scholarly journals OUR EXPERIENCE OF USING AUTOLOGICAL BLOOD SERUM IN COMPLEX TREATMENT OF BACTERIAL CORNEAL ULCERS IN PATIENTS WITH DIABETES MELLITUS DEPENDING ON THESEVERETY OF DIABETIC POLYNEUROPATHY

2020 ◽  
pp. 92-98
Author(s):  
O. V. Zavoloka ◽  
P. A. Bezditko ◽  
M. A. Karliychuk ◽  
N. M. Bezega
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Corneal Ulcer ◽  
Diabetic Polyneuropathy ◽  
Autologous Serum ◽  
Eye Drops ◽  
Corneal Sensitivity ◽  
Corneal Ulcers ◽  
Patients With Diabetes

Summary. Diabetic keratopathy, which develops against the background of diabetic corneal neuropathyshould be taken into account when choosing tactics for the treatment of bacterial corneal ulcers in patients with diabetes mellitus. The aim of the study was to determine the effectiveness of treatment of bacterial corneal ulcers with the help of additional local use of autological serum eye drops in patients with type 1 diabetes depending on the severity of diabetic polyneuropathy (DPN). Materials and methods. The results of observation of 10 patients (10 eyes) with bacterial corneal ulcer and type 1 diabetes mellitus, in which delayed healing of corneal ulcer defect were noted and the absence of microorganisms ware confirmed by repeated bacteriological examinations of corneal smears and scrapings,were analyzed. In addition to standard therapy, all patients 2 weeks after the start of treatment were additionally prescribed eye drops with autologous serum. Patients were divided into 2 groups according to the stage of severity of DPN: the first group consisted of 5 patients with symptomatic stage, the second - 5 patients with a stage of severe complications. In addition to standard, ophthalmic examination methods included bacteriological examination, fluorescein test, OCT of the anterior segment of the eye on the device TOPCON 3D OCT-2000, non-contact examination of corneal sensitivity. Results and discussion. It was found that the threshold of corneal sensitivity in patients with bacterial corneal ulcer at the stage of severe complications of DPN was higher than that in symptomatic DPN by an average of 16.6 % during the observation. The degree of pericorneal injection and infiltration of the cornea, as well as the size and depth of the ulcerative defect of the cornea at the stage of severe complications exceeded the corresponding indicators of patients with symptomatic DPN during the observation. Normalization of conjunctival color and reepithelialization of the cornea in all patients with severe complications occurred 3 days later than in patients with symptomatic DPN. Conclusions. The course of bacterial keratitis in patients with diabetes mellitus depends on the severity of DPN: a pronounced violation of corneal innervation at the stage of severe complications of DPN, manifested by a decrease in its sensitivity, leads to prolongation of treatment, even with additional use of eye drops with autologous serum.

scholarly journals PECULIARITIES OF BACTERIAL KERATITIS IN PATIENTS WITH DIABETES MELLITUS DEPENDING ON THE SEVERETY OF DIABETIC POLINEUROPATHY

2019 ◽  
pp. 46-50
Author(s):  
O.V. Zavoloka
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Bacterial Keratitis ◽  
Corneal Sensitivity ◽  
Conjunctival Hyperemia ◽  
Corneal Opacification ◽  
Corneal Innervation ◽  
Patients With Diabetes

Summery. The dependence of the peculiarities of bacterial keratitis on the severity of DPN was proven with the help of 15 patients with type 1 diabetes mellitus. During all periods of observation, the severity of conjunctival hyperemia, the size of erosion and the threshold of corneal sensitivity at the stage of severe complications exceeded the corresponding indicators of patients with asymptomatic DPN. Normalization of conjunctival color in all patients with severe complications occurred at 8 days, and reepithelialization of the cornea 4 days later than in asymptomatic DPN. On the last 22nd day of observation, the corneal opacification of the peripheral localization remained in 33.3% of patients (2 patients) with the stage of severe complications, whereas in all patients with asymptomatic DPN the cornea was already transparent on the 14th day of observation. The threshold of corneal sensitivity at 22nd day in patients with severe complications was 35.3% higher than with asymptomatic DPN (p <0.05). So, patients with severe complications DPN with bacterial keratitis show a more pronounced violation of corneal innervation, which manifests by decrease of its sensitivity, and leads to prolongation of the duration of the disease.

Model estimates of the results of diabetes patients using modern glucometers with tri-color technology for displaying test results

2019 ◽  
pp. 81-89
Author(s):  
Larisa Dmitrievna Popovich ◽  
Svetlana Valentinovna Svetlichnaya ◽  
Aleksandr Alekseevich Moiseev
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Economic Benefits ◽  
Test Results ◽  
Self Monitoring ◽  
Patients With Diabetes ◽  
The Impact

Diabetes – a disease in which the effect of the treatment substantially depends on the patient. Known a study showed that the use of glucometers with the technology of three-color display of test results facilitates self-monitoring of blood sugar and leads to a decrease in glycated hemoglobin (HbAlc). Purpose of the study: to modeling the impact of using of a glucometer with a color-coded display on the clinical outcomes of diabetes mellitus and calculating, the potential economic benefits of reducing the hospitalization rate of patients with diabetes. Material and methods. Based on data from two studies (O. Schnell et al. and M. Baxter et al.) simulation of the reduction in the number of complications with the use of a glucometer with a color indication. In a study by O. Schnell et al. a decrease of HbA1c by 0.69 percent is shown when using the considered type of glucometers, which was the basis of the model. Results. In the model, the use of a glucometer with a color-coded display for type 1 diabetes led to a decrease in the total number of complications by 9.2 thousand over 5 years per a cohort of 40 thousand patients with different initial levels of HbA1c. In a cohort of 40 thousand patients with type 2 diabetes, the simulated number of prevented complications was 1.7 thousand over 5 years. When extrapolating these data to all patients with diabetes included in the federal register of diabetes mellitus (FRD), the number of prevented complications was 55.4 thousand cases for type 1 diabetes and 67.1 thousand cases for type 2 diabetes. The possible economic effect from the use of the device by all patients with a diagnosis of diabetes, which are included in the FRD, estimated at 1.5 billion rubles for a cohort of patients with type 1 diabetes and 5.3 billion rubles for patients with type 2 diabetes. Conclusion. Improving the effectiveness of self-monitoring, which is the result of the use of glucometers with color indicators, can potentially significantly reduce the incidence of complications in diabetes and thereby provide significant economic benefits to society.

Association of Polymorphic Markers of the Antioxidant Enzyme Genes with Diabetic Polyneuropathy in Type 1 Diabetes Mellitus

2004 ◽  
Vol 38 (2) ◽  
pp. 200-204 ◽  
Author(s):  
E. V. Zotova ◽  
K. V. Savost'yanov ◽  
D. A. Chistyakov ◽  
T. R. Bursa ◽  
I. V. Galeev ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Antioxidant Enzyme ◽  
Diabetic Polyneuropathy ◽  
Polymorphic Markers

The state of the vegetative nervous system, characteristics of muscular electrogenesis, peripheral hemodynamics, and their changes under the influence of the procedure of hydrodynamic tablet therapy (HDTT) in the children presenting with type 1 diabetes mellitus

2016 ◽  
Vol 15 (3) ◽  
pp. 120-124
Author(s):  
N. V Lagunova ◽  
T. F Golubova ◽  
Irina Anatol’evna Polenok ◽  
A. V Kurganova
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Diabetic Polyneuropathy ◽  
The State ◽  
Bioelectrical Activity ◽  
Health Resort ◽  
Vegetative Nervous System ◽  
Functional Studies

The clinical, neurological, and functional studies in the children suffering from type 1 diabetes mellitus have demonstrated that practically every fourth patient presented with the complaints and symptoms of this pathology associated with the development of diabetic polyneuropathy, the reduced bioelectrical activity, and the changes of peripheral blood circulation strongly depending on the duration and the quality of compensation of the disease. Under the influence of the treatment under the conditions of a spa and health resort facility with the inclusion of hydrodynamic tablet therapy, the positive dynamics of the parameters of interest was documented in the form of the improvement of the state of carbohydrate metabolism, clinical and neurological characteristics, and the effectiveness of the functional methods for the examination of the children presenting with type 1 diabetes.

Chronic gastroduodenal ulcers in patients with diabetes mellitus

2003 ◽  
Vol 49 (1) ◽  
pp. 5-10
Author(s):  
Yu. L. Fedorchenko
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Clinical Course ◽  
Gastrin Level ◽  
Gastric Ulcers ◽  
Peptic Ulcers ◽  
Duodenal Ulcers ◽  
Patients With Diabetes ◽  
H Pylori

The clinical picture, course, and treatment of gastroduodenal ul­cers (GDU) in diabetics were studied. A total of 395 diabetics were examined; GDU were detected in 36. The incidence of gas­tric and duodenal ulcers was similar in patients with insulin-de­pendent diabetes mellitus, while in patients with non-insulin-de- pendent diabetes gastric ulcers predominated. The clinical pic­ture of the disease, gastric acid production, Helicobacter pylori infection, and blood gastrin levels were studied in all patients with ulcers. The efficiency of GDU treatment with quamatel, raniti­dine, and antacids was evaluated. The clinical course of GDU in diabetics was asymptomatic. The highest incidence of H. pylori, infection was observed in patients with type 1 diabetes with con­comitant peptic ulcers. Serum gastrin levels were more frequently increased in patients with type 1 diabetes and duodenal ulcers and normal in patients with type 2 diabetes. Quamatel therapy was highly effective in diabetics with GDU. Ulcers healed in 85% patients and blood gastrin level significantly decreased after 3- week therapy. GDU in diabetics are characterized by specific lo­cation, clinical course, laboratory and instrumental features, which allows a differentiated approach to therapy of these pa­tients.

Polymorphic markers of the NO synthase genes and genetic predisposition to diabetic polyneuropathy in type 1 diabetes mellitus

2005 ◽  
Vol 39 (2) ◽  
pp. 200-205
Author(s):  
E. V. Zotova ◽  
O. E. Voron’ko ◽  
T. R. Bursa ◽  
I. V. Galeev ◽  
I. A. Strokov ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Genetic Predisposition ◽  
Diabetic Polyneuropathy ◽  
No Synthase ◽  
Polymorphic Markers

scholarly journals The Association between Depression and Type 1 Diabetes Mellitus: Inflammatory Cytokines as Ferrymen in between?

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Kexin Wang ◽  
Fangna Li ◽  
Yixin Cui ◽  
Chunhui Cui ◽  
Zhenzhen Cao ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Inflammatory Cytokines ◽  
Age Of Onset ◽  
Autoimmune Response ◽  
Immunological Mechanism ◽  
Patients With Diabetes ◽  
Organ Specific

The depression incidence is much higher in patients with diabetes mellitus (DM), and the majority of these cases remain under-diagnosed. Type 1 diabetes mellitus (T1D) is now widely thought to be an organ-specific autoimmune disease. As a chronic autoimmune condition, T1D is characterized by T cell-mediated selective loss of insulin-producing β-cells. The age of onset of T1D is earlier than T2D, and T1D patients have an increased vulnerability to depression due to its diagnosis and treatment burden occurring in a period when the individuals are young. The literature has suggested that inflammatory cytokines play a wide role in both diseases. In this review, the mechanisms behind the initiation and propagation of the autoimmune response in T1D and depression are analyzed, and the contribution of cytokines to both conditions is discussed. This review outlines the immunological mechanism of T1D and depression, with a particular emphasis on the role of tumor necrosis factor-α (TNF-α), IL-1β, and interferon-γ (IFN-γ) cytokines and their signaling pathways. The purpose of this review is to highlight the possible pathways of the cytokines shared by these two diseases via deciphering their cytokine cascades. They may provide a basic groundwork for future study of the possible mechanism that links these two diseases and to develop new compounds that target the same pathway but can conquer two diseases.

Hyperglycaemic crises in adult patients with diabetes mellitus

2011 ◽  
pp. 1874-1888 ◽  
Author(s):  
Abbas E. Kitabchi ◽  
Ebenezer Nyenwe
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Mortality Rate ◽  
Incidence Rate ◽  
Hospital Admissions ◽  
Population Based ◽  
Patients With Diabetes ◽  
The Usa ◽  
The Uk

Diabetic ketoacidosis (DKA) and hyperosmolar nonketotic state (HONK; also referred to, in the USA, as hyperglycaemic hyperosmolar state) are the two most serious, potentially fatal acute metabolic complications of diabetes mellitus. In the USA, the annual incidence rate for DKA ranges from 4.6 to 8 episodes per 1000 patients with diabetes of all ages, and 13.4 per 1000 patients in subjects younger than 30 years old (1). The incidence rate in the USA is comparable to the rates in Europe, with estimates of 13.6 per 1000 patients with type 1 diabetes in the UK (2), and 14.9 per 1000 patients with type 1 diabetes in Sweden (3). In the USA, hospitalization for DKA has risen by more than 30% in the last decade, with DKA accounting for approximately 1 35 000 hospital admissions in 2006 (4). The incidence of HONK is difficult to determine because of the lack of population–based studies and the multiple combined illnesses often found in these patients. In general, it is estimated that the rate of hospital admissions due to HONK is lower than it is for DKA and HONK accounts for less than 1% of all primary diabetic admissions (5). The mortality rate in patients with DKA has significantly decreased in experienced centres since the advent of low-dose insulin and appropriate fluid-/electrolyte-replacement protocols. Among adults with DKA in the USA, the overall mortality rate is less than 1% (4). A trend toward remarkable reduction in mortality from DKA has been reported in Europe as well, with one UK university recording no deaths among 46 patients who were admitted for DKA between 1997 and 1999 (2). The incidence and mortality of DKA remains high in developing countries, owing to socioeconomic factors. For instance, in Nairobi, Kenya, the incidence of DKA was about 80 per 1000 hospitalized diabetic patients in a study reported in 2005, and mortality rate was as high as 30% (6). The mortality rate of patients with HONK remains high even in the developed world, at approximately 11%. The prognosis of both conditions is substantially worsened with increased age, presence of coma, and hypotension (7). Despite threat to life, DKA is also expensive, with estimated annual direct and indirect cost of 2 billion US dollars (8).

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