Clinical and pharmacological data in COVID-19 hospitalized nonagenarian patients

Introduction. Despite the impact of SARS-CoV-2 infection in geriatrics, data on nonagenarian patients is scarce. The aim of this study is to describe the clinical features of COVID19-diagnosed nonagenarians, as well as its clinical evolution and therapeutic response. Material and methods. Retrospective observational study of nonagenarians, admitted for COVID-19. Sociodemographic and clinical variables were registered, including previous polypharmacy. Blood analysis data and COVID-19-specific treatment were registered. Results. A total of 79 patients were included, with 50.6% (40 patients) of mortality. None of the comorbidities registered correlated with mortality, which was significantly higher among patients with moderate/complete functional dependence, compared to those mild-dependents/independents (59.5% vs 40.5%; p=0.015). Most prescribed drugs were hydroxychloroquine/chloroquine and azithromycin. Non-survivors presented higher counts of leukocytes and neutrophils, and higher lymphopenia. Conclusions. Nonagenarians with functional dependence presented higher mortality, irrespective of comorbidities or treatment received. Implementing an integral geriatric evaluation would enhance the implementation of personalized therapeutic strategies for nonagenarians.

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The impact of fluorescein-guided technique in the surgical removal of CNS tumors in a pediatric population: results from a multicentric observational study

Journal of Neurosurgical Sciences ◽

10.23736/s0390-5616.19.04601-0 ◽

2020 ◽

Vol 63 (6) ◽

Author(s):

Camilla de Laurentis ◽

Julius Höhne ◽

Claudio Cavallo ◽

Francesco Restelli ◽

Jacopo Falco ◽

...

Keyword(s):

Observational Study ◽

Pediatric Population ◽

Cns Tumors ◽

Surgical Removal ◽

The Impact

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Faculty Opinions recommendation of The impact of a diagnosis of fibromyalgia on health care resource use by primary care patients in the UK: an observational study based on clinical practice.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.10199.467691 ◽

2006 ◽

Author(s):

Michael Ward

Keyword(s):

Primary Care ◽

Health Care ◽

Clinical Practice ◽

Observational Study ◽

Resource Use ◽

Health Care Resource ◽

Primary Care Patients ◽

Health Care Resource Use ◽

The Uk ◽

The Impact

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The impact of duration observations on precision of results GNSS measurements

Geodesy and Cartography ◽

10.22389/0016-7126-2017-921-3-7-13 ◽

2017 ◽

Vol 921 (3) ◽

pp. 7-13 ◽

Cited By ~ 1

Author(s):

S.V. Grishko

Keyword(s):

Measurement Accuracy ◽

Functional Dependence ◽

Observation Time ◽

Satellite Networks ◽

Satellite Measurements ◽

Proposed Model ◽

Actual Error ◽

Gnss Measurements ◽

The Impact ◽

Qualitative Characteristics

This paper shows that the accuracy of relative satellite measurements depend not only on the length of the baseline, as it is regulated by the rating formula of accuracy of GNSS equipment, but also on the duration of observations. As a result of the strict adjustment much redundant satellite networks with different duration of observations obtained covariance matrix of baselines, the most realistic reflecting the actual error of satellite observations. Research of forms of communication of these errors from length of the baseline and duration of its measurement is executed. A significant influence of solar activity on accuracy of satellite measurements, in general, leads to unequal similar series of measurements made at different periods, for example, in the production of monitoring activities. The model of approximation of the functional dependence of accuracy of the baseline from its length and duration of observations having good qualitative characteristics is offered. Based on the proposed model, we analyzed the dynamics of changes in measurement accuracy with an increase in observation time.

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The impact of multimorbidity on foot health outcomes in podiatry patients with musculoskeletal foot pain: a prospective observational study

Journal of Foot and Ankle Research ◽

10.1186/s13047-019-0346-x ◽

2019 ◽

Vol 12 (1) ◽

Author(s):

Gordon J. Hendry ◽

Linda Fenocchi ◽

Helen Mason ◽

Martijn Steultjens

Keyword(s):

Observational Study ◽

Health Outcomes ◽

Prospective Observational Study ◽

Foot Pain ◽

Foot Health ◽

The Impact

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Assessing the impact of COVID-19 on the health of geriatric patients: The European GeroCovid Observational Study

European Journal of Internal Medicine ◽

10.1016/j.ejim.2021.01.017 ◽

2021 ◽

Author(s):

Caterina Trevisan ◽

Susanna Del Signore ◽

Stefano Fumagalli ◽

Pietro Gareri ◽

Alba Malara ◽

...

Keyword(s):

Observational Study ◽

Geriatric Patients ◽

The Impact

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Natural History of NAFLD

Journal of Clinical Medicine ◽

10.3390/jcm10061161 ◽

2021 ◽

Vol 10 (6) ◽

pp. 1161

Author(s):

Raluca Pais ◽

Thomas Maurel

Keyword(s):

Liver Disease ◽

Natural History ◽

Disease Progression ◽

Specific Treatment ◽

Alcoholic Fatty Liver ◽

Individual Level ◽

Close Relationship ◽

History Of ◽

The Individual ◽

The Impact

The epidemiology and the current burden of chronic liver disease are changing globally, with non-alcoholic fatty liver disease (NAFLD) becoming the most frequent cause of liver disease in close relationship with the global epidemics of obesity, type 2 diabetes and metabolic syndrome. The clinical phenotypes of NAFLD are very heterogeneous in relationship with multiple pathways involved in the disease progression. In the absence of a specific treatment for non-alcoholic steatohepatitis (NASH), it is important to understand the natural history of the disease, to identify and to optimize the control of factors that are involved in disease progression. In this paper we propose a critical analysis of factors that are involved in the progression of the liver damage and the occurrence of extra-hepatic complications (cardiovascular diseases, extra hepatic cancer) in patients with NAFLD. We also briefly discuss the impact of the heterogeneity of the clinical phenotype of NAFLD on the clinical practice globally and at the individual level.

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