scholarly journals Glyco-gold nanoparticles: synthesis and applications

2017 ◽  
Vol 13 ◽  
pp. 1008-1021 ◽  
Author(s):  
Federica Compostella ◽  
Olimpia Pitirollo ◽  
Alessandro Silvestri ◽  
Laura Polito

Glyco-gold nanoparticles combine in a single entity the peculiar properties of gold nanoparticles with the biological activity of carbohydrates. The result is an exciting nanosystem, able to mimic the natural multivalent presentation of saccharide moieties and to exploit the peculiar optical properties of the metallic core. In this review, we present recent advances on glyco-gold nanoparticle applications in different biological fields, highlighting the key parameters which inspire the glyco nanoparticle design.

2019 ◽  
Author(s):  
Sara Ghiassian ◽  
Lihai Yu ◽  
Pierangelo Gobbo ◽  
Ali nazemi ◽  
Tommaso Romagnoli ◽  
...  

A bioorthogonal gold nanoparticle template displaying interfacial nitrone functional groups for bioorthogonal interfacial strain-promoted alkyne-nitrone cycloaddition (I-SPANC) reactions has been synthesized. The Nitrone-AuNPs were characterized in detail using <sup>1</sup>H NMR spectroscopy, TEM, TGA, and XPS and a nanoparticle raw formula was calculated. The ability to control the conjugation of molecules of interest at the molecular level onto the Nitrone-AuNPs template allowed us to create a methodology for the synthesis of AuNP-based radiolabeled probes with a high degree of loading using copper free, strained-promoted cycloaddition. To this end, we also describe the synthesis of a new prosthetic group containing a strained-alkyne capable of clicking hot <sup>18</sup>F-label onto complementary azide or nitrone labelled agents.


2019 ◽  
Author(s):  
Sara Ghiassian ◽  
Lihai Yu ◽  
Pierangelo Gobbo ◽  
Ali nazemi ◽  
Tommaso Romagnoli ◽  
...  

A bioorthogonal gold nanoparticle template displaying interfacial nitrone functional groups for bioorthogonal interfacial strain-promoted alkyne-nitrone cycloaddition (I-SPANC) reactions has been synthesized. The Nitrone-AuNPs were characterized in detail using <sup>1</sup>H NMR spectroscopy, TEM, TGA, and XPS and a nanoparticle raw formula was calculated. The ability to control the conjugation of molecules of interest at the molecular level onto the Nitrone-AuNPs template allowed us to create a methodology for the synthesis of AuNP-based radiolabeled probes with a high degree of loading using copper free, strained-promoted cycloaddition. To this end, we also describe the synthesis of a new prosthetic group containing a strained-alkyne capable of clicking hot <sup>18</sup>F-label onto complementary azide or nitrone labelled agents.


Polyhedron ◽  
2017 ◽  
Vol 135 ◽  
pp. 41-48 ◽  
Author(s):  
Elena A. Kuzmina ◽  
Tatiana V. Dubinina ◽  
Anton V. Zasedatelev ◽  
Anton V. Baranikov ◽  
Maria I. Makedonskaya ◽  
...  

2014 ◽  
Vol 50 (35) ◽  
pp. 4635-4638 ◽  
Author(s):  
Revital Kaminker ◽  
Michal Lahav ◽  
Marc Altman ◽  
Guennadi Evmenenko ◽  
Pulak Dutta ◽  
...  

A gold nanoparticle platform enhances the optical properties and order in a metal–organic network (MON).


2018 ◽  
pp. 837-858 ◽  
Author(s):  
Irshad Ahmad Wani

Gold nanoparticles are the subject of intense studies due to the exceptional photo-optical properties combined with the biocompatibility and has proved to be a powerful tool in various nanomedicinal applications. This book chapter discusses the recent advances and current challenges facing the biomedical applications of gold nanoparticles of various sizes and shapes. This chapter summarizes the applications of gold nanoparticles in biomedical area including diagnostic imaging, biosensing, drug delivery, and photothermal and photodynamic strategies etc. The key advantages of the gold nanoparticles including their ease of synthesis and functionalization together with biodistribution and toxicity has also been discussed.


2018 ◽  
Vol 9 (1) ◽  
pp. 134-140 ◽  
Author(s):  
V. A. Ogarev ◽  
V. M. Rudoi ◽  
O. V. Dement’eva

Nanomaterials ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 939 ◽  
Author(s):  
Lucas Freitas de Freitas ◽  
Gustavo Varca ◽  
Jorge dos Santos Batista ◽  
Ademar Benévolo Lugão

At a nano-level, optical properties of gold are unique and gave birth to an emerging platform of nanogold-based systems for diverse applications, because gold nanoparticle properties are tunable as a function of size and shape. Within the available techniques for the synthesis of gold nanoparticles, the radiolytic synthesis allows proper control of the nucleation process without the need for reducing agents, in a single step, combined or not with simultaneous sterilization. This review details and summarizes the use of radiation technologies for the synthesis and preparation of gold nanoparticles concerning fundamental aspects, mechanism, current pathways for synthesis and radiation sources, as well as briefly outlines final applications and some toxicity aspects related to nanogold-based systems.


2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Aiwu Wang ◽  
Hoi Pong Ng ◽  
Yi Xu ◽  
Yuyu Li ◽  
Yuhong Zheng ◽  
...  

In today’s science, with the use of nanotechnology, nanomaterials, which behave very differently from the bulk solid, can be made. One of the capable uses of nanomaterials is bioapplications which make good use of the specific properties of nanoparticles. However, since the nanoparticles will be used bothin-vivoandin-vitro, their stability is an important issue to the scientists, concern. In this dissertation, we are going to test the stability of gold nanoparticles in a number of media including the biocompatible medium and their behaviors will be illustrated in terms of optical properties change and aggregation degree. Herein, we report the synthesis of gold nanoparticles of different shapes and applications for the rice growth with significant difference. The gold nanoparticles can inhibit the elongation of rice root without inhibiting the germination of rice seeds.


2018 ◽  
Vol 6 (21) ◽  
pp. 5624-5629 ◽  
Author(s):  
Dajiang Yu ◽  
Xingming Sun ◽  
Xin Chen ◽  
Wencan Ma ◽  
Jibin Sun ◽  
...  

Gold nanoparticles were reduced in situ by a new hydrosilane reductant in organosilicon oligomer to fabricate nonlinear optical limiting materials.


2016 ◽  
Vol 2016 ◽  
pp. 1-29 ◽  
Author(s):  
Cuiping Yao ◽  
Luwei Zhang ◽  
Jing Wang ◽  
Yulu He ◽  
Jing Xin ◽  
...  

Gold nanoparticles exhibit very unique physiochemical and optical properties, which now are extensively studied in range of medical diagnostic and therapeutic applications. In particular, gold nanoparticles show promise in the advancement of cancer treatments. This review will provide insights into the four different cancer treatments such as photothermal therapy, gold nanoparticle-aided photodynamic therapy, gold nanoparticle-aided radiation therapy, and their use as drug carrier. We also discuss the mechanism of every method and the adverse effects and its limitations.


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