scholarly journals Hyaluronic-Acid Based Hydrogels for 3-Dimensional Culture of Patient-Derived Glioblastoma Cells

10.3791/58176 ◽  
2018 ◽  
Author(s):  
Weikun Xiao ◽  
Arshia Ehsanipour ◽  
Alireza Sohrabi ◽  
Stephanie K. Seidlits
Keyword(s):  
Hyaluronic Acid ◽  
Glioblastoma Cells ◽  
3 Dimensional

scholarly journals Hyaluronic acid-conjugated liposome nanoparticles for targeted delivery to CD44 overexpressing glioblastoma cells

Oncotarget ◽  
2016 ◽  
Vol 7 (23) ◽  
pp. 34158-34171 ◽  
Author(s):  
Stephen L. Hayward ◽  
Christina L. Wilson ◽  
Srivatsan Kidambi
Keyword(s):  
Hyaluronic Acid ◽  
Targeted Delivery ◽  
Glioblastoma Cells

scholarly journals Hyaluronic acid induces ROCK-dependent amoeboid migration in glioblastoma cells

2020 ◽  
Vol 8 (17) ◽  
pp. 4821-4831
Author(s):  
Yixiao Cui ◽  
Sara Cole ◽  
Joel Pepper ◽  
José Javier Otero ◽  
Jessica O. Winter
Keyword(s):  
Hyaluronic Acid ◽  
Dependent Manner ◽  
Glioblastoma Cells

Hyaluronic acid induces mesenchymal to amoeboid migration in glioblastoma (GB) cells in a ROCK-dependent manner.

130 Effects of Ultrasonic Stimulation and Hyaluronic Acid on Chondrocytes in 3-Dimensional Culture

2005 ◽  
Vol 2004.17 (0) ◽  
pp. 255-256
Author(s):  
Takahiro YAGI ◽  
Toshihiko SHIRAISHl ◽  
Shin MORISHITA ◽  
Ryohei TAKEUCHI ◽  
Tomoyuki SAITO ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
3 Dimensional ◽  
Ultrasonic Stimulation

Facile design of autogenous stimuli-responsive chitosan/hyaluronic acid nanoparticles for efficient small molecules to protein delivery

2020 ◽  
Vol 8 (32) ◽  
pp. 7275-7287
Author(s):  
Parinaz Sabourian ◽  
Jeff Ji ◽  
Victor Lotocki ◽  
Alexandre Moquin ◽  
Ramez Hanna ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hyaluronic Acid ◽  
Small Molecules ◽  
Protein Delivery ◽  
Stimuli Responsive ◽  
Glioblastoma Cells ◽  
One Pot ◽  
Self Assembled

Chitosan is functionalized with oxidative stress-sensitive thioketal entities in a one-pot methodology, and self-assembled into drugs or protein loaded dual stimuli responsive nanoparticles, which kill glioblastoma cells and increase nerve outgrowth.

3-Dimensional functionalized polycaprolactone-hyaluronic acid hydrogel constructs for bone tissue engineering

2017 ◽  
Vol 44 (4) ◽  
pp. 428-437 ◽  
Author(s):  
Stephen M. Hamlet ◽  
Cedryck Vaquette ◽  
Amit Shah ◽  
Dietmar W. Hutmacher ◽  
Saso Ivanovski
Keyword(s):  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
3 Dimensional ◽  
Hyaluronic Acid Hydrogel

scholarly journals A Novel Cross-Linked Hyaluronic Acid Porous Scaffold for Cartilage Repair

Cartilage ◽  
2015 ◽  
Vol 7 (3) ◽  
pp. 265-273 ◽  
Author(s):  
Christoph Bauer ◽  
Manuela Berger ◽  
Renate R. Baumgartner ◽  
Sonja Höller ◽  
Hannes Zwickl ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Hyaluronic Acid ◽  
Articular Chondrocytes ◽  
Porous Scaffold ◽  
Cartilage Regeneration ◽  
Cell Number ◽  
Cell Content ◽  
3 Dimensional ◽  
Chondrogenic Phenotype ◽  
Differentiation Status

Purpose An important feature of biomaterials used in cartilage regeneration is their influence on the establishment and stabilization of a chondrocytic phenotype of embedded cells. The purpose of this study was to examine the effects of a porous 3-dimensional scaffold made of cross-linked hyaluronic acid on the expression and synthesis performance of human articular chondrocytes. Materials and Methods Osteoarthritic chondrocytes from 5 patients with a mean age of 74 years were passaged twice and cultured within the cross-linked hyaluronic acid scaffolds for 2 weeks. Analyses were performed at 3 different time points. For estimation of cell content within the scaffold, DNA-content (CyQuant cell proliferation assay) was determined. The expression of chondrocyte-specific genes by embedded cells as well as the total amount of sulfated glycosaminoglycans produced during the culture period was analyzed in order to characterize the synthesis performance and differentiation status of the cells. Results Cells showed a homogenous distribution within the scaffold. DNA quantification revealed a reduction of the cell number. This might be attributed to loss of cells from the scaffold during media exchange connected with a stop in cell proliferation. Indeed, the expression of cartilage-specific genes and the production of sulfated glycosaminoglycans were increased and the differentiation index was clearly improved. Conclusions These results suggest that the attachment of osteoarthritic P2 chondrocytes to the investigated material enhanced the chondrogenic phenotype as well as promoted the retention.

scholarly journals Hypoxia activates enhanced invasive potential and endogenous hyaluronic acid production by glioblastoma cells

2018 ◽  
Vol 6 (4) ◽  
pp. 854-862 ◽  
Author(s):  
Jee-Wei Emily Chen ◽  
Jan Lumibao ◽  
Audrey Blazek ◽  
H. Rex Gaskins ◽  
Brendan Harley
Keyword(s):  
Hyaluronic Acid ◽  
Survival Rate ◽  
Brain Cancer ◽  
Acid Production ◽  
Adult Brain ◽  
Glioblastoma Cells ◽  
Invasive Potential ◽  
Short Survival ◽  
Hyaluronic Acid Production

Glioblastoma (GBM) is the most common, aggressive, and deadly form of adult brain cancer, and is associated with a short survival rate (median 12–15 months, 5+ year less than 5%).

Sign in / Sign up

Export Citation Format

Share Document