Inhibitory Effect of Hot-Water Extract of Paeonia japonica on Oxidative Stress and Identification of Its Active Components

AbstractTurmeric (Curcuma longa) is a widely used spice that has various biological effects, and aqueous extracts of turmeric exhibit potent antioxidant activity and anti-inflammatory activity. Bisacurone, a component of turmeric extract, is known to have similar effects. Oxidative stress and inflammatory cytokines play an important role in ethanol-induced liver injury. This study was performed to evaluate the influence of a hot water extract of C. longa (WEC) or bisacurone on acute ethanol-induced liver injury. C57BL/6 mice were orally administered WEC (20 mg/kg body weight; BW) or bisacurone (60 µg/kg BW) at 30 min before a single dose of ethanol was given by oral administration (3·0 g/kg BW). Plasma levels of aspartate aminotransferase and alanine aminotransferase were markedly increased in ethanol-treated mice, while the increase of these enzymes was significantly suppressed by prior administration of WEC. The increase of alanine aminotransferase was also significantly suppressed by pretreatment with bisacurone. Compared with control mice, animals given WEC had higher hepatic tissue levels of superoxide dismutase and glutathione, as well as lower hepatic tissue levels of thiobarbituric acid-reactive substances, TNF-α protein and IL-6 mRNA. These results suggest that oral administration of WEC may have a protective effect against ethanol-induced liver injury by suppressing hepatic oxidation and inflammation, at least partly through the effects of bisacurone.

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Allelopathic Potential of Papaver Somniferum L. on Seed Germination Against Three Different Varities of Zea Mays

10.21203/rs.3.rs-181838/v1 ◽

2021 ◽

Author(s):

Muntaha Tul Sidra ◽

SAYEDA SARAH MUBARAK ◽

FATIMA KHAN SHERWANI ◽

NAZMA AZEEM

Keyword(s):

Zea Mays ◽

Aqueous Extract ◽

Water Extract ◽

Inhibitory Effect ◽

Papaver Somniferum ◽

Hot Water ◽

Allelopathic Effect ◽

Inhibitory Effects ◽

Allelopathic Potential ◽

Hot Water Extract

Abstract Aims To evaluate the allelopathic effect of Papaver somniferum against the 3 varieties of Zea mays seeds cv. Azam, Pahari and Iqbal. Methods Aqueous extracts were made by soaking the powder of dried leaves of Papaver somniferum. For the aqueous extract treatment, the extract was soaked in distilled water for 24 and 48 hours separately. For mulching treatment, the seeds were sowed in soil and sprinkled powder of leaves. For litter, the petri dishes were grounded with randomly cut pieces of filter paper wetted with extract. For hot water treatment the water was boiled for 5 minutes. The powder was then mixed in boil water. Results Azam got effected in 24h extract in aqueous extract treatment while Pahari in 48h treatment. In mulching all the three varieties got inhibited by extract. Azam showed resistance toward the inhibitory effect of extract in litter experiments. Iqbal was affected in hot water extract. Conclusion It is concluded that the extracts obtained from Papaver somniferum showed inhibitory effects on all the three varieties except few exceptions of maize. The plumule and radical growth got affected the most.

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Antifungal ability and decay resistance of Fokienia hodginsii heartwood extract and its inhibitory effect on Gloeophyllum trabeum

BioResources ◽

10.15376/biores.15.2.2784-2799 ◽

2020 ◽

Vol 15 (2) ◽

pp. 2784-2799

Author(s):

Jian-Fei Wu ◽

Xue-Feng Zhuang ◽

Hong-mei Yuan ◽

Quan Li ◽

Wei Wang ◽

...

Keyword(s):

Methanol Extract ◽

Mass Loss Rate ◽

Water Extract ◽

Decay Resistance ◽

Inhibitory Effect ◽

Hot Water ◽

Gloeophyllum Trabeum ◽

Test Pieces ◽

Hot Water Extract ◽

Acetone Extracts

The inhibitory ability of Fokienia hodginsii heartwood (FHH) extracts on Trametes versicolor (TV) and Gloeophyllum trabeum (GT) as well as the toxic effect of its heartwood extracts on GT were studied. The growth inhibition ability of the samples was analyzed using the growth rate method. The results showed that in the experiment of inhibiting TV, extracts using hot water had little effect, acetone extracts had the best inhibiting effect, and the lowest value of acetone EC50 was 0.409 g/L. The parameter EC50 is the concentration of the corresponding agent that inhibits the growth of 50% fungi. In the antifungal experiment of GT, methanol extract had the best inhibition effect, and the lowest EC50 value was 0.283 g/L. The antifungal effect of five solvent extracts of FHH was good when the concentration was 10% (w/w), and at this time, the mass loss rate of the test pieces was below 11%, all of them were Class I, indicating a strong antifungal level. After observing the samples of GT with SEM, it was found that the structure of methanol extract treatment was more complete and the antiseptic effect was better than that of the hot water extract treatment.

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Protective Effect of Ferments of Hot-water Extract Mixture from Rhodiola sachalinensis and Red Ginseng on Oxidative Stress-induced C2C12 Myoblast

The Korean Journal of Food And Nutrition ◽

10.9799/ksfan.2013.26.3.485 ◽

2013 ◽

Vol 26 (3) ◽

pp. 485-491

Author(s):

Bo-Ra Yoon ◽

Young-Hyun Kim ◽

Jong-Seok Lee ◽

Hee-Do Hong ◽

Young-Kyoung Rhee ◽

...

Keyword(s):

Oxidative Stress ◽

Protective Effect ◽

Water Extract ◽

Hot Water ◽

C2c12 Myoblast ◽

Red Ginseng ◽

Rhodiola Sachalinensis ◽

Hot Water Extract

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Synbiotic Effect of Probiotic ( Bifidobacterium sp ) and Prebiotics (Chicory and Inulin ) aganist some pathogenic bacteria

Baghdad Science Journal ◽

10.21123/bsj.6.2.354-360 ◽

2009 ◽

Vol 6 (2) ◽

pp. 354-360

Author(s):

Baghdad Science Journal

Keyword(s):

Pseudomonas Aeruginosa ◽

Antimicrobial Activity ◽

Pathogenic Bacteria ◽

Water Extract ◽

Inhibitory Effect ◽

Hot Water ◽

Hot Water Extract ◽

Esherichia Coli ◽

Synergistic Inhibitory Effect ◽

Chicory Roots

The Antimicrobial activity of Probiotic Bifidobacterium sp and Prebiotics : chicory roots ( Hot water extract ) and Inulin ( 10 % ) against some Pathogenic bacteria (Esherichia coli , Proteus mirabilis , Klebsiella sp , Pseudomonas aeruginosa , Serratia marcescens was studied . The combination of Probiotic and Prebiotics (Synbiotic) (Bifidobacterium sp + chicory ) and (Bifidobacterium sp + Inulin ) also tested for their antimicrobial activity against Pathogenic bacteria . Results showed that Bifidobacterium sp had good antimicrobial activity against all the Pathogenic bacteria tested , followed by chicory and inulin . The synergistic inhibitory effect of Synbiotic (Bifidobacterium sp + chicory ) and ( Bifidobacterium sp + inulin ) on Pathogenic bacteria was higher than the effect of Bifidobacterium sp alone, chicory alone and inulin alone.

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