Synthesis and Characterization of New Heterocyclic Condensed Systems with Bridgehead Nitrogen from Thiazolo[3,2-b][1,2,4]triazol-6(5H)-ones Class with Potential Antimicrobial Activity

2008 ◽  
Vol 59 (9) ◽  
Author(s):  
Stefania-Felicia Barbuceanu ◽  
Ioana Saramet ◽  
Gabriela Laura Almajan ◽  
Constantin Draghici ◽  
Isabela Tarcomnicu ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Sodium Acetate ◽  
Chloroacetic Acid ◽  
Synthesis And Characterization ◽  
Ring Compounds ◽  
Fused Ring ◽  
Bridgehead Nitrogen ◽  
Condensed Systems ◽  
Potential Antimicrobial Activity

In this study, the synthesis and characterization of new thiazolo[3,2-b][1,2,4]triazol-6(5H)-ones 3-5 are described starting from 5-[4-(4-X-phenylsulfonyl)phenyl]-4H-1,2,4-triazole-3-thioles 2. The treatment of 1,2,4-triazole-3-thioles 2 with chloroacetic acid and substituted or non-substituted benzaldehydes in the presence of sodium acetate, acetic acid and acetic anhydride gave fused ring compounds 3-5. The structures of thiazolo-triazolones 3-5 have been elucidate by elemental analysis and IR, UV, 1H-NMR, 13C-NMR, MS spectra. Some of the newly synthesized products were tested for their antimicrobial effects.

DESIGN, SYNTHESIS, AND CHARACTERIZATION OF THE SOME NOVEL 2‐AMINO-PYRIDINE‐3‐ CARBONITRILE AND 2‐AMINO-4H-PYRAN‐3‐CARBONITRILE DERIVATIVES AGAINST ANTIMICROBIAL ACTIVITY AND ANTIOXIDANT ACTIVITY

2020 ◽  
pp. 125-134
Author(s):  
SURENDRA BABU LAGU ◽  
RAJENDRA PRASAD YEJELLA
Keyword(s):  
Antimicrobial Activity ◽  
Antioxidant Activity ◽  
Antimicrobial Activities ◽  
Docking Studies ◽  
Synthesis And Characterization ◽  
Zone Of Inhibition ◽  
Design Synthesis ◽  
Instrumental Methods ◽  
Objective Investigation

Objective: Investigation, the series of newer 2‐amino-pyridine‐3‐carbonitrile and 2‐amino-4H-pyran‐3‐carbonitrile derivative were synthesized and evaluated antimicrobial activities and antioxidant activity. Methods: Novel synthesized chalcones were further condensation to give 2-amino-3-cyanopyridine and 2-amino-3-cyanopyrans in the presence of malononitrile, pyridine, and ammonia acetate. The product is characterized by conventional and instrumental methods. Pyridine and 4-H-Pyran and their analogs occupy prime position due to their diverse applications. Results: The compounds A3C and B3C exhibited marked zone of inhibition with 30.02±0.02 mm and 29.06±0.01 mm, respectively. Docking studies suggested possible interactions with dihydrofolic reductase 4 with 9.15 and −9.67 kcal/mol, respectively. The IC50 30.28±0.01 exhibited A3C by 2,2-diphenylpicrylhydrazyl methods which is better among the series. The 2-amino-3-cyanopyridine derivatives were found good activity than 2-amino-3-cyanopyrane derivative. Among all synthesized compounds few having potent activity and some are near to the standard. Conclusion: Antimicrobial activity and antioxidant of the newly synthesized pyrans and pyridines derivatives will definitely inspire future researchers for the preparation of new analogs.

scholarly journals Synthesis and characterization of new complexes of Co+2 , Ni+2 , Cu+2 and Zn+2 with (Sodium acetate thio ) ethylene ligands

2013 ◽  
Vol 10 (3) ◽  
pp. 650-657
Author(s):  
Baghdad Science Journal
Keyword(s):  
Content Analysis ◽  
General Formula ◽  
Metal Content ◽  
Sodium Acetate ◽  
Magnetic Measurement ◽  
Synthesis And Characterization ◽  
Square Planar ◽  
Square Planar Complexes ◽  
Uv Visible

This research involves the preparation of new ligands 1,1,2,2- tetrakis (sodium acetate thio)ethylene(L1) and 1,1,2- tris(sodiumacetatethio) ethylene(L2), through the reaction of disodium thioglycolate) with tetra chloro ethylene or tri chloro ethylene in (1:4) or (1:3) moler ratio . Homodinucliar complexes of general formlu [M2(L1)] and [M2(L2)ClH2O] , when M= Co(II), Ni(II), Cu (II) and Zn(II) also mono nuclear complexes of general formula [M(L2)] . The prepared complexes were characterized using spectral method (UV/Visible/ IR) , metal content analysis , magnetic and atomic measurements . The spectral and magnetic measurement indicats that some complexes have tetrahedral or square planar complexes environtment .

Synthesis and characterization of new water soluble 9,10-anthraquinonе and evaluation of its antimicrobial activity

2018 ◽  
Vol 1168 ◽  
pp. 22-27 ◽  
Author(s):  
Stanislava Yordanova ◽  
Evgenia Vasileva-Tonkova ◽  
Desislava Staneva ◽  
Stanimir Stoyanov ◽  
Ivo Grabchev
Keyword(s):  
Antimicrobial Activity ◽  
Water Soluble ◽  
Synthesis And Characterization

scholarly journals Synthesis and characterization of green tea (Camellia sinensis (L.) Kuntze) extract and its major components-based nanoflowers: a new strategy to enhance antimicrobial activity

RSC Advances ◽  
2017 ◽  
Vol 7 (70) ◽  
pp. 44303-44308 ◽  
Author(s):  
Ayşe Baldemir ◽  
N. Buse Köse ◽  
Nilay Ildız ◽  
Selen İlgün ◽  
Sadi Yusufbeyoğlu ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Agent ◽  
Green Tea ◽  
Camellia Sinensis ◽  
Synthesis And Characterization ◽  
New Strategy ◽  
Main Components ◽  
First Time

In this study, for the first time, a novel organic–inorganic nanobio-antimicrobial agent called “nanoflowers” (Nfs) from Camellia sinensis (L.) Kuntze extracts and its main components were produced and the increase in the antimicrobial activity of Nfs was elucidated.

Synthesis and characterization of novel dimerics-triazine derivatives as potential anti-bacterial agents against MDR clinical isolates

2018 ◽  
Vol 42 (13) ◽  
pp. 10676-10688 ◽  
Author(s):  
Doaa R. Ramadan ◽  
Aly A. Elbardan ◽  
Adnan A. Bekhit ◽  
Ayman El-Faham ◽  
Sherine N. Khattab
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Bases ◽  
Mammalian Cells ◽  
High Selectivity ◽  
Bacterial Activity ◽  
Selectivity Index ◽  
Synthesis And Characterization ◽  
Triazine Derivatives ◽  
Ampicillin Trihydrate

Several dimerics-triazine Schiff bases displayed more potent anti-bacterial activity compared with ampicillin trihydrate. They revealed significantly low MIC values towards the tested MDR strains and showed a high selectivity index towards antimicrobial activity againstK. pneumoniaeandMRSA1compared to mammalian cells.

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