The problem of low adherence to antiresorptive therapy with bisphosphonates: solutions

Over the past several decades, there has been a global aging of the population around the world. The demographic situation in the Russian Federation is no exception, being a natural result of an increase in the life expectancy of the population. In clinical practice, geriatric diseases have been identified and are widely studied, which deserve priority attention due to a sharp decline in the quality of life of elderly patients. Osteoporosis is called a “silent epidemic” among elderly and senile patients. This disease is associated with a high risk of low-traumatic fractures of various localization. The imperfect rehabilitation program after complex fractures and its insufficient funding are forcing clinicians to focus on more cost-effective solutions to this problem – the prevention and treatment of osteoporosis. Osteomodifying agents are widely used by physicians of various specialties. Bisphosphonates effectively reduce the risk of low-traumatic fractures against the background of an increase in bone mineral density. The level of effectiveness of bisphosphonates depends on the patient’s adherence to antiresorptive therapy and the degree of compensation for vitamin D and serum calcium. Low adherence to osteoporosis therapy is based on the need for long-term use of bisphosphonates and a different spectrum of adverse events. In the article, using alendronate as an example, the problem of low adherence to antiresorptive therapy will be considered and ways to solve it are presented.

Features of Population Reproduction and Assessment of Demographic Security of the Republic of Khakassia in the Context of Siberian and All-Russian Trends in the Post-Soviet Period

The article compares the changes in the demographic situation in the Republic of Khakassia with the regional demographic development of the neighboring republics of Altai and Tyva, as well as Krasnoyarsk Krai against the background of Siberian and all-Russian trends for the period 1990–2020. A comparative analysis of the main indicators of population reproduction of these territories was carried out using the method of multi-regional demographic analysis of dynamic series based on Rosstat data. The conclusion is made about the decrease in the level of demographic security in recent years in the Republic of Khakassia, as well as the country as a whole, due first to a decrease in fertility, and then an increase in mortality against the background of the population ageing.

The Population Census: a Tool for Consolidating or Irritating Society?

The article provides a historical digression into the population census as the only tool that makes it possible to assess the current socio-economic and socio-demographic situation in a particular territory. The possible factors causing distrust and fear among the population that arise in the process of organizing and conducting this labor-intensive process are listed. Among them: legal support; methodological foundation; consciousness and responsibility of scribes; psychological attitude of respondents.

State Policy Towards Demographic Changes in Poland

The aim of the article is to show that the modern civilization of technological, medical, structural and world-view progress determines the negative changes in the structure of families and the growth of the elderly population. Among the research hypotheses, in particular, it should be pointed out that the modern family policy should take into account the procreative context, as well as the family context with the participation of the older generation, as a consumer and participant in market services. The conclusions proposed by the authors concern a number of solutions in the field of social policy. The unfavorable demographic situation in the European Union raises specific challenges for social and demographic policy, among which, we should point out the changes in attitudes and individual behavior towards marriage and starting a family, changes in procreation attitudes, improving the quality of life of all generations, ensuring active participation of all generations in the demographic and socio-economic development of the country. The article has been written using the following research methods: descriptive, comparative and historical analysis.

Economic-geographical assessment of the demographic situation and economic potential of the inter-capital Belarusian-Russian borderlands

Geographic research of the phenomenon of inter-capital space of the Belarusian-Russian border region is an actual research area problem for the socio-economic geography of Belarus and Russia. This is due to the objective need to develop mechanisms of overcoming the demographic and economic peripherality of the region and embedding regional economic systems of border regions into the system of local relations. The purpose of the research is to identify the current distinctive features of the demographic and economic development of the inter-capital space of the Belarusian-Russian border region with the establishment of its niche from the point of the central-peripheral approach. During the analysis of the demographic situation of the inter-capital space of the Belarusian-Russian borderlands, it was established that, generally, in 1999–2019, its main feature was peripherality with the three zones established – the central demographic periphery, the buffer demographic periphery and the demographic semi-periphery – with a predominance in the structure of the first zone. Geographically, the central periphery zone is formed mainly by the rural borderland areas. According to the results of the analysis of the industrial development level, it was discovered that the inter-capital space of the Belarusian-Russian borderlands is characterised by a high degree of spatial inequality due to the development of large industrial centers around the existing periphery. This research had established a spatial differentiation of the transportation accessibility (by the connectivity of administrative centers of the borderlands) and the productivity of road transportation. The economicgeographical analysis of the foreign trade had revealed the diversity of directions and intensity of foreign goods trade between the Belarusian-Russian borderlands, mainly expressed in the predominance of the export-oriented regions with the per capita foreign trade turnover estimated at up to 2000 US dollars.

The health of the region's population in the new life realities during the Coronavirus Disease 2019 pandemic

Main problem: Among the numerous threats to international security and personal security, one of the central problems remains ensuring a stable and effective system of global governance in the field of healthcare. The article is devoted to the problem of public health as an indicator of regional development during the coronavirus pandemic. This article actualizes socio-economic problems in the context of threats to the external environment that affected the EAEU countries, as well state of health of the population of the Pavlodar region and the measures taken by the state in connection with the COVID-19 pandemic that has engulfed the world. Problems of a socio-economic nature can be solved by joint efforts of state structures, private, medium and small businesses. At the same time, joint programs are an important priority area of partnership during the development of the pandemic, in the cancers of which the transition to the organization of public order with enhanced quarantine restrictions will be carried out. Financing of such activities can be carried out from various sources, including grant funds aimed at finding new medicines. Regional specifics are important, since the level of spread of dangerous diseases depends on many factors. In connection with the existing prerequisites, based on an in-depth analysis of the medical and demographic situation, morbidity and disability of the population of the Pavlodar region, it is advisable to give a comprehensive assessment of the health status of residents of the region during the coronavirus pandemic. Purpose: based on an in-depth analysis of the medical and demographic situation, morbidity and disability of the population of the Pavlodar region, to give a comprehensive assessment of the health status of residents of the region during the coronavirus pandemic. Methods: In accordance with the tasks set, the following methods were used: analytical, statistical, comparative, theoretical and system analysis, psychological analysis methods, sociological methods (questionnaire, survey). Results and their significance: The results obtained can be used in the course of further study of the laws of functioning of the social sphere of the regional economy and the principles of functioning of the health management system of the Pavlodar region.

The EAEU Demography and Human Capital: Trends and Losses in the Context of a Pandemic

Demographic dynamics becomes crucially important for successful scenario of the future for both Eurasian integration and each EAEU member state. The “pandemic crisis” caused an increase in excess mortality, reduced social well-being and created serious legal and managerial conflicts. Within the EAEU new barriers to mobility and migration have emerged and social tension has increased. In the existing realities the current supranational solutions are insufficient, they are poorly focused on achieving the demographic security of the EAEU member states. Coordinated actions are needed to significantly improve the demographic situation in the EAEU.

Socio-geographic analysis of the demographic situation in Vinnytsia Oblast: current condition and peculiarities of development

The article contains analysis of the current demographic situation in Vinnytsia Oblast. We determined causes and factors influencing the development of the demographic situation in Vinnytsia Oblast. The paper reveals the specifics of development of the demographic processes in Vinnytsia Oblast according to the data of the Main Statistic Service in Vinnytsia Oblast for the period from 1959 to January 1, 2020. We determined how the totals of the urban and rural populations have changed. Based on the analysis of statistical and literature sources, we researched the specifics of natural movement of population, its sex and age structure, migration, distribution of the employed population and unemployment rate. We provide characteristics of specifics of the territorial differentiation of parameters of birth, death rates, natural increment (decline), migration, sex and age structure in Vinnytsia Oblast. We analyzed the specifics of employment of population in Vinnytsia Oblast, levels of economic activity and unemployment. We etermined modern tendencies of natural movement of the population, its impact on the prospects of further changes. We found out the problems of current demographic development in Vinnytsia Oblast based on determining modern specifics of the demographic parameters of the population in the researched area. The paper suggests ways to improve the demographic situation in Vinnytsia Oblast in the immediate future. As a result of the research, the demographic situation in Vinnytsia oblast was found to be negative. We observed a number of negative tendencies and patterns, including decrease in the rural population; decrease in the birth rate in the period from 1995 to 2020; high death rates due to diseases of blood circulation and malignant tumors; high parameters of aging of the population, especially in rural areas; decrease in the number of the employable population in the Oblast, etc.

Demographic situation in Saratov oblast

The article summarizes the results of the reproduction and migration development of Saratov oblast n in the 20th — early 21st centuries. The origin of demographic waves in the age and sex structure of the population of the region over a century is substantiated. It is shown what demographic and social consequences led to such development of the region, in which depopulation has not stopped since 1992. There are identified the features of the current migration situation in Saratov oblast. The circle of close migration partners of the region and changes in its migration ties over 50 years is revealed. The character of the exchange of population with other regions of Russia is examined. The main factors of the negative demographic situation in the region are considered. The primary factor is the low level of socio-economic development, wages and incomes of the population. As a consequence, together with high proportion of the urban population and poor ecology this results in a low birth rate and a higher mortality rate than the national average. The latter factor is associated not only with the more "old" (than in the Russian Federation as a whole) age and sex structure of the population of the region. The unfavorable socio-economic situation in the region also generates an increased mortality rate for separate classes and causes of death. Indirectly, this is evidenced by a significantly higher (than in the Russian Federation as a whole) mortality of the population of Saratov oblast from diseases of the digestive system and from alcohol poisoning. In addition, the outflow of young people to economically more developed regions of the country and the decline in fertility leads to a decrease in the proportion of women in the most active childbearing age, which causes an even greater decline in the birth rate. And decrease in the share of young people as a whole leads to an increase in the pension burden on the able-bodied population and to a further decrease in the incomes of the entire population of the region. A general conclusion is made that it is necessary to more actively and effectively pursue a policy of equalizing the socio-economic and demographic development of the regions of Russia. It is necessary to create zones of advanced development not only in the Far East or in the Arctic. It is necessary to develop the economy and the social sphere in all underdeveloped regions of Russia at a faster pace.

Socio-Demographic Situation in Kazakhstan: Problems of Reproduction

An increase in the birth rates and a decrease in mortality is currently one of the priority lines of the development of society. From a purely technocratic standpoint, development of the population should be based on accurate knowledge of the number of consumers and the movement of needs, without which it is impossible to solve many social problems in general. The paper addresses a question of the need to orient the economy towards the development of a person and the population as a whole. The purpose and objectives of the study were to identify the dynamics of the population size, natural increase, the main trends in the growth of birth rate, the analysis of the causes of death, including infant mortality, the study of the marriage and divorce rates, migration. In the main part of the paper, the indicators of the population size in the republic over the past 17 years and in recent years are considered, including: the main trends in population growth, factors affecting the growth and decrease in mortality, causes of infant mortality, migration balance, marriage and divorce rates, both in the republic as a whole and region-wise. In conclusion, proposals were made to create favourable conditions for the demographic growth of population of the republic. Today, the solution of problems in the field of demographic policy is becoming increasingly important. It is necessary to accurately determine the priority paths of demographic growth, taking into account the specifics of the development of the population of Kazakhstan. In the future, this would facilitate the solution of demographic problems in terms of improving the demographic situation, which will contribute to the prosperity of the whole state.