The peculiarities of cytokine status in children suffering from persistent allergic rhinitis during early stages of allergenspecific immunotherapy

Background. To study dynamics of cytokine status during early stages of allergen-specific immunotherapy (ASIT) in children suffering from persistent allergic rhinitis (PAR). Methods. 30 children suffering from PAR have received complete course of ASIT. Serum levels ofILL-4, -5, -6, -8, -12, -13, sIL-2R were studied in 0, 7, 30 and 90 days and have been analyzed differentially in groups with good/excellent and incomplete effectiveness of treatment. Results. Good/excellent effectiveness of completed course of ASIT has been demonstrated in 17/30 (56,7%) children, partial effectiveness has been demonstrated for 13/30 (43,3%) ones.The decreased IL-12 and IL-6 levels and the increase of sIL-2R production were described for good/excellent results of treatment, but insufficient effectiveness was characterized by delayed dynamics of these cytokines. IL-8 level was increased in both groups but decreased effectiveness was associated with early start and long duration of it. IL-4 production was decreased in the good/ excellent group while on the second one changes of cytokine level were absent. IL-13 and IL-5 synthesis were increased in both groups. Conclusion. The effectiveness of ASIT in PAR patients depends on synthesis dynamics of ILL-4, -6, -8, -12, sIL-2R at the early treatment stages.

Download Full-text

Clinical and allergological characteristic of children with allergic rhinitis receiving allergen-specific immunotherapy in Altai region

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja468 ◽

2015 ◽

Vol 12 (2) ◽

pp. 64-67

Author(s):

N V Shakhova ◽

V V Gordeev ◽

U F Lobanov ◽

T S Ardatova ◽

M V Surcova

Keyword(s):

Allergic Rhinitis ◽

Medical Record ◽

Allergic Conjunctivitis ◽

Specific Immunotherapy ◽

Primary Diagnosis ◽

House Dust Mites ◽

Allergen Specific Immunotherapy ◽

Altai Region ◽

Persistent Allergic Rhinitis ◽

Record Card

The purpose of this study. To investigate clinical characteristics of the allergic rhinitis in children receiving allergen-specific immunotherapy. Methods. The epidemiologic observational multicenter study was conducted with the allergists of Altai region. The participating allergists filled out the specially designed medical record card on children with allergic rhinitis receiving ASIT. The study lasted from October 2013 to March 2014. Results. Allergists have filled out medical record cards of 165 children with allergic rhinitis receiving ASIT. The average age of children was 10,5±2,3 years, with the average of 4,8±2,5 years of allergic rhinitis prior to the start of ASIT. 159 (96,2%) children had moderate/severe allergic rhinitis, and 121 (73,3%) children had persistent allergic rhinitis. In 123 (74,5%) children rhinitis was accompanied by allergic conjunctivitis, and in 70 (42,2%) children - by bronchial asthma. 69 (41,8%) children receiving ASIT were mono-sensitized, 96 (58,2%) children were polysensitized. 48,5% of children were sensitized to house dust mites, 63,6% to tree pollen, 48,5% to meadow grass pollen, 30,9% to weed pollen, and in 21,8% sensitization to epidermal allergens was found. Conclusion. The findings of the study showed that in most cases (96,2%), children with allergic rhinitis receiving ASIT had moderate/severe rhinitis and in 73,3% symptoms were persistent. In 74,5% of cases, allergic rhinitis was accompanied by allergic conjunctivitis. Most part of children receiving ASIT had multiple sensitization (58,2%). Also a delayed beginning of ASIT was observed - 4,8±2,5 year from primary diagnosis to ASIT initiation.

Download Full-text

EFFICIANCY OF IMMUNOTHERAPY IN PATIENTS WITH PERSISTENT ALLERGIC RHINITIS

Bulletin physiology and pathology of respiration ◽

10.12737/article_5c1264ee93f132.73406573 ◽

2018 ◽

Vol 1 (70) ◽

pp. 32-37

Author(s):

Марина Антонюк ◽

Marina Antonyuk ◽

С Сулейманов ◽

S Suleymanov ◽

Татьяна Гвозденко ◽

...

Keyword(s):

Allergic Rhinitis ◽

Immune System ◽

Inflammatory Cytokines ◽

Proinflammatory Cytokines ◽

Specific Immunotherapy ◽

Low Doses ◽

Allergen Specific Immunotherapy ◽

Specific Diagnosis ◽

Persistent Allergic Rhinitis ◽

Effect Of Treatment

The dynamics of parameters of cytokine status in patients with allergic rhinitis in view of efficiency of allergen-specific immunotherapy (ASIT) was studied in this work. 62 subjects with moderate persistent rhinitis at the age of 18-40 years old were included in the study. For specific diagnosis and treatment there we used standard allergens. ASIT was performed by the classical scheme. The concentrations of IL-4, IL-5, IL-6, IL-8 in the blood serum were measured by the enzyme immunoassay. A good or excellent effect of treatment with ASIT was achieved in 62.9% of cases, and satisfactory one in 37.1% of cases. The analysis of the dynamics of IL-4, IL-5, IL-6, IL-8 concentrations showed that the efficiency of ASIT in patients with allergic rhinitis depends on the ability of the immune system to activation by low doses of the allergen, quite fast suppression of proinflammatory cytokines induced by them, and active functioning of the system of anti-inflammatory cytokines.

Download Full-text

Effect of Vitamin D Adjuvant and Allergen Specific Immunotherapy on Serum IL-10 and IL-17 Levels in Childhood Asthma: A Controlled Clinical Trial

10.51429/ejmm30122 ◽

2021 ◽

Vol 30 (1) ◽

pp. 175-181

Author(s):

Lobna A. El-Korashi ◽

Ola E. Nafea ◽

Lamiaa G. Zake ◽

Faika Arab ◽

Reham H. Anis

Keyword(s):

Childhood Asthma ◽

Specific Immunotherapy ◽

Pediatric Asthma ◽

Serum Levels ◽

Atopic Asthma ◽

Subcutaneous Immunotherapy ◽

Controlled Clinical Trial ◽

Inhaled Corticosteroid ◽

Allergen Specific Immunotherapy ◽

Few Data

Background: 1, 25-dihydroxy vitamin D3 (VitD3) can improve the effect of allergenspecific immunotherapy (SIT). Few data is available about its role in childhood asthma. Objective: To assess the immunological and clinical efficacy of VitD3 as an adjuvant to allergen specific immunotherapy in pediatric asthma. Methodology: Sixty nine children with atopic asthma were divided into three groups: a group received subcutaneous immunotherapy (SCIT) in combination with VitD3 (n=23), another group received SCIT alone (n=23), and the last group VitD3 alone (n=23). All children were assessed at baseline, and six months for rate of inhaled corticosteroid (ICS) discontinuation, and serum levels of IL-10, and IL-17A. Results: In the SCIT + vitD3, ICS discontinuation rate was higher compared to VitD3 alone group and SCIT alone group at the end of 6th month (P=0.555 and 0.016 respectively). The combined SCIT+ VitD3 group showed significant increase of serum IL-10 level in comparison to SCIT alone group and VitD3 alone group (P=0.000) and significant decrease in serum IL-17A level compared to VitD3 alone group (P= 0.011) Conclusion: VitD3 enhance the clinical and immunological outcomes of SIT in pediatric asthma. Further investigation is needed to evaluate this effect in a larger scale to confirm its role as an adjunct to SIT.

Download Full-text

Effects of allergen-specific immunotherapy on functions of helper and regulatory T cells in patients with seasonal allergic rhinitis

European Cytokine Network ◽

10.1684/ecn.2011.0277 ◽

2011 ◽

Vol 22 (1) ◽

pp. 15-23 ◽

Cited By ~ 10

Author(s):

Cengiz Kirmaz ◽

Ozlem Ozenturk Kirgiz ◽

Papatya Bayrak ◽

Ozge Yilmaz ◽

Seda Vatansever ◽

...

Keyword(s):

T Cells ◽

Allergic Rhinitis ◽

Regulatory T Cells ◽

Seasonal Allergic Rhinitis ◽

Specific Immunotherapy ◽

Allergen Specific Immunotherapy

Download Full-text

Mite-Allergic Rhinitis: How to Evaluate Clinical Efficacy in Allergen-Specific Immunotherapy Trials?

Current Treatment Options in Allergy ◽

10.1007/s40521-014-0040-y ◽

2015 ◽

Vol 2 (1) ◽

pp. 1-9 ◽

Cited By ~ 6

Author(s):

Oliver Pfaar ◽

Roy Gerth van Wijk

Keyword(s):

Allergic Rhinitis ◽

Clinical Efficacy ◽

Specific Immunotherapy ◽

Allergen Specific Immunotherapy

Download Full-text

Allergen Specific Immunotherapy Decreases IL-17 and Increases IL-35 in Allergic Rhinitis Patients

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2016.12.500 ◽

2017 ◽

Vol 139 (2) ◽

pp. AB152

Author(s):

Waheed Fawzy Hessam

Keyword(s):

Allergic Rhinitis ◽

Specific Immunotherapy ◽

Allergen Specific Immunotherapy

Download Full-text

Long-term effects of allergen-specific subcutaneous immunotherapy for house dust mite induced allergic rhinitis

The Journal of Laryngology & Otology ◽

10.1017/s0022215117002110 ◽

2017 ◽

Vol 131 (11) ◽

pp. 997-1001 ◽

Cited By ~ 5

Author(s):

E Sahin ◽

D Dizdar ◽

M E Dinc ◽

A A Cirik

Keyword(s):

Allergic Rhinitis ◽

House Dust ◽

House Dust Mite ◽

Specific Immunotherapy ◽

Subcutaneous Immunotherapy ◽

Long Term Effects ◽

Allergen Specific Immunotherapy ◽

Dust Mite ◽

Symptom Scores

AbstractBackground:Allergic rhinitis is strongly associated with the presence of house dust mites. This study investigated the long-term effects of allergen-specific immunotherapy. Allergen-specific immunotherapy was applied over three years. The study was based on a 10-year follow up of patients with allergic rhinitis.Methods:The study was conducted between 2001 and 2015. Skin prick test results and symptom scores were evaluated before (26 patients) and after 3 years (20 patients) of allergen-specific immunotherapy (using data from a previously published study), and 10 years after allergen-specific immunotherapy had ended (20 of 26 patients).Results:The symptom scores before allergen-specific immunotherapy were significantly higher than those obtained after 3 years of allergen-specific immunotherapy and 10 years after allergen-specific immunotherapy (p < 0.0175). There were no significant differences between the scores obtained at 3 years and 10 years after allergen-specific immunotherapy (p > 0.0175).Conclusion:Subcutaneous immunotherapy is an effective treatment for house dust mite induced allergic rhinitis.

Download Full-text