scholarly journals INHERITED THROMBOPHILIA SECONDARY TO PROTEIN S DEFICIENCY ASSOCIATED WITH ISCHEMIC STROKE. CASE REPORT

2016 ◽  
Vol 15 (4) ◽  
pp. 187-191
Author(s):  
Diana Matcau ◽  
◽  
Claudia Barsan ◽  
Traian Flavius Dan ◽  
Camelia Barbusi ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Oral Contraceptive ◽  
Magnetic Resonance ◽  
Laboratory Data ◽  
Protein S ◽  
Protein S Deficiency ◽  
Inherited Thrombophilia ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pills ◽  
S Deficiency

Thrombophilia is characterized by an increased tendency to arterial and venous thrombus formation. Inherited thrombophilia can be secondary to protein S deficiency. Concomitant use of oral contraceptive pills increases the risk of venous thromboembolism and arterial thrombosis. We report a case of a 34-year-old female who used oral contraceptive pills for many years, who developed acute ischemic stroke of right occipital lobe with secondary left superior homonymous quadrantanopia. We have run several tests to establish the ischemic stroke etiology: unenhanced brain and cervical spine computed tomography, brain magnetic resonance imaging and magnetic resonance angiography (including MR venography), computed tomographic angiography, echocardiography, extracranial duplex ultrasound and laboratory data (including thrombophilia testing). The laboratory investigations confirmed that the ischemic stroke of our patient resulted from a severe inherited thrombophilia secondary to protein S deficiency.

scholarly journals A Female with Recurrent Venous Thrombosis

1970 ◽  
Vol 13 (1) ◽  
pp. 100-102
Author(s):  
Aparna Das ◽  
AKM Aminul Hoque ◽  
Ratan Dasgupta ◽  
Ahmedul Kabir ◽  
Gobinda Banik ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Venous Thrombosis ◽  
Protein S ◽  
Protein S Deficiency ◽  
Low Level ◽  
S Deficiency ◽  
Thrombophilia Screening ◽  
Recurrent Venous Thrombosis

A 50- year-old female was presented with recurrent venous thrombosis with ischemic stroke due to protein S deficiency. Other causes of recurrent venous thrombosis were excluded by different investigations. We only found low level of protein S. In most of the cases, thrombophilia screening is not usaally done. So, this report will illustrate the importance of thrombophlia screening in patient having recurrent venous thrombosis. DOI: http://dx.doi.org/10.3329/jom.v13i1.10085 JOM 2012; 13(1): 100-102

scholarly journals Free protein S deficiency in acute ischemic stroke. A case-control study.

Stroke ◽  
1993 ◽  
Vol 24 (2) ◽  
pp. 224-227 ◽  
Author(s):  
S A Mayer ◽  
R L Sacco ◽  
A Hurlet-Jensen ◽  
T Shi ◽  
J P Mohr
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Case Control Study ◽  
Protein S ◽  
Case Control ◽  
Protein S Deficiency ◽  
Free Protein ◽  
S Deficiency ◽  
Control Study

Prothrombin G20210A mutation and oral contraceptive use increase upper-extremity deep vein thrombotic risk

2003 ◽  
Vol 89 (03) ◽  
pp. 452-457 ◽  
Author(s):  
Yolanda Mira ◽  
Jose Mateo ◽  
Cristina Falco ◽  
Piedad Villa ◽  
Amparo Estelles ◽  
...  
Keyword(s):  
Oral Contraceptive ◽  
Upper Extremity ◽  
Protein C ◽  
Protein S ◽  
Prothrombin G20210a ◽  
Protein S Deficiency ◽  
Factor V Leiden Mutation ◽  
G20210a Mutation ◽  
S Deficiency ◽  
Deep Vein

SummaryThe role played by a hypercoagulable state, either inherited or acquired, in the pathogenesis of upper-extremity deep vein thrombosis (UEDVT) remains a question of debate. We performed a case-control study including 79 patients with a first objectively confirmed episode of UEDVT, 31 secondary and 48 primary, and 165 healthy controls. Nine patients (11.4%) with UEDVT were carriers of the prothrombin G20210A mutation vs. six (3.7%) in controls; P = 0.025, OR: 3.39 (95% CI 1.16 to 9.88). No statistical difference was observed between cases and controls for the factor V Leiden mutation, AT, protein C or protein S deficiency and anticardiolipin antibodies (ACAs). Thirteen (35.1%) UEDVT patients were oral contraceptive (OC) users vs. 12 (16%) controls; P = 0.020, OR: 2.89 (95% CI 1.16-7.21). When secondary UEDVT patients were compared with controls, no differences were observed in any of the risk factors analysed. On the other hand, when primary UEDVT was considered, six (12.5%) patients were carriers of the prothrombin G20210A mutation vs. six (3.7%) controls; P = 0.031, OR: 3.76 (95% CI 1.15-12.26). Regarding ACAs, a borderline statistical significance was observed when primary UEDVT was compared with controls, P = 0.048; OR: 4.88 (95% CI 1.05-22.61). In primary UEDVT, 52% of the fertile women were OC users vs. 16% of controls; P = 0.001, OR:5.78 (95% CI 2.13-15.67). When the interaction of both factors, i.e. prothrombin G20210A mutation and OC intake, were considered, the risk increased markedly, indicating a synergistic effect as observed with other thrombotic locations. In patients with primary UEDVT screening for antithrombin, protein C and protein S deficiency and APC resistance would not be justified, although it might be reasonable to determine the carrier status of the prothrombin G20210A mutation only in OC users.

Midbrain infarction in inherited protein S deficiency: a rare association

2021 ◽  
Vol 14 (10) ◽  
pp. e246073
Author(s):  
Manali Chandra ◽  
Atanu Chandra ◽  
Sayantan Chakraborty ◽  
Joydeep Ghosh
Keyword(s):  
Ischaemic Stroke ◽  
Protein S ◽  
Sudden Onset ◽  
Laboratory Evaluation ◽  
Protein S Deficiency ◽  
Inherited Thrombophilia ◽  
S Deficiency ◽  
Arterial Ischaemic Stroke ◽  
Midbrain Infarction

Inherited thrombophilic disorders are well‐established predisposing factors for venous thromboembolism, but their role in arterial ischaemic stroke is uncertain. The exact mechanism of arterial thrombosis in thrombophilias remains elusive. Herein, we report a case of a 30-year-old woman who was admitted to our facility with sudden-onset right-sided ptosis and ophthalmoplegia. Detailed clinical features, neuroimaging and laboratory evaluation clinched the diagnosis of ischaemic stroke in midbrain due to microvascular obstruction associated with isolated protein S deficiency. She was treated with oral anticoagulant (warfarin) and physiotherapy; without any improvement of her symptoms at 2 months of follow-up. A high index of clinical suspicion is needed in any case of young ischaemic stroke in absence of common cardiac and vascular risk factors, to recognise the presence of inherited thrombophilia.

scholarly journals Hereditary protein S deficiency leads to ischemic stroke

2015 ◽  
Vol 12 (3) ◽  
pp. 3279-3284 ◽  
Author(s):  
ZHAO-HUI WANG ◽  
ZHI-JUN ZHAO ◽  
KANG XU ◽  
GUO-BING SUN ◽  
LIN SONG ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Protein S ◽  
Protein S Deficiency ◽  
S Deficiency

scholarly journals Protein S Deficiency: Ischemic Stroke in Young adult – A Case Report

2013 ◽  
Vol 28 (1) ◽  
pp. 59-62
Author(s):  
Hasan Zahidur Rahman ◽  
Sharif Uddin Ahmed ◽  
Mohammad Najim Uddin ◽  
Masud Rana ◽  
Anis Ahmed ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Young Adult ◽  
Economic Cost ◽  
Protein S ◽  
Protein S Deficiency ◽  
Major Health Problem ◽  
Stroke In Young Adults ◽  
S Deficiency ◽  
The Uk ◽  
Stroke In Young

Stroke is the third most common cause of mortality in Westernised countries and Accounts for 12% of all deaths in the UK. The economic cost of stroke is enormous. Twelve per cent of first strokes occur in patients under 45 years of age, of which approximately 50% are ischaemic in nature. Stroke in young adult poses a major health problem. The causes of ischaemic stroke in young adults are many and diverse.Such patients usually require more extensive investigations in order to find an underlying cause than more elderly patients. Principal causes are cardioembolism, premature atherosclerosis, haematological and immunological disorders and migraine. Thrombophilic factors have been implicated in 4-8% of the young adult strokes worldwide. Protein S deficiency is a rare cause of ischemic stroke in young population. Only a few sporadic cases have been described in the literature. We are reporting a case of protein S deficiencyrelated ischemic stroke in a 40-year-old man. Early diagnosis and targeted approach can help such patients to prevent recurrent thrombotic episodes.Bangladesh Journal of Neuroscience 2012; Vol. 28 (1): 59-62

Ischemic Stroke with Protein S Deficiency Treated by Apixaban

2020 ◽  
Vol 29 (4) ◽  
pp. 104608
Author(s):  
Ikkei Ohashi ◽  
Shinichi Wada ◽  
Fumitaka Yoshino ◽  
Takahiro Kuwashiro ◽  
Shinya Matsumoto ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Protein S ◽  
Protein S Deficiency ◽  
S Deficiency
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