scholarly journals PENGARUH SENAM KAKI TERHADAP PENYEMBUHAN LUKA DIABETIK PADA PASIEN DIABETES MELLITUS DI RUANG RAWAT INAP RA1 DAN RA2 PENYAKIT DALAM RSUP. H. ADAM MALIK MEDAN

2020 ◽  
Vol 3 (1) ◽  
pp. 265-271
Author(s):  
Dewi Astuti Pasaribu ◽  
Septian Mixrova Sebayang
Keyword(s):  
Diabetes Mellitus ◽  
Wound Healing ◽  
Diabetic Foot ◽  
Intervention Group ◽  
T Test ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Diabetic Wound ◽  
Post Test ◽  
Diabetic Wound Healing

Diabetic foot ulcers (DFUs) are a serious complication of diabetes mellitus (DM) that can be slow to heal, result in repeated hospitalizations, require intense and costly treatment, and reduce the quality of life. The purpose of this study was to investigate the effect of foot exercises on wound healing in type 2 diabetic patients with a diabetic foot ulcer. Quasi-experimental study using before and after changes to wound healing in between February until May 2019.Thirty patients from an inpatient rooms with ulcers who met study criteria agreed to participate. Subjects were recruited by the researchers in the hospital where they received treatment. Data were collected using investigator-developed forms: patient information form and the diabetic foot exercises log. Patients in the intervention group received standard wound care and performed daily foot exercises for 3 week. Diabetic wound healing of the patients in the intervention were examined and measured at the 3rd weeks. To analyze and compare the data, frequency distribution, mean (standard deviation), and the paired samples t test were used. The mean of diabetic wound healing were 3.50, 2.90, and 2.40 in the study intervention group in 1st, 2nd, and 3rd weeks, respectively. Significant differences were found between diabetic wound healing in pre-test and post-test group (p=0.041). An important finding in this study was the DFU area decreased more in those who exercised more. Findings suggest foot exercises should be included in the treatment plan when managing patients with diabetic foot ulcers.     Abstrak Luka kaki diabetic adalah suatu komplikasi yang serius pada diabetes mellitus dimana dapat memperlambat penyembuhan, hospitalisasi berulang, membutuhkan pengobatan yang mahal dan menurunkan kualitas hidup. Tujuan penelitian ini adalah untuk mengetahui efek senam kaki terhadap penyembuhan luka pada pasien diabetes mellitus tipe 2. Jenis penelitian Quasi eksperimen digunakan untuk melihat perubahan sebelum dan sesudah penyembuhan luka dari Februari sampai Mei 2019. Tiga puluh pasien dari ruang inap dengan luka menjadi kriteria inklusi sebagai responden. Responden direkrut oleh peneliti di rumah sakit dimana pasien sedang menjalani perawatan. Pengumpulan data menggunakan kuesioner data demografi dan lembar observasi penyembuhan luka. Pasien akan diberikan latihan selama 3 minggu. Penyembuhan luka diabetic pada pasien akan dikaji dan diukur sampai minggu ke tiga. Untuk menganalisis dan membandingkan data, distribusi frekuensi, mean (standar deviasi), dan paired t test dilakukan. Mean penyembuhan luka diabetik diantaranya 3.50, 2.90 dan 2.40 pada kelompok intervensi pada minggu pertama, kedua, dan ketiga secara berurutan. Perbedaan signifikan penyembuhan luka diabetic antara kelompok pre-test dan post-test (p=0.041). Suatu temuan penting bahwa area luka kaki diabetic semakin menurun pada orang yang melakukan senam. Temuan ini juga senam kaki sebaiknya dimasukkan dalam rencana perawatan ketika merawat pasien dengan luka kaki diabetik.

Therapeutic Properties of Honey for the Management of Wounds; Is There a Role in the Armamentarium of Diabetic Foot Ulcer Treatment? Results From In vitro and In vivo Studies

2021 ◽  
pp. 153473462110268
Author(s):  
Ioanna A. Anastasiou ◽  
Ioanna Eleftheriadou ◽  
Anastasios Tentolouris ◽  
Georgia Samakidou ◽  
Nikolaos Papanas ◽  
...  
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Diabetic Animal ◽  
Cochrane Library ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Diabetic Wound ◽  
Diabetic Wound Healing ◽  
Therapeutic Properties

Diabetic foot ulcers are one of the most dreadful complications of diabetes mellitus and efforts to accelerate diabetic wound healing are of paramount importance to prevent ulcer infections and subsequent lower-limb amputations. There are several treatment approaches for the management of diabetic foot ulcers and honey seems to be a safe and cost-effective therapeutic approach on top of standard of care. The aim of this review was to summarize the therapeutic properties of honey and the data regarding its possible favorable effects on diabetic wound healing. A literature search of articles from 1986 until April 2021 was performed using MEDLINE, EMBASE, and the Cochrane Library to assess for studies examining the therapeutic wound healing properties of honey, it's in vitro effect, and the efficacy and/or mechanism of action of several types of honey used for the treatment of diabetic animal wounds. Honey has antioxidant, anti-inflammatory, and antibacterial properties and in vitro studies of keratinocytes and fibroblasts, as well as studies in diabetic animal models show that treatment with honey is associated with increased re-epithelialization and collagen production, higher wound contraction, and faster wound healing. The use of honey could be a promising approach for the management of diabetic foot ulcers.

Single Cell RNA-Seq Analyses of Healthy Lower Extremity Skin and Diabetic Foot Ulcers Uncover Distinct Immune Landscape of Diabetic Wound Healing

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 647-P ◽  
Author(s):  
GEORGIOS THEOCHARIDIS ◽  
SWATI S. BHASIN ◽  
KONSTANTINOS KOUNAS ◽  
MANOJ K. BHASIN ◽  
ARISTIDIS VEVES
Keyword(s):  
Wound Healing ◽  
Lower Extremity ◽  
Single Cell ◽  
Diabetic Foot ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Diabetic Wound ◽  
Rna Seq ◽  
Diabetic Wound Healing

scholarly journals MANAJEMEN ULKUS KAKI DIABETIKUM : EFEKTIFITAS FOOT EXERCISE TERHADAP RISIKO DFU (DIABETIC FOOT ULCERS) PASIEN DIABETES MELLITUS DI AL HIJRAH WOUND CARE CENTER

2019 ◽  
Vol 14 (2) ◽  
pp. 95-101
Author(s):  
Fahruddin Kurdi ◽  
Ratna Puji Priyanti
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Foot ◽  
Wound Care ◽  
Care Center ◽  
Foot Ulcers ◽  
P Value ◽  
Diabetic Foot Ulcers ◽  
Post Test ◽  
Diabetic Foot Screening ◽  
Diabetes Melitus

ABSTRAK Jumlah penderita DM (diabetes melitus) saat ini semakin meningkat. Salah satu komplikasi yang terjadi yaitu DFU (diabetic foot ulcers). Banyak cara yang dapat dilakukan untuk mencegah DFU, salah satunya dengan diabetic foot exercise. Penelitian ini bertujuan untuk mengetahui efektifitas diabetic foot exercise terhadap risiko dfu (diabetic foot ulcers) pasien diabetes mellitus. Penelitian menggunakan design pre-eksperimen dengan pendekatan one-group pra-post test design. Populasi penderita diabetes yang berjumlah 60 orang, besar sampel 40 orang yang diambil menggunakan teknik purposive sampling. Resiko DFU dinilai menggunakan inlow’s 60-second diabetic foot screening tool dengan metode observasi. Analisa data menggunakan uji statistik Wilcoxon. Hasil penelitian ini didapatkan bahwa sebelum dilakukan diabetic foot exercise sebagian besar reponden mempunyai risiko sedang sebanyak 30 orang (75%), sesudah dilakukan diabetic foot exercise diperoleh bahwa sebagian besar responden risiko rendah sebanyak 32 orang (80%). Uji statistik Wilcoxon diperoleh nilai p value = 0,001 dimana nilai p value<α (0,05) yang berarti ada pengaruh diabetic foot exercise terhadap risiko diabetic foot ulcers. Diabetes foot exercise sangat efektif untuk penderita diabetes dalam mencegah risiko DFU. Penderita diabetes dapat melakukan diabetic foot exercise 2 kali dalam seminggu secara teratur.  Kata Kunci : Diabetes mellitus, Diabetic foot ulcers, diabetic foot exercise

Effect of Family Empowerment on HbA1c Levels and Healing of Diabetic Foot Ulcers

2020 ◽  
pp. 153473462093012
Author(s):  
Rasnah Appil ◽  
Elly Lilianty Sjattar ◽  
Saldy Yusuf ◽  
Kasmawati Kadir
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Healing Process ◽  
Intervention Group ◽  
Foot Ulcers ◽  
Control Group ◽  
Wound Healing Process ◽  
Diabetic Foot Ulcers ◽  
Family Empowerment ◽  
Hba1c Levels

Objective. To evaluate the effectiveness of family empowerment through educational interventions against HbA1c level and healing progress of diabetic foot ulcers. Method. A quasi-experimental design was employed involving 33 participants from 4 wound care clinics in Makassar, eastern Indonesia. The intervention group consisted of 17 participants and their families; the control group was composed of 16 participants who received nonstructural education. Family empowerment was measured by the Indonesian version of the Family Empowerment Scale instrument. Glycemic control was evaluated with HbA1c levels, and the wound healing process was evaluated on the Diabetic Foot Ulcers Assessment Scale. Result. After 3 months, Family Empowerment Scale scores improved, particularly in the subdomain of family knowledge (16.59 ± 3.92 vs 13.38 ± 1.26; P = .005) and attitude (3.65 ± 0.93 vs 2.75 ± 0.45; P = .002). After 3 months of intervention, HbA1c decreased (from 10.47 ± 2.44% to 8.81 ± 1.83%), compared with the control group ( P = .048). Meanwhile, an independent t test further revealed that the wound healing process tended to be better with the intervention group (4.71 ± 7.74) compared with the control group (17.25 ± 17.06), with P = .010 at the third month. Conclusion. Family-based education intervention creates family empowerment to control HbA1c levels and accelerate wound healing of diabetic foot ulcer.

scholarly journals Novel long non-coding RNA lnc-URIDS delays diabetic wound healing by targeting Plod1

2020 ◽  
Author(s):  
Ada Admin ◽  
Mengdie Hu ◽  
Yuxi Wu ◽  
Chuan Yang ◽  
Xiaoyi Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Wound Healing ◽  
Diabetic Foot ◽  
Dermal Fibroblasts ◽  
Diabetic Wound ◽  
Delayed Wound Healing ◽  
Impaired Wound Healing ◽  
Diabetic Wound Healing

Impaired wound healing is one of the main reasons that leads to diabetic foot ulcerations. However, the exact mechanism of delayed wound healing in diabetes mellitus is not fully understood. Long non-coding RNAs (lncRNAs) are widely involved in a variety of biological processes and diseases, including diabetes and its associated complications. Here, w<a>e identified a novel lncRNA MRAK052872, named lnc-URIDS (lncRNA <u>U</u>p<u>R</u>egulated <u>i</u>n <u>D</u>iabetic <u>S</u>kin), which regulates wound healing in diabetes mellitus. </a>Lnc-URIDS was highly expressed in diabetic skin and dermal fibroblasts treated with advanced glycation end products (AGEs). Lnc-URIDS knockdown promoted migration of dermal fibroblasts under AGEs treatment <i>in vitro</i> and accelerated diabetic wound healing <i>in vivo</i>. Mechanistically, <a>lnc-URIDS interacts with procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 (Plod1), a critical enzyme responsible for collagen cross-linking. </a><a>The binding of lnc-URIDS to Plod1 results in a decreased protein stability of Plod1, which ultimately leads to the dysregulation of collagen production and deposition and delays wound healing. Collectively, this study identifies a novel lncRNA that regulates diabetic wound healing by targeting Plod1. </a><a>The findings of the present study offer some insight into the potential mechanism for the delayed wound healing in diabetes and provide a potential therapeutic target for diabetic foot.</a>

scholarly journals Targeting MMP-9 in Diabetic Foot Ulcers

2019 ◽  
Vol 12 (2) ◽  
pp. 79 ◽  
Author(s):  
Jeffrey I. Jones ◽  
Trung T. Nguyen ◽  
Zhihong Peng ◽  
Mayland Chang
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Healing Process ◽  
Foot Ulcers ◽  
Wound Healing Process ◽  
Diabetic Foot Ulcers ◽  
Novel Approach ◽  
Medical Need ◽  
Diabetic Wound Healing ◽  
Diabetic Wounds

Diabetic foot ulcers (DFUs) are significant complications of diabetes and an unmet medical need. Matrix metalloproteinases (MMPs) play important roles in the pathology of wounds and in the wound healing process. However, because of the challenge in distinguishing active MMPs from the two catalytically inactive forms of MMPs and the clinical failure of broad-spectrum MMP inhibitors in cancer, MMPs have not been a target for treatment of DFUs until recently. This review covers the discovery of active MMP-9 as the biochemical culprit in the recalcitrance of diabetic wounds to healing and targeting this proteinase as a novel approach for the treatment of DFUs. Active MMP-8 and MMP-9 were observed in mouse and human diabetic wounds using a batimastat affinity resin and proteomics. MMP-9 was shown to play a detrimental role in diabetic wound healing, whereas MMP-8 was beneficial. A new class of selective MMP-9 inhibitors shows clinical promise for the treatment of DFUs.

scholarly journals Novel long non-coding RNA lnc-URIDS delays diabetic wound healing by targeting Plod1

2020 ◽  
Author(s):  
Ada Admin ◽  
Mengdie Hu ◽  
Yuxi Wu ◽  
Chuan Yang ◽  
Xiaoyi Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Wound Healing ◽  
Diabetic Foot ◽  
Dermal Fibroblasts ◽  
Diabetic Wound ◽  
Delayed Wound Healing ◽  
Impaired Wound Healing ◽  
Diabetic Wound Healing

Impaired wound healing is one of the main reasons that leads to diabetic foot ulcerations. However, the exact mechanism of delayed wound healing in diabetes mellitus is not fully understood. Long non-coding RNAs (lncRNAs) are widely involved in a variety of biological processes and diseases, including diabetes and its associated complications. Here, w<a>e identified a novel lncRNA MRAK052872, named lnc-URIDS (lncRNA <u>U</u>p<u>R</u>egulated <u>i</u>n <u>D</u>iabetic <u>S</u>kin), which regulates wound healing in diabetes mellitus. </a>Lnc-URIDS was highly expressed in diabetic skin and dermal fibroblasts treated with advanced glycation end products (AGEs). Lnc-URIDS knockdown promoted migration of dermal fibroblasts under AGEs treatment <i>in vitro</i> and accelerated diabetic wound healing <i>in vivo</i>. Mechanistically, <a>lnc-URIDS interacts with procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 (Plod1), a critical enzyme responsible for collagen cross-linking. </a><a>The binding of lnc-URIDS to Plod1 results in a decreased protein stability of Plod1, which ultimately leads to the dysregulation of collagen production and deposition and delays wound healing. Collectively, this study identifies a novel lncRNA that regulates diabetic wound healing by targeting Plod1. </a><a>The findings of the present study offer some insight into the potential mechanism for the delayed wound healing in diabetes and provide a potential therapeutic target for diabetic foot.</a>

scholarly journals Effectiveness of topical insulin in the management of diabetic foot ulcers.

2019 ◽  
Vol 26 (09) ◽  
pp. 1487-1490
Author(s):  
Shafaatullah ◽  
Sadaf Iqbal ◽  
Bushra Zulfiqar ◽  
Shayan Zufishan
Keyword(s):  
Diabetes Mellitus ◽  
Wound Healing ◽  
Blood Glucose ◽  
Diabetic Foot ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Ulcer Size ◽  
Before And After ◽  
Mean Size ◽  
The Mean

Introduction: Diabetes mellitus is one of the most common metabolic disorders affecting a large part of our population. Apart from its effect on all organ systems, these metabolic derangements affect other processes in the body as well. Diabetic wounds are difficult to treat with conventional treatments. Delayed wound healing has led to increased morbidity and mortality in the population. Increased blood glucose leads to ineffective angiogenesis and less collagen deposition. In various studies long acting insulin zinc suspension has been shown to augment wound healing without any harmful effects. Objectives: To find out the advantages of topical insulin in the management of diabetic foot ulcers. Study Design: Observational study. Setting: Plastic Surgery and General Surgery Department, Baqai Medical University Karachi. Period: January 2014 to December 2016. Material and Methods: Patients visiting the Surgical OPD with diabetes mellitus and concomitantly having foot ulcers were included in the study. Diabetics having blood glucose levels of 110-130 gm/dl and ulcers measuring more than one cm on the dorsum of the foot were included in the study. All patients having foot ulcers were treated by daily topical spray of 1cc saline mixed with 5 units of insulin. This treatment was continued for 12 weeks or till the time ulcer was completely healed (whichever was earlier) and ulcer size was measured weekly. Ulcer size and depth before and after treatment was measured. Results: We had a total of 65 participants, among them there were 52 males and 13 females presenting with diabetic foot ulcer. Around 87.6% (n=57) patients had type 2 diabetes mellitus whereas 12.3% (n=8) patients had type 1 diabetes mellitus. Upon examination of the patient the location, size and depth of the ulcer was measured as well. These parameters were measured before and after treatment by topical insulin spray. Right foot ulcers were present in 64.6% of the patients and 35.38% patients had left foot ulcers. The mean size and depth of ulcer was 5.1 + 1.1 cm2 and 8.7 + 0.12 mm respectively. After treatment the mean size and depth of ulcer was found to be 1 + 0.04cm2 and 1.4 + 0.12mm respectively. Conclusion: There was significant improvement after treatment of diabetic foot ulcers with topical insulin spray. The wound size and depth were considerably decreased. This treatment had more promising results than conventional treatment methods for diabetic foot ulcers.

scholarly journals A COMPARATIVE STUDY OF IONIC SILVER BASED DRESSINGS VERSUS CONVENTIONAL DRESSINGS IN MANAGEMENT OF DIABETIC FOOT ULCERS.

2020 ◽  
pp. 77-79
Author(s):  
Ravishankar. N ◽  
Shivakumar. S ◽  
Abirami. K
Keyword(s):  
Wound Healing ◽  
Comparative Study ◽  
Diabetic Foot ◽  
T Test ◽  
Foot Ulcers ◽  
Colloidal Silver ◽  
Diabetic Foot Ulcers ◽  
Ulcer Area ◽  
Ionic Silver ◽  
End Point

AIMS: To compare the efficacy of ionic silver-based dressings with conventional saline dressings in the management of diabetic foot ulcers. OBJECTIVES: To study the efficacy of ionic silver based amorphous hydrogel dressing containing colloidal silver in management of diabetic foot ulcer healing and to compare the time taken for wound healing, number of days taken to reach the end point and cost-effectiveness, with that of conventional saline dressings. METHODS: This was a case control, prospective, comparative study conducted in Department of Surgery, JSS Hospital, Mysuru. Totally 100 patients with diabetic foot ulcers were included, equally divided into -cases (received colloidal silver dressings) and controls (received saline dressings), Simple randomization was done. Study Duration- 18 Months. Data collected regarding changes in wound size, presence of granulation tissue, slough, presence or absence of discharge, was analysed - by Chi square test, Independent T test and Paired T test. RESULTS: There was significant percentage reduction in ulcer area, 66.76±16.8 % in colloidal silver group, compared to only 2.71±4.53% in conventional saline group. The number of days to end point was significantly lesser in colloidal silver group, compared to conventional group (23.16±8.16 days vs 48.34±18.06 days), reduction of ulcer area (from 100%) was more at day 14 (48% in silver group, 89.69% in conventional group). CONCLUSION: The faster rate of wound healing in lesser number of days with significantly more reduction in ulcer area over a period of time, shows that ionic silver based amorphous hydrogel wound dressings with colloidal silver is more efficient than conventional saline dressings in diabetic foot ulcers management. As the number of dressings and number of days to end point is significantly lesser, ionic silver-based dressings are a comparatively more cost-effective treatment option as per our study.

scholarly journals Therapeutic Effects of Medicinal Plants on Diabetic Foot Ulcers: A Systematic Review

2021 ◽  
Vol 7 (3) ◽  
pp. 167
Author(s):  
Efa Refiani ◽  
Rita Maliza ◽  
Husna Fitri ◽  
Putri Lestari
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Wound Healing ◽  
Medicinal Plants ◽  
Diabetic Foot ◽  
Healing Process ◽  
Foot Ulcers ◽  
Therapeutic Effects ◽  
Diabetic Foot Ulcers ◽  
Active Compounds

Diabetic Foot Pain and Ulcers is one of the complications diseases caused by Diabetes Mellitus (DM). Based on data from the Ministry of Health in 2014, diabetic foot ulcers in Indonesia 54%. Diabetic foot ulcer disease can cause infection and tissue death. Treatment of diabetic foot ulcers has been treated with ointments or gels containing antimicrobials, biomaterials, and active compounds, accelerating the wound healing process. The active compounds from medicinal plants that play a role in the treatment of diabetic foot ulcers have been widely reported. The purpose of writing this article is to look at the therapeutic effects of active compounds that play a role in wound healing. In this systematic review, we searched the PubMed, Science Direct, and Google Scholar databases to identify primer articles that were published from 2010 to 2020. Ten studies were selected and published between 2015-2020. Furthermore, the plant species used for the treatment of diabetic foot ulcers contain active phenolic, gallic acid, flavonoids, gallic acid, flavonoids, and tannins compounds that play a role in the acceleration of the healing process of diabetic foot ulcers. Keywords: Diabetes mellitus, diabetic foot ulcers, the active compound, medicinal plants

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