scholarly journals Conditioning of Praziquantel and Florfenicol for some Heterologous Coinfections of Farmed Carp

2019 ◽  
Vol 70 (7) ◽  
pp. 2404-2409
Author(s):  
Andrei Cristian Lupu ◽  
Mihaela Bombos ◽  
Cristian Alin Barbacariu ◽  
Constantin Roman ◽  
Raluca Mindru ◽  
...  
Keyword(s):  
Controlled Release ◽  
Sunflower Oil ◽  
Castor Oil ◽  
Water Diffusion ◽  
Route Of Administration ◽  
Effective Alternative ◽  
Sorbitan Monooleate ◽  
Fish Diseases ◽  
The Stability

Coinfections can alter the course and severity of different fish diseases. Suspensions of praziquantel (PZQ) and florfenicol (FFC ) based on sunflower oil can be an effective alternative for treating fish coinfections. The use of polyoxyethylene (20) sorbitan monooleate in the presence of ethoxylated castor oil in the preparation of PZQ and FFC suspensions has improved the stability of these suspensions. This PZQ and FFC preparation can be used in the treatment of parasitic/bacterial heterologous coinfections. The suspension of the PZQ and FFC preparation can be administered by water-diffusion, having a controlled release. The compounds are biodegradable and the route of administration remains safe for the environment.

Effect of Coconut Oil and Surfactants on Stability of Nanoemulsions

2012 ◽  
Vol 506 ◽  
pp. 429-432 ◽  
Author(s):  
Suchada Piriyaprasarth ◽  
Pornsak Sriamornsak ◽  
Gaysorn Chansiri ◽  
W. Promboot ◽  
U. Imerb ◽  
...  
Keyword(s):  
Castor Oil ◽  
Coconut Oil ◽  
Temperature Cycling ◽  
Polysorbate 80 ◽  
Sorbitan Monooleate ◽  
Polyethylene Glycol 400 ◽  
Polysorbate 20 ◽  
Temperature Cycling Test ◽  
The Stability ◽  
Oil Sunflower

The objective of this study was to investigate the effect of coconut oil and different surfactants on stability of nanoemulsions that were prepared by simple homogenization (13,500 rpm, 10 minutes). Coconut oil, sunflower oil and castor oil at the concentration of 20-40% w/w were used as the oil phase. Polysorbate 20, polysorbate 80 and Cremophore RH40 were used as surfactant whereas sorbitan monooleate and polyethylene glycol 400 were used as co-surfactants. The formulations containing coconut oil in the range of 20-40% w/w and the ratio of polysorbate 80 to sorbitan monooleate of 2:1 and 3:1 provided nanosized emulsions (100-500 nm). The zeta potential values ranged from-41.51 to-16.97 mV. The prepared nanoemulsions were stable for at least 7 days at 8 °C. The temperature cycling test (storage at 4 °C for 24 hours and at 45 °C for 24 hours) was performed. It was found that the formulation containing 30% w/w of coconut oil, 22.5% w/w of polysorbate 80 and 7.5% w/w of sorbitan monooleate was stable for 1 cycle. The results indicated that a decrease in the concentration of surfactant and an increase in the concentration of oil affected the stability of nanoemulsions.

Controlled release of a highly hydrophilic API from lipid microspheres obtained by prilling: Analysis of drug and water diffusion processes with X-ray-based methods

2012 ◽  
Vol 158 (3) ◽  
pp. 393-402 ◽  
Author(s):  
Perrine Pivette ◽  
Vincent Faivre ◽  
Lucia Mancini ◽  
Claire Gueutin ◽  
Georges Daste ◽  
...  
Keyword(s):  
Controlled Release ◽  
Diffusion Processes ◽  
Water Diffusion ◽  
X Ray

scholarly journals Effects of pH and Electrolytes on Castor Oil Emulsions with Various Stabilisers Using Khaya senegalensis Gum as an Emulsifier

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Deryl Nii Okantey Kuevi ◽  
Noble Kuntworbe ◽  
Enoch Ayertey
Keyword(s):  
Castor Oil ◽  
Xanthan Gum ◽  
Hydroxypropyl Methylcellulose ◽  
Physical Stability ◽  
Tween 80 ◽  
Volume Data ◽  
Emulsifying Property ◽  
Khaya Senegalensis ◽  
Effects Of Ph ◽  
The Stability

Dispersed systems such as emulsions are easily destabilised during processing and storage since they are thermodynamically unstable systems. It is for this reason emulsifiers/stabilisers are frequently employed in pharmaceutical emulsion formulations to increase their short- and long-term kinetic stability. This current study seeks to investigate the potential emulsifying property of gums obtained from Khaya senegalensis (family: Meliaceae) trees. Gums were collected, authenticated, oven-dried, milled, filtered, and purified using 96% ethanol. The microbial quality of the gum was assessed following the BP (2013) specifications. The purified gum was free from some selected pathogenic microorganisms, rendering the gum safe for consumption. The emulsifying property was investigated by formulating emulsions using castor oil and employing the dry gum method. The ratios of oil-to-water-to-gum for the formulation of a stable emulsion were determined. The stability of the emulsion was evaluated, and an effort was made to improve the stability by incorporating Tween 80, hydroxypropyl methylcellulose, and xanthan gum. From the results, it can be inferred that Tween 80 (0.5%) was able to stabilise the emulsion. Addition of xanthan gum worsened the creaming. The effects of pH (4.0, 5.5, 7.2, 9.0, and 11.0) and electrolytes (0.1 M of NaCl, KCl, and CaCl2) on the physical stability of oil-in-water emulsions were studied during 12 weeks of storage. Percentage creaming volume and whether there was phase inversion were the criteria used as the evaluation parameter. From the percentage creaming volume data, emulsions formulated with both gums showed the lowest creaming volumes at pH of 7.2, followed by the acidic regions (pH 4.0, 5.5), with the basic regions (pH 9.0, 11.0) recording the highest creaming volumes. The effects of the various electrolytes at a constant concentration of 0.1 M on the o/w emulsions were found in this order NaCl < KCl < CaCl2. This study proves that Khaya senegalensis gum can successfully be employed as an emulsifying agent in pharmaceutical formulations.

scholarly journals Fabrication and evaluation of slow-release lignin-based avermectin nano-delivery system with UV-shielding property

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Dongmei Mo ◽  
Xiangying Li ◽  
Yong Chen ◽  
Yang Jiang ◽  
Chunfang Gan ◽  
...  
Keyword(s):  
Electron Microscope ◽  
Controlled Release ◽  
Delivery System ◽  
High Speed ◽  
Large Scale ◽  
Diazonium Salt ◽  
Sodium Lignosulfonate ◽  
Ultrasonic Dispersion ◽  
Transmission Electron ◽  
The Stability

AbstractNanopesticide is one of the best pesticide formulation technologies to overcome the disadvantages of traditional pesticides, which has received great attention from the international community. Using high-speed emulsification and ultrasonic dispersion technology, an avermectin nano-delivery system (Av-NDs) with a particle size of 80–150 nm was prepared through embedding the pesticide molecule utilizing the cross-linking reaction between sodium lignosulfonate and p-phenylenediamine diazonium salt. The formulation and composition of Av-NDs were optimized, the morphology of Av-NDs was analyzed by scanning electron microscope, transmission electron microscope and dynamic light scattering, and the structure of Av-NDs was characterized by UV, IR and 1H NMR. Anti-photolysis and controlled-release tests show that the stability of Av-NDs is 3–4 times of the original avermectin (Av) and possesses the pH-responsive controlled release property. Furthermore, the insecticidal activity of Av-NDs is better than that of avermectin suspension concentrate (Av-SC). The Av-NDs with anti-photolysis and controlled-release characteristics is suitable for large-scale industrial production and is capable to be utilized as effective insecticide in the field.

Effects of Several Natural Macromolecules on the Stability and Controlled Release Properties of Water-in-Oil-in-Water Emulsions

2016 ◽  
Vol 64 (19) ◽  
pp. 3873-3880 ◽  
Author(s):  
Jinlong Li ◽  
Yiheng Shi ◽  
Yunping Zhu ◽  
Chao Teng ◽  
Xiuting Li
Keyword(s):  
Controlled Release ◽  
Oil In Water ◽  
The Stability

Study on pharmacokinetics of nimodipine nano-controlled release agent modified by host-guest reaction of β-cyclodextrin in rats

2021 ◽  
Vol 11 (6) ◽  
pp. 839-845
Author(s):  
Xiaoxiu Fu ◽  
Lin Ma ◽  
Yang Cao ◽  
Hengzhong Xu ◽  
Yan Guo
Keyword(s):  
Controlled Release ◽  
The Elderly ◽  
Rat Plasma ◽  
Cerebrovascular Diseases ◽  
Absolute Bioavailability ◽  
Release Agent ◽  
Dihydropyridine Calcium Channel Antagonist ◽  
Oral Preparation ◽  
Ischemic Cerebrovascular Diseases ◽  
The Stability

Nimodipine (NIMO) has been identified as a second-generation dihydropyridine calcium channel antagonist. NIMO’s specificity for the cerebrovascular smooth muscle contributes to its broad usage in treating ischemic cerebrovascular diseases in the elderly. Therefore, enhancing NIMO’s therapeutic effect and reducing its adverse reactions caused by short-term repeated use have become a focus of research. As a result, a new controlled-release preparation of NIMO, the carboxymethyl chitosan/nimodipine-hydroxypropyl-β-cyclodextrin nanoparticle (Nano-NIMO), was constructed based on hydroxypropyl-β-cyclodextrin. The novel composite Nano-NIMO preparation could significantly improve the stability of NIMO in rat plasma, achieving an absolute bioavailability as high as 62.3%, which is three times that of the traditional NIMO oral preparation. Therefore, Nano-NIMO is expected to provide a new direction for the preparation of modified controlled-release Nano- NIMO agents.

Preparation and Characterization of Controlled-Release Avermectin/Castor Oil-Based Polyurethane Nanoemulsions

2017 ◽  
Vol 66 (26) ◽  
pp. 6552-6560 ◽  
Author(s):  
Hong Zhang ◽  
He Qin ◽  
Lingxiao Li ◽  
Xiaoteng Zhou ◽  
Wei Wang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Castor Oil

scholarly journals PREPARATION AND CHARACTERIZATION OF GLIADIN NANOPARTICLES FOR BRAIN DRUG DELIVERY

2018 ◽  
Vol 11 (7) ◽  
pp. 345
Author(s):  
Ankit Dubey Naveneet Dubey ◽  
Suman Ramteke ◽  
Deepti Jain
Keyword(s):  
Controlled Release ◽  
Nasal Spray ◽  
Phosphate Buffer ◽  
Spherical Particles ◽  
Brain Targeting ◽  
Brain Drug Delivery ◽  
The Stability ◽  
Nano Size

Objectives: The aim of the present work is to prepare and evaluate nasal controlled release gliadin nanoparticles of sumatriptan for antimigraine activity to improve patients’ compliance by simplifying its administration, improving its therapeutic effect, and reducing its dose-related side effects through brain targeting. Methods: Sumatriptan containing gliadin nanoparticles were prepared by desolvation method using Pluronic F-68 as a stabilizing agent. Results: The results show that this method is reproducible very easy and led to the efficient entrapment of drug as well as the formation of spherical particles ranging from 1 to 181 nm, respectively. The controlled release behavior of gliadin nanoparticles was evaluated both in phosphate buffer saline 7.4 pH and in phosphate buffer 6.8 pH, respectively, at 37±1°C. Their brain targeting properties were determined by the nasal route through in vitro and in vivo methods. Conclusion: The optimized nanoparticles showed higher release rate than other marketed formulation like a tablet, nasal spray this may be due to nano size of the particles, glutaraldehyde was added to this system that increased hardness and F-68 increased the stability of nanoparticles .tablet, nasal spray this may be due to nano size of the particles, glutaraldehyde was added to this system that increased hardness and F-68 increased the stability of nanoparticles. The in vivo results showed that within 15 min maximum concentration of sumatriptan was observed in brain as compare to plasma which could be due to small particle size and lipophilic nature of gliadin nanoparticles. 

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