Melioidosin is a main virulent factor of Bulkholderia pseudomallei

2014 ◽  
Vol 33 (12) ◽  
pp. 1281-1286
Author(s):  
Guang-qiang MA ◽  
Qian WANG ◽  
Jin-hua ZHU ◽  
He-ping YE ◽  
Zhi-ming YUAN ◽  
...  
Keyword(s):  
Virulent Factor

scholarly journals Molecular analysis of enterolysin a and entL gene cluster from natural isolate Enterococcus faecalis BGPT1-10P

Genetika ◽  
2013 ◽  
Vol 45 (2) ◽  
pp. 479-492 ◽  
Author(s):  
Katarina Veljovic ◽  
Amarela Terzic-Vidojevic ◽  
Maja Tolinacki ◽  
Milan Kojic ◽  
Ljubisa Topisirovic
Keyword(s):  
Functional Analysis ◽  
Nucleotide Sequence ◽  
Enterococcus Faecalis ◽  
Broad Spectrum ◽  
Candida Species ◽  
Genetic Information ◽  
Natural Isolate ◽  
Gene Encoding ◽  
Dna Fragment ◽  
Virulent Factor

Strain Enterococcus faecalis BGPT1-10P was isolated from artisanal semi-hard homemade cheese from Stara Planina, Serbia. Results showed that BGPT1-10P synthesized a heat labile bacteriocin with a broad spectrum of activity, including Listeria and Candida species. Further analysis revealed that synthesized bacteriocin is enterolysin A. Moreover, the entL gene encoding enterolysin A was found to be located on the chromosome. The entL gene was cloned and sequenced. Analysis of nucleotide sequence showed that the entL gene in natural isolate En. faecalis BGPT1-10P is identical to that of the entL gene described previously in En. faecalis LMG 2333. Within the cloned DNA fragment containing the entL gene, four ORFs were detected. One of them was identified as the scpE gene, which encodes a virulent factor staphopain peptidase. Functional analysis of the entL gene showed that the complete genetic information necessary for the synthesis of enterolysin A were directly linked solely to it. Strain BGPT1-10P also synthesized gelatinase and citolysin, and contained a set of virulent factors. In addition, BGPT1-10P carries the ermB and tetM genes conferring the resistance to erythromycin and tetracycline, respectively.

“GINGIPAINS”- A Pathogenic Virulent Factor For Periodontal Diseases

2011 ◽  
Vol 4 (4) ◽  
pp. 401-403
Author(s):  
Dr. Anvitha Sharath Kumar ◽  
◽  
Dr. Kusuma. N Dr. Kusuma. N
Keyword(s):  
Periodontal Diseases ◽  
Virulent Factor

scholarly journals Co-aggregation as a virulent factor of Streptococcus sanguis isolated from infective endocarditis.

1999 ◽  
Vol 41 (3) ◽  
pp. 117-122 ◽  
Author(s):  
Kuniyasu Ochiai ◽  
Ken Kikuchi ◽  
Kazuo Fukushima ◽  
Tomoko Kurita-Ochiai
Keyword(s):  
Infective Endocarditis ◽  
Streptococcus Sanguis ◽  
Virulent Factor

scholarly journals Mechanistic Understanding of Candida albicans Biofilm Formation and Approaches for Its Inhibition

2021 ◽  
Vol 12 ◽  
Author(s):  
Tanu Atriwal ◽  
Kashish Azeem ◽  
Fohad Mabood Husain ◽  
Afzal Hussain ◽  
Muhammed Nadeem Khan ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Biofilm Formation ◽  
Animal Tissues ◽  
Intrinsic Resistance ◽  
Phenotypic Characteristics ◽  
Antimicrobial Drugs ◽  
Exopolymeric Substances ◽  
Recent Developments ◽  
Virulent Factor

In recent years, the demand for novel antifungal therapies has increased several- folds due to its potential to treat severe biofilm-associated infections. Biofilms are made by the sessile microorganisms attached to the abiotic or biotic surfaces, enclosed in a matrix of exopolymeric substances. This results in new phenotypic characteristics and intrinsic resistance from both host immune response and antimicrobial drugs. Candida albicans biofilm is a complex association of hyphal cells that are associated with both abiotic and animal tissues. It is an invasive fungal infection and acts as an important virulent factor. The challenges linked with biofilm-associated diseases have urged scientists to uncover the factors responsible for the formation and maturation of biofilm. Several strategies have been developed that could be adopted to eradicate biofilm-associated infections. This article presents an overview of the role of C. albicans biofilm in its pathogenicity, challenges it poses and threats associated with its formation. Further, it discusses strategies that are currently available or under development targeting prostaglandins, quorum-sensing, changing surface properties of biomedical devices, natural scaffolds, and small molecule-based chemical approaches to combat the threat of C. albicans biofilm. This review also highlights the recent developments in finding ways to increase the penetration of drugs into the extracellular matrix of biofilm using different nanomaterials against C. albicans.

A highly versatile convergent/divergent “onion peel” synthetic strategy toward potent multivalent glycodendrimers

2014 ◽  
Vol 50 (87) ◽  
pp. 13300-13303 ◽  
Author(s):  
Rishi Sharma ◽  
Naresh Kottari ◽  
Yoann M. Chabre ◽  
Leïla Abbassi ◽  
Tze Chieh Shiao ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Multivalent Ligands ◽  
Onion Peel ◽  
Synthetic Strategy ◽  
Virulent Factor

Both convergent and divergent strategies for the synthesis of “onion peel” glycodendrimers are reported which resulted in one of the best multivalent ligands known against the virulent factor from a bacterial lectin isolated from Pseudomonas aeruginosa.

Retracted: Role of Extracellular Phospholipase B ofCandida albicansas a Virulent Factor in Experimental Keratomycosis

2009 ◽  
Vol 34 (9) ◽  
pp. 761-768 ◽  
Author(s):  
Lin Ma ◽  
Lixin Xie ◽  
Xiaoguang Dong ◽  
Weiyun Shi
Keyword(s):  
Phospholipase B ◽  
Virulent Factor
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