Type 2 Diabetes Mellitus-Induced Hyperglycemia in Patients with NAFLD and Normal LFTs: Relationship to Lipid Profile, Oxidative Stress and Pro-Inflammatory Cytokines

Abstract Background: This research aimed to study the effect of coriander seed supplementation on serum glycemic indices, lipid profile and oxidative stress parameters in patients with type 2 diabetes mellitus (T2DM).Methods: In this randomized double-blinded, placebo-controlled trial, eligible 40 T2DM patients aged 30-60 years were recruited from Sina Hospital (Tabriz, Iran) and randomly assigned into two groups to receive either coriander seed powder (1000 mg/day, n=20) or placebo (1000 mg/day, n=20) for 6 weeks. Anthropometric measurements, dietary intake, and biochemical parameters including fasting blood sugar (FBS), serum insulin, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), total cholesterol (TC), triglyceride (TG), high- and low-density lipoprotein cholesterols (HDL-C and LDL-C), malondialdehyde (MDA), and total antioxidant capacity (TAC) were assessed before and after supplementation.Results: Anthropometric measurements were not significantly different between intervention and placebo groups. Coriander seed supplementation led to significant within-group reductions in FBS (156.15±23.19 to 130.30±21.15), serum insulin (17.72±0.47 to 17.12±0.76), HOMA-IR (6.82±0.95 to 5.52±0.99), TC (183.85±55.68 to 145.20±31.36), TG (152.50±37.59 to 130.40 ±27.96), LDL-C (127.35±23.45 to 111.40±25.71), and MDA (1.65±0.15 to 1.49±0.15), whereas there were significant increases observed in serum TAC (1.93±0.12 to 1.97±0.09) (P<0.05). Post-dose comparisons showed significant between-group differences for FBS, serum insulin, HOMA-IR, TC, TG, LDL-C, MDA, and TAC levels after adjusting for baseline values (P<0.05).Conclusions: Coriander seed supplementation was able to improve glycemic indices, lipid profile and oxidative stress status in T2DM and it may be useful complementary treatment in management of these patients.Trial registration: The study protocol was registered on the Iranian Registry of Clinical Trials website (IRCT20190224042821N2) on 2019/Oct/11.

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Association of Fibroblast Growth Factor 21 with Lipid Profile, MDA and AOPP in Patients with Type 2 Diabetes Mellitus

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i55b33863 ◽

2021 ◽

pp. 179-186

Author(s):

P. Divya ◽

R. Inmozhi Sivakamasundari ◽

T. K. Jithesh ◽

K. Santha ◽

K. Shifa ◽

...

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Growth Factor ◽

Lipid Profile ◽

Fibroblast Growth Factor 21 ◽

Diabetic Patients ◽

Fibroblast Growth

Background: Diabetes mellitus is rising all over the world due to population growth, aging, urbanisation, and the increase of obesity due to physical inactivity, characterized by persistent high blood glucose levels associated with aberrations in lipid, carbohydrate, and protein metabolisms leading to water and electrolyte imbalance. Cardiovascular diseases are the leading causes of mortality in diabetic patients. Mechanisms such as oxidative stress, lipid metabolism imbalance, as well as myocardial cell apoptosis are key factors to facilitate the progression of Diabetic cardiomyopathy. Aim: The aim of this study was to assess FGF-21 levels and their association with lipid profile parameters and oxidative stress in patients with type 2 diabetes mellitus. Methods: A patient based cross-sectional study was conducted among the subjects with history of type 2 DM for the past 10 years. Results: Variations in FBS, T.C, TG, LDL, HDL, VLDL, FGF-21, MDA and AOPP levels among cases and controls were depicted in Table 2. There was an increase in all these parameters in cases compared to controls whereas HDL showed a decrease among cases. Conclusion: Our study concluded that there is a significant correlation between fibroblast growth factor 21 (FGF-21), oxidative stress, and abnormal lipid profile in type 2 diabetic patients. We would recommend further studies to explore the role of FGF21 as an important marker in predicting cardiovascular risk in diabetic patients.

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Helminth infection modulates systemic pro-inflammatory cytokines and chemokines implicated in type 2 diabetes mellitus pathogenesis

PLoS Neglected Tropical Diseases ◽

10.1371/journal.pntd.0008101 ◽

2020 ◽

Vol 14 (3) ◽

pp. e0008101 ◽

Cited By ~ 5

Author(s):

Anuradha Rajamanickam ◽

Saravanan Munisankar ◽

Chandrakumar Dolla ◽

Pradeep A. Menon ◽

Kannan Thiruvengadam ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Inflammatory Cytokines ◽

Helminth Infection ◽

Cytokines And Chemokines ◽

Pro Inflammatory Cytokines

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Implications of resistin in type 2 diabetes mellitus and coronary artery disease: Impairing insulin function and inducing pro‐inflammatory cytokines

Journal of Cellular Physiology ◽

10.1002/jcp.28913 ◽

2019 ◽

Vol 234 (12) ◽

pp. 21758-21769 ◽

Cited By ~ 8

Author(s):

Melissa Emamalipour ◽

Khaled Seidi ◽

Ali Jahanban‐Esfahlan ◽

Rana Jahanban‐Esfahlan

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Coronary Artery Disease ◽

Type 2 Diabetes Mellitus ◽

Coronary Artery ◽

Inflammatory Cytokines ◽

Artery Disease ◽

Pro Inflammatory Cytokines

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Cytokine status of patients with chronic obstructive pulmonary disease and type 2 diabetes mellitus

Kazan medical journal ◽

10.17750/kmj2017-222 ◽

2017 ◽

Vol 98 (2) ◽

pp. 222-226

Author(s):

S A Nedomolkina ◽

O V Velikaya ◽

V I Zoloedov

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Chronic Obstructive Pulmonary Disease ◽

Type 2 Diabetes Mellitus ◽

Pulmonary Disease ◽

Inflammatory Cytokines ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Pro Inflammatory Cytokines

The review article is devoted to an actual problem of modern medicine - combined pathology of chronic obstructive pulmonary disease and type 2 diabetes mellitus. These 2 diseases take the first place in the structure of people’s mortality. The rate of chronic obstructive pulmonary disease and type 2 diabetes mellitus increases annually along with life length and according to different data reaches 35.8%. In the article scientists’ modern perception and known facts from scientific literature are presented. Special attention is given to cytokine status in chronic obstructive pulmonary disease and type 2 diabetes mellitus. Cytokines classification based on mechanism of action and their role in pathogenesis is presented. Systemic inflammation characteristic for both diseases presents as the increase of pro-inflammatory cytokines level in the blood and decrease of anti-inflammatory cytokines. Determining cytokines in patients with chronic obstructive pulmonary disease and type 2 diabetes mellitus has prognostic value. Mutual negative influence of these two diseases is directly associated with the increase of pro-inflammatory cytokines which are considered the reason for insulin resistance and type 2 diabetes mellitus. Despite the attempts to study cytokine status in patients with chronic obstructive pulmonary disease and type 2 diabetes mellitus the issues of treatment of combined pathology, diagnostic concentration of pro-inflammatory and anti-inflammatory cytokines, their role in pathogenesis and clinical presentation are still an open question. Certainly it is necessary to continue studying the cytokine status in patients with chronic obstructive pulmonary disease and type 2 diabetes mellitus to answer those questions.

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