scholarly journals Efficacy of acupuncture for melasma: a protocol of systematic review and meta-analysis

Author(s):  
Liheng Tang ◽  
◽  
Jin Xian ◽  
Ye Zhang ◽  
Changyun Zhang ◽  
...  

Review question / Objective: How effective is acupuncture in treating melasma compared to conventional treatment? Condition being studied: Melasma is a common acquired hyperpigmentation of the skin. The clinical manifestations are light brown or dark brown patches symmetrically distributed on the cheeks, forehead and mandibular with different shades and unclear borders. Melasma particularly affects women during menstruation, especially in thirties and forties Asian women. The incidence of Asian women of childbearing age is as high as 30%. Current treatments for melasma include topical drugs, chemical peeling agents, laser and light treatments, and systemic drugs. Despite the strong demand for treatment, the treatment of melasma is still very challenging, the results are inconsistent, and the recurrence rate is almost constant.

2019 ◽  
Vol 39 (2) ◽  
Author(s):  
Yonghui Song ◽  
Ying Chen ◽  
Qian Xu

Abstract Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is expressed constitutively on regulatory T cells. So far, several studies have focused on association between CTLA-4 gene polymorphisms and recurrent pregnancy loss (RPL). However, above association between the CTLA-4 gene polymorphism and RPL susceptibility is uncertain. Therefore, we performed a timely meta-analysis of all current publications to clarify this relationship. We located articles from the PubMed and Chinese language (WanFang) databases that were published up until July 25, 2018. Finally, we obtained six case–control studies, containing 2405 total cases and 2607 total controls, based on search criteria for abortion susceptibility related to the CTLA-4 +49 G/A polymorphism. The odds ratios (OR) and 95% confidence intervals (CIs) revealed association strengths. There was significantly decreased association between this polymorphism and whole population risk (e.g. AA vs. GG: OR = 0.56, 95% CI = 0.38–0.81, P=0.002). Additionally, in ethnicity subgroups, similar association was found both in China (e.g. AA vs. GG: OR = 0.49, 95% CI = 0.39–0.63, P=0.002) and non-China (e.g. AG vs. GG: OR = 0.46, 95% CI = 0.34–0.63, P<0.001). Current analysis suggested CTLA-4 +49 G/A polymorphism may weakly decrease RPL risk for women of childbearing age.


BMJ Open ◽  
2016 ◽  
Vol 6 (12) ◽  
pp. e012255 ◽  
Author(s):  
Tawanda Chivese ◽  
Werfalli Mahmoud ◽  
Itai Magodoro ◽  
Andre P Kengne ◽  
Shane A Norris ◽  
...  

World Science ◽  
2018 ◽  
Vol 1 (10(38)) ◽  
pp. 28-32
Author(s):  
Донська Ю. В. ◽  
Лоскутова Т. О. ◽  
Сімонова Н. В. ◽  
Петулько А. П.

The worsening demographic situation encourages the search for new reserves to improve reproductive potential. The maximum incidence of chronic endometritis (97.6%) is 26-35 years old - the most important in the implementation of reproductive function. The lack of a single concept for the pathogenesis of HE, the purge of clinical manifestations impedes the creation of well-grounded therapy in women of childbearing age. The aim of the study was to increase the effectiveness of treatment of patients with confirmed chronic endometritis in order to restore fertility. It is proved that the use of the scheme, which includes antibacterial (doxycycline 100 mg orally 2 times a day and metronidazole 500 mg 2 times a day for 14 days in one menstrual cycle) and cyclic progestogen (didrogesterone at a dose of 20 mg per day with 15 to 25 days of the menstrual cycle - within three months), therapy can restore the morpho-functional endometrium potential by 88% compared with the initial rates.


BMJ Open ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. e024345
Author(s):  
Tawanda Chivese ◽  
Mahmoud M Werfalli ◽  
Itai Magodoro ◽  
Rekai Lionel Chinhoyi ◽  
A P Kengne ◽  
...  

ObjectivesThe aim of this research was to estimate the prevalence of type 2 diabetes mellitus (T2DM), impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), in African women of childbearing age.Study designSystematic review and meta-analysis of relevant African studies published from January 2000 to December 2016.Data sourcesWe searched several databases, including EMBASE, MEDLINE, CINAHL, grey literature and references of included studies.SettingStudies carried out in African communities or any population-based studies were included.ParticipantsWe included studies, carried out in Africa, with non-pregnant women of childbearing age. Studies must have been published between the years 2000 and 2016.OutcomesThe primary outcome was prevalent T2DM. The secondary outcomes were IFG and IGT.Data extraction and synthesisTwo reviewers independently extracted data and, using the adapted Hoy risk of bias tool, independently assessed for risk of bias. We used random-effects meta-analysis models to pool prevalence estimates across studies. We used Cochran’s Q statistic and the I2 statistic to assess heterogeneity.ResultsA total of 39 studies from 27 countries were included, totaling 52 075 participants, of which 3813 had T2DM. The pooled prevalence of T2DM was 7.2% (95% CI 5.6% to 8.9%) overall and increased with age. The pooled prevalence was 6.0% (95% CI 4.2% to 8.2%) for impaired fasting glycemia while the prevalence of IGT ranged from 0.9% to 37.0% in women aged 15–24 and 45–54 years, respectively. Substantial heterogeneity across studies was not explained by major studies characteristics such as period of publication, rural/urban setting or whether a study was nationally representative or not.ConclusionThis review highlights the need for interventions to prevent and control diabetes in African women of childbearing age, in view of the significant prevalence of T2DM and prediabetes.PROSPERO registration numberCRD42015027635


2021 ◽  
Vol 13 (1) ◽  
pp. 37-44
Author(s):  
M. V. Radzikhovskaya ◽  
O. S. Anisimova ◽  
H. D. Magadeev ◽  
M. G. Moskvicheva ◽  
L. F. Telesheva ◽  
...  

Objective: to determine the prevalence and severity of clinical and cytological manifestations of papillomavirus infection in HIV-infected women of childbearing age in relation to immunological and virological parameters.Materials and methods. Statistical data were obtained through direct randomised inclusion of 182 HIV-infected women of fertile age who were being followed up at the AIDS Centre during their initial gynaecological examinations. Statistical processing of the findings was carried out using IBM SPSS Statistics software.Results and discussion. The results of the study showed a high detection rate of chronic papillomavirus infection of high carcinogenic risk (HPV HRS) among HIV-infected women, which is a prognostically unfavorable factor for the development of pathological changes in the cervix and was confirmed in a study by extended colposcopy. It was found that the concentration of HPV VKR increases against the background of a decrease in the immune status, and there is an indirect relationship between the level of HIV viral load and the concentration of HPV VKR.Conclusion. The feasibility of HPV vaccination among HIV-infected girls and women aged 9–45 has been demonstrated.


2019 ◽  
Vol 10 ◽  
Author(s):  
Minghua Tang ◽  
Daniel N. Frank ◽  
Antoinette Tshefu ◽  
Adrien Lokangaka ◽  
Shivaprasad S. Goudar ◽  
...  

Author(s):  
Rosa Camila Lucchetta ◽  
Sophia de Andrade Cavicchioli ◽  
Ana Luísa Rodriguez Gini ◽  
Marcela Forgerini ◽  
Fabiana Rossi Varallo ◽  
...  

2021 ◽  
Vol 10 (1) ◽  
pp. 68
Author(s):  
Dewi Aulia Nuraini ◽  
Abdu Nafan Aisul Muhlis

The rapid increase of population growth yearly is a problem that Indonesia generally faces. Various efforts to resolve this problem have been done by the government, one of which is the Family Planning Program and strategies for the use of contraception. Intra-Uterine Device (IUD) is one contraception type that remains unpopular, with only 6.6% of users in 2018. One of the factors assumed to affect the contraceptive use is spouse support. The aim of this study was to analyze and then summarize the findings on the correlation between husband support and the use of IUD in women of childbearing age. Ten studies with certain criterias that had been selected from various databases were used in the meta-analysis. The data were analyzed with the Comprehensive Meta-Analysis 2 trial version. Based on the analysis, husband support was a factor correlated with the use of IUDs in women of childbearing age (p = 0.000).


Sign in / Sign up

Export Citation Format

Share Document