Primary Packaging and Stability Evaluation of a Serum Used for the Periorbital Area of the Sensitive Eye

The aim of this study was the development and formulating of an eye contour serum containing hyaluronic acid (HA) and the assessment of stability tests performed for the cosmetic product, transfered into a glass cosmetic bottle with polipropylene (PP) pump and cap. Sample of cosmetic serum were stored using 20 mL glass bottles with PP (Polypropylene) pump and cap. The developed cosmetic formulation was monitored under accelerated stability studies, performed over a period of 30 days while maintaining the product at 4, 20 and 40�C. Quality control initial, and after initiating the accelerated stability test was performed for the developed cosmetic formulation.

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Influence of Packaging and Stability Test Assessment of an Anti-aging Cosmetic Cream

Materiale Plastice ◽

10.37358/mp.18.3.5043 ◽

2018 ◽

Vol 55 (3) ◽

pp. 426-430

Author(s):

Anca Maria Juncan ◽

Luca Liviu Rus

Keyword(s):

Quality Control ◽

Stability Test ◽

Stability Studies ◽

Stability Tests ◽

Cosmetic Product ◽

Accelerated Stability ◽

Test Assessment ◽

Cosmetic Formulation ◽

Plastic Containers

The aim of this study was the development and formulating of a cosmetic product and the assessment of compatibility tests performed on the product, transfered to the cosmetic jar. Sample of cosmetic cream were stored using 50 mL PP (Polypropylene) plastic containers. The developed cosmetic formulation was monitored under accelerated stability studies. Accelerated stability tests were performed over a period of 30 days while maintaining the product at 4, 20 and 40�C. Quality control initial, and after initiating the accelerated stability test was performed for the developed cosmetic formulation.

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Packaging Evaluation and Safety Assessment of a Cosmetic Product

Materiale Plastice ◽

10.37358/mp.18.4.5093 ◽

2018 ◽

Vol 55 (4) ◽

pp. 644-647

Author(s):

Anca Maria Juncan

Keyword(s):

Quality Control ◽

Safety Assessment ◽

Stability Test ◽

Stability Studies ◽

Cosmetic Product ◽

Accelerated Stability ◽

Cosmetic Formulation

The aim of this study was the development and formulating of a cosmetic product for bodycare and the assessment of compatibility tests performed on the product, transfered into a poliethylene (PE) cosmetic bottle. Sample of cosmetic cream were stored using 200 ml PE plastic bottles with PP (Polypropylene) cap. The developed cosmetic formulation was monitored under accelerated stability studies, performed over a period of 30 days while maintaining the product at 4, 20 and 40�C. Quality control initial, and after initiating the accelerated stability test was performed for the developed cosmetic formulation.

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Quality-by-Design-Based Development of n-Propyl-Gallate-Loaded Hyaluronic-Acid-Coated Liposomes for Intranasal Administration

Molecules ◽

10.3390/molecules26051429 ◽

2021 ◽

Vol 26 (5) ◽

pp. 1429

Author(s):

Fakhara Sabir ◽

Gábor Katona ◽

Edina Pallagi ◽

Dorina Gabriella Dobó ◽

Hussein Akel ◽

...

Keyword(s):

Hyaluronic Acid ◽

Zeta Potential ◽

Propyl Gallate ◽

Quality By Design ◽

In Vitro Release ◽

Brain Diseases ◽

Stability Studies ◽

Accelerated Stability ◽

Vitro Release

The present study aimed to develop n-propyl gallate (PG)-encapsulated liposomes through a novel direct pouring method using the quality-by-design (QbD) approach. A further aim was to coat liposomes with hyaluronic acid (HA) to improve the stability of the formulation in nasal mucosa. The QbD method was used for the determination of critical quality attributes in the formulation of PG-loaded liposomes coated with HA. The optimized formulation was determined by applying the Box–Behnken design to investigate the effect of composition and process variables on particle size, polydispersity index (PDI), and zeta potential. Physiochemical characterization, in vitro release, and permeability tests, as well as accelerated stability studies, were performed with the optimized liposomal formulation. The optimized formulation resulted in 90 ± 3.6% encapsulation efficiency, 167.9 ± 3.5 nm average hydrodynamic diameter, 0.129 ± 0.002 PDI, and −33.9 ± 4.5 zeta potential. Coated liposomes showed significantly improved properties in 24 h in an in vitro release test (>60%), in vitro permeability measurement (420 μg/cm2) within 60 min, and also in accelerated stability studies compared to uncoated liposomes. A hydrogen-peroxide-scavenging assay showed improved stability of PG-containing liposomes. It can be concluded that the optimization of PG-encapsulated liposomes coated with HA has great potential for targeting several brain diseases.

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Application of Accelerated Stability Studies on Linagliptin by HPTLC

Asian Journal of Chemistry ◽

10.14233/ajchem.2017.20140 ◽

2017 ◽

Vol 29 (1) ◽

pp. 94-98 ◽

Cited By ~ 1

Author(s):

Santosh R. Butle ◽

Padmanabh B. Deshpande

Keyword(s):

Stability Studies ◽

Accelerated Stability

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Accelerated stability studies on 16-methylene-17α-acetoxy-19-nor-pregn-4-ene-3,20-dione (Nestorone™)

Steroids ◽

10.1016/0039-128x(95)00074-z ◽

1995 ◽

Vol 60 (8) ◽

pp. 534-539 ◽

Cited By ~ 3

Author(s):

S Ahmed

Keyword(s):

Stability Studies ◽

Accelerated Stability

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Optimization of Performance Variables of Exemestane Nanosuspension Using Box-Behnken Design to Improve Dissolution and Oral Bioavailability

Current Drug Delivery ◽

10.2174/1567201818999210112190716 ◽

2021 ◽

Vol 18 ◽

Author(s):

Komal Parmar ◽

Jay Shah

Keyword(s):

Oral Bioavailability ◽

In Vitro Dissolution ◽

Pharmacokinetic Parameters ◽

Average Particle ◽

Stability Studies ◽

Box Behnken Design ◽

Media Milling ◽

Dissolution Properties ◽

Accelerated Stability

Purpose: Present investigation was aimed to fabricate nanocrystal of exemestane, an anticancer drug with poor dissolution properties and oral bioavailability. Methods: Influence of various process parameters on the formulation of exemestane nanosuspension using media milling technique were investigated in the trial batches. Box-Behnken design was applied with independent variables identified in the preliminary studies, viz. X1-Milling time, X2-Amount of stabilizer and X3-Amount of milling agent. In vitro dissolution and in vivo studies were carried out. Solid state characterization (PXRD, SEM, and DSC) studies demonstrated physical changes in drug due to nano-crystallization. Accelerated stability studies of optimized formulation were carried out. Results: Individual process attributes exhibited significant effect on the average particle size of exemestane nanosuspension. Dissolution studies revealed enhancement in drug release rate as compared to pure exemestane powder. The in vivo pharmacokinetic parameters of exemestane nanosuspension showed significant improvement in Cmax and AUC0-t, about 283.85% and 271.63% respectively suggesting amelioration in oral bioavailability by 2.7-fold as compared to pure exemestane. Accelerated stability studies of the optimized formulation suggested stability of the nanocrystals for at least sixmonth period. Conclusion: Nanocrystals prepared by media milling technique were successful in improving the poor dissolution properties and oral bioavailability of exemestane.

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Stability evaluation of tocopheryl acetate and ascorbyl tetraisopalmitate in isolation and incorporated in cosmetic formulations using thermal analysis

Brazilian Journal of Pharmaceutical Sciences ◽

10.1590/s1984-82502010000100015 ◽

2010 ◽

Vol 46 (1) ◽

pp. 129-134 ◽

Cited By ~ 9

Author(s):

Mariana Mandelli de Almeida ◽

Cibele Rosana Ribeiro de Castro Lima ◽

Joyce Santos Quenca-Guillen ◽

Elder Moscardini Filho ◽

Lucildes Pita Mercuri ◽

...

Keyword(s):

Thermal Analysis ◽

Raw Materials ◽

Skin Aging ◽

Tocopheryl Acetate ◽

Stability Evaluation ◽

Scanning Calorimetry ◽

Cosmetic Formulations ◽

Cosmetic Formulation ◽

Excellent Tool

In view of the increase in the number of cosmetic preparations containing antioxidant vitamins, chiefly, due to their action in preventing the process of skin aging, there is a need to develop pre-formulation studies and to validate analytical methods in order to obtain high quality products. Thus, the objective of this research was to evaluate and compare the thermal behavior of tocopheryl acetate and ascorbyl tetraisopalmitate as raw materials, and incorporated into a base cream. Thermogravimetry (TG / DTG) and differential scanning calorimetry (DSC) were used for this purpose. Both vitamins were found to be stable up to 250ºC. The base cream (placebo) and the sample (base cream containing the vitamins) presented different weight loss. Thermal analysis has shown itself to be an excellent tool for the characterization of these vitamins and can be used in routine analysis for quality control of this type of cosmetic formulation.

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