scholarly journals CHANGE IN THE ACTIVITY OF PENTOXYPLIN UNDER THE ACTION OF A PULSE MAGNETIC FIELD DEPENDING ON THE DRUG COMPOSITION

2020 ◽  
Vol 22 (5) ◽  
pp. 23-27
Author(s):  
N.A. Rodenko ◽  
◽  
I.A. Belyaeva ◽  
A.V. Samorodov ◽  
◽  
...  
Keyword(s):  
Magnetic Field ◽  
Medicinal Product ◽  
High Intensity ◽  
Antiplatelet Agent ◽  
Pulsed Magnetic Field ◽  
Pure Substance ◽  
Single Turn ◽  
Abrupt Changes ◽  
Antiaggregatory Activity ◽  
Intensity Magnetic Field

According to the results of the study, it was found that irradiation of the tabletted preparation of pentoxifylline leads to an increase in its antiaggregatory activity. The aim of this work is to study the effect of a pulsed magnetic field of high intensity on the antiaggregatory activity of the pure substance of petoxifylline. When exposed to a pulsed magnetic field on the pure substance of pentoxifylline (without the presence of excipients), changes in the antiaggregatory activity of the drug were not detected. Irradiation with a pulsed magnetic field was carried out on an MIU-15 setup at various magnetic field strengths with single-turn and multi-turn inductors with the number of pulses n = 1. The authors put forward a hypothesis that excipients in a tabletted medicinal product affect the change in biological activity after exposure to the drug by a pulsed magnetic field of high intensity. The study of the pure substance of pentoxifylline for antiaggregatory activity was carried out on an AT-02 platelet aggregation analyzer. Control samples of the medicinal product were not exposed to the magnetic field. It is assumed that the presence of excipients in the tablet form of pentoxifylline after exposure to a pulsed magnetic field can cause a change in the conformation of the drug molecule. In addition, a transition from one conformation to another is possible due to abrupt changes in properties, i.e. when exposed to a high-intensity magnetic field. An antiplatelet agent with excipients, being in a magnetic field, goes into a more active state, after which it retains it for some time, in which an increase in pharmacological activity is manifested.

scholarly journals INFLUENCE OF A PULSE MAGNETIC FIELD OF HIGH VOLTAGE ON THE INDICATORS OF ANTI-AGGREGATION ACTIVITY OF THE CHEMICAL SUBSTANCE AND THE PREPARED PHARMACY PREPARATION PENTOXYPLIN

2021 ◽  
Vol 23 (4) ◽  
pp. 45-50
Author(s):  
I.A. Belyaeva ◽  
◽  
L.I. Bashirova ◽  
V.A. Glushchenkov ◽  
N.A. Rodenko ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Pulse Magnetic Field ◽  
Pharmaceutical Preparation ◽  
Chemical Substance ◽  
Pure Substance ◽  
Effect Of Impurities ◽  
One Step ◽  
Biological Effectiveness ◽  
Antiaggregatory Activity ◽  
Aggregation Activity

It was found that the pharmaceutical preparation of pentoxifylline, treated with a pulsed magnetic field (PMF), changes the antiaggregatory properties.The pharmaceutical preparation contains the pure substance of pentoxifylline and a number of excipients. To understand the mechanism of changes in the antiaggregatory activity of a pharmaceutical preparation, the goal was to further investigate the effect of PMF parameters on its chemically pure substance.PMF processing was carried out on the «MIU Bio» installation with a single exposure at a field strength in the range (0.48–1.17) 106 A/m at discharge circuit frequencies (8–50) 103 Hz.Experiments have shown that the effect of PMF on the pure substance of pentoxifylline did not cause significant changes in its antiaggregatory activity. This result made it possible to get one step closer to understanding the mechanism of the effect of PMF on a given drug. Apparently, the reason for the change in the biological effectiveness of the pharmaceutical pentoxifylline treated with PMF lies in the effect of impurities, which will be the focus of further research.

Changes in the Antibacterial Activity of Benzylpenicillin Exposed to a Pulsed High-Intensity Magnetic Field

BIOPHYSICS ◽  
2019 ◽  
Vol 64 (2) ◽  
pp. 214-223
Author(s):  
V. A. Glushchenkov ◽  
T. I. Vasilyeva ◽  
P. P. Purigin ◽  
I. A. Belyaeva ◽  
N. A. Rodenko ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Antibacterial Activity ◽  
High Intensity ◽  
Intensity Magnetic Field

scholarly journals Changes in the activity of various platelet antiplatelet agents when exposed to a high-intensity pulsed magnetic field

2019 ◽  
Vol 59 (9) ◽  
pp. 117-124
Author(s):  
Irina A. Belyaeva ◽  
◽  
Vladimir A. Glushchenkov ◽  
Natalia A. Rodenko ◽  
Tatiana I. Vasilyeva ◽  
...  
Keyword(s):  
Magnetic Field ◽  
High Intensity ◽  
Enzyme Inhibitors ◽  
Antiplatelet Agents ◽  
Modern Technology ◽  
Pulsed Magnetic Field ◽  
Antiplatelet Activity ◽  
Camp Phosphodiesterase ◽  
Significant Difference ◽  
The Impact

Pulse magnetic fields are widely used in modern technology. We studied the antiaggregation properties of pentoxifylline and aspirin irradiated by a pulsed magnetic field at certain parameters: intensity H, frequency f, number of pulses n. The impact of a pulsed magnetic field was carried out both on powdered and dissolved drugs in solution. The aim of the study is to study the effect of high-intensity PMF on the antiplatelet activity of pentoxifylline and aspirin Evaluation of the anti-aggregation effect was carried out using the method of thromboelastography. on a TEG 5000 apparatus. In the analysis of thromboelastograms, the general coagulation tendency was, the functional activity of platelets and fibrinogen, the activity of fibrinolysis, and the physicomechanical properties of the formed clots were determined. Since thrombosis poses a threat to human health, today the use of antiplatelet agents for the prevention of cardiovascular disease is beyond doubt. It was found that exposure to a pulsed magnetic field causes significant changes in the antiplatelet activity of only the pentoxifylline molecule. The effect of PMF on the aspirin molecule has not been identified. This is due, in one hand, to a significant difference in the structure of molecules, as well as to the reaction mechanism in which the studied antiplatelet agents are involved. It can be predicted that the effect of pulsed fields on drugs, which are heterocyclic compounds, antimetabolites, and competitive enzyme inhibitors, can enhance the biological effect of these drugs. A hypothesis was put forward to increase the antiplatelet activity of pentoxifylline by exposure to PMF associated with a change in the conformation of the molecule and an increase in affinity for the active site of cAMP-phosphodiesterase.

DC radial glow discharge in axial magnetic field at low pressures

2019 ◽  
Vol 88 (3) ◽  
pp. 30801
Author(s):  
Shen Gao ◽  
Jianyuan Feng ◽  
Wenqi Li ◽  
Jihe Cai
Keyword(s):  
Magnetic Field ◽  
Glow Discharge ◽  
Plasma Density ◽  
High Intensity ◽  
Axial Magnetic Field ◽  
Spatial Density ◽  
Glow Plasma ◽  
Low Pressures ◽  
Moving Path ◽  
Intensity Magnetic Field

The influence of magnetic field on DC radial glow plasma was studied by self-designed coaxial glow discharge device, and the influence of magnetic field on the spatial distribution of plasma density is studied. The experimental results show that the spatial density distribution of plasma from cathode to anode increases gradually in the high-intensity magnetic field, and decreases gradually in the absence of magnetic field. Theoretical analysis of the above results show that the high-intensity magnetic field increases the moving path of the electrons, enhances the collision efficiency between the electrons and the neutral atoms, and makes the discharge plasma density remarkably enhanced.

Use of Semi-Dipole Magnetic Field for Spacecraft Radiation Protection

2012 ◽  
Vol 190 ◽  
pp. 713-716
Author(s):  
Tara Ahmadi
Keyword(s):  
Magnetic Field ◽  
Radiation Protection ◽  
Human Body ◽  
High Intensity ◽  
Cosmic Radiation ◽  
Radiation Effects ◽  
Permanent Magnets ◽  
Low Intensity ◽  
Dipole Magnetic Field ◽  
Intensity Magnetic Field

There are various methods to shield spacecraft from energetic particles, like one based on the usage of the permanent magnets. At the same time this method is not perfect; it only suggests low intensity magnetic field because of neglecting galactic cosmic radiation effects on human body. In this paper, hyper thin rings as a shield for spacecraft are suggested. Although these rings are lighter than permanent magnets, their ability to protect spaceship with a safe and high intensity magnetic field is higher than the magnets.

Effect of high intensity magnetic field on intermetallic compounds growth in SnBi/Cu microelectronic interconnect

2011 ◽  
Vol 509 (33) ◽  
pp. 8475-8477 ◽  
Author(s):  
C.Z. Liu ◽  
T.Y. Kang ◽  
W. Wei ◽  
K. Zheng ◽  
L. Fu ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Intermetallic Compounds ◽  
High Intensity ◽  
Intensity Magnetic Field

scholarly journals Extraction of Manganese and Iron from a Refractory Coarse Manganese Concentrate

Metals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 563
Author(s):  
Junhui Xiao ◽  
Kai Zou ◽  
Tao Chen ◽  
Wenliang Xiong ◽  
Bing Deng
Keyword(s):  
Magnetic Field ◽  
Magnetic Separation ◽  
High Intensity ◽  
Magnetic Field Intensity ◽  
Test Results ◽  
Calcium Hypochlorite ◽  
Iron Concentrate ◽  
Low Intensity ◽  
Manganese Concentrate ◽  
Intensity Magnetic Field

In this research, the coarse manganese concentrate was collected from a manganese ore concentrator in Tongren of China, and the contents of manganese and iron in coarse manganese concentrate were 28.63% and 18.65%, respectively. The majority of the minerals in coarse manganese concentrate occur in rhodochrosite, limonite, quartz, olivine, etc. Calcium chloride, calcium hypochlorite, coke, and coarse manganese concentrate were placed in a roasting furnace to conduct segregation roasting, which resulted in a partial chlorination reaction of iron to produce FeCl3, ferric chloride reduced to metallic iron and adsorbed onto the coke, and rhodochrosite broken down into manganese oxide. Iron was extracted from the roasted ore using low-intensity magnetic separation, and manganese was further extracted from the low-intensity magnetic separation tailings by high-intensity magnetic separation. The test results showed that iron concentrate with an iron grade of 78.63% and iron recovery of 83.60%, and manganese concentrate with a manganese grade of 54.04% and manganese recovery of 94.82% were obtained under the following optimal conditions: roasting temperature of 1273 K, roasting time of 60 min, calcium chloride dosage of 10%, calcium hypochlorite dosage of 5%, coke dosage of 10%, coke size of −1 mm, grinding fineness of −0.06 mm occupying 90%, low-intensity magnetic field intensity of 0.14 T, and high-intensity magnetic field intensity of 0.65 T. Most minerals in the iron concentrate were Fe, Fe3O4, and a small amount of SiO2 and CaSiO3; the main minerals in the manganese were MnO, and a small amount of Fe3O4, SiO2, and CaSiO3. The thermodynamic calculation results are in good agreement with the test results.

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