scholarly journals Bacterial Profile and Antimicrobial Susceptibility Pattern of Aerobic Vaginal Pathogens in Gynae Patients Visiting to Khyber Teaching Hospital Peshawar

2021 ◽  
Vol 8 (4) ◽  
pp. 48-54
Author(s):  
Muhammad Asghar ◽  
Naheed . ◽  
Aakash Ahmad Khattak ◽  
Sadiq Azam ◽  
Noor Rehman ◽  
...  

OBJECTIVES:   The aim of this study was to determine the prevalent aerobic vaginal bacteria and their antibiogram to commonly prescribed antibiotics for the treatment of aerobic vaginitis (AV).  METHODOLOGY:  A total of 200 high vaginal swabs (HVS) samples were collected from different AV suspected patients visiting Khyber Teaching Hospital (KTH) and processed for identification of bacterial isolates followed by antibiotic susceptibility patterns as per CLSI protocols.  RESULTS:  Out of 200 clinical samples, 70 (35%) HVS isolates yielded bacterial growth. Of the isolates, E.coli was the common pathogen 36 (51.4%) followed by S.aureus 20 (28.5%), Enterobacter spp 08 (11.4%), Pseudomonas spp 04 (5.7%) and Citrobacter spp 02 (2.8%). The highest prevalence was observed in the age group of 21-35 years (31.4%) followed by age groups 16-20 years (25.7%) and 26-30 years. S.aureus isolates (n=20) were resistant to ciprofloxacin (90%), cephradine (70%), erythromycin (70%), gentamicin (50%) and cefotaxime (40%) while 1 (5%) of each isolate was resistant to methicillin and vancomycin. Majority of the gram-negative isolates (n=50) were resistant to cotrimoxazole, cephalosporins, quinolones, aminoglycosides and susceptible to carbapenems, tigecycline, sulbactam and tazobactam.  CONCLUSION:  Aerobic vaginitis should be treated very selectively in order not to kill the beneficial bacteria. Before treating AV, the causative agents should be accurately identified and tested for drug susceptibility patterns and empirical antibiotic therapy should be avoided.

1981 ◽  
Vol 44 (2) ◽  
pp. 124-127 ◽  
Author(s):  
L. RESTAINO ◽  
W. M. HILL

Antibiotic susceptibility patterns for Yersinia enterocolitica strains involving 10 different serotypes were analyzed and compared. All Y. enterocolitica were susceptible to colistin, gentamicin, kanamycin, neomycin and doxycycline, whereas all isolates displayed resistance to penicillin G, methicillin (derivative of penicillin), novobiocin, and clindamycin. The antibiograms for the Y. enterocolitica isolates were in some instances related to the somatic serotypes, especially serotype 0:8 for which the antimicrobial susceptibility pattern displayed the greatest disparity. By eliminating the antibiograms for the four serotype 0:8 strains, antimicrobial susceptibility patterns for atypical and typical strains were similar.


2020 ◽  
Author(s):  
Christina Okello ◽  
Loice Achieng ◽  
Christina Mwachari ◽  
Davies Otieno ◽  
Frederick Otieno ◽  
...  

Abstract Staphylococcus aureus is a leading cause of hospital and community acquired infections globally. Surveillance of prevalence and antibiotic susceptibility patterns is important to ensure appropriate antibiotic prescription. The aim of this study was to determine the prevalence and susceptibility patterns of Staphylococcus aureus isolated from clinical specimens in a tertiary referral and training hospital.A retrospective study was conducted at the Mater Misericordiae Hospital, Nairobi.It involved analyzing records of specimens analyzed between January 2014 and December 2018. Strains phenotypically resistant to <3 non β-lactam antimicrobial categories were defined as non-multidrug-resistant MRSA (nmMRSA) and strains that were resistant to ≥3 non-β-lactam antimicrobial groups were defined as multidrug-resistant MRSA (mMRSA). A specimen was categorized as Penicillin susceptible (PSSA) if susceptible to Penicillin and Oxacillin, MSSA if resistant to Penicillin and susceptible to Oxacillin, and MRSA if resistant to Oxacillin and Penicillin.ResultsPSSA accounted for 60.85%, (401/659)of S.aureus cultured.The prevalence of MSSA was 38.54%(254/659).MRSA was the least prevalent.(0.61%,4/659).No multi-drug Methicillin resistant S. aureus were isolated in the five-year period.PSSA accounted for 60.85%(401/659)of all S.aureus isolates.100% of MRSA isolated was sensitive to Vancomycin, Linezolid, Tigecycline, Tetracycline and Rifampicin. MRSA was resistant to Clindamycin and Erythromycin.Conclusion;The prevalence of MRSA was low compared to previous studies.All strains isolated were non-multidrug resistant.There was no resistance to Vancomycin detected.Penicillins are still a viable option in the treatment of majority of S.aureus infections in our setting.


2020 ◽  
Author(s):  
Christina Okello ◽  
Loice Achieng ◽  
Enoch Omonge ◽  
Frederick Otieno ◽  
Davies Otieno ◽  
...  

Abstract Staphylococcus aureus (S. aureus) is a leading cause of hospital and community acquired infections globally. Methicillin-resistant Staphylococcus aureus (MRSA) prevalence has been reported to be high in various settings and is associated with increased morbidity, mortality and risk of nosocomial outbreaks. Surveillance of prevalence and antibiotic susceptibility patterns is important to ensure appropriate antibiotic prescription. The objective of our study was to establish the prevalence of S. aureus, to identify patterns of susceptibility to commonly used antibiotics and quantify contemporary penicillin resistance among S. aureus. A retrospective study was conducted at the Mater Misericordiae Hospital, Nairobi. The study involved a review of non-duplicate records of specimens analyzed between January 2014 and December 2018.A specimen was categorized as Penicillin susceptible (PSSA) if susceptible to Penicillin and Oxacillin, MSSA if resistant to Penicillin but susceptible to Oxacillin, and MRSA if resistant to Oxacillin. We present proportions of S. aureus that was PSSA, MSSA and MRSA. Multivariate logistic regression was used to determine the association between the presence of S. aureus isolates and the source of the clinical specimen (in vs. outpatient), age and gender. A total of 659 specimens of S. aureus were analyzed in the 5-year period. ​​PSSA was the most prevalent organism seen (60.85%) while MRSA was the least prevalent (0.61 %). Most S. aureus was isolated in pus from wound swabs-644 (73. 3%). A significant increase in susceptibility of S. aureus to Penicillin and Amoxicillin-clavulanic acid was observed during the study period however, sensitivity to Amoxicillin declined. This study demonstrated a high prevalence of Penicillin Sensitive S. aureus and a low prevalence of MRSA.


Author(s):  
Sangeeta Gahlot ◽  
Makkhan Lal Saini

Background: The present study aimed to find out the antimicrobial susceptibility pattern of the organisms isolated from cases of VAP Methods: This study was carried out in the Department of Microbiology,  by taking samples from clinically suspected cases of  VAP from different ICU( Medical, Surgical, Neonatal and Pediatric ICU) at tertiary care hospital attached to S. P. Medical College, Bikaner. Results: Out of 79 GNB, 63 (79.74%) isolates were found to be MDR, including 10 (66.67%)) isolates of MDR Pseudomonas. Conclusion: Adherence to infection control protocols and short term use of invasive devices and judicious use of antibiotics are also important in preventing VAP caused by these MDR pathogens Keywords: VAP, MDR, ICU


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