scholarly journals Intervention effect of continuous nursing on cure rate and whole-course treatment rate of pulmonary tuberculosis patients: A Meta-analysis

2022 ◽  
Author(s):  
Jingyu Meng ◽  
◽  
Jiaqin Pei ◽  
Li Zhang
Keyword(s):  
Pulmonary Tuberculosis ◽  
Meta Analysis ◽  
Cure Rate ◽  
Treatment Rate ◽  
Intervention Effect ◽  
Tuberculosis Patients

scholarly journals Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0259006
Author(s):  
Ashutosh Nath Aggarwal ◽  
Ritesh Agarwal ◽  
Sahajal Dhooria ◽  
Kuruswamy Thurai Prasad ◽  
Inderpaul Singh Sehgal ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pulmonary Tuberculosis ◽  
Patient Outcomes ◽  
Meta Analysis ◽  
Severe Disease ◽  
Random Effects Models ◽  
Tuberculosis Patients ◽  
Active Pulmonary Tuberculosis ◽  
Risk Of Mortality ◽  
Related Mortality

Objective The proportion of COVID-19 patients having active pulmonary tuberculosis, and its impact on COVID-19 related patient outcomes, is not clear. We conducted this systematic review to evaluate the proportion of patients with active pulmonary tuberculosis among COVID-19 patients, and to assess if comorbid pulmonary tuberculosis worsens clinical outcomes in these patients. Methods We queried the PubMed and Embase databases for studies providing data on (a) proportion of COVID-19 patients with active pulmonary tuberculosis or (b) severe disease, hospitalization, or mortality among COVID-19 patients with and without active pulmonary tuberculosis. We calculated the proportion of tuberculosis patients, and the relative risk (RR) for each reported outcome of interest. We used random-effects models to summarize our data. Results We retrieved 3,375 citations, and included 43 studies, in our review. The pooled estimate for proportion of active pulmonary tuberculosis was 1.07% (95% CI 0.81%-1.36%). COVID-19 patients with tuberculosis had a higher risk of mortality (summary RR 1.93, 95% CI 1.56–2.39, from 17 studies) and for severe COVID-19 disease (summary RR 1.46, 95% CI 1.05–2.02, from 20 studies), but not for hospitalization (summary RR 1.86, 95% CI 0.91–3.81, from four studies), as compared to COVID-19 patients without tuberculosis. Conclusion Active pulmonary tuberculosis is relatively common among COVID-19 patients and increases the risk of severe COVID-19 and COVID-19-related mortality.

scholarly journals Issue Thérapeutique Des Patients Tuberculeux Pulmonaires Biologiquement Confirmés Dans La Zone Sanitaire De Parakou-N’Dali De 2011 À 2015

2016 ◽  
Vol 12 (33) ◽  
pp. 340
Author(s):  
CA Dovonou ◽  
CA Alassani ◽  
S Ade ◽  
CA Attinsounon ◽  
S Ahoui ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Treatment Failure ◽  
Therapeutic Outcome ◽  
Cure Rate ◽  
Therapeutic Success ◽  
Prospective Data ◽  
Tuberculosis Patients ◽  
Factors Associated ◽  
Study Population ◽  
Health Zone

Objective: The objective of this study is to describe the therapeutic outcome and factors associated with treatment failure in laboratory confirmed pulmonary tuberculosis patients. Methods: He acted in a descriptive and analytical study referred to prospective data collection. The study population consisted of laboratory confirmed pulmonary tuberculosis patients in the health zone Parakou-N'Dali from 2011 to 2015. Results: A total of 313 TB patients were enrolled. The average age of patients was 37.4 ± 14.3 years. The sex ratio was 2.1. Two hundred sixtyfive (265) patients were cured, a cure rate of 84.66%; 5 patients had completed treatment. Therapeutic success was observed in 270 patients (86.26%); the rate of treatment failure was 2.24%. Twenty-nine (29) patients died (9.26%); 6 patients were lost to follow and only 1 was transferred. Factors associated with treatment failure were the BMI screening to the lower than 18.5 kg/m2 (p = 0.000) and hospitalization (p = 0.002).Conclusion: The therapeutic outcome of patients with pulmonary tuberculosis in the health zone Parakou-N'Dali was characterized by a low rate process complete, lost sight and transfers.

scholarly journals Impact of vitamin D status and cathelicidin antimicrobial peptide on adults with active pulmonary TB globally: A systematic review and meta-analysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252762
Author(s):  
Ester Lilian Acen ◽  
Irene Andia Biraro ◽  
William Worodria ◽  
Moses L. Joloba ◽  
Bill Nkeeto ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Pulmonary Tuberculosis ◽  
Meta Analysis ◽  
Vitamin D Status ◽  
Tuberculosis Patients ◽  
Pulmonary Tb ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Tuberculosis Disease

Background Tuberculosis remains a global threat and a public health problem that has eluded attempts to eradicate it. Low vitamin D levels have been identified as a risk factor for tuberculosis infection and disease. The human cathelicidin LL-37 has both antimicrobial and immunomodulatory properties and is dependent on vitamin D status. This systematic review attempts to compare vitamin D andLL-37 levels among adult pulmonary tuberculosis patients to non-pulmonary TB individuals between 16–75 years globally and to determine the association between vitamin D and cathelicidin and any contributing factor among the two study groups. Methods/Design We performed a search, through PubMed, HINARI, Google Scholar, EBSCOhost, and databases. A narrative synthesis through evaluation of vitamin D and LL-37 levels, the association of vitamin D and LL-37, and other variables in individual primary studies were performed. A random-effect model was performed and weighted means were pooled at a 95% confidence interval. This protocol is registered under the International Prospective Register of Systematic Reviews (PROSPERO), registration number CRD42019127232. Results Of the 2507 articles selected12 studies were eligible for the systematic review and of these only nine were included in the meta-analysis for vitamin D levels and six for LL-37 levels. Eight studies were performed in Asia, three in Europe, and only one study in Africa. The mean age of the participants was 37.3±9.9 yrs. We found low vitamin D and high cathelicidin levels among the tuberculosis patients compared to non-tuberculosis individuals to non-tuberculosis. A significant difference was observed in both vitamin D and LL-37 levels among tuberculosis patients and non-tuberculosis individuals (p = < 0.001). Conclusion This study demonstrated that active pulmonary tuberculosis disease is associated with hypovitaminosis D and elevated circulatory cathelicidin levels with low local LL-37 expression. This confirms that vitamin D status has a protective role against tuberculosis disease.

scholarly journals Delay in treatment seeking and associated factors among suspected pulmonary tuberculosis patients in public health facilities of Adama town, eastern Ethiopia

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Tirusew Maru Wondawek ◽  
Musa Mohammed Ali
Keyword(s):  
Pulmonary Tuberculosis ◽  
Low Income ◽  
Health Facilities ◽  
Treatment Seeking ◽  
Cure Rate ◽  
Eastern Ethiopia ◽  
Tuberculosis Patients ◽  
Female Sex ◽  
Delay In Seeking Treatment ◽  
Delay In Treatment

Abstract Background In low-income countries, delays in treatment seeking among tuberculosis patients contribute to easy transmission and high prevalence of tuberculosis. Objective The aim of this study was to determine the magnitude of delays in treatment-seeking and risk factors among pulmonary tuberculosis suspected patients in health facilities located in Adama, Ethiopia. Method A health-facility based cross-sectional study was conducted at Adama from December 20, 2015, to March 1, 2016, among 598 tuberculosis suspected patients. Data was collected from all study participants on the same day of tuberculosis diagnosis using a structured questionnaire. Epi-Info 3.5.3 and Statistical package for the social sciences (SPSS) version 16.0 were used for data entry and analysis respectively. A bivariate and multivariable regression model was used to investigate the association between delay in seeking-treatment and various factors. Odds ratio with 95% CI and P-value < 0.05 were considered as cut off point to measure the strength and significance of the association. Results Among 598 pulmonary tuberculosis suspected patients, 79 (13.2%) were smear-positive. Among smear-positive participants, 61(77.2%) delayed seeking treatment and 275 (46%) patients delayed seeking treatment for > 30 days. The following factors were significantly associated with a delay in seeking treatment: female sex OR = 1.57, 95% CI (1.14, 2.18), low monthly income OR = 1.45, 95% CI (1.05, 2.01), lack of knowledge regarding tuberculosis OR = 1.67, 95% CI (1.13, 2.48), and cure rate of tuberculosis OR = 1.836, 95% CI (1.25, 2.69). Conclusion Nearly half of pulmonary tuberculosis suspected patients delayed seeking treatment in our study area. Female sex, low income, family size of five and greater, no knowledge about tuberculosis and cure rate were factors contributing to delay in treatment-seeking among suspected tuberculosis patients.

Factors Associated with Treatment Outcomes in Patients with Pulmonary Tuberclosis

2021 ◽  
Vol 15 (9) ◽  
pp. 3091-3095
Author(s):  
Akram Afzal ◽  
Murad Ahmad ◽  
Haseeb Ghaffar
Keyword(s):  
Pulmonary Tuberculosis ◽  
Treatment Outcomes ◽  
Successful Treatment ◽  
Tuberculosis Treatment ◽  
P Value ◽  
Treatment Rate ◽  
Cross Sectional ◽  
Tuberculosis Patients ◽  
Factors Associated ◽  
Treatment Category

Background and Aim: Tuberculosis (TB) is one of the major sources of health problems in developing countries. An effective strategy for tuberculosis treatment can be evaluated with key indicators known as TB control program with their treatment outcomes. Hence, the purpose of this study was to evaluate the factors associated with the treatment outcome of pulmonary tuberculosis in patients. Methods: This cross-sectional study was carried out on 129 Tuberculosis patients in the department of Pulmonology, Gulab Devi Hospital Lahore from November 2020 to April 2021. Demographic details, clinical examination, and treatment outcomes were evaluated. All the data were extracted from the hospital medical records. Successful treatment outcomes predictors were assessed using bivariate and multivariate regression. SPSS version 20 was used for data analysis. Results: Of the total 129 tuberculosis patients, 59 (46%) were male and 70 (54%) were females. The overall mean age was 26.54±5.62 years. The overall prevalence of successful treatment rate was 113 (87.6%). Out of 113, the prevalence of cured and complete treatment patients was 57 (50.4%) and 56 (49.6%) respectively. Based on logistic regression models, various parameters with their respective adjustment odds ratio (AOR) were as follows; age 21-40 years (AOR= 2.67, 95% CI=1.32-6.12, p-value=0.003), treatment category (AOR=4.62, 95% CI=1.12-16.74, p-value=0.027), and smear-positive pulmonary tuberculosis (AOR=3.47; 95% CI=1.76-6.69, p-value<0.001) were significantly related with treatment outcomes. Conclusion: Our study reported that the overall prevalence of successful treatment was 87.6%. Though, the rate of overall successful treatment was found satisfactory, but, to meet international standard strategy for tuberculosis, still, improvement needs to be achieved. Age, treatment category, and tuberculosis types were significantly correlated with treatment outcomes. Keywords: Pulmonary Tuberculosis; Treatment Outcomes; TB Smears

Detection of Mycobacterium tuberculosis in smear negative sputum by PCR

2012 ◽  
Vol 6 (2) ◽  
pp. 2-6 ◽  
Author(s):  
Mohammad Jobayer ◽  
SM Shamsuzzaman ◽  
Kazi Zulfiquer Mamun
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Accurate Method ◽  
Major Health Problem ◽  
Major Health ◽  
Tuberculosis Patients ◽  
Diagnostic Potential ◽  
Total Death ◽  
Smear Negative ◽  
Negative Sputum

Pulmonary tuberculosis is a major health problem in Bangladesh that is responsible for about 7% of total death in a year. This study was conducted to isolate and identify Mycobacterium tuberculosis from sputum and to evaluate the efficacy of PCR as a modern diagnostic tool, for diagnosis of pulmonary tuberculosis, especially in the smear negative cases. One hundred and fifty suspected pulmonary TB patients (male/ female: 97/53) were included in this study. Single morning sputum was collected from each patient and diagnostic potential of PCR was compared with staining and culture. Twenty five (16.7%) sputum were positive by ZN stained smear. Among 125 smear negative samples, 13 (10.4%) yielded growth in culture in LJ media and 21 (16.8%) samples were positive by PCR. The sensitivity and specificity of PCR in smear negative cases was 100% and 92.9% respectively. Mean detection time in PCR was 24 hours. PCR detected M. tuberculosis in 21 smear negative and 9 culture negative samples. For diagnosis of tuberculosis in smear negative cases, PCR directly from sputum was a very sensitive and accurate method. In conclusion, PCR may be done, especially in clinically suspected pulmonary tuberculosis patients who remain negative by conventional methods.DOI: http://dx.doi.org/10.3329/bjmm.v6i2.19368 Bangladesh J Med Microbiol 2012; 06(02): 2-6

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