Beneficial Effects of Acanthopanax senticosus Extract in Type II Diabetes Animal Model via Down-Regulation of Advanced Glycated Hemoglobin and Glycosylation End Products

The work is devoted to assessing the effect of thioctic acid on the main laboratory parameters of carbohydrate metabolism (blood glucose, C-peptide and insulin levels, glycated hemoglobin) in diabetes mellitus against the background of glucose-lowering therapy with metformin hydrochloride. The studies were conducted with the participation of 32 volunteers aged 52 to 63 years, 26 of whom type II diabetes mellitus proceeded with III-degree obesity. At the time of the study, all patients were taking metformin hydrochloride (MH) as a hypoglycemic agent. The experiment was carried out for 3 months. All study participants were divided into groups: the first group - the control group, who took only MG 850 mg once a day for; the second group, patients with normal body weight, who took metformin hydrochloride 850 mg and thioctic acid (TA) 600 mg per day; the third group - obese patients receiving the test compound at the same dosage. After 3 months of treatment, all patients underwent biochemical blood tests for the following parameters: blood glucose, glycated hemoglobin, C-peptide and insulin levels. The results obtained indicate that thioctic acid contributed to a more pronounced decrease in carbohydrate metabolism in comparison with the group of patients receiving only MH as a hypoglycemic agent. It was noted that the normalization of the studied parameters was expressed in the group of patients with normal body weight. Thus, the additional introduction of thioctic acid into the treatment regimen for patients with type II diabetes mellitus contributes to a more effective decrease in carbohydrate metabolism and compensation of the disease in comparison with standard therapy.

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Clinical Study of Ultrasonic Extreme Velocity Imaging Pulse Wave Technique in Carotid Elasticity in Patients with Type II Diabetes Mellitus

Journal of Biomaterials and Tissue Engineering ◽

10.1166/jbt.2021.2668 ◽

2021 ◽

Vol 11 (6) ◽

pp. 1138-1143

Author(s):

Fang Ma ◽

Jimei Xu ◽

Weiwei Yang ◽

Fuqin Bian

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Type Ii Diabetes ◽

Pulse Wave ◽

Glycated Hemoglobin ◽

Type Ii Diabetes Mellitus ◽

Type Ii ◽

Carotid Imt ◽

Wave Technology ◽

Biochemical Indices

In this study, extreme velocity ultrasonic imaging pulse wave technology was used to detect the main indices of atherosclerosis such as carotid intima-media thickness (IMT) and carotid elasticity, and biochemical indices such as glycated hemoglobin, blood glucose and blood lipids in one hundred twenty 18–60-year-old patients with type II diabetes mellitus (T2DM) and 120 healthy controls. We analyzed the correlations between carotid elasticity, carotid IMT, and a range of biochemical indices. The results indicated that when the carotid IMT in young and middle-aged patients with T2DM was within the normal range (0.56±0.03 mm), the carotid artery elasticity was abnormal [Pulse wave propagation velocity (PWV)-BS = 7.69± 1.26 m/s; PWV-ES = 8.34±1.51 m/s; P < 0.05]. Additionally, PWV-BS was positively correlated with age, course of the disease, glycated hemoglobin (HbA1c), and fasting blood glucose (FBG) (r = 0.297, 0.377, 0.369, 0.382), and PWV-ES was positively correlated with age, course of the disease, HbA1c, and FBG (r = 0.318, 0.386, 0.392, 0.339). This finding provides a basis for extreme velocity ultrasonic imaging pulse wave technology to become a new method for the early screening of atherosclerosis in patients with T2DM; this is important for timely clinical intervention in patients with T2DM.

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Hepatocyte growth factor exerts beneficial effects on mice with type II diabetes‑induced chronic renal failure via the NF‑κB pathway

Molecular Medicine Reports ◽

10.3892/mmr.2018.9297 ◽

2018 ◽

Author(s):

Guiming Cheng ◽

Xun Tang ◽

Jun Zhang

Keyword(s):

Renal Failure ◽

Chronic Renal Failure ◽

Growth Factor ◽

Hepatocyte Growth Factor ◽

Type Ii Diabetes ◽

Type Ii ◽

Beneficial Effects ◽

Hepatocyte Growth

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Hemoglobin associated acetaldehyde correlates with the self-administered alcoholism screening test but not glycated hemoglobin in type II diabetes mellitus

Alcohol ◽

10.1016/0741-8329(91)90774-q ◽

1991 ◽

Vol 8 (3) ◽

pp. 183-185 ◽

Cited By ~ 12

Author(s):

Charles M. Peterson ◽

B. Keyes Scott ◽

Lois Jovanovic-Peterson

Keyword(s):

Diabetes Mellitus ◽

Screening Test ◽

Type Ii Diabetes ◽

Glycated Hemoglobin ◽

Type Ii Diabetes Mellitus ◽

The Self ◽

Type Ii

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Leptin and Its Relation to Obesity and Insulin in the SHR/N-corpulent Rat, A Model of Type II Diabetes Mellitus

International Journal of Experimental Diabetes Research ◽

10.1155/edr.2001.217 ◽

2001 ◽

Vol 2 (3) ◽

pp. 217-223 ◽

Cited By ~ 16

Author(s):

Manuel T. Velasquez ◽

Sam J. Bhathena ◽

Carl T. Hansen

Keyword(s):

Animal Model ◽

Plasma Glucose ◽

Type Ii Diabetes ◽

Plasma Insulin ◽

Entire Group ◽

Type Ii ◽

Fasting Plasma ◽

Obesity And Diabetes ◽

Obese Rats ◽

Plasma Leptin

The spontaneously hypertensive/NIH-corpulent (SHR/N-cp) rat is a genetic animal model that exhibits obesity, metabolic features of hyperinsulinemia, hyperglycemia, and hyperlipidemia, which are characteristic of type II diabetes and mild hypertension. To determine the role of leptin, the protein product of theobgene, in the development of obesity and diabetes in this model, we measured steady-state circulating levels of leptin in obese and lean SHR/N-cp rats and examined the relation between plasma leptin levels and metabolic variables at the stage of established obesity in these animals. Mean fasting plasma leptin concentration was 8-fold higher in obese than in lean rats (p<0.01). This was associated with a 6-fold elevation in plasma insulin in the obese group. Fasting levels of plasma glucose, cholesterol, and triglyceride were all significantly higher in obese rats than in lean controls. Spearman correlation analysis showed a significant positive correlation between plasma leptin concentration and body weight among the animals (r=0.73, p<0.01). Similarly, plasma insulin concentration was significantly correlated with BW in all animals (r=0.54, p<0.05). There was also a significant positive.correlation between plasma leptin and plasma insulin in the entire group (r=0.70, p<0.01). However, this relationship was significant only for lean rats but not for obese rats (r=0.59, p<0.05 for lean rats, and r=0.23, p=NS, for obese rats). Plasma leptin also correlated positively with fasting plasma glucose (r=0.75, p<0.05), total cholesterol (r=0.63, p<0.05), and triglyceride (r=0.67, p <0.05). The marked elevation of plasma leptin in obese SHR/N-cp rats suggests that obesity in this animal model is related to up-regulation of the ob gene. Circulating leptin appears to be one of the best biological markers of obesity and that hyperleptinemia is closely associated with several metabolic risk factors related to insulin resistance in the diabesity syndrome.

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