scholarly journals Survival Analysis of Time to Retest for HIV Among Men Who Have Sex with Men from Metro Manila, Philippines: A Single-Center Prospective Study

2020 ◽  
Vol 2 (2) ◽  
pp. 98-111
Author(s):  
Samuel Brando Piamonte ◽  
Jhoanne Ynion
Keyword(s):  
Prospective Study ◽  
Hiv Testing ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Access To Treatment ◽  
Metro Manila ◽  
Sex With Men ◽  
Repeat Hiv Testing ◽  
Test Result ◽  
Hiv Aids

Background: Regular HIV testing means early detection of the virus and prompt access to treatment. However, factors affecting retesting following receipt of a non-reactive test result are not yet well understood. This study aims to determine the predictors of time to repeat HIV testing among men who have sex with men (MSM) from Metro Manila, Philippines within six months following receipt of a non-reactive test result. Methods: A prospective study was implemented at a community-based HIV testing and counseling center. A total of 250 non-reactive MSM from Metro Manila and with a recent risk of acquiring HIV were the respondents. At baseline, data on socio-demographic factors were gathered; while at follow-up, repeat test status of each participant within six months after baseline was collected. Results: Two retests per 1,000 person-weeks were recorded. Mean survival time was 23.93 weeks, 95% CI: [23.18 - 24.68]. Cox proportional hazards regression demonstrated that statistically significant factors of time to retest were age (HR = 0.90, 95% CI [0.85, 0.96]) and number of tests in lifetime (HR = 1.12, 95%CI [1.06, 1.18]). Conclusion: Although the average time to return is within the recommended period of three to six months, the low return rate suggests the call for encouraging repeat HIV testing among MSM with non-reactive results and recent risk of acquiring HIV. Repeat testing has been shown to be facilitated by age and previous testing history. HIV/AIDS counselors and program administrators can aim for MSM who are older and with relatively low testing history to help meet the global target of ending the HIV/AIDS global epidemic.

scholarly journals Sociodemographic, lifestyle and therapeutic predictors of 2-year survival in HIV-infected persons receiving antiretroviral therapy in Benin

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Charles Sossa Jerome ◽  
Maurice Agonnoudé ◽  
Ghislain Emmanuel Sopoh ◽  
Ali Imorou Bah-Chabi ◽  
Amédée De Souza ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Proportional Hazards Regression ◽  
Persons Living With Hiv ◽  
Immunodeficiency Virus ◽  
Living With Hiv ◽  
Transversal Study ◽  
Death Data ◽  
Hiv Aids

The benefits of antiretroviral therapy (ART) for treating human immunodeficiency virus (HIV) infection have been well described. The objective of this study was to identify the predictors of two-year survival in persons living with HIV/AIDS (PLWHA) in Benin. This retrospective transversal study included all patients from 46 HIV/AIDS therapy sites across Benin who started ART between July 1st, 2011 and June 30th, 2012. The independent variables were patients’ sociodemographic, clinical, biological and therapeutic characteristics and their ART regimen. The main dependent variable was the time of death. Data were collected from medical records, using documentary review. Cox proportional hazards regression models were used to investigate factors associated with survival. Among the 771 PLWHA participants of the study, 18 (2.3%) died within the two-year period. The estimated mortality of the 771 PLWHA was 3% at 24 months. Among the sociodemographic, lifestyle and therapeutic characteristics studied, the main predictor of two-year mortality was poor adherence [odds ratio = 4.15, 95% confidence interval (1.55- 11.28)]. This study confirms that improving the survival of PLWHA receiving ART requires enhanced adherence.

scholarly journals Characteristics and consequences of medical care interruptions in HIV-infected patients in France

2016 ◽  
Vol 144 (11) ◽  
pp. 2363-2370 ◽  
Author(s):  
L. CUZIN ◽  
P. DELLAMONICA ◽  
Y. YAZDANPANAH ◽  
S. BOUCHEZ ◽  
D. REY ◽  
...  
Keyword(s):  
Medical Care ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Time Interval ◽  
Hiv Diagnosis ◽  
Viral Loads ◽  
Treatment Benefits ◽  
Cox Proportional Hazards Models ◽  
Sex With Men

SUMMARYTo describe the consequences of medical care interruptions (MCIs) we selected patients with at least two medical encounters between January 2006 and June 2013 in the Dat'AIDS cohort. Patients with any time interval >15 months between two visits were defined as having a MCI, as opposed to uninterrupted follow-up (UFU). Patients’ characteristics at the time of HIV diagnosis and at the censoring date were compared between groups. Cox proportional hazards models were built to assess the role of interruptions on survival (total and AIDS-free). Of 11 116 patients, 824 had at least one MCI. These patients were younger at the time of HIV diagnosis (30vs. 33 years,P< 0·0001). MCI was less frequent in men having sex with menvs.heterosexual patients [odds ratio (OR) 0·81, 95% confidence interval (CI) 0·69–0·96)], and a centre effect was described. MCI was independently associated with AIDS (OR 2·54, 95% CI 2·10–3·09) and death (OR 2·65, 95% CI 1·94–3·61). At the censoring date, 52·2% of patients with at least one MCI had viral load below detectionvs.85·3% of the UFU group (P< 0·0001). In conclusion, MCIs were associated with patients’ survival and with the proportion of viral loads below detection in our cohort, compromising individual and collective treatment benefits.

scholarly journals Factors related to HIV testing frequency in MSM based on the 2011–2018 survey in Tianjin, China: a hint for risk reduction strategy

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhongquan Liu ◽  
Yang Chen ◽  
Tingting Yao ◽  
Tiantian Zhang ◽  
Desheng Song ◽  
...  
Keyword(s):  
Hiv Testing ◽  
Cost Effective ◽  
Snowball Sampling ◽  
Logistic Analysis ◽  
Testing Frequency ◽  
Ordinal Logistic Regression Analysis ◽  
Young Msm ◽  
Sex With Men ◽  
Low Educated ◽  
Hiv Aids

Abstracts Background In recent years, HIV testing has become one of the effective strategies to reduce the risk of the infection. Frequent quarterly HIV testing can be cost effective. Therefore, an in-depth study of factors related to the testing behavior of men who have sex with men (MSM) were analyzed to optimize intervention strategies. Methods From March 2011 to October 2018, the project was implemented in a Tianjin (China) bathhouse, and 5165 MSM were surveyed using snowball sampling. Factors related to HIV testing behavior were analyzed by ordinal logistic regression analysis after grouping according to testing frequency, and comprehensive analysis was performed. Results The multivariate logistic analysis showed that 6 variables including young MSM (OR = 0.67, 95% CI: 0.49–0.92, p = 0.01), low-educated MSM (OR = 0.60, 95% CI: 0.48–0.77, p < 0.0001), low HIV/AIDS knowledge (95% CI: 0.57–0.83, p < 0.0001), marital status (OR = 1.30, 95% CI: 1.07–1.57, p = 0.007), acceptance of condom promotion and distribution (OR = 14.52, 95% CI: 12.04–17.51, p < 0.0001), and frequency of condom use (p < 0.05) could link to HIV testing behaviors. Conclusions In order to achieve the 95–95-95 goal, target publicity, HIV/AIDS education and promotion of HIV self-testing kits should be carried out to encourage frequent HIV testing among MSM who are young (especially students), married to women, poorly educated and who are reluctant to always use condoms.

scholarly journals “I am not promiscuous enough!”: Exploring the low uptake of HIV testing by gay men and other men who have sex with men in Metro Manila, Philippines

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0200256 ◽  
Author(s):  
Jan W. de Lind van Wijngaarden ◽  
Andrew D. Ching ◽  
Edmund Settle ◽  
Frits van Griensven ◽  
Rolando C. Cruz ◽  
...  
Keyword(s):  
Hiv Testing ◽  
Gay Men ◽  
Metro Manila ◽  
Sex With Men

scholarly journals Barriers to Acceptance of Provider-Initiated Testing and Counseling among Men Who Have Sex with Men in Shenyang, China: A Cross-Sectional Study

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Qinghai Hu ◽  
Junjie Xu ◽  
Zhenxing Chu ◽  
Jing Zhang ◽  
Ke Yun ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Hiv Testing ◽  
Cross Sectional Study ◽  
Multivariate Logistic Regression Model ◽  
People Living With Hiv ◽  
Cross Sectional ◽  
Aids Knowledge ◽  
Sex With Men ◽  
Testing And Counseling ◽  
Hiv Aids

A high prevalence of HIV infection is present among men who have sex with men (MSM) in China, but many people living with HIV or AIDS (PLWHs) are unaware of their HIV infection status. Provider-initiated HIV testing and counseling (PITC) is a streamlined model that can significantly enhance HIV detection and detect infections earlier. However, PITC has not yet been widely applied, and no studies have been conducted on MSM’s attitudes towards PITC in China. In this study, a total of 438 MSM were recruited in Shenyang city. A multivariate logistic regression model showed that certain conditions made MSM more accepting of PITC: those who had attended VCT (voluntary counseling and testing) more than three times (odds ratio [OR]: 2.95, 95% CI: 1.36–6.37), those who considered PITC beneficial for family and friends (OR: 1.91, 95% CI: 1.25–2.92), those who obtained HIV/AIDS knowledge from brochures (OR: 2.52, 95% CI: 1.64–3.87), those who obtained HIV/AIDS knowledge from the Internet (OR: 1.66, 95% CI: 1.07–2.58), and those who were highly aware of their own risk of being infected with HIV (OR: 2.84, 95% CI: 1.37–5.91). To improve acceptance of PITC among MSM in China, stronger efforts are needed to lower the psychosocial barriers to receiving PITC, to promote HIV/AIDS awareness, and to encourage the extension of HIV testing.

scholarly journals HIV/AIDS-Related Stigmatizing and Discriminatory Attitudes and Recent HIV Testing Among Men Who Have Sex With Men in Beijing

2012 ◽  
Vol 16 (3) ◽  
pp. 499-507 ◽  
Author(s):  
Xuefeng Li ◽  
Hongyan Lu ◽  
Xiaoyan Ma ◽  
Yanming Sun ◽  
Xiong He ◽  
...  
Keyword(s):  
Hiv Testing ◽  
Sex With Men ◽  
Hiv Aids

scholarly journals Construction and validation of a prognostic nomogram for predicting the survival of HIV/AIDS adults who received antiretroviral therapy: a cohort between 2003 and 2019 in Nanjing

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Fangfang Jiang ◽  
Yuanyuan Xu ◽  
Li Liu ◽  
Kai Wang ◽  
Lu Wang ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Calibration Curve ◽  
Proportional Hazards ◽  
Area Under The Curve ◽  
Cox Proportional Hazards ◽  
People Living With Hiv ◽  
Health Administration ◽  
Training Set ◽  
Cd4 Cell Count ◽  
Hiv Aids

Abstract Background Great achievements have been achieved by free antiretroviral therapy (ART). A rapid and accurate prediction of survival in people living with HIV/AIDS (PLHIV) is needed for effective management. We aimed to establish an effective prognostic model to forecast the survival of PLHIV after ART. Methods The participants were enrolled from a follow-up cohort over 2003-2019 in Nanjing AIDS Prevention and Control Information System. A nested case-control study was employed with HIV-related death, and a propensity-score matching (PSM) approach was applied in a ratio of 1:4 to allocate the patients. Univariable and multivariable Cox proportional hazards analyses were performed based on the training set to determine the risk factors. The discrimination was qualified using the area under the curve (AUC) and concordance index (C-Index). The nomogram was calibrated using the calibration curve. The clinical benefit of prognostic nomogram was assessed by decision curve analysis (DCA). Results Predictive factors including CD4 cell count (CD4), body mass index (BMI) and hemoglobin (HB) were determined and incorporated into the nomogram. In the training set, AUC and C-index (95% CI) were 0.831 and 0.798 (0.758, 0.839), respectively. The validation set revealed a good discrimination with an AUC of 0.802 and a C-index (95% CI) of 0.786 (0.681, 0.892). The calibration curve also exhibited a high consistency in the predictive power (especially in the first 3 years after ART initiation) of the nomogram. Moreover, DCA demonstrated that the nomogram was clinically beneficial. Conclusion The nomogram is effective and accurate in forecasting the survival of PLHIV, and beneficial for medical workers in health administration.

Repeat HIV Testing Among Hispanic Men Who Have Sex With Men—A Sign Of Risk, Prevention, or Reassurance?

2003 ◽  
Vol 15 (1_supplement) ◽  
pp. 105-116 ◽  
Author(s):  
M. Isabel Fernández ◽  
Tatiana Perrino ◽  
G. Stephen Bowen ◽  
Scott Royal ◽  
Leah Varga
Keyword(s):  
Hiv Testing ◽  
Risk Prevention ◽  
Hispanic Men ◽  
Sex With Men ◽  
Repeat Hiv Testing

Is a delay in ALK inhibitor initiation associated with poorer survival? A retrospective analysis based on real-world data.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e18240-e18240
Author(s):  
Daniel Sheinson ◽  
William Bruce Wong ◽  
Ning Wu ◽  
Aaron Scott Mansfield
Keyword(s):  
Median Time ◽  
Proportional Hazards ◽  
Fold Increase ◽  
Cox Proportional Hazards ◽  
Real World Data ◽  
Alk Inhibitor ◽  
Immortal Time Bias ◽  
Early Cohort ◽  
The Impact ◽  
Test Result

e18240 Background: The time between a patient’s positive biomarker test result and initiation of targeted therapy may vary due to a number of factors, including the use of chemotherapy prior to or after the biomarker test result. The objective of this study was two-fold: first, to investigate the impact of delayed ALK inhibitor (ALKi) therapy on overall survival (OS) and second, to examine the association between the use of chemotherapy prior to or after biomarker testing and OS. Methods: The Flatiron Health EHR-derived database was used to identify patients with ALK-positive (ALK+) advanced NSCLC diagnosed between 1/1/2011 - 9/30/2018. The median time from ALK+ test result to ALKi start was used to separate patients into early versus delayed treatment cohorts. To account for potential immortal time bias, times from ALK+ test result to ALKi start from the delayed cohort were sampled with replacement and used to create modified index dates among the early cohort. Cox proportional hazards models adjusting for baseline characteristics (i.e. ECOG) were used to assess the association between delayed ALKi start and OS and the use of chemotherapy with OS. Results: 422 patients with ALK+ aNSCLC were included in this analysis with a median time from test result to ALKi start of 3 weeks. 88 patients (20.9%) received chemotherapy prior to starting their ALKi. Delayed ALKi use was associated with a 2.3 fold increase in risk of mortality (HR [95% CI]: 2.30 [1.28, 4.15], p < 0.01). There was no difference in survival observed between those who had received chemotherapy prior to initiating their ALKi and those who did not receive chemotherapy (HR [95% CI]: 0.99 [0.62, 1.58]). Among those who initiated chemotherapy prior to their ALK+ test result, the continued use of chemotherapy prior to initiating an ALKi did not result in differences in OS compared to those who switched to an ALKi without continuing chemotherapy (HR [95% CI]: 1.03 [0.44, 2.41]). Conclusions: Delayed initiation of ALKi may result in poor outcomes in patients with ALK+ NSCLC. Receipt of chemotherapy prior to ALKi or the duration of chemotherapy did not impact survival. Future strategies to improve the time to therapy initiation may be useful in improving patient outcomes.

Repeat HIV Testing, Risk Behaviors, and HIV Seroconversion Among Young Men Who Have Sex With Men

2002 ◽  
Vol 29 (1) ◽  
pp. 76-85
Author(s):  
Duncan A. MacKellar ◽  
Linda A. Valleroy ◽  
Gina M. Secura ◽  
Brad N. Bartholow ◽  
William McFarland ◽  
...  
Keyword(s):  
Hiv Testing ◽  
Risk Behaviors ◽  
Young Men ◽  
Hiv Seroconversion ◽  
Sex With Men ◽  
Repeat Hiv Testing
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