL-17A) using flow cytometry technique.The results of this study were as follows: we have shown a combined T-helper (Th) immune response in asthma patients, with its origin depending on the degree of the disease control. Th2 (62%), Th1/Th2 (20%) and Th1 (18%) types of immune response have been detected in the patients with controlled BA. Th2/Th17 (49%), Th1/Th17 (13%) and Th17 (37%) types of immune response have been identified in the patients with partially controlled BA. It has been shown, that Th1 immune response in patients with controlled asthma is induced by intracellular infection. The formation of the Th1/Th2 phenotype is associated with a site of chronic bacterial infection revealed, and with persistence of viral infection in the body. This phenotype can be used as an indicator of asthma worsening. Further studies in the role of prevalent immune response type in the development of partially controlled BA have shown that activation of Th17 lymphocytes is associated with prolonged course of the disease. Irrespectively of initial phenotype, the development of Th17-dependent immune response seems to result from a durable systemic persistent inflammation.The views on the key role of Th1/Th2 balance in the development of asthma are accomplished by evidence of Th17 lymphocyte involvement into the process, and Th1/Th17, Th2/Th17 phenotypes seem to be the polar features of the disease. Estimation of intensity and phenotype of inflammation in BA will permit a more objective evaluation of the therapy applied, and to choose further management strategies.

scholarly journals Experience of modern skin care series Atopic® using in atopic dermatitis children

2017 ◽  
Vol 14 (2) ◽  
pp. 76-81
Author(s):  
O G Elisyutina ◽  
A O Litovkina ◽  
E S Fedenko
Keyword(s):  
Immune Response ◽  
Atopic Dermatitis ◽  
Inflammatory Disease ◽  
Skin Care ◽  
Barrier Dysfunction ◽  
Epidermal Barrier ◽  
Endogenous Factors ◽  
Complex Therapy ◽  
Allergic Skin ◽  
Disease Stages

Atopic dermatitis - chronic allergic skin inflammatory disease with genetic predisposition, dysbalance of immune response, dysfunction of an epidermal barrier and influence of various exogenous and endogenous factors. Epidermal barrier dysfunction leads to rising of permeability of a skin for allergens, microbs and nonspecific stimuli, as well as to sensitivity to various external influences. Clinically these implications are shown by skin xerosis symptoms therefore. According to modern clinical guidelines, the moisturizing agents, so called emollients, have to be used at all disease stages. Own data on use of modern skin care series Atopic® in complex therapy of atopic dermatitis patients are presented in the article.

Neuroimmune mechanisms of pruritus in atopic dermatitis

2022 ◽  
pp. 12-16
Author(s):  
Y. A. Kandrashkina ◽  
E. A. Orlova ◽  
A. A. Pribytkov
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Skin Disease ◽  
Neurogenic Inflammation ◽  
New Methods ◽  
Neuroimmune Interactions ◽  
High Prevalence ◽  
Depth Study

Atopic dermatitis is a chronic hereditary recurrent skin disease. One of the most pronounced symptoms of this dermatosis is itchy skin. Pruritus accompanies atopic dermatitis in more than 80% of cases. This review presents modern data on the mechanisms of pruritus formation in atopic dermatitis. The issues of etiological factors, neuroimmune interactions, peculiarities of skin dysfunction, as well as the role of stress are considered. The relevance of studying the topic is due to the high prevalence of atopic dermatitis among the population, a decrease in the quality of life and the lack of effective therapy. Analysis of the literature indicates the need for a comprehensive assessment of the pathogenetic mechanisms of the development of pruritus in atopic dermatitis. A more in-depth study of the mechanisms of neurogenic inflammation in atopic dermatitis will contribute to the development of new methods of diagnosis and treatment.

scholarly journals Т-regulatory cells in atopic dermatitis immune response

2011 ◽  
Vol 10 (4) ◽  
pp. 82-88
Author(s):  
D. S. Gonsorunova ◽  
L. M. Ogorodova ◽  
O. S. Fyodorova ◽  
Ye. M. Kamaltynova ◽  
Ye. G. Belonogova ◽  
...  
Keyword(s):  
Immune Response ◽  
Atopic Dermatitis ◽  
Chronic Disease ◽  
Clinical Study ◽  
Regulatory Cells ◽  
Immune Mechanisms ◽  
Current Review ◽  
Skin Reactivity ◽  
Study Results ◽  
High Level

Atopic dermatitis — is a chronic disease, with immune mechanisms leading to high level of immunoglobulin Е and abnormal skin reactivity. The current review is presenting the experimental and clinical study results regarding to Т-regulatory cells participation in atopic dermatitis immune response.

The Role of Immune Response to Staphylococcus aureus Superantigens and Disease Severity in Relation to the Sensitivity to Tacrolimus in Atopic Dermatitis

2006 ◽  
Vol 141 (3) ◽  
pp. 281-289 ◽  
Author(s):  
Hisayo Fukushima ◽  
Toshihiko Hirano ◽  
Naoko Shibayama ◽  
Keishi Miwa ◽  
Tomonobu Ito ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Immune Response ◽  
Atopic Dermatitis ◽  
Disease Severity

scholarly journals Skin Microbiota in Atopic Dermatitis

2020 ◽  
Vol 13 (4) ◽  
pp. 374-382
Author(s):  
Jessica Herlianez Saiful ◽  
Satya Wydya Yenny
Keyword(s):  
Immune Response ◽  
Atopic Dermatitis ◽  
Microbial Community ◽  
Immune Responses ◽  
Skin Diseases ◽  
Major Influence ◽  
First Line ◽  
Skin Microbiota ◽  
Immune Mediators

In human body, the skin is the largest organ that has the function of mediating contact with the outside world and providing our body first line of defense against all kinds of pathogens, poisons and dangerous environments. The role of skin which are physical and immunological, supported by the microbial community that inhabits the skin. Skin microbiota contributes to barrier function by competing with pathogens and dealing with immune cells in the skin, to modulate local and systemic immune responses. Skin microbiota and immune mediators, for example complement system, have two-way interactions, and this shows that commensal microbes must be considered an important part of healthy skin. Many evidence shows that the composition of microbiota, especially in the intestines and also on the skin, can have a major influence on an individual's health. The influence of gut microbiota and its influence on the immune response has been widely studied, but the link of skin microbiota, immune response and certain skin diseases has not been widely discussed in the literature. Skin microbiota is expected to be affected in certain dermatological conditions, such as in psoriasis and in atopic dermatitis, which further shows the importance of the skin microbial community for human health. Understanding of skin microbiota role in pathogenesis of atopic dermatitis is still needed.

scholarly journals Prinzmetal angina. Questions of pathogenesis, clinic, diagnosis and treatment

2019 ◽  
Vol 91 (11) ◽  
pp. 116-123
Author(s):  
B L Shklovskiy ◽  
A A Prokhorchik ◽  
A N Pyr’ev ◽  
V I Baksheev
Keyword(s):  
High Risk ◽  
Sudden Cardiac Death ◽  
Cardiac Arrhythmias ◽  
Cardiac Death ◽  
Variant Angina ◽  
Cardioverter Defibrillator ◽  
New Methods ◽  
Electrocardiographic Monitoring ◽  
Methods Of Treatment

Current problems of Prinzmetal angina (vasospastic angina, variant angina) considers in this review. Attention is drawn to early diagnosis, which should be comprehensive, taking into account possible atypical courses and the development of complications. The important role of electrocardiographic monitoring (including using implantable recorders) is highlighted. It is emphasized that patients with cardiac arrhythmias, syncope are at high risk of developing sudden cardiac death. In this category of patients, it is recommended to timely determine the indications for implantation of a cardioverter - defibrillator. Authors consider the prospects of using new methods of treatment of angina pectoris.

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