scholarly journals Low-Dose Radiation Therapy for COVID-19 Pneumonia: review

2020 ◽  
pp. 30-34
Author(s):  
N. Kolotilov
Keyword(s):  
Radiation Therapy ◽  
Low Dose ◽  
Ore Deposits ◽  
Molecular Targeting ◽  
Positive Experience ◽  
Low Dose Radiation ◽  
Coronavirus Infection ◽  
Positive Results ◽  
Dose Radiation ◽  
Radiolabeled Antibodies

The use of low-dose radiation therapy (LDRT) in patients with pneumonia from 1905 to 1943 provided positive results in 83.08 % of cases. Interest in LDRT is supported by researchers of radiation hormesis in the 21st century. Attention is drawn to the dynamics of coronavirus infection in the regions of Ukraine and the Kirovograd region with a minimum incidence. It is known that 95 % of uranium ore deposits in Ukraine are concentrated in the Kirovograd region. The positive experience of LDRT in Iran, India, USA, Spain for the treatment of patients with COVID-19 is described. LDRT (<100 cGy) is known to be anti-inflammatory, and therefore pulmonary LDRT has the potential to reduce the severity of pneumonia and reduce mortality. LDRT deserves a clinical study. A new direction in radiation therapy – Auger therapy based on radiolabeled antibodies – is planned to be used as a molecular targeting radiotherapy agent directly to the SARS-CoV-2.

Review of Radiation Technologies for the Treatment of Covid-19 Coronavirus Infection

2021 ◽  
Vol 66 (1) ◽  
pp. 59-62
Author(s):  
E Sarapultseva ◽  
A Garmash ◽  
E Gromushkina ◽  
E Gameeva ◽  
D Maksarova
Keyword(s):  
Clinical Trials ◽  
Radiation Therapy ◽  
Low Dose ◽  
Circulatory System ◽  
Scientific Data ◽  
Low Dose Radiation ◽  
Radiation Induced ◽  
Coronavirus Infection ◽  
Dose Radiation

Due to the long-term lack of effective pharmacological concepts, the situation with the spread of a new coronavirus infection in 2019 (COVID-19) has aroused interest in considering the possible use of radiation technologies, including historical reports on the treatment of patients with pneumonia using low-dose radiation therapy. A brief review of articles on clinical trials of radiation technologies in the fight against COVID-19 is conducted. The authors of most of the analyzed articles, as well as the authors of this review, conclude that the available scientific data do not justify clinical trials of low-dose radiation therapy for the treatment of COVID-19 pneumonia due to the unclear benefits and risks of mortality from radiation-induced diseases, including radiogenic cancer and diseases of the circulatory system.

scholarly journals Possibilities of low-dose radiation therapy in the treatment of intrapulmonary injuries caused by COVID-19 infection

2021 ◽  
Vol 25 (1) ◽  
pp. 27-34
Author(s):  
E. Y. Khomutova ◽  
P. V. Novikov ◽  
A. S. Shatalov
Keyword(s):  
Radiation Therapy ◽  
Low Dose ◽  
Severe Pneumonia ◽  
Economic Benefits ◽  
Low Dose Radiation ◽  
Clinical Observations ◽  
Predicting Success ◽  
Recovery Times ◽  
Coronavirus Infection ◽  
Dose Radiation

This paper examines the relevance of the use of a single irradiation of lungs in treatment of pneumonia caused by a new coronavirus infection. Clinical observations are presented that demonstrate perspectives in the treatment of this disease. Patients with severe pneumonia who were prescribed LD-RT (low-dose radiation therapy) at a dose of 0.5–1.5 Gy showed shorter recovery times and no complications. This method of treatment has shown its effectiveness in a number of studies from different countries, predicting success and economic benefits in its further use and study. A literature search containing information on relevant studies was carried out in PubMed, EMBASE, Web of Science and Google Scholar systems. Attention was focused on full-text articles given their general availability in a pandemic.

Plasma cell infiltration of the upper aerodigestive tract treated with radiation therapy

2001 ◽  
Vol 115 (11) ◽  
pp. 928-930 ◽  
Author(s):  
Gerald Fogarty ◽  
Hugh Turner ◽  
June Corry
Keyword(s):  
Radiation Therapy ◽  
Plasma Cell ◽  
Low Dose ◽  
Symptomatic Improvement ◽  
Upper Aerodigestive Tract ◽  
Low Dose Radiation ◽  
Base Of Tongue ◽  
First Case ◽  
Mucosal Lining ◽  
Dose Radiation

A case of chronic, fluctuating plasma cell gingivostomatitis that progressed despite chemotherapy and surgery is reported. This is the first case reported of treatment with radiation therapy, and one of the few cases reported where the infiltrate has reached the larynx. After receiving low dose radiation therapy, via a conformal technique encompassing the respiratory mucosal lining from the base of tongue to carina, there has been symptomatic improvement.

Low-dose radiation therapy for hand osteoarthritis: shaking hands again?

2021 ◽  
Author(s):  
B. Álvarez ◽  
A. Montero ◽  
R. Alonso ◽  
J. Valero ◽  
M. López ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Low Dose ◽  
Hand Osteoarthritis ◽  
Low Dose Radiation ◽  
Dose Radiation

Combining Low-Dose Radiation Therapy and Magnetic Resonance Guided Focused Ultrasound to Reduce Amyloid-β Deposition in Alzheimer’s Disease

2021 ◽  
pp. 1-4
Author(s):  
Paolo Farace ◽  
Stefano Tamburin
Keyword(s):  
Alzheimer’S Disease ◽  
Clinical Trials ◽  
Radiation Therapy ◽  
White Matter ◽  
Magnetic Resonance ◽  
Low Dose ◽  
Focused Ultrasound ◽  
Amyloid Β ◽  
Low Dose Radiation ◽  
Dose Radiation

Amyloid-β deposition is one of the neuropathological hallmarks of Alzheimer’s disease (AD), but pharmacological strategies toward its reduction are poorly effective. Preclinical studies indicate that low-dose radiation therapy (LD-RT) may reduce brain amyloid-β. Animal models and proof-of-concept preliminary data in humans have shown that magnetic resonance guided focused ultrasound (MRgFUS) can reversibly open the blood-brain-barrier and facilitate the delivery of targeted therapeutics to the hippocampus, to reduce amyloid-β and promote neurogenesis in AD. Ongoing clinical trials on AD are exploring whole-brain LD-RT, which may damage radio-sensitive structures, i.e., hippocampus and white matter, thus contributing to reduced neurogenesis and radiation-induced cognitive decline. However, selective irradiation of cortical amyloid-β plaques through advanced LD-RT techniques might spare the hippocampus and white matter. We propose combined use of advanced LD-RT and targeted drug delivery through MRgFUS for future clinical trials to reduce amyloid-β deposition in AD since its preclinical stages.

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